Clinical trials: Androgens
Prostate Cancer
ASCVD Management Using CCTA in Prostate Cancer Patients on ADT
This is a randomized pilot study of Coronary CT Angiography (CCTA) for coronary atherosclerosis vs. Usual Care in patients with prostate cancer who are either planning to begin, or are currently taking androgen deprivation…
- Trial name
- NCT05879913
- Testing
- Coronary CT Angiography (CCTA)
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Polycystic Ovary Syndrome
Effects of Flutamide on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is the major cause of infertility in the United States. Many women with PCOS demonstrate insulin resistance and a compensatory hyperinsulinemia.This is due to both an intrinsic form of insulin…
- Trial name
- PCOS (NCT00729560)
- Testing
- Flutamide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Virginia Commonwealth University
Prostate Cancer
Lenalidomide and GM-CSF in Treating Patients With Prostate Cancer
RATIONALE: Lenalidomide may stop the growth of prostate cancer by blocking blood flow to the tumor. GM-CSF may stimulate the immune system in different ways and stop tumor cells from growing.
- Trial name
- NCT00939510
- Testing
- sargramostim, lenalidomide, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Robert Dreicer MD
Recurrent Prostate Cancer
Effects of Muscadine Grape Extract in Men With Prostate Cancer on Androgen Deprivation Therapy
It is estimated that one-third of the more than 7 million deaths from cancer worldwide are attributable to potentially modifiable risk factors, with 374,000 deaths preventable through diet modification alone.
- Trial name
- NCT03496805
- Testing
- MGE, ADT
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- Wake Forest University Health Sciences
Prostate Cancer Metastatic
Androgen Deprivation Therapy (ADT) Versus ADT Plus Prostate Cryotherapy for Metastatic Prostate Cancer (mPCa)
Patients with primary diagnosed metastatic prostate cancer are randomly divided into two groups. One group receive standard of care ADT continually. Another group receive ADT plus prostate cryotherapy.
- Trial name
- NCT03129854
- Testing
- prostate cryotherapy
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Sun Yat-sen University
Metastatic, Androgen Independent Prostate Cancer, Prostate Cancer
The Use of RAD001 With Docetaxel in the Treatment of Metastatic, Androgen Independent Prostate Cancer
The purpose of this study is to evaluate the safety and optimal dose of RAD001 and docetaxel plus prednisone in men with hormone refractory, metastatic prostate cancer (Phase I).
- Trial name
- NCT00459186
- Testing
- RAD001, Docetaxel, Prednisone
- Where
- 5 sites in United States
- Volunteers
- 19 people
- Sponsor
- Dana-Farber Cancer Institute
Turner Syndrome
Effects of Adrenal Androgens on Gender-typed Behavior in Girls With Turner Syndrome
Turner syndrome (TS) is a genetic disorder in which there is loss of all or part of the second X chromosome and occurs in 1/2500 live female births.
- Trial name
- NCT05346159
- Testing
- the correlation between level of adrenal androgen and gender-typed behavior in Girls with TS
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Sohag University
Prostate Cancer Metastatic
ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)
This is a Phase III, international, multicentre, randomised, double-blinded placebo controlled trial, evaluating the efficacy and safety of ADT +/- darolutamide in castration-naïve de novo metastatic prostate cancer patients with…
- Trial name
- GETUG-AFU 40 (NCT04916613)
- Testing
- Darolutamide 300 mg, Androgen deprivation therapy
- Where
- 95 sites in Belgium, France and 10 more
- Volunteers
- 300 people
- Sponsor
- UNICANCER
Prostate Cancer, Cardiovascular Diseases
CV CARE: CardioVascular Care in PC Patients
This research is being done to test a program to assess and manage reversible cardiovascular (CV) risk factors in participants with prostate cancer starting androgen deprivation therapy (ADT), with the goal of integrating a…
- Trial name
- NCT06202820
- Testing
- CV Care Program
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Dana-Farber Cancer Institute
Metastatic Castrate Resistant Prostate Cancer (mCRPC), Prostate Cancer (Adenocarcinoma)
A Study of Mevrometostat With Enzalutamide in People With Prostate Cancer Who Have Previously Received Androgen Receptor Pathway Inhibitor Therapy
The purpose of this study is to find out whether mevrometostat in combination with enzalutamide delays cancer progression in people with metastatic castration-resistant prostate cancer (mCRPC) who have previously received…
- Trial name
- MOMENT (NCT07592910)
- Testing
- Mevrometostat, Enzalutamide
- Volunteers
- 60 people
- Sponsor
- Prostate Cancer Clinical Trials Consortium
Prostate Cancer
Hormone Therapy Plus Radiation Therapy in Treating Patients With Prostate Cancer
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Hormone therapy using leuprolide and flutamide may fight prostate cancer by reducing the production of androgens.
- Trial name
- NCT00003124
- Testing
- flutamide, leuprolide acetate, radiation therapy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Herbert Irving Comprehensive Cancer Center
Hypoactive Sexual Desire Disfunction
Effects of Tribulus Terrestris in Women With Hypoactive Sexual Desire Disorder
Hypoactive Sexual Desire Disorder (HSDD) is the most prevalent female sexual dysfunction in society and is strongly linked to the quality of life of women.
- Trial name
- NCT01971099
- Testing
- tribulus terrestris
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Federal University of Minas Gerais
Neoadjuvant Therapy \ High Risk Prostate Cancer \ Docetaxel
Androgen Deprivation Therapy Combined With Docetaxel for High Risk Prostate Cancer
This randomized, controlled, single center clinical trial aims to evaluate the efficacy and safety of Androgen Deprivation Therapy Combined with Docetaxel for High Risk Prostate Cancer with a six-month treatment cycle.
- Trial name
- NCT04869371
- Testing
- Docetaxel injection, Triptorelin Pamoate for Injectable Suspension, Prednisone Acetate Tablets
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Hongqian Guo
Androgen Axis Suppression, Prostatectomy
PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.
1. Personalize treatment for prostate cancer based on how aggressive the disease is and 2. Learn if apalutamide-based treatment can help to reduce fatigue and other side effects of treatment in participants who are being treated…
- Conditions
- Androgen Axis Suppression, Prostatectomy, Prostate Cancer
- Trial name
- NCT06274047
- Testing
- Apalutamide, Androgen Deprivation Therapy
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer, Biochemical Recurrence
Salvage Radiotherapy Combined With Androgen Deprivation Therapy (ADT) With or Without Rezvilutamide in the Treatment of Biochemical Recurrence After Radical Prostatectomy for Prostate Cancer
To evaluate the efficacy and safety of rezvilutamide in combination with androgen deprivation therapy(ADT) and standard salvage radiation therapy(SRT) or SRT combination with ADT in prostate cancer patients with biochemical…
- Trial name
- NCT06305832
- Testing
- Rezvilutamide, Androgen deprivation therapy (ADT), SRT
- Where
- 2 sites in China
- Volunteers
- 102 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Prostate Cancer
Long-Term Safety and Tolerability of Degarelix One-Month Dosing Regimen in Korean Patients
This is an open-label, multi-centre single arm trial to investigate long-term safety and tolerability of degarelix in Korean patients with prostate cancer.
- Trial name
- NCT01215513
- Testing
- Degarelix
- Where
- 11 sites in South Korea
- Volunteers
- 127 people
- Sponsor
- Ferring Pharmaceuticals
Adenocarcinoma of the Prostate
Adjuvant Androgen Suppression Plus Radiation Therapy for High-Risk Localized Adenocarcinoma Prostate
To evaluate the efficacy of LHRH agonist with adjuvant pelvic radiation therapy in post radical prostatectomy patients with high risk pathological features for failure.
- Trial name
- NCT01255891
- Testing
- Androgen suppression plus radiation therapy
- Where
- 2 sites in Canada
- Volunteers
- 46 people
- Sponsor
- Dr. Tamim Niazi
Prostate Cancer
A Phase II Study of Ara-C (Cytarabine) in Men With Androgen Independent Prostate Cancer
This is a single-arm, open label phase II trial of the investigational agent, Ara-C (cytarabine), in patients diagnosed with hormone refractory prostate cancer whose disease has progressed on or deemed not suitable for standard…
- Trial name
- SLAP (NCT00480090)
- Testing
- Cytarabine
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer, Prostatic Neoplasms
PROWESS (PROstate Cancer Wearables Exercise and Structured Supports): A Pilot Supportive Care Intervention
The goal of this research study is to conduct an open pilot of a behavioral change intervention called PROstate Cancer Wearables, Exercise, and Structured Supports (PROWESS) for integrating health behavior change tools and to…
- Trial name
- NCT05755490
- Testing
- PROWESS
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Hypoactive Sexual Desire Disorder
Dehydroepiandrosterone (DHEA) Treatment in Women and Men Experiencing Hypoactive Sexual Desire Disorder
Hypoactive Sexual Desire Disorder (HSDD) is a common syndrome characterized by low sexual desire causing marked distress. The involvement of DHEA in sexual function is unknown, however, DHEA treatment increased desire in…
- Trial name
- NCT00916396
- Testing
- Dehydroepiandrosterone
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
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