Clinical trials: Anesthesia, Dental
Esketamine
Effect of Subanesthetic Dose Esketamine on Propofol-refentanil Closed-loop Targeted Controlled Infusion
The propofol-refentanil program-controlled closed-loop target-controlled infusion system based on NI guidance has been clinically verified.
- Trial name
- NCT05943028
- Testing
- Subanesthetic dose of esketamine
- Volunteers
- 48 people
- Sponsor
- bo xu
Anesthesia
Effects of One-handed and Two-handed Mask Ventilation Techniques on Global and Regional Lung Ventilation
Two-handed mask ventilation has been shown to provide higher tidal volume than one-handed mask ventilation. The effects of the two techniques on respiratory mechanics during induction of general anesthesia, however, still need to…
- Trial name
- NCT04617665
- Testing
- One-handed mask ventilation, Two-handed mask ventilation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fudan University
Nausea and Vomiting, Postoperative, Cesarean Delivery
Frequency of Occurrence and Risk Factors of Postoperative Nausea and Vomiting During Elective C-section Under Spinal Anesthesia With Preventive Medication
The aim of this study is to learn about the incidence and risk factors of nausea and vomiting during planned caesarean section under spinal anesthesia.
- Conditions
- Nausea and Vomiting, Postoperative, Cesarean Delivery, Spinal Anesthesia, Antiemetic Therapy
- Trial name
- NCT06927830
- Where
- 2 sites in Belgium
- Volunteers
- 400 people
- Sponsor
- University of Liege
Spinal Anesthesia, Local Anesthetic
Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia for Elective Infra-Umbilical Surgeries
Pediatric anesthesia presents distinctive challenges, particularly concerning appropriate dosage administration of local anesthetics for spinal anesthesia (SA).
- Conditions
- Spinal Anesthesia, Local Anesthetic, Bupivacaine
- Trial name
- NCT06801600
- Testing
- Weight-based dosing, Age-based dosing
- Volunteers
- 60 people
- Sponsor
- Cairo University
Hemodynamics
Remimazolam and Propofol Anesthesia in Elderly Patients
Remimazolam is a recently developed ultra-short agonist acting at the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)A receptor.
- Trial name
- NCT05201300
- Testing
- Remimazolam Besylate 6 mg/kg/hr, Remimazolam Besylate 12 mg/kg/hr, Propofol
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Ajou University School of Medicine
Incomplete Reversal of Neuromuscular Block, Postoperative Respiratory Complications
Multi-center Study of Residual Neuromuscular Block Incidence in the Post-anesthesia Care Unit
Residual neuromuscular block (RNMB) is frequent in the immediate postoperative period and is a source of complications, mainly respiratory. The incidence is variable due to multiple factors. In Spain the incidence is unknown.
- Trial name
- ReCuSS (NCT02226809)
- Testing
- Accelerometry
- Where
- 25 sites in Spain
- Volunteers
- 763 people
- Sponsor
- University of Valencia
Lumbosacral, Erector Spinae Plane Block
Lumbosacral Erector Spinae Plane Block Versus Psoas Muscle Compartment With Sciatic Nerve Block for Anesthesia for Unilateral Lower Limb Operations in Critically Ill Patients
This study aims to compare lumbosacral erector spinae plane block and psoas muscle compartment with sciatic nerve block in unilateral lower limb operations in critically ill patients.
- Conditions
- Lumbosacral, Erector Spinae Plane Block, Psoas Muscle Compartment Block, Sciatic Nerve Block
- Trial name
- NCT06580704
- Testing
- Lumbosacral Erector Spinae Plane Block, Psoas Muscle Compartment With Sciatic Nerve Block
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Tanta University
Hypotension on Induction
FloPatch for Prevention of Hypotension After Induction of General Anesthesia
This study is being conducted to find out if a special device called FloPatch™, which sticks to a persons skin and uses ultrasound to check the blood flow in their neck, can tell if someone going to have low blood pressure after…
- Trial name
- HI-CAP (NCT06316817)
- Testing
- FloPatch
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- Mount Sinai Hospital, Canada
Aging, Inflammation
Macrophage/Monocyte Driven Inflammation and Anesthetic Sensitivity in Aging
The goal of this observational study is to determine whether macrophage/monocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery.
- Conditions
- Aging, Inflammation, Blood-Brain Barrier Permeability, Anesthesia Brain Monitor
- Trial name
- MACRO-AGE (NCT07372417)
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Hemodynamic (MAP) Stability
Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean Section
In North America, norepinephrine, ephedrine, and epinephrine have been recommended as first-choice vasopressors for the treatment of spinal hypotension during cesarean delivery.
- Trial name
- NCT07480889
- Testing
- Epinephrine (Adrenaline) bolus then infusion, Epinephrine (Adrenaline) infusion
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Laparoscopic Surgery, Target Controlled Infusion
Comparison of Target Controlled Infusion Anesthesia and Inhalation Anesthesia in Pediatric Laparoscopic Surgeries
Comparison of Target Controlled Infusion Anesthesia and Inhalation Anesthesia in Pediatric Laparoscopic Surgeries
- Trial name
- NCT06571682
- Testing
- Target Controlled Infusion, Inhalation anesthetic
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Knee Osteoarthritis
Population Pharmacokinetics of Ropivacaine
The aim of this study was to investigate the pharmacokinetics of free and total ropivacaine after unilateral and bilateral TKA. A population model was successfully built and peak free ropivacaine concentration stayed below…
- Trial name
- NCT04702282
- Testing
- ropivacain concentration measurements
- Volunteers
- 28 people
- Sponsor
- Hvidovre University Hospital
Abdominoplasty
Abdominoplasty Under Epidural Anesthesia
Abdominoplasty is one of the most popular body-contouring procedures, yet it is also among the most hazardous aesthetic procedures currently performed.
- Trial name
- NCT01389635
- Where
- Israel
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Spinal Anesthesia
Spinal Anaesthesia for Knee Arthroscopy: Does Lignocaine Shorten the Effect of Bupivacaine
The purpose of the study is to investigate if a small amount of lignocaine added to bupivacaine for spinal anesthesia to patients planned for arthroscopic knee surgery, can shorten the duration of the sensoric and the motoric…
- Trial name
- NCT01245868
- Testing
- Lidocaine, bupivacaine
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Frederikssunds Hospital, Denmark
Anesthesia, Procedural Complication
Ultrasound Predictors of Difficult Spinal Anesthesia
This prospective observational study aims to investigate about the efficacy of spine ultrasound in predicting difficult spinal anesthesia
- Trial name
- SPINAL-US (NCT05115591)
- Testing
- Spinal Ultrasound, Spinal Anesthesia
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Campus Bio-Medico University
Neuromuscular Blockade, Anesthesia
Sugammadex Dosing: Anaesthesiologist Clinical Perception Versus Quantitative Monitoring
Many clinicians continue to rely on subjective evaluation in making decisions about the adequacy of neuromuscular function before tracheal extubation rather than using quantitative monitoring.
- Conditions
- Neuromuscular Blockade, Anesthesia, TOF, Curarization, Postoperative Residual
- Trial name
- NCT04762420
- Testing
- Dose of sugammadex according to SSD and QSD
- Where
- Portugal
- Volunteers
- 66 people
- Sponsor
- Hospital do Divino Espírito Santo de Ponta Delgada
Pain, Postoperative, Spinal Disease
Comparison of Ultrasound-guided Bilateral ESP Block and Wound Infiltration for Spinal Surgical Analgesia
The aim of our study is to determine the superior procedure in analgesia management by comparing the traditional wound infiltration technique with the ultrasound-guided bilateral erector spina plan block technique in spinal…
- Conditions
- Pain, Postoperative, Spinal Disease, Anesthesia, Local, Anesthesia, Regional
- Trial name
- NCT04642625
- Testing
- Visual Analog Score, patient satisfaction
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Trakya University
Preeclampsia
Ephedrine, Phenylephrine and Metaraminol Effects on Maternal Cardiac Output, Uterine Blood Flow and Fetal Circulation
It is a prospective clinical trial with random distribution that intends to investigate maternal and fetal effects of ephedrine, phenylephrine and metaraminol during cesarean delivery in patients with pre-eclampsia.
- Trial name
- NCT02245191
- Testing
- Ephedrine, Phenylephrine, Metaraminol
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Hypospadia, Phimosis
Intelligence Changes Following Minor Surgery
Animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. However results from human studies are conflicted.
- Conditions
- Hypospadia, Phimosis, Inguinal Hernia
- Trial name
- NCT01483313
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- RenJi Hospital
Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Correlation Between VCL, AC and Spread of Intrathecal Hyperbaric Bupivacaine in the Term Parturient
Currently there is no guideline to decide on the most appropriate dose of spinal anaesthesia. This study is planned to find out factors that influence the effect of spinal anaesthesia in pregnant mother going for Caesarean…
- Trial name
- NCT03606525
- Testing
- subarachnoid block
- Where
- Malaysia
- Volunteers
- 130 people
- Sponsor
- University of Malaya