Clinical trials: Anesthesia, Inhalation
Airway Complication of Anesthesia, Ventilation Therapy; Complications
Structural Modification In Supraglottic Airway Device
The proposed A/Z modification of a supraglottic airway (SGA) incorporates an opening in the SGA body that enables access to the endotracheal tube (ETT) through the body of the SGA without the need of using an exchange catheter…
- Conditions
- Airway Complication of Anesthesia, Ventilation Therapy; Complications, Hypoxia, Hypoventilation
- Trial name
- NCT04498598
- Testing
- A/Z Supraglottic airway
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The Cleveland Clinic
Lung Cancer, OLV
Spontaneous Breathing Mode: A Risk for Hypoxemia During OLV?
Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch.
- Conditions
- Lung Cancer, OLV, Hypoxemia During Surgery
- Trial name
- OLV (NCT07494006)
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
Laparoscopic Surgery, Target Controlled Infusion
Comparison of Target Controlled Infusion Anesthesia and Inhalation Anesthesia in Pediatric Laparoscopic Surgeries
Comparison of Target Controlled Infusion Anesthesia and Inhalation Anesthesia in Pediatric Laparoscopic Surgeries
- Trial name
- NCT06571682
- Testing
- Target Controlled Infusion, Inhalation anesthetic
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Anesthesia Intubation Complication, Mechanical Ventilation Complication
Endotracheal Tube Audible Leak Test
The endotracheal tube (ETT) leak test (LT), or audible leak test is a widely performed assessment to verify appropriate tube size in neonates, infants and children.
- Trial name
- NCT02461017
- Testing
- Assess for Audible Endotracheal Leak, Assess for Endotracheal Leak with direct visualization under rigid bronchoscope
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Mississippi Medical Center
Inhalation Anesthesia
Comparing Nebulized Ketamine,Nebulized Ketamine and Precedex and IM Ketamine for Analgesia in Pediatric Burn
The present study compares efficacy of nebulised ketamine and combination of nebulised dexmedetomidine and ketamine and intramuscular ketamine for procedural sedation and analgesia in pediatric burn injuries
- Trial name
- NCT07086690
- Testing
- Group (1): Patients will receive nebulized ketamine (2 mg/kg), Group (2): Patients will receive nebulized combination of dexmedetomidine and ketamine (1 μg/kg + 1 mg/kg), Patients will receive intramuscular ketamine (4 mg/kg, intramuscularly) 15 mins before starting the procedure.
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Ventilatory Depression
Correlation of ETCO2 to PaCO2 Measured by Sentri Nasal Cannula
Sampling end tidal gas via nasal prong has been shown to be a noninvasive and reliable method of monitoring end-tidal CO2 in spontaneously breathing patients.
- Trial name
- NCT03374644
- Testing
- SentriTM ETCO2 adult nasal cannula
- Volunteers
- 40 people
- Sponsor
- University of Malaya
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Microsurgical Free Flaps
Sevoflurane Protective Effect on Ischemia-reperfusion Injury. Multicenter, Randomized Controlled Trial
This study aimed to evaluate the possible protective effect of anesthetic technique balanced(with sevoflurane) compared with total intravenous anesthetic technique (propofol,remifentanil).
- Trial name
- NCT01905501
- Testing
- Balanced anesthesia, Total intravenous anesthesia
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Regina Elena Cancer Institute
Acute Ischemic Stroke Patients
Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke
This study is being done to compare outcomes after surgery for individuals who receive anesthesia through by inhaling medication and individuals who receive anesthesia intravenously by needle when experiencing treatment for their…
- Trial name
- NCT07001267
- Testing
- Anesthesia drugs during the surgery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Kansas Medical Center
Airway Management, Induction of Anesthesia
The 90% Effective Ventilation Pressure (EP90) for Esophageal Insufflation Avoidance During Anesthesia Induction
Exploring the 90% Effective Ventilation Pressure (EP90) for Esophageal Insufflation Avoidance During Anesthesia Induction: The aim is to determine the optimal ventilation pressure for esophageal insufflation avoidance during…
- Trial name
- NCT07340255
- Testing
- Ultrasonic and inflation determination
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Cough
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK2339345.
This is a study of the sodium channel inhibitor, GSK2339345. Cohort 1 will assess the safety, tolerability and PK of single ascending doses of GSK2339345 administered via an aqueous droplet inhaler in healthy subjects.
- Trial name
- NCT01587716
- Testing
- GSK2339345 (Inhaled) Single Dose, GSK2339345 (Inhaled) Repeat Dose
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anesthesia, General, Electroencephalography
Anesthesia and EEG Discontinuity in Infants
This study is a randomized controlled trial to evaluate whether EEG-guided calibration of inhalation agents can reduce occurrence of EEG discontinuity in infants during general anesthesia.
- Conditions
- Anesthesia, General, Electroencephalography, Infant, Anesthesia, Inhalation
- Trial name
- NCT05906225
- Testing
- EEG guided anesthesia, Conventional anesthesia
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Hospital
Fospropofol Disodium
Effects of Fospropofol Disodium TIVA and IVIH on Surgical Field Quality in Adult ESS
Endoscopic sinus surgery (ESS) is a primary surgical approach for treating chronic rhinosinusitis, nasal polyps, and other conditions that are unresponsive to conservative therapy.
- Trial name
- NCT07788157
- Testing
- Fospropofol disodium, Propofol
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Tongji Hospital
Lower Eyelid Bags
The Effect of Inhalation Aromatherapy on Intraoperative Fear in Patients Undergoing Lower Blepharoplasty Under Local Anesthesia: A Randomized Controlled Trial
This study is a single-center, randomized, controlled, open-label clinical trial designed to evaluate the intervention effect of inhaled aromatherapy on intraoperative fear in patients undergoing lower blepharoplasty (eyelid bag…
- Trial name
- NCT07766902
- Testing
- inhaled aromatherapy
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Surgery-Complications, Anesthesia Complication
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major…
- Conditions
- Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia
- Trial name
- THRIVE (NCT05991453)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 24 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- Washington University School of Medicine
Abdominal Surgery
Effects of ACBT and Blow Bottle Technique in Patients With Abdominal Surgeries Under General Anesthesia
A postoperative pulmonary complication (PPC) is the most common serious complication after Abdominal surgery under GA which lead to longer hospital stays and have deleterious outcomes on lung volumes, mucociliary clearance…
- Trial name
- NCT06454305
- Testing
- Active cycle of breathing technique, Blow Bottle Technique
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Pulmonary Atelectasis
Fraction of Inspired Oxygen and Atelectasis in Children
Investigators hypothesized that maintaining low fraction of inspired oxygen would be beneficial to prevent anesthesia-induced atelectasis in mechanically ventilated children undergoing general anesthesia.
- Trial name
- NCT02870842
- Testing
- Lung ultrasound, Respiratory management
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Hospital
Respiratory Function Tests, Anesthesia, General
PSV on Ventilation Inhomogeneity and Lung Function in Patients Under SB Across LMA
General anesthesia has been demonstrated to have a negative impact on lung function. Both surgery and patient position influence the perioperative lung function.
- Conditions
- Respiratory Function Tests, Anesthesia, General, Patient Positioning, Ventilation
- Trial name
- VINHO (NCT02986269)
- Testing
- general anesthesia across LMA, Spontaneous breathing(SB), Pressure Support Ventilation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Walid HABRE
Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists
Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying
This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients.
- Conditions
- Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists, Intermittent Fasting, Intraoperative Complication Due to Anesthesia
- Trial name
- NCT07140289
- Testing
- Ultrasound of gastric contents
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wael Saasouh, MD
Video-assisted Thoracoscopic Lung Surgery；Anesthesia
Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS
Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery.
- Trial name
- NCT06367218
- Testing
- opioid based strategy, opioid-free strategy, Laryngeal mask airway; Preserved spontaneous breathing
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Tongji Hospital