Clinical trials: Anesthesia, Recovery
Postoperative Delirium
EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients
The investigators intend to recruit 600 participants to see if alpha power during anesthesia is influenced by analgesic medication and associated with a reduction of delirium following surgery.
- Trial name
- ALPHA-DEX (NCT04443517)
- Testing
- Alpha Optimization, Emergence from anesthesia with Dexmedetomidine
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Columbia University
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia
General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Postoperative, Anesthesia Recovery Period
- Trial name
- NORA (NCT06905340)
- Testing
- NOL (Nociception Level Index), Control (Standard treatment)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Brain Neoplasms, Surgery
Small-dose Dexmedetomidine Effects on Recovery Profiles of Supratentorial Tumors Patients From General Anesthesia
An excellent recovery profile is critical for neurosurgical anesthesia. Rapid awakening, smooth blood pressure and heart rate (HR), a higher degree of coordination, painless or mild pain, as well as better tolerance to…
- Trial name
- NCT02007798
- Testing
- dexmedetomidine, normal saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China Medical University, China
Breast Cancer
The Effect of Ultrasonography-guided Fascial Plane Blocks in Breast Cancer Surgery Patients
The aim of this study was to evaluate the efficacy of serratus anterior plane (SAP) block, pectoserratus plane (PECS II) block, and erector spinae plane (ESP) block on postoperative acute pain, quality of recovery and chronic…
- Trial name
- NCT06419504
- Testing
- SAP block group, PECS II block group, ESP block group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Antalya Training and Research Hospital
Deep Brain Stimulation Surgery, Electrophysiology
Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp…
- Conditions
- Deep Brain Stimulation Surgery, Electrophysiology, General Anesthesia, Consciousness, Loss of
- Trial name
- NCT06400901
- Testing
- No interventions
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Ruijin Hospital
Anesthesia, Analgesia
Genetic Variants and Perioperative Morbidity and Mortality
Prospective association study to analyse perioperative patients' outcome. Outcome comprises intraoperative and postoperative complications e.g.
- Conditions
- Anesthesia, Analgesia, Surgical Procedure, Operative
- Trial name
- NCT02124499
- Where
- Switzerland
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pain, Postoperative, Pain, Acute
Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective laparoscopic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04858711
- Testing
- ketamine-lidocaine-dexmedetomidine, fentanyl
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Anesthesia and Thirst
Effect of Small-volume Oral Spray in the After Anesthesia Recovery Room for Thirst Patients
Currently, there are limited studies performed on the treatment of perioperative thirst and the methods provided by literature possess a risk of choking.
- Trial name
- NCT05172648
- Testing
- oral spry, Cotton swab
- Where
- Taiwan
- Volunteers
- 209 people
- Sponsor
- National Taiwan University Hospital
Opioid Free Anesthesia, Laparoscopic Bariatric Surgeries
Opioid Free Anesthesia Versus Opioid Based Anesthesia
This Study aims to evaluate the efficacy of opioid free general anesthesia in achieving enhanced recovery after surgery (ERAS) in laparoscopic bariatric surgery in terms of post-operative recovery time, cumulative pethidine…
- Trial name
- NCT06650371
- Testing
- Fentanyl infusion, Dexamedomedine and ketamine infusion
- Volunteers
- 36 people
- Sponsor
- Ain Shams University
Quality of Life, Pain, Postoperative
Quality of Recovery After General or Spinal Anesthesia for Inguinal Hernia Repair
Different anesthetic techniques have been proposed for carrying out Inguinal hernia repair, including local anesthesia, regional and general.
- Conditions
- Quality of Life, Pain, Postoperative, Personal Satisfaction, Postoperative Complication
- Trial name
- NCT02696122
- Testing
- Local Group, Spinal anesthesia
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Hypothermia Following Anesthesia, Hypothermia; Anesthesia
Preoperative Warming, Hypothermia and Functional Recovery in Total Hip Arthroplasty
This prospective, randomized, single-center study compares intraoperative heat loss at the core temperature level in patients scheduled for direct anterior total hip arthroplasty under general anesthesia and who will or will not…
- Trial name
- NCT05213377
- Testing
- Preoperative warming
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University of Liege
Mastectomy, Pain, Postoperative
Erector Spina Plane Block vs Serratus Anterior Plane Block for Postoperative Mastectomy Pain
The aim of this study is to compare the efficiency of serratus anterior plane block and erector spina plane block on analgesic consumption, postoperative pain and patient's satisfaction and recovery quality in patients undergoing…
- Conditions
- Mastectomy, Pain, Postoperative, Recovery Period, Anesthesia
- Trial name
- NCT04296188
- Testing
- serratus anterior plane block, erector spina plane block
- Volunteers
- 60 people
- Sponsor
- Tokat Gaziosmanpasa University
Anesthesia, Healthy
REcovery From DEXmedetomidine-induced Unconsciousness
This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography…
- Conditions
- Anesthesia, Healthy, Consciousness, Level Altered
- Trial name
- REDEX (NCT06003127)
- Testing
- Transcranial Magnetic Stimulation-Electroencephalography
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Motility Function
Esophageal Manometry During Recovery From Anesthesia: Pilot Study
1. An intact pharyngoesophageal reflex is essential to protect the upper airway from aspiration of either mouth contents or regurgitated gastric refluxate. This reflex is essential at protecting the airway in all patients. 2.
- Trial name
- EMAP (NCT02661386)
- Testing
- Motility Procedure
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Early Recovery in Elderly Patients, Cognitive Function
Effects of Sevoflurane vs Desflurane on Early Recovery and Cognitive Function in Elderly Patients Undergoing Scheduled Non-Cardiac Surgery
The goal of this clinical study is to compare the effects of desflurane versus sevoflurane on early postoperative recovery and cognitive function in elderly patients (aged 60 years and older, ASA I-III) undergoing elective…
- Trial name
- NCT07289945
- Testing
- Sevoflurane, Desflurane
- Where
- Tunisia
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Hopital Charles Nicolle
Postoperative Quality of Recovery, Postoperative Quality of Recovery in the Postanesthesia Care Unit
Quality of Recovery in the Post-anesthesia Care Unit
This prospective observational study aims to identify the minimal clinically important difference of the QoR-PACU2 questionnaire.
- Trial name
- MiDiQoR (NCT06905353)
- Volunteers
- 188 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Shoulder Arthroscopy
Comparison of Postoperative Quality of Recovery by Anesthetic Method in Patients Undergoing Shoulder Arthroscopy
The aim of this study is to compare the quality of recovery in patients undergoing arthroscopic shoulder surgery depending on the type of anesthesia used: 1.
- Trial name
- NCT06638112
- Testing
- Brachial Plexus Block, General Anesthesia (control group)
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital
Recovery From Anesthesia
Improved Patient Recovery After Anesthesia
The proposed study will measure the incidence of adverse events and the decrease in time to meet discharge criteria from the post anesthesia care unit when hypercapnic and hyperpnoea are used during emergence.
- Trial name
- NCT01477398
- Testing
- QED-100
- Volunteers
- 31 people
- Sponsor
- University of Utah
Aneurysm Cerebral
Dexmedetomidine Improves Recovery After Cranial Aneurysm Surgery
Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries.
- Trial name
- DACA (NCT03355534)
- Testing
- Intravenous dexmedetomidine, nasal dexmedetomidine, intravenous saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zhihong LU
Recovery From Anesthesia
The Effect of Preoperative Aminophylline
Several clinical studies and case reports suggested that aminophylline antagonizes the effects of diazepam , barbiturates , sevoflurane ,morphineand propofol.However, the available results from uncontrolled clinical settings make…
- Trial name
- NCT04151381
- Testing
- Aminophylline
- Where
- 2 sites in Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University