Clinical trials: Anesthesia,Obstetrical
Post-Dural Puncture Headache
Effect of Small Versus Large Epidural Needles on Postdural Puncture Headache Study
The purpose of this study is to determine the effect of 19g versus =>18g traditional Tuohy-type epidural needles on the incidence and severity of postdural puncture headache (PDPH).
- Trial name
- NCT00370604
- Testing
- 19g Tuohy-type epidural needle, 23g catheter, => 18g Tuohy-type needle
- Where
- 4 sites in Canada
- Volunteers
- 1,081 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Postdural Puncture Headache, Postoperative Nausea and Vomiting
Ondansetron and Dexamethasone for Prevention of PDPH, Nausea, and Vomiting
This prospective, randomized, double-blind, placebo-controlled study was conducted at the Obstetrics and Gynecology Department of El-Minia University Hospital from October 2018 to October 2019.
- Conditions
- Postdural Puncture Headache, Postoperative Nausea and Vomiting, Obstetric Anesthesia Problems
- Trial name
- PDPH-N/V (NCT07068230)
- Testing
- Ondansetron 8mg, Dexamethasone, Saline
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Pregnancy
Intrathecal Clonidine in Cesarean Section May Lead to Worse Blood Gas Results in the Newborns
The purpose of this study is to evaluate effects of intravenous clonidine in acute and chronic post-cesarean pain, possible adverse effects over mother-newborn pair, in comparison to intrathecal adjuvant clonidine and placebo.
- Trial name
- NCT02550444
- Testing
- Intrathecal Clonidine, Intravenous Clonidine
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Hypotension
Hemodynamic Monitoring in Obstetrics
Spinal anesthesia has long been considered the first choice technique in caesarean section, but although it is a reliable and safe procedure, it is in some cases associated with undesirable effects.
- Trial name
- NCT03755271
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- University of Catania
Cesarean Section, Pregnancy
Intra-abdominal Pressure, Abdominal Circumference, and Spinal Block Level in Cesarean Section
Spinal anesthesia is commonly used for cesarean section and provides effective anesthesia with rapid onset. However, the spread of spinal anesthesia may vary among pregnant women due to physiological and anatomical changes during…
- Conditions
- Cesarean Section, Pregnancy, Elective Cesarean Section
- Trial name
- NCT07406373
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Kutahya Health Sciences University
Obese, Cesarean Section
Conventional Palpation Versus Ultrasound Assisted Spinal Anesthesia in Obstetrics
Spinal anesthesia in obese parturients is commonly difficult yet there are no guidelines to direct best practice. The failure leads to suboptimal patient outcomes.
- Conditions
- Obese, Cesarean Section, Anesthesia Spinal
- Trial name
- NCT05846100
- Testing
- Preprocedural spinal ultrasound, fictional preprocedure spinal ultrasound
- Where
- Tunisia
- Volunteers
- 90 people
- Sponsor
- Mongi Slim Hospital
Epidural, Labor Pain
Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour
Labour pain can be intensified for labour inductions and women undergoing inductions often have earlier and more frequent requests for analgesia.
- Conditions
- Epidural, Labor Pain, Induction of Labor Affected Fetus / Newborn, Obstetric Anesthesia Problems
- Trial name
- NCT04011098
- Testing
- Epidural Fentanyl Bolus, Standard Epidural Group
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
High Risk Pregnancy, Multidisciplinary Communication
The Center for Peripartum Optimization
In January 2017 investigators started a Center for Peripartum Optimization (CPO) with the aim of optimizing a patient's clinical status in an outpatient setting to minimize unnecessary laboratory tests and studies, costly…
- Conditions
- High Risk Pregnancy, Multidisciplinary Communication, Communication, Obstetric Complication
- Trial name
- NCT03522909
- Testing
- Seen in clinic
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Neurodevelopmental Disorders, Behavior
Effect of Obstetric Anesthesia and Delivery Mode On Neurodevelopmental And Behavioural Outcomes In A Population-Based Birth Cohort
The study aims to determine: 1. The association between Obstetric anesthesia events at delivery (such as mode of anesthesia, drugs given, desaturation and hypotension) on pediatric neurodevelopmental and behavioural outcomes. 2.
- Trial name
- NCT05196750
- Testing
- Behavioural questionnaires and assessments on mother and child
- Where
- 2 sites in Singapore
- Volunteers
- 1,176 people
- Sponsor
- National University Hospital, Singapore
Hypotension
Up-Down Determination of the ED90 of Metaraminol to Treat Hypotension During Cesarean Section
The purpose of this study is to find the best dose of metaraminol to be used in patients during elective cesarean sections.
- Trial name
- NCT01108874
- Testing
- Metaraminol
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Anesthesia, Obstetrical, Anesthesia, Spinal
Phenylephrine and Hypotension During Spinal Anesthesia for Cesarean Section
Pregnant women with a positive preoperative Supine stress test were found to be a subgroup at increased risk of symptomatic hypotension after spinal anesthesia
- Trial name
- NCT02958215
- Testing
- Phenylephrine
- Where
- Egypt
- Volunteers
- 980 people
- Sponsor
- Assiut University
Infectious Complications (Epidural Abscess or Meningitis), Obstetrical Neuraxial Anaesthesia
Primary Immunodeficiencies and Obstetrical Neuraxial Anaesthesia
The purpose of this study is to evaluate if neuraxial anesthesia (epidural or intradural anesthesia) used during childbirth is associated with more frequent infectious complications in patients with primary immunodeficiencies…
- Trial name
- ANEU-DIP (NCT06449066)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, Spinal, Anesthesia, Obstetrical
The Effect of Injection Rate of Local Anesthetic in Caesarean Section
This randomized double-blind study aimed to compare the effects of two different subaracnoid lokal anesthetic injection rate in cesarean section. Totally 67 patients were included.
- Trial name
- NCT05091294
- Testing
- Local anesthetic injection rate in spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Preeclampsia
Peripartum Anesthetic Management of Patients With Preeclampsia
The investigators will conduct a prospective, observational multicentral international study of perioperative management of patients with preeclampsia.
- Trial name
- NCT05237011
- Where
- Israel
- Volunteers
- 1,500 people
- Sponsor
- Shaare Zedek Medical Center
Anesthesia, Obstetrical
The Comparison Of Nerve Blocks In Cesarean Delivery
The purpose of this study is to investigate the effect of different kinds of popular peripheral nerve blocks for postoperative analgesia after cesarean delivery is completed, compared with traditional epidual analgesia.
- Trial name
- NCT03333902
- Testing
- QLB, Intravenous patient controlled analgesia (PCA)
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Feng Xia
Twin Pregnancy, Neonate
Neonatal Outcomes in Twin Pregnancies
Multiple pregnancies are associated with increased maternal and fetal risks compared to singleton pregnancies. Additionally, the cesarean section rate is quite high in multiple pregnancies.
- Trial name
- NCT05104255
- Testing
- Spinal anesthesia, General anesthesia
- Volunteers
- 527 people, healthy volunteers welcome
- Sponsor
- Derince Training and Research Hospital
Anesthesia
Automated UltraSound Software for Identification of Lumbar Vertebral Levels
A novel automated ultrasound software system has been developed which identifies for the practitioner the intervertebral spaces in the lumbar area.
- Trial name
- AUSSI (NCT02982317)
- Testing
- Manual palpation identification lumbar spine, Automated ultrasound technology identification, Lumbar level identification gold standard ultrasound
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- University of British Columbia
Obstetrics: Elective Caesarean Delivery
Effects of Spinal Anesthesia on the Fetal Autonomic Nervous System
Elective cesarean deliveries account for over 10% of births in France and are often scheduled around 39 weeks of gestation. When feasible, spinal anesthesia is considered the gold standard in such a clinical situation.
- Trial name
- RACHISNA (NCT07333729)
- Testing
- Recording of fetal and maternal heart rate
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Labor Pain
The Effect of a Culturally Sensitive Educational Intervention on Acceptance of Neuraxial Anesthesia
The purpose of this study is to see if an educational intervention provided to pregnant women in early labor has an effect on their decision to use epidural anesthesia for relief of labor pain.
- Trial name
- NCT02672397
- Testing
- Additional Epidural Education
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Obstetric Anesthesia Problems, Placenta Accreta
Fibrinogen Concentrate and Placenta Acreta Spectrum
The aim of this study is to evaluate the relationship between fibrinogen use and bleeding in patients who underwent cesarean section with a prediagnosis of PAS.
- Trial name
- NCT05938062
- Testing
- the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital