Clinical trials: Anesthesia; Functional
Morbidity, Mortality
Outcome of Patients After Total Knee Replacement: A Comparison of Femoral Nerve Block and Epidural Anesthesia
Total knee replacement is very common in Germany. After surgery patients have severe pain in the knee; initiation of the physiotherapy, however, is important in the first three days after surgery.
- Conditions
- Morbidity, Mortality, Complications, Function
- Trial name
- NCT01631799
- Testing
- Femoral catheter, Epidural catheter
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Rostock
Ventilator Lung, Anesthesia; Functional
Minimal Flow Application in One Lung Ventilation
Interest in low fresh gas flow anesthesia has increased in recent years. The high standard of anesthesia machines, the presence of monitors that continuously and thoroughly analyze the anesthetic gas composition, and the…
- Trial name
- NCT04376307
- Testing
- minimal flow anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Breast Cancer
Effects of Dexmedetomidine on Breast Cancer Cell Function in Vitro
Dexmedetomidine is widely used as an anaesthetic for general anesthesia during surgery. Previous studies in cells and animals show that dexmedetomidine may promote cancer growth.
- Trial name
- NCT03108937
- Testing
- Dexmedetomidine, saline
- Where
- China
- Volunteers
- 24 people
- Sponsor
- RenJi Hospital
Regional Anesthesia Morbidity, Complication Following Peripheral Nerve Block
Comparison of the Effects of Interscalene Block and Superior Trunk Block on Pulmonary Functions
The interscalene block (ISB) is one of the peripheral nerve blocks providing surgical anesthesia and postoperative analgesia in shoulder arthroscopy, eliminating the need for general anesthesia.
- Conditions
- Regional Anesthesia Morbidity, Complication Following Peripheral Nerve Block, Phrenic Nerve Paralysis
- Trial name
- NCT06703281
- Testing
- Interscalene Nerve Block, Superior trunk block
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Gazi University
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Kasai Operation, Biliary Atresia
The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai Operation
Biliary atresia (BA) is a perinatal disease of unclear etiology, characterized by inflammation and obliteration of intrahepatic and extrahepatic bile ducts, leading to cholestasis and cirrhosis.
- Trial name
- NCT01443572
- Testing
- desflurane anesthetics, sevoflurane anesthetics
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Oxygenation Index
Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia
This was a multicenter, prospective, parallel-grouping, randomized controlled clinical study comparing low FiO2 (40%) and high FiO2 (80%) levels in older patients undergoing laparoscopic gastrointestinal surgery.
- Trial name
- NCT06359106
- Testing
- 80% Oxygen, 40% Oxygen
- Where
- 16 sites in China
- Volunteers
- 1,176 people
- Sponsor
- China Medical University, China
Pain, Postoperative, Anesthesia, Local
Postoperative Analgesia in Laparoscopic Abdominal Surgery After Exparel Via TAP or Local Infiltration
This study evaluates differences in how administering liposomal bupivacaine via two different methods affects postoperative pain control in laparoscopic abdominal surgery patients.
- Conditions
- Pain, Postoperative, Anesthesia, Local, Anesthesia; Functional, Anesthesia
- Trial name
- NCT03927326
- Testing
- Exparel 266 MG Per 20 ML Injection
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Washington
Anesthesia
Transesophageal Echocardiographic Evaluation of the Effect of Dexmedetomidine Infusion as an Adjuvant to General Anesthesia on the Cardiac Function
Dexmedetomidine is a selective alpha-2 adrenergic agonist that can be considered as an adjuvant to propofol or inhalational anesthetics.
- Trial name
- NCT02300649
- Testing
- Dexmedetomidine, Transesophageal echocardiography(TEE), Saline will be infused for 60 minutes at the same rates as dexmedetomidine group.
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Heart Rate Low, Anesthesia; Functional
A Study on Safety and Efficacy of Propofol in Small Children Under 2 Years of Age
This retrospective study the safety and efficacy of intravenous propofol used in children under 2 years of age during general anesthesia for surgery.
- Trial name
- NCT03132688
- Testing
- Propofol
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Achilles Tendon Rupture, Percutaneous Repair
Comparison of Functional Bracing vs Rigid Immobilization After Modified Percutaneous Achilles Tendon Repair
Rationale There is ongoing controversy over the optimal treatment and rehabilitation strategy of an acute Achilles tendon rupture (ATR).
- Conditions
- Achilles Tendon Rupture, Percutaneous Repair, Local Anesthesia, Postoperative Complications
- Trial name
- NCT04692883
- Testing
- Percutaneous suturing
- Where
- Slovenia
- Sponsor
- University Medical Centre Maribor
Cognitive Impairment, Femoral Fractures
Sedation and Postoperative Cognitive Functions
Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study.
- Trial name
- NCT05737459
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Surgical Complications From General Anesthesia, Hypertension
Monitoring Hypertensive Patients's Cerebral Oxygen Saturation
The purpose of this study is to determine whether there is a significant decrease in cerebral oxygen saturation in hypertensive patients undergoing major abdominal surgery and their correlation with standard monitoring parameters.
- Conditions
- Surgical Complications From General Anesthesia, Hypertension, Cerebral Ischemia, Cerebral Anoxia
- Trial name
- MHPCOS (NCT02147275)
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Huazhong University of Science and Technology
Anesthesia, Pain
Nitrous Oxide Neuroimaging
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide.
- Conditions
- Anesthesia, Pain, Amnesia
- Trial name
- NONI (NCT06702631)
- Testing
- Nitrous oxide, Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Anesthesia; Functional, Anesthesia
The Efficacy of 20 mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery
This clinical trial aims to investigate the efficacy of 20 mg Parecoxib when it is given as an addition to 20 ml 0.75% ropivacaine in patients receiving ultrasound-guided supraclavicular brachial plexus block prior to the upper…
- Trial name
- RCT (NCT03480165)
- Testing
- Parecoxib 20 MG/ML, Ropivacaine
- Where
- Malaysia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Postoperative Complications
Effects of Procedure Started in the Morning and Afternoon on Early Postoperative Sleep Function and Postoperative Recovery in Patients Under General Anesthesia
The present study was conducted in laparoscopic hysteromyoma patients, aiming to compare the effects of morning surgery with afternoon surgery on early postoperative sleep function and postoperative recovery under general…
- Trial name
- NCT04103528
- Testing
- morning surgery, afternoon surgery
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Labour Analgesia, Epidural Anaesthesia
An Observational Study Investigating the Positioning of Epidural Catheters and Their Function During Labour Analgesia
This is a small observational study investigating the physical changes that occur to epidural catheters after insertion for obstetric anaesthesia.
- Trial name
- NCT02924779
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rotkreuzklinikum München gGmbH
Laparoscopic Surgery
Effects of Continuous Dexmedetomidine Infusion on Systemic Microvascular Function in Laparoscopic Cholecystecthomy
The microcirculation represents the primary site of exchange of oxygen and nutrients for tissues, and the preservation of microcirculatory perfusion is essential for the maintenance of organ function.
- Trial name
- NCT04946396
- Testing
- dexmedetomidine intravenous infusion, 0.9%sodium chloride
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Anesthesia
Perioperative Audio for Anaesthesia
Induction and emergence from propofol can be a difficult process for patients and healthcare workers, and long recovery times in particular can limit the rate of care.
- Trial name
- NCT05291832
- Testing
- Brain.fm Music, Spectrally-matched Noise
- Where
- United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Brain.fm, Inc.
Endoscopic Sinus Surgery
PRD-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the utility of Pupillary Dilatation Reflex (PRD) for monitoring pain perception intraoperatively and its influence on intraoperative blood loss, quality of surgical field using…
- Trial name
- FESSPRD (NCT03417206)
- Testing
- Remifentanil, pupillary dilatation reflex
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia