Clinical trials: Anesthesia; Reaction
Trachea Intubation
Surgical Pleth Index: Predicting the Optimal Timing for Tracheal Intubation During General Anesthesia
Surgical pleth index (SPI) has been widely investigated in assessing the nociceptive level, and tracheal intubation is a noxious stimulus during the induction of anesthesia.
- Trial name
- NCT04608240
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Fudan University
Hernia, Anesthetics Adverse Reaction
Local or Regional or General Anesthesia for Hernia Repair: a Randomized Controlled Trial
This present randomized trial is designed to evaluate the postoperative pain,inflammatory marker, postoperative analgesic medication, length of hospital stay and the modifications of inflammatory mediators in patients undergoing…
- Conditions
- Hernia, Anesthetics Adverse Reaction, Inflammation
- Trial name
- NCT01845376
- Testing
- local anesthesia group, spinal anesthesia group, general anesthesia group
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Mingkwan Wongyingsinn, MD
Postoperative Pain, Reaction; Anesthesia
Transversus Abdominis Plane Block for Pain Relieve in Children Undergoing Groin Surgery
For surgery in the region of the lower abdominal wall the administration of local anesthetic drugs in the epidural space via the caudal route is the preferentially used technique since several decades.
- Trial name
- TAP (NCT00970086)
- Testing
- Bupivacain/levobupivacaine
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Basel, Switzerland
Delayed Recovery From Anaesthesia
Measurement of Psychomotor Recovery After Anesthesia Using 4CRT
The aim of the investigation is to validate the SmartPhone-based 4-Reaction Choice Time Test (4CRT) as a measure for recovery of the psychomotor function in patients after general anesthesia.
- Trial name
- 4CRT (NCT02232139)
- Testing
- Midazolam
- Where
- Germany
- Volunteers
- 124 people
- Sponsor
- University Medicine Greifswald
Analgesic Adverse Reaction
Psoas Compartment Block (PCB) Versus L.A Infiltration and Remifentanil Infusion During EVAR
Endovascular aneurysm repair (EVAR) was introduced in 1990 for the first time as a minimally invasive procedure instead of the conventional open surgical repair, with the aim to decrease morbidity and mortality .
- Trial name
- NCT03443518
- Testing
- Psoas Compartment Block (PCB), Local Anesthesia infiltration, Normal saline 0.9% IV infusion
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- Dr. Erfan and Bagedo General Hospital
Hypersensitivity Reaction
Serum Tryptase Concentration During General Anaesthesia With Rocuronium
Rocuronium is a aminosteroid structured, non-depolarizing neuromuscular blocking agents (NMB). Epidemiological data presents that the frequency of hypersensitivity reactions caused by rocuronium have been increased.
- Trial name
- NCT04035707
- Testing
- Rocuronium, general volatile anaesthesia
- Volunteers
- 126 people
- Sponsor
- Medical University of Bialystok
Obstetric Anesthesia Problems, Bupivacaine Adverse Reaction
Thoraco Lumbar Vertebral Length and Bupivacaine Dosage in C-Section
Our hypothesis is that the bupivacaine dose determined according to the thoracolumbar vertebral body length (VBL) is more effective in achieving a lower hypotension rate during spinal anesthesia for cesarean delivery than the…
- Trial name
- bupivacaine (NCT06869434)
- Testing
- Group VBL (Thoracolumbal vertebral body length) received 0.2 mg x VBL cm of %0.5 hyperbaric bupivacaine, Group FD (fixed dose) received a volume of 0.5% hyperbaric bupivacaine based on a dose calculated according to the patient's height 0.065 mg/cm, Group AD (adjusted dosage) got intrathecal heavy bupivacaine (0.5%) tailored to the patient's height and weight.
- Where
- Turkey (Türkiye)
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Cornea, Anesthesia; Reaction
The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients
To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
- Trial name
- NCT03006211
- Testing
- Nitrogen protoxide, Oxygen
- Volunteers
- 40 people
- Sponsor
- Inonu University
Anesthesia; Reaction, Adverse Effect of Other General Anesthetics
Influence of Anesthesia Technique on Postoperative Evolution After Urogenital Surgical Interventions
The study hypothesis is that regional anesthesia offers better outcome for the patients who underwent robot assisted laparoscopic urogenital surgery.
- Conditions
- Anesthesia; Reaction, Adverse Effect of Other General Anesthetics, Adverse Anesthesia Outcome, Acute Kidney Injury
- Trial name
- ROBOTNGAL (NCT01898897)
- Testing
- epidural catheter insertion, robot assisted laparoscopic urogenital surgery
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Vascular Stiffness, Hypotension on Induction
The Relationship Between BCM, Arterial Stiffness and Hemodynamic Instability During Induction of General Anesthesia
Arterial hypotension during induction of general anesthesia is a risk factor for developing postoperative cardiovascular complications.
- Conditions
- Vascular Stiffness, Hypotension on Induction, Anesthesia; Reaction
- Trial name
- NCT03237429
- Testing
- bioimpedance spectroscopy
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Sedative Adverse Reaction
Effect of Sedation on Pulmonary Aeration in Children
Pediatric sedation is an anesthesiological technique with a good safety profile, but various complications might ensure, especially from the respiratory point of view.
- Trial name
- LunSed (NCT03392012)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- IRCCS San Raffaele
Multiparametric Magnetic Resonance Imaging, Propofol Adverse Reaction
Safety Evaluation of Propofol Sedation for Magnetic Resonance Imaging in Pediatric Patients
Propofol is often used for sedation in children undergoing magnetic resonance imaging. The investigators will perform a chart review of 4 month of activity (about 100 cases) and review the incidence and severity of adverse events…
- Conditions
- Multiparametric Magnetic Resonance Imaging, Propofol Adverse Reaction, Sedation Complication, Anesthesia; Adverse Effect
- Trial name
- NCT04455776
- Testing
- Propofol
- Where
- Belgium
- Volunteers
- 99 people
- Sponsor
- Brugmann University Hospital
Anesthesia; Reaction
Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly
The investigators aim to examine target-controlled propofol infusion as a technique of anesthesia for surgery of hip fracture under ultrasound guidance lumbar and sacral plexus block or lumbar, sacral and paravertebral nerve…
- Trial name
- NCT02104908
- Testing
- paravertebral nerve, lumbar and sacral plexus block
- Volunteers
- 80 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Fentanyl Adverse Reaction, Caudal Anesthesia
Fast Tracking Impact on Fentanyl Consumption and Parents Satisfaction
The investigators are measuring fentanyl consumption in micrograms used during anesthesia for patients on fast track congenital cardiac surgeries
- Trial name
- NCT04376541
- Testing
- Fentanyl
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Sedative Adverse Reaction, Analgesic Adverse Reaction
The Use of Midazolam and Remifentanil During Dialysis Access Procedures
BACKGROUND: Sedation and analgesia are related to unexpected adverse events in chronic renal failure patients undergoing arteriovenous fistula placement procedures under monitored anesthesia care (MAC).
- Conditions
- Sedative Adverse Reaction, Analgesic Adverse Reaction, Midazolam Adverse Reaction, Adverse Reaction to Drug
- Trial name
- NCT04226443
- Testing
- Midazolam intravenous injection, Remifentanil intravenous bolus dose
- Volunteers
- 99 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Tonsillitis, Post-operative Nausea and Vomiting (PONV)
Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
This is a prospective, randomized, controlled, non-inferiority study of patients undergoing tonsil surgeries at Boston Children's Hospital Waltham.
- Conditions
- Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction
- Trial name
- NCT06326983
- Testing
- Dexmedetomidine, Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Boston Children's Hospital
General Anesthetic Drug Adverse Reaction
Postoperative Effects of Propofol Versus Sevoflurane Anesthesia
Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life.
- Trial name
- NCT05935930
- Testing
- Propofol 10 MG/ML Injection, Sevoflurane Inhalation Liquid
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Damanhour Teaching Hospital
Local Anaesthetic Drug Adverse Reaction
Computer - Controlled Intraligamentary Local Anaesthesia In Extraction of Primary Molars
Background: Exodontia poses a psychological threat for children, increasing the need for profound local anesthesia to assure painless extraction and maintain child cooperation on the dental chair.
- Trial name
- NCT04739735
- Testing
- Dental Local Anaesthesia
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alexandria University
General Anesthetic Drug Adverse Reaction
Romanian Entropy Clinical Study Network
The critically ill patient is one of the most complex cases with regard to the optimization of the anesthesia, as well as postoperative management.
- Trial name
- ROEntropy (NCT03210077)
- Testing
- Monitoring
- Where
- Romania
- Volunteers
- 500 people
- Sponsor
- Romanian Society of Anesthesia and Intensive Care
Chronic Insomnia, Sleep Deprivation
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep disorders.
- Conditions
- Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder
- Trial name
- PSHW (NCT06644573)
- Testing
- PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nyree Penn