Clinical trials: Anesthesia; Reaction
Anesthesia; Reaction
Dexmedetomidine Combined With the Closed Loop of Target Controlled Infusion of Propofol for Anesthesia With Intraoperative Wake up
The study designed to explore the efficacy and safety of the closed loop of target controlled infusion dexmedetomidine combined with propofol for anesthesia with intraoperative wake up.
- Trial name
- NCT02143362
- Testing
- Anesthesia induction,propofol, remifentanil ,cisatracurium, Anesthesia maintenance , propofol,remifentanil,cisatracurium, Awaken test
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Anesthesia
Prediction of Hemodynamic Reactivity During General Anesthesia Using Analgesia/Nociception Index (ANI)
The aim of this study is to evaluate the performance of Analgesia/Nociception Index for the prediction of hemodynamic reactivity in adult patients undergoing ear-nose-throat or lower limb orthopedic surgery on…
- Trial name
- NCT01839513
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Edouard Herriot
Anesthesia, Propofol Adverse Reaction
Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)
The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using…
- Conditions
- Anesthesia, Propofol Adverse Reaction, Etomidate Adverse Reaction, Anesthesia Complication
- Trial name
- PEAC (NCT05358535)
- Testing
- Admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), Admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
General Anesthetic Drug Adverse Reaction
Factors Affecting the Effective End-tidal Concentration of Desflurane Anaesthesia
There is accumulating evidence that inappropriate depth of anaesthesia is associated with increased risk of postoperative complications including risk of death.
- Trial name
- NCT02617680
- Testing
- desflurane - oxygen in air, desflurane - oxygen in nitric oxide
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Hradec Kralove
Anesthesia, Anesthesia; Reaction
Individual Cerebral Hemodynamic Oxygenation Relationships
This is a randomized controlled trial in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two…
- Trial name
- ICHOR (NCT04435834)
- Testing
- Propofol or Sevoflurane
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Matthew Borzage
Microcirculation, Fluid Therapy
Effects of Fluid Therapy on Microcirculatory Reactivity
Through preoperative fluid therapy, to investigate whether it can alleviate the microcirculation dysfunction after induction of anesthesia, and reduce the incidence of perioperative fluid therapy-related complications, thereby…
- Trial name
- NCT04982016
- Testing
- crystal therapy, colloid therapy
- Volunteers
- 126 people
- Sponsor
- Beijing Anzhen Hospital
General Anesthesia
Analgesia Nociception Index Guided Remifentanil Administration During Propofol Anesthesia for Laparoscopic Surgery
The Physiodoloris (MetroDoloris, Lille, France) monitor, CE marqued, uses the ECG signal in order to compute the Analgesia Nociception Index (ANI) which has been shown to measure the relative parasympathetic tone, and hence to…
- Trial name
- AIVOC-ANI (NCT01893723)
- Testing
- ANI guided remifentanil, ANI blind arm
- Where
- 5 sites in Belgium, France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Lille
Pain, Postoperative, Ketamine Adverse Reaction
Efficacy of Ketamine in Post Anesthesia Recovery Room
Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.
- Conditions
- Pain, Postoperative, Ketamine Adverse Reaction, Pain, Refractory, Pain, Intractable
- Trial name
- NCT04701008
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Spinal Anesthesia
Changes in the Microvascular Reactivity on Leg During Spinal Anesthesia
Anesthesia alters microcirculation and tissue oxygen saturation (StO2). We sought to examine changes in StO2 using near-infrared spectroscopy and a vascular occlusion test (VOT) during spinal anesthesia.
- Trial name
- NCT04806997
- Testing
- Vascular occlusion test
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Pusan National University Hospital
Pain, Postoperative, Adverse Reaction to Epidural Anesthesia
Pediatric Caudal Anesthesia Block. And Pain Control
Caudal epidural block CEB is the most commonly performed neuraxial block to provide effective pain relief and analgesia in patients undergoing infra-umbilical pediatric surgery.
- Conditions
- Pain, Postoperative, Adverse Reaction to Epidural Anesthesia, Anesthesia, Caudal
- Trial name
- CEB (NCT05581940)
- Testing
- Group A Caudal Epidural Anesthesia with bupivacaine 0.25% and group B with opioid intervenors
- Where
- Bahrain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Salmaniya Medical Complex
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
General Anesthetic Drug Adverse Reaction, Perioperative/Postoperative Complications
Observational of Emergence Time Between Patients Receive General Anesthesia With BIS or Spectrogram EEG Monitor
The bispectral index parameter is used to guide the titration of general anesthesia, however; conflicting results between different studies cannot prove the benefit of EEG monitor on improvement of OR efficiency.
- Trial name
- NCT05208502
- Testing
- DSA monitor
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- National Taiwan University Hospital
Circadian Rhythm, Ciprofol
Effect of Circadian Rhythm on the Sedative Efficacy and Recovery Quality of Ciprofol General Anesthesia: A Multi-Center Observational Study
The goal of this multi-center observational study is to learn about the effect of circadian rhythm (morning vs. afternoon surgery) on the sedative efficacy, hemodynamic stability (especially induction-associated hypotension), and…
- Conditions
- Circadian Rhythm, Ciprofol, Hemodynamic Instability, Anesthetics Adverse Reaction
- Trial name
- NCT07686432
- Testing
- Surgery commences in the morning., Surgery commences in the afternoon.
- Volunteers
- 480 people
- Sponsor
- Jie Chen
Anesthesia; Reaction
Prediction of Block Height of Spinal Anesthesia
Spinal anesthesia is one of the most used techniques for surgery. Anesthesiologists usually check the block height (dermatome) of spinal anesthesia before surgery start.
- Trial name
- NCT05024838
- Testing
- Machine learning methods
- Where
- Taiwan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Propofol Adverse Reaction
Propofol Induction Based on Lean Body Weight on the Depth of Anesthesia
Propofol has significant hemodynamic side effects. It is a lipophilic agent and is generally used at a dose of 2-2.5 mg/kg for induction.
- Trial name
- propofol (NCT06862349)
- Testing
- Group T received propofol at a dose of 2-2.5 mg/kg based on total body weight, Group L received propofol at 2-2,5mg/kg dose based on lean body weight, which was calculated from CT imaging by a radiologist.
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Flumazenil Adverse Reaction, Remimazolam
Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam
Remimazolam is a medication that has the advantage of a short half-life and reversibility with flumazenil. In clinical situations, the use of flumazenil for the reversal of sedation is common, but there is no precise indication…
- Conditions
- Flumazenil Adverse Reaction, Remimazolam, Hip Joint, Elderly Patients
- Trial name
- NCT05939674
- Testing
- Flumazenil, normal saline
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Pusan National University Yangsan Hospital
Drug Reaction to Analgesic Nos
Topical Anesthetic for Procedures Through the Nose
To determine if RX0041-002 is a safe and effective topical anesthetic.
- Trial name
- NCT02667054
- Testing
- RX0041 4%, RX0041 8%
- Where
- 2 sites in United States
- Volunteers
- 648 people
- Sponsor
- Pharmaceutical Project Solutions, Inc.
Obesity, Anesthesia
Influence of Obesity on Microvascular Reactivity During General Anesthesia
The purpose of this study was to investigate the effect of obesity on changes in microvascular reactivity and tissue oxygen saturation (StO2) during general anesthesia using near-infrared spectroscopy in conjunction with vascular…
- Conditions
- Obesity, Anesthesia, Microcirculation
- Trial name
- NCT05829785
- Testing
- Near-infrared spectroscopy monitor
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Pusan National University Hospital