Clinical trials: Anesthesia
Anesthetic Effectiveness
Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to the tooth as a supplemental injection, works very well following a…
- Trial name
- NCT01567839
- Testing
- Mandibular buccal Infiltration injection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Minimal Flow Anesthesia, General Anaesthesia
Minimal Flow Anesthesia and Infection Risk
This study is being done to find out if the heat and moisture that build up during minimal flow anesthesia can lead to the growth of germs (microorganisms) inside the anesthesia equipment.
- Conditions
- Minimal Flow Anesthesia, General Anaesthesia, Inhalation Anesthesia, Infection Risk
- Trial name
- NCT07092046
- Testing
- Sevoflurane (Volatile Anesthetic), Propofol 1%, Remifentanil 2 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Hypotension, Labor Complication
Leg Elevation to Prevent Hypotension During Labor
When hypotension is related to epidural placement, this can occur within 15-60 minutes after placement. The purpose of this study is to build upon this preliminary work and to use a randomized controlled trial to examine the…
- Trial name
- NCT05674838
- Testing
- Leg Elevation
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Crohn's Disease, Inflammatory Bowel Disease
A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Techniques
Postoperative pain can pose significant challenges in the postoperative recovery of patients undergoing major colorectal surgery. Traditionally, opioids have played an important role in treating postoperative pain.
- Conditions
- Crohn's Disease, Inflammatory Bowel Disease, Postoperative Pain
- Trial name
- NCT02538679
- Testing
- US TAP Bupivacaine/Epinephrine, Lap TAP Bupivacaine/Epinephrine
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Lumbar Puncture, Topical Analgesia
Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children
The purpose of this study is to evaluate the effectiveness of a needle-free jet-injection system with 1% buffered lidocaine for local anesthesia for lumbar punctures compared to a topical anesthetic agent.
- Trial name
- JTIP (NCT01628874)
- Testing
- J-Tip, EMLA, Lidocaine
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Epinephrine Causing Adverse Effects in Therapeutic Use
Cardiovascular Effects of Racemic Epinephrine Pellets
The primary aim of this study was to determine if topical racemic epinephrine pellets affect heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) or mean arterial pressure (MAP) in children receiving…
- Trial name
- NCT04688346
- Testing
- HemeRX epinephrine pellets
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Washington
Brain Activity Under Sedation
EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia
The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness.
- Trial name
- NCT01543633
- Testing
- Propofol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anesthesia
EEG Studies of Ketamine General Anesthesia
We are doing this research study to find out how and where ketamine acts in the brain. Ketamine is an anesthetic (a drug or agent used to decrease or eliminate the feeling of pain by putting you in an unconscious state).
- Trial name
- NCT03553758
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Saphenous Nerve Block
Saphenous Nerve Block for Foot and Ankle Surgery
Patients undergoing foot and ankle surgery have the option of having a nerve block administered by their Anesthesiologist. The nerve block numbs the foot and results in less post-operative nausea and vomiting, and better pain…
- Trial name
- NCT02382744
- Testing
- Ultrasound Guidance, Ultrasound guidance + nerve stimulation
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pain, Acute, Anesthesia, Local
Variable Perception of Cutaneous Stimulation
Perception of cutaneous sensory stimulation shows a large range of variability across multiple populations. Understanding this variability is critical to medical practice as interpretation of discomfort and pain is critical to…
- Conditions
- Pain, Acute, Anesthesia, Local, Dermatology/Skin - Other
- Trial name
- NCT03467685
- Testing
- Vibratory Anesthetic Device (VAD)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Anesthetics, Local
Split Face Study of the Duration of Local Anesthetics
This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for.
- Trial name
- NCT05767749
- Testing
- lidocaine + epinephrine 1:100,000, Ropivacaine 0.5% Injectable Solution, Bupivacaine 0.5% Injectable Solution
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Analgesia, Anesthesia
Neuroimaging Study of Dexmedetomidine-Induced Analgesia
Neuroimaging data will be collected for patients that are given low doses of dexmedetomidine in order to understand its analgesic effects.
- Trial name
- NCT04656470
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Changes in Brain Network Connectivity
Anesthesia and Functional Connectivity: An Analysis of fMRI Changes
Functional connectivity is defined as a correlation in neural activity between distinct regions of the brain. Several recent studies have demonstrated areas of low-frequency functional connectivity inherent to brain tissue at…
- Trial name
- NCT02196259
- Testing
- Anesthetics, Dissociative
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anesthesia, Local
A Safety Study of of AG-920 Sterile Topical Ophthalmic Solution
A Phase 3, randomized, placebo-controlled, double-masked, parallel study in healthy subjects. It is designed to evaluate the ocular safety of a single topical ocular administration of AG-920 sterile topical ophthalmic solution…
- Trial name
- NCT05501860
- Testing
- AG-920
- Where
- 2 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Visual Acuity
An Investigation of the Impact of Localized Topical Anesthesia of the Ocular Surface on End-of-day Contact Lens Discomfort
This is a controlled, randomized, subject-masked, 3x3 crossover, non-dispensing, contralateral study. Twenty subjects will be recruited based on their scores (with their habitual lenses) from the Contact Lens Dry Eye…
- Trial name
- NCT03733899
- Testing
- Local Anesthesia
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Hypoxia, Endoscopy
Nasal Continuous Positive Airway Pressure Versus Standard Care During Procedural Sedation for Gastrointestinal Endoscopy
This study is a randomized controlled trial comparing oxygen delivery by nasal mask with continuous positive airway pressure versus standard care (nasal cannula or standard facemask) during propofol-based sedation for…
- Conditions
- Hypoxia, Endoscopy, Anesthesia Morbidity
- Trial name
- NCT03369197
- Testing
- Nasal Mask, Control: Nasal Cannula
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pain
Femoral Nerve Block Versus Adductor Canal Nerve Block for Peri-Operative Analgesia Following Anterior Cruciate Ligament (ACL) Reconstruction: Evaluation of Post-operative Pain and Strength
All patients over the age of 16 undergoing primary or revision anterior cruciate ligament reconstruction with the use of bone-patellar-bone autograft are eligible for the study.
- Trial name
- NCT03033589
- Testing
- Marcaine 0.25 % Injectable Solution
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Healthy Volunteer
Study to Compare Active Tymbion Iontophoresis to Sham Tymbion Iontophoresis for Anesthesia of the Tympanic Membrane
A prospective, multicenter study to determine if active Tymbion iontophoresis is superior to sham Tymbion iontophoresis in providing anesthesia to the tympanic membrane (TM).
- Trial name
- ADEPT (NCT03119181)
- Testing
- Tymbion Lidocaine/epinephrine solution, Device: Iontophoresis System (IPS) with Drug: Tymbion lidocaine/epinephrine solution
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tusker Medical
Communication, Preoperative
Anesthesia Counseling, Consent, & Professionalism
The anesthesia consent form has become a standard before surgery. However, verbal aspects of anesthesia consent and of the value of the preoperative anesthesia discussion has not been addressed.
- Conditions
- Communication, Preoperative, Ethics
- Trial name
- ACCP (NCT06010836)
- Testing
- Script guided conversation
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Continuous Positive Airway Pressure, Hypoxia
Positive Pressure at Induction of Anesthesia in Children
SCENARIO: Hypoxemia is one of the most common adverse events during the induction of general anesthesia and may culminate with more serious complications such as cardiac arrest and death.
- Conditions
- Continuous Positive Airway Pressure, Hypoxia, General Anesthesia
- Trial name
- NCT03432390
- Testing
- Continuous Positive Airway Pressure, Open system ventilation
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira