Clinical trials: Anesthesia
Cataract
Anesthetic and Dilating Gel for Cataract Surgery
To prepare the eye for cataract surgery, drugs must be given to the eye to allow for surgery to take place. Traditionally, dilating drops and drops containing NSAIDs (to control inflammation) are given to the patient well in…
- Trial name
- NCT00335400
- Testing
- Anesthetic Dilating Gel
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen's University
Adverse Effect of Drugs and Medicaments in Therapeutic Use, Adverse Effects in the Therapeutic Use of Anaesthetics
The Effect of Opioid Free Anesthesia in Bariatric Surgeries
This is a prospective randomized controlled study that will be carried out on morbid obese patients admitted to Tanta University hospitals for laparoscopic bariatric surgeries.
- Trial name
- Opioidfree (NCT04048200)
- Testing
- Fentanyl, Dexmedetomidine Ketamine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Glioblastoma, Glioblastoma Multiforme
The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients.
The trial is designed as a multicenter randomized controlled study. 246 patients with presumed Glioblastoma Multiforme in eloquent areas on diagnostic MRI will be selected by the neurosurgeons according the eligibility criteria…
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, Astrocytoma, Grade IV
- Trial name
- SAFE (NCT03861299)
- Testing
- Awake craniotomy, Craniotomy under general anesthesia
- Where
- 5 sites in Belgium, Netherlands
- Volunteers
- 246 people
- Sponsor
- Jasper Gerritsen
Burst Suppression, Electroencephalogram
Impact of Interscalene Block Combined With General Anesthesia on Burst Suppression in Shoulder Surgery Patients
This prospective, randomized, double-blind clinical study aimed to investigate the effects of combining general anesthesia with an interscalene brachial plexus block (ISB) on burst suppression ratio (BSR) and…
- Conditions
- Burst Suppression, Electroencephalogram, Interscalene Brachial Plexus Block
- Trial name
- NCT07081672
- Testing
- Ultrasound-guided interscalene brachial plexus block (ISB), General Anesthesia (control group)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Gastroesophageal Function During General Anesthesia
Gastroesophageal Function During Anesthesia
General anesthesia may predispose patients to aspiration of gastroesophageal contents because of depression of protective reflexes during loss of consciousness.
- Trial name
- NCT03332901
- Testing
- this is an observational study, no intervention required
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital
Anesthesia
Pharmacokinetic Study of Intravenous Lidocaine in Young and Elderly Patients
Aging is accompanied by a gradual alteration in the functional reserve of several organs and a change in body composition that can affect the pharmacokinetics, response, and safety profile of medications.
- Trial name
- ElderLIDO_1 (NCT06795100)
- Testing
- Pre-inclusion, Inclusion, Lidocaine
- Where
- 2 sites in France
- Volunteers
- 67 people
- Sponsor
- Rennes University Hospital
Pain
Intraperitoneal Application of Levobupivacaine During Laparoscopic Surgery in Kids.
Pain after laparoscopic surgery has been associated with surgical manipulations, including intraperitoneal insufflation of carbon dioxide (CO2), resulting in peritoneal stretching, diaphragmatic irritation, changes in…
- Trial name
- NCT02037711
- Testing
- Levobupivacaine 0.5%, Normal saline
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Regional Anesthesia for Postnephrectomy Pain
Ultrasound- Guided Mid Point Transverse Process to Pleura Block
Radical nephrectomy is the surgical process for the resection of malignant tumors of the kidney necessitating a subcostal flank incision.Mild to severe pain is observed in the postoperative period Ineffective pain management…
- Trial name
- NCT05806229
- Testing
- Mid transverse process to pleura block (MTP)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Hypotension
Hemodynamic Monitoring in Obstetrics
Spinal anesthesia has long been considered the first choice technique in caesarean section, but although it is a reliable and safe procedure, it is in some cases associated with undesirable effects.
- Trial name
- NCT03755271
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- University of Catania
Postoperative Delirium, Postoperative Pain, Acute
Postoperative Delirium and Analgesia in Elderly Patients
This study aims to evaluate the effects of different postoperative analgesic approaches on postoperative delirium in elderly patients undergoing total knee arthroplasty.
- Trial name
- NCT07849517
- Testing
- adductor canal block and biFes block including bupivacain, Periarticular infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Pain Measurement, Visual Analog Pain Scale
The Analgesic Effect of Intrathecal Hydromorphone Injection on Spinal Anesthesia
The purpose of this study is to evaluate the adequate dose of intrathecal hydromorphone injection for postoperative pain relief after knee arthroscopic surgery.
- Trial name
- NCT01172782
- Testing
- Hydromorphone
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Postoperative Pain, Topical Anaesthesia
Topical Lidocaine After Arthroscopy on Knee
More than half of the patients suffer from intensive pain 1-2 days after arthroscopy in the knee. Walking function and physical activities are affected by this intensive pain although local anaesthetic is given in the joint and…
- Trial name
- NCT02460627
- Testing
- Lidocaine adhesive tape, Adhesive tape
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Usability, Anesthesia
Usability Comparison of a mHealth Application for Pre-anesthesia Evaluation Before and After Re-design of User Interface
Pre-anesthesia assessment is an important part of anesthesiologists daily routine. A thorough assessment leads to an impeccable anesthesia plan.
- Trial name
- NCT04070261
- Testing
- iOS application usability test
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Periodontitis, Gingivitis and Periodontal Diseases
Effectiveness of Intraseptal Anesthesia for Periodontal Surgical Procedures
The primary aim of this study is to evaluate the efficacy of intraseptal anesthesia using 0.3 mL of 4% articaine with 1:100,000 epinephrine (4% Ar+Ep) for periodontal flap surgery in patients with periodontitis and for…
- Trial name
- NCT07212270
- Testing
- periodontal flap surgery, gingivectomy and gingivoplasty
- Where
- Serbia
- Volunteers
- 60 people
- Sponsor
- University of Belgrade
C.Medical Procedure; Digestive System, Disorder of Upper Gastrointestinal Tract
Lidocaine Spray on an Endoscope to Improve Tolerance to Endoscopy
The investigators tested whether a new method which additional lidocaine spray on the tip of endoscope can increase the tolerance of examinee during endoscopy than conventional pharyngeal anesthesia alone.
- Conditions
- C.Medical Procedure; Digestive System, Disorder of Upper Gastrointestinal Tract, Tolerance
- Trial name
- NCT02307773
- Testing
- Case Group
- Where
- South Korea
- Volunteers
- 497 people
- Sponsor
- Cheju Halla General Hospital
Fluid Responsiveness Predictability, Hemodynamic Monitoring
Comparison of Acoustic Variability Index (AVI) and Pulse Pressure Variation (PPV) for Predicting Fluid Responsiveness in Mechanically Ventilated Patients
The goal of this clinical trial is to learn if a new medical device called ResQ works to predict fluid needs in adults undergoing surgery under general anesthesia.
- Conditions
- Fluid Responsiveness Predictability, Hemodynamic Monitoring, Anesthesia, General
- Trial name
- NCT07516470
- Testing
- Biological Signal Processing Device for Acoustic Variability Index, Patient monitor for pulse pressure variation, Hemodynamic monitor for cardiac Output and stroke volume variation
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Signal House Co., Ltd.
Immune Suppression
The Immune Modulation of Bilateral Paravertebral Block and Propofol in Spine Surgery.
General anesthesia has an important effect on inflammatory cytokines. Inhalational agents as isoflurane and sevoflurane attenuate immune function expressed by neutrophil chemoattractant-1 as well as inflammatory enzyme and also…
- Trial name
- NCT03437213
- Testing
- Total intravenous anesthesia group, Total intravenous plus block group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alaa Mazy Mazy
Cognitive Decline
Combined Lumbosacral Nerve Block Versus Spinal Anesthesia for Cognitive Function After Hip Prothesis
Hip fracture is a potentially devastating event, and serious surgical and medical complications occur frequently especially for elderly patients. Delirium is one of the common complications after hip surgery.
- Trial name
- NCT03794427
- Testing
- unilateral lumbosacral nerve block, Spinal anesthesia
- Where
- Lebanon
- Volunteers
- 50 people
- Sponsor
- Makassed General Hospital
Anesthesia
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be performed with a lower total dose of local anesthesia (and greater patient safety) when using 0.5% lidocaine with 1:200,000 epinephrine…
- Trial name
- NCT00594542
- Testing
- lidocaine
- Volunteers
- 149 people
- Sponsor
- University of Pennsylvania