Clinical trials: Anesthesia , Analgesia
Cesarean Section, Analgesia
Prevalence of Insufficient Analgesia in Caesarean Section Under Neuroaxial Anesthesia (PAICAN)
Pain during caesarean section under neuraxial anesthesia is often underestimated and could be related to perinatal psycholocal disorders.
- Trial name
- PAICAN (NCT06824740)
- Where
- Spain
- Volunteers
- 318 people
- Sponsor
- Parc de Salut Mar
Postoperative Pain
Comparison of Pain Relief Duration With Dexmedetomidine Versus Fentanyl Added to Spinal Anesthesia in Patients Undergoing Lower Limb Orthopedic Surgery
The goal of this randomized clinical trial is to compare how long effective pain relief lasts when dexmedetomidine or fentanyl is added to hyperbaric bupivacaine during spinal anesthesia for lower limb orthopedic surgery.
- Trial name
- NCT07770542
- Testing
- Dexmedetomidine & Bupivacaine., fentanyl and bupivacaine
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Allama Iqbal Teaching Hospital
Anesthesia, Regional, Anesthesia and Analgesia
Difference in Occurrence of Rebound Pain in Patients Undergoing Surgery Under Popliteal Block or Ankle Block
This is a monocentric, comparative prospective randomized controlled trial. Patients will be randomised into 2 groups and will receive either a sciatic popliteal nerve block or an ankle block (single dose locoregional block…
- Trial name
- CBFR (NCT05734469)
- Testing
- Forefoot bone surgery
- Volunteers
- 90 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Postoperative Pain
Analgesic Effect of Intraoperative Esmolol in Mastectomies
This study aims to compare the quality of perioperative analgesia of esmolol in patients undergoing mastectomy.
- Trial name
- Esmobreast (NCT02466542)
- Testing
- Esmolol group
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Base
Patient With Bronchial Endoscopy
Contribution of Hypnotic Analgesia to Local Anesthesia During Bronchial Endoscopy.
Bronchial endoscopy (or bronchial fibroscopy) is an invasive diagnostic examination performed extremely frequently in the Pneumology department of the Dijon University Hospital, with an average of 1200 procedures per year.
- Trial name
- HypnoFibro (NCT03703960)
- Testing
- hypnotic analgesia, music
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Acute Pain, Anesthesia
Effectiveness of Retrolaminar Block in Lumbar Spine Fusion With Multimodal Analgesia
This randomized, blinded, controlled clinical trial aims to evaluate the effectiveness of ultrasound-guided retrolaminar block in reducing postoperative opioid consumption in patients undergoing lumbar spine fusion surgery under…
- Conditions
- Acute Pain, Anesthesia, Lumbar Spine Disease
- Trial name
- RBLUF (NCT07291388)
- Testing
- retrolaminar block
- Where
- Chile
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Pain
Topic Cervical Anesthesia for Pain Control During Endouterine Manual Aspiration
To compare the effectiveness of lidocaine gel plus paracervical blockade vs. Paracervical blockade alone in the management of pain during endouterine manual aspiration.
- Trial name
- NCT03397082
- Testing
- Lidocaine gel
- Where
- Panama
- Volunteers
- 86 people
- Sponsor
- Saint Thomas Hospital, Panama
Regional Anaesthesia
Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery
this study is designed to evaluate and compare the efficacy of dexmedetomidine and nalbuphine as adjuvants to 0.5% bupivacaine in ultrasound-guided infraclavicular brachial plexus block for patients undergoing elective upper limb…
- Trial name
- NCT07279727
- Testing
- Nalbuphine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
Regional Anesthesia Block
A Comparing Transversalis Fascia Plane Block and Quadratus Lumborum Block for Post-Cesarean Pain Management: Efficacy, Execution Time, and Practicality
Transversalis Fascia Plane Block (TFPB) and Quadratus Lumborum Block (QLB) provide superior analgesia to Transversus Abdominis Plane Block (TAPB) for post-cesarean pain management.
- Trial name
- NCT06874569
- Testing
- TAP Block:, TFP Block:, QLB:
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Aswan University
Postamputation Pain, Lower Limb Amputation
Acute Post-Amputation Pain Management After Combat-Related Lower Limb Injury
Acute post-amputation pain remains a significant clinical challenge in patients with combat-related lower limb injuries and may negatively affect early rehabilitation, mobility, and opioid consumption.
- Conditions
- Postamputation Pain, Lower Limb Amputation, Combat Trauma
- Trial name
- APAPMACRLLI (NCT07863921)
- Testing
- Continuous Peripheral Nerve Blocks, Peripheral Nerve Cryoablation, Standard multimodal analgesia
- Where
- Ukraine
- Volunteers
- 36 people
- Sponsor
- Kharkiv National Medical University
Lung Cancer, Thoracic Surgery
Epidural Anesthesia-analgesia and Long-term Survival After Lung Cancer Surgery
Available studies suggest that regional anesthesia-analgesia may decrease the occurrence of recurrence/metastasis in patients after cancer surgery. However, evidences from prospective studies are still lacking.
- Conditions
- Lung Cancer, Thoracic Surgery, Anesthesia, Epidural, Neoplasm Recurrence, Local
- Trial name
- NCT02801409
- Testing
- General anesthesia alone, Combined epidural-general anesthesia
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University First Hospital
Post Operative Pain
Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve Block
Background: Multimodal analgesia for control of postoperative pain in cardiac surgical patients helps in early recovery and ambulation.
- Trial name
- NCT05897307
- Testing
- Ropivacaine
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Fayoum University Hospital
Hepatectomy
Intravenous Lidocaine for Hepatectomy
Liver resection is increasingly performed for hepatic tumors, mainly primary liver cancers and resectable metastases, but also for some benign lesions.
- Trial name
- ILHEP (NCT07590830)
- Testing
- Standardized General Anesthesia Induction and Maintenance Protocol incorporating Intravenous Lidocaine
- Where
- 9 sites in France
- Volunteers
- 312 people
- Sponsor
- Rennes University Hospital
Anesthesia, Conduction, Arthroplasty, Replacement, Knee
Concentration Effect of Local Anesthetics on Femoral Nerve Block Efficiency
US-guided femoral nerve block is used effectively in post-operative pain management in the surgical treatment of the lower extremity.
- Conditions
- Anesthesia, Conduction, Arthroplasty, Replacement, Knee, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- NCT03623230
- Testing
- Ultrasound Guided Femoral Nerve Block, Dressing, Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Bozyaka Training and Research Hospital
Labor Pain
Pain Selective Anesthesia for Labor Mobility (PSALM Study): a Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine for Labor Epidural Analgesia
The current "gold standard" epidural analgesia for labor is associated with unwanted side effects, such as motor block (affecting ambulation and the ability to push) and sympathetic blockade (causing maternal hypotension).
- Trial name
- PSALM (NCT06302257)
- Testing
- Chlorprocaine, Lidocaine, Lidocaine-chlorprocaine combination
- Where
- 3 sites in Israel
- Volunteers
- 303 people
- Sponsor
- Hadassah Medical Organization
Pain Management
Local Anesthesia for Facial Fractures
The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics.
- Trial name
- LAFF (NCT06429501)
- Testing
- Bupivacaine/Epinephrine, Saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Total Hip Arthroplasty (THA), Intrathecal Anesthesia
Assessing the Time-Course of Dexmedetomidine-Induced Analgesia Via EEG
Objective: To investigate the temporal dynamics of dexmedetomidine's analgesic effects in the brain using EEG. Methods: Eligible patients scheduled for total hip arthroplasty under intrathecal anesthesia received a continuous…
- Conditions
- Total Hip Arthroplasty (THA), Intrathecal Anesthesia, Hip Osteoarthritis
- Trial name
- NCT06946277
- Testing
- Preemptive Analgesia Of Dexmedetomidine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- China International Neuroscience Institution
Pain Management, Anesthesia , Analgesia
Comparison Between External Oblique Intercostal Plane Block and Rectus Sheath Block Combined With Transversus Abdominis Plane Block
Effective perioperative pain management remains a cornerstone in enhancing recovery and improving patient outcomes in laparoscopic cholecystectomy.
- Conditions
- Pain Management, Anesthesia , Analgesia, Nerve Block
- Trial name
- NCT07384000
- Testing
- External intercostal plane puncture, control group (nalbuphine), the single-puncture technique of (rectus sheath block) combined with (Transversus abdominis plane block)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Anesthesia, Urologic Diseases
Sedation and Analgesia Using PFK Versus General Anesthesia in Urological Procedures
Anesthesia in urological surgeries might constitute a great challenge to anesthesiologists. Especially that a great proportion of these patients are elderly with a lot of comorbidities.
- Trial name
- NCT04285528
- Testing
- General anesthetia Fentanyl and Propofol, PFK
- Where
- Jordan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University