Clinical trials: Anesthesia Effectiveness
Preoperative Anxiety, Preoperative Sedation
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period.
- Conditions
- Preoperative Anxiety, Preoperative Sedation, Children, Dexmedetomidine
- Trial name
- NCT06853431
- Testing
- dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Mechanical Ventilation Complication, Upper Airway Obstruction
Nasal Mask Ventilation During the Induction of General Anesthesia
Recently, the investigators demonstrated that nasal route ventilation is superior to the nasal-oral combined ventilation in the absence of jaw thrust and chin up maneuvers.
- Trial name
- NCT01651286
- Testing
- nasal mask, full face mask
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Postoperative Pain
Comparison of Pre-op and Post-op Pectoralis Nerve Block
The investigators will compare whether patients will have better pain control if they were to receive (PEC I/II block) before surgery or after mastectomy.
- Conditions
- Breast Cancer, Postoperative Pain, Anesthesia, Nerve Block
- Trial name
- NCT03653988
- Testing
- PEC I/II blocks by anesthesiologist - pre-operative, PEC I/II blocks by surgeon - intra-operative
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Melinda Seering
Analgesia, Arthropathy of Knee
Comparison of Two Different Regional Analgesia Techniques for Patients Undergoing Total Knee Arthroplasty
The objective of this clinical trial is to compare two regional analgesia techniques in patients undergoing total knee arthroplasty: IPACK (Infiltration of local anesthetic between the Popliteal Artery and Capsule of the Knee) vs…
- Conditions
- Analgesia, Arthropathy of Knee, Postoperative Pain
- Trial name
- PIPACK (NCT06179641)
- Testing
- Selective tibial nerve block, IPACK block
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Local Anesthesia
Safety and Efficacy Study of an Iontophoretic Patch Containing Lidocaine and Epinephrine for Venipuncture in Healthy Adult Volunteers
The purpose of this study is to evaluate the effectiveness of administering Lidocaine and Epinephrine using an iontophoretic device treatment to provide local anesthesia to healthy adult volunteer subjects undergoing venipuncture.
- Trial name
- NCT00889642
- Testing
- Iontophoretic Drug Delivery System with Lidocaine/Epinephrine, Iontophoretic Drug Delivery System with Epinephrine
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dharma Therapeutics Inc.
Pain, Postoperative, Pain Syndrome
Bilateral Erector Spinae Plane Block (ESPB) in Laparoscopic Cholecystectomies
The aim of the trial is to study the efficacy of bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic cholecystectomy
- Conditions
- Pain, Postoperative, Pain Syndrome, Pain, Acute, Anesthesia
- Trial name
- NCT04587973
- Testing
- Group Dexmedetomidine, Group Ropivacaine, Group Control
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Anesthesia, Pediatric Cancer
the Efficacy and Safety of Sugammadex in Children 0-2 Years Old
Sugammadex is a selective antidote to muscle relaxants rocuronium bromide and vecuronium bromide. Sugammadex is a modified gamma-cyclodextrin, a compound that selectively binds rocuronium bromide and vecuronium bromide.
- Conditions
- Anesthesia, Pediatric Cancer, Pediatric Tumor, Pediatric Hepatoblastoma
- Trial name
- NCT03728543
- Testing
- Sugammadex
- Where
- Russia
- Volunteers
- 62 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Hypothermia
Effectiveness of Nefopam for Thermoregulation During Surgery
Nefopam may help blunt thermoregulatory defenses, thus facilitating induction of therapeutic hypothermia
- Trial name
- NCT03122665
- Testing
- Nefopam Low dose, Nefopam High dose
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Anesthesia, Respiratory Diseases
Efficacy of Different Anesthesia Methods in Transbronchial Biopsy
This study investigates the efficacy of different anesthesia methods (general anesthesia with laryngeal mask airway and local nebulized anesthesia) for transbronchial biopsy using an electronic bronchoscope.
- Conditions
- Anesthesia, Respiratory Diseases, Biopsy
- Trial name
- EDAMTBB (NCT06454513)
- Testing
- general anesthesia
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Sichuan Provincial People's Hospital
General Anesthesia
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05486416
- Testing
- HSK3486, Propofol
- Where
- 28 sites in United States, Poland and 1 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Anesthesia, Dental
Using Anesthetic Gel Patches to Reduce Pain of Palatal Injection
Local anesthetic administration step is mandatory step for controlling pain before dental procedures. The aim of this study was to compare effectiveness of topical Benzocaine 18% gel patch form and Benzocaine 20% topical gel in…
- Trial name
- NCT04317508
- Testing
- Topicale GelPatch (Benzocaine 18%), Benzocaine oral gel 20%
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Dina Youssef Attia
Postoperative Pain, Cesarean Section
Intrathecal Morphine 75 mcg Versus 100 mcg for Post-Cesarean Analgesia: A Randomized Double-blind Trial
This study evaluates the efficacy and safety of two different doses of intrathecal morphine (75 mcg versus 100 mcg) for postoperative analgesia in patients undergoing elective cesarean delivery under spinal anesthesia.
- Conditions
- Postoperative Pain, Cesarean Section, Obstetric Anesthesia
- Trial name
- ITM-CESAREAN (NCT07516717)
- Testing
- Intrathecal Morphine
- Where
- Venezuela
- Volunteers
- 240 people
- Sponsor
- Hospital Universitario de Caracas
Postoperative Pain, Pain
Comparison of Analgesic Efficacy of Intrathecal Bupivacaine Versus Bupivacaine Plus Dexmedetomidine in Patients Undergoing Orthopedic Surgeries.
Clinical Trial Overview: Intrathecal Bupivacaine vs. Bupivacaine + Dexmedetomidine Primary Objective Duration of Analgesia:** To compare the mean duration of postoperative pain relief between hyperbaric bupivacaine alone versus…
- Conditions
- Postoperative Pain, Pain, Orthopaedic Surgery, Anesthesia, Spinal
- Trial name
- NCT07866508
- Testing
- Dexmedetomidine plus Hyperbaric Bupivacaine, Hyperbaric bupivacaine % 0.5
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheikh Khalifa Bin Zayed Al Nahyan Combined Military Hospital Muzaffarabad
Wounds Injuries, Anesthesia, Local
Single-centre Study to Investigate Safety and Efficacy of Tri-Solfen in Wound Debridement
This is a Phase IIa open, randomised, single and parallel group, therapy controlled, single centre study, which has been divided into 3 sequential phases, which are designed to study respectively, (a) the time taken to achieve…
- Trial name
- NCT03865147
- Testing
- Tri-Solfen Gel (Lidocaine HCl, Bupivacaine HCl, Adrenaline Acid Tartrate /Cetrimide), EMLA cream, Post Operative Analgesia (Paracetamol, Ibuprofen)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Medical Ethics UK Ltd
Breast Cancer, Pain, Acute
ESP in Breast Surgery Due to Cancer
Patients scheduled for breast surgery due to cancer. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Conditions
- Breast Cancer, Pain, Acute, Anesthesia, Local
- Trial name
- NCT04726878
- Testing
- Erector spinae plane block, General anesthesia, Patient-controlled analgesia
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Medical University of Lublin
Cholecystectomy, Postoperative Pain
Erector Spinae Plane Block Versus External Oblique Intercostal Plane Block for Analgesia in Open Cholecystectomy
This randomized controlled trial aims to compare the analgesic efficacy of bilateral ultrasound-guided erector spinae plane block (ESPB) versus bilateral external oblique intercostal plane (EOI) block in patients undergoing open…
- Conditions
- Cholecystectomy, Postoperative Pain, Erector Spinae Plane Block, Regional Anesthesia
- Trial name
- NCT07533279
- Testing
- Erector Spinae Plane Block, External Oblique Intercostal Plane Block
- Volunteers
- 66 people
- Sponsor
- Sohag University
Dental Anxiety, Dental Pain
Comfort-in Needle-Free Injection System in Pediatric Dental Anesthesia
This randomized split-mouth clinical trial evaluated the efficacy of the Comfort-in needle-free injection system compared with conventional dental injection for local anesthesia during pulpotomy treatment in children.
- Conditions
- Dental Anxiety, Dental Pain, Pulpotomy, Local Anesthesia
- Trial name
- NCT07585812
- Testing
- Comfort-in Needle-Free Injection System, Conventional Dental Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Headache Disorders, Central Nervous System Diseases
Is Sphenopalatine Ganglion Block Treatment Effective on Postspinal Headaches
This study evaluates effect of sphenopalatine ganglion block in post dural puncture headache. Half of participants will receive standard supportive treatment and other half of patients will be performed sphenopalatine ganglion…
- Trial name
- SPG (NCT03512977)
- Testing
- sphenopalatine ganglion block, conservative treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Derince Training and Research Hospital
Conscious Sedation Failure During Procedure, Analgesia
Lidocaine as Local Anesthetics in Children Under Ketamine Sedation
Ketamine seems an obvious choice in the setting of an emergency department in laceration repair. Lidocaine is the local anesthetics widespread used. Ketamine leads to dissociative amnesia.
- Conditions
- Conscious Sedation Failure During Procedure, Analgesia, Anesthesia
- Trial name
- NCT02205502
- Testing
- Lidocaine, Normal saline
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Postoperative Pain
The Analgesic Efficacy of Bilateral Erector Spinae Plane Block in Comparison With Intrathecal Morphine After Elective Cesarean Section
The aim of this study was to assess the analgesic efficacy of bilateral erector spinae plane block in comparison with intrathecal morphine after elective cesarean section under spinal anesthesia.
- Trial name
- NCT03935412
- Testing
- Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Fayoum University
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