Clinical trials: Anesthesia Effectiveness
Insomnia
Study on the Efficacy and Safety of Anesthesia-Induced Sleep Therapy for Refractory Insomnia
The incidence of refractory insomnia is rising annually, with traditional therapies offering limited efficacy. Anesthesia-Induced Sleep (AIS), involving anesthetic infusion like dexmedetomidine, is emerging.
- Trial name
- NCT07255027
- Testing
- Dexmedetomidine and conventional oral drug, Conventional oral drug therapy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Pain Perception of the New Device, The Pain Related Behavior
Computer Controlled Local Anesthesia in Children
Introduction: Effective pain control is critical in pediatric dentistry. The effectiveness of pain control in children can be influenced by child characteristics .
- Conditions
- Pain Perception of the New Device, The Pain Related Behavior, The Effectiveness of Anesthesia
- Trial name
- STA machine (NCT02025140)
- Testing
- Computer controlled anesthesia, conventional anesthesia syringe
- Where
- Saudi Arabia
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Anesthesia
The Efficacy of Pregabalin on the Duration of the Spinal Anesthesia and the Early Postoperative Pain After Total Knee Arthroplasty
the purpose of this study is to evaluate the effectiveness of administration of pregabalin 2 hours preoperatively on the onset and the duration of the spinal anesthesia in total knee arthroplasty and the role of pregabalin in…
- Trial name
- NCT05071118
- Testing
- Pregabalin 150mg
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Hemodynamic Instability During Anesthesia, Induction Anesthesia
Low-dose Propofol Plus High-dose Alfentanil in Rapid Sequence Induction
This study compares four different anesthesia induction regimens to see which one provides the most stable blood pressure and heart rate during rapid sequence intubation.
- Conditions
- Hemodynamic Instability During Anesthesia, Induction Anesthesia, Intubation
- Trial name
- NCT07730918
- Testing
- propofol, alfentanil, Sufentanil
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Aoyang Hospital Affiliated to Jiangsu University
Anesthesia, Local
Intraligamental Local Anesthesia Versus Infiltration Technique for Extraction of Grade II Mobility Maxillary Molars
The study aims to assess the use of intraligamental local anesthetic injection compared to buccal infiltration for extraction of maxillary molars suffering grade II mobility in terms of pain control and extraction duration.
- Trial name
- NCT05875350
- Testing
- Intraligamental local anesthetic injection
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Mechanically Ventilated and Intubated Subjects
A Safety and Efficacy Study of Dexmedetomidine in ICU Patients Requiring Continuous Sedation
The purpose of this study is to evaluate the safety and efficacy of dexmedetomidine in ICU subjects who are initially intubated, mechanically ventilated and require sedation for beyond 24 hours.
- Trial name
- NCT00216190
- Testing
- Dexmedetomidine HCL Injection, Midazolam Injection
- Where
- 96 sites in United States, Argentina and 3 more
- Volunteers
- 420 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Anesthesia, Local Anesthesia
Can Caudal Dexmedetomidine Provide Effective Analgesia?
The goal of this clinical trial is to evaluate if caudal dexmedetomidine can provide effective analgesia during inguinoscrotal surgeries in pediatrics, if used caudally alone (and not as an adjunct to caudal bupivacaine).
- Trial name
- NCT05902780
- Testing
- Caudal Bupivacaine injection, Caudal Dexmedetomidine Injection
- Volunteers
- 50 people
- Sponsor
- Benha University
Sedative
Median Effective Dose of Remimazolam for Sedation in Elderly Patients
Currently used drugs for monitored general anesthesia include propofol, midazolam, and dexmedetomidine. Each drug has different advantages and disadvantages.
- Trial name
- NCT05468996
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Post Operative Pain
The Efficacy of PSB and Recto-intercostal Block Combination on Postoperative Pain in Patients Undergoing Cardiac Surgery Via Sternotomy: Case Series
The aim of this study was to investigate the effectiveness of the combination of Superficial Parasternal Block and Recto-Intercostal Fascial Plane Block in patient groups undergoing cardiac surgery via sternotomy by evaluating…
- Trial name
- NCT06553560
- Testing
- Parasternal Block and Recto-İntercostal Fascial Plane Block
- Volunteers
- 10 people
- Sponsor
- Cumhuriyet University
Traumatic Rib Fracture
Thoracic Blocks Versus Thoracic Epidural and Patient Controlled Anesthesia in Traumatic Rib Fracture Patients
The primary objective of this study is to investigate whether continuous PVB is equal in efficacy to epidural anesthesia in terms of analgesia in patients with INR lower than 1.2, or is continuous ICNB equal in efficacy to PCA in…
- Trial name
- NCT01599403
- Testing
- Paravertebral Block, Intercostal Nerve Block, Epidural Block
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Loop Ileostomy, Colorectal Disorders
Quadratus Lumborum Block : Local Anesthesia Versus Placebo
Opioid analgesics have many side effects. Quadratus lumborum (QL) block is one kind of regional nerve block that can reduce the side effects of opioid analgesics.
- Trial name
- NCT03411096
- Testing
- Quadratus lumborum block using ropivacaine, Quadratus lumborum block with normal saline
- Where
- South Korea
- Volunteers
- 57 people
- Sponsor
- Kyungpook National University Hospital
Anesthesia
Anesthetic Efficacy of X-tip Intraosseous Injection
Hypothesis: X-tip intraosseous is an effective supplementary injection in mandibular hot teeth as well as Periodontal Ligament (PDL) injection Purposes: Comparing the anesthetic efficacy of X-tip intraosseous and PDL injection in…
- Trial name
- NCT01214369
- Testing
- Type of Supplementary Injection
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Anesthesia, General
Efficacy and Safety of Ciprofol Compared to Propofol for Nonintubated General Anesthesia in Patients Undergoing TAVR
The purpose of this study is to explore the efficacy and safety of ciprofol compared to propofol for non-intubated general anesthesia in patients undergoing transcatheter aortic valve replacement (TAVR).
- Trial name
- NCT05035069
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Adverse Effect
90% Effective Dose of Phenylephrine Infusions Under Intensive and Standard Treatment in Preeclamptic Patients
The objective of this study is to investigate the 90% effective dose of phenylephrine infusions for preventing postspinal anesthesia hypotension under intensive and standard treatment in preeclamptic patients during cesarean…
- Trial name
- NCT06151470
- Testing
- Alpha-Agonist, α-adrenergic receptor agonist
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Pre-operative Anxiety
Helping Parents to Decide Whether They Want to be With Their Child During Anesthesia Induction
Children are distressed at anesthesia induction and this distress can result in maladaptive recovery outcomes. Having parents be present at anesthesia induction (PPIA) has been suggested as a potential intervention to decrease…
- Trial name
- PPDT (NCT01858142)
- Testing
- Parental presence decision tool, Standard preparation
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- IWK Health Centre
Acute Pain, Anesthesia
Effectiveness of Retrolaminar Block in Lumbar Spine Fusion With Multimodal Analgesia
This randomized, blinded, controlled clinical trial aims to evaluate the effectiveness of ultrasound-guided retrolaminar block in reducing postoperative opioid consumption in patients undergoing lumbar spine fusion surgery under…
- Conditions
- Acute Pain, Anesthesia, Lumbar Spine Disease
- Trial name
- RBLUF (NCT07291388)
- Testing
- retrolaminar block
- Where
- Chile
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Postoperative Pain
Comparison of Pain Relief Duration With Dexmedetomidine Versus Fentanyl Added to Spinal Anesthesia in Patients Undergoing Lower Limb Orthopedic Surgery
The goal of this randomized clinical trial is to compare how long effective pain relief lasts when dexmedetomidine or fentanyl is added to hyperbaric bupivacaine during spinal anesthesia for lower limb orthopedic surgery.
- Trial name
- NCT07770542
- Testing
- Dexmedetomidine & Bupivacaine., fentanyl and bupivacaine
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Allama Iqbal Teaching Hospital
Postoperative Pain, Anesthesia, Regional
Mid-Transverse Process to Pleural (MTP) Block and Erector Spinal Plan (ESP) Block in Spinal Surgery
Ethics committee approval was taken on October 22, 2019, numbered 19/342. 120 adult patients who will undergo spine stabilization surgery between October 2019 and January 2020 in "Gülhane Training and Research Hospital" were…
- Conditions
- Postoperative Pain, Anesthesia, Regional, Spinal Stenosis
- Trial name
- NCT04193488
- Testing
- MTP block, ESP block, No Block group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Dental Education, Inferior Alveolar Nerve Block
Virtual Reality Training for Inferior Alveolar Nerve Block in Dental Students
This randomized controlled study aims to evaluate the effectiveness of virtual reality simulator-based training in teaching the inferior alveolar nerve block (IANB) technique to third-year dental students.
- Trial name
- VR-IANB (NCT07653854)
- Testing
- SIMtoCARE Virtual Reality Simulator, Conventional Training
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Hypoxemia, Conscious Sedation
Impact of Nasal Mask Versus Nasal Cannula Oxygenation on Hypoxemia in Gastrointestinal Endoscopy: A Brain Function Monitoring (SedLine)-Guided Randomized Controlled Trial (NAMSHIC)
This randomized controlled trial compared the efficacy of a nasal mask versus a standard nasal cannula for oxygen delivery during gastrointestinal endoscopic procedures performed under target controlled propofol infusion…
- Trial name
- NAMSHIC (NCT07500779)
- Testing
- Nasal Mask Oxygenation, Nasal Cannula Oxygenation
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey