Clinical trials: Anesthesia Effectiveness
Aortic Aneurysm, Abdominal, Pain
Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery
The ETAP study aim to assess the effect of the addition of an ultrasound-guided transversus abdominis plane (TAP) block to a multimodal intravenous analgesia protocol on the postoperative pain control in open surgical repair of…
- Conditions
- Aortic Aneurysm, Abdominal, Pain, Anesthesia, Local
- Trial name
- ETAP (NCT02292667)
- Testing
- TAP block, PCA with Chlorhydrate of Morphine, Acetaminophen
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Postoperative Pain, Adults
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in adults in perioperative settings.
- Conditions
- Postoperative Pain, Adults, Anesthesia
- Trial name
- NCT04837170
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Volunteers
- 12,000 people
- Sponsor
- Chinese PLA General Hospital
Supraglottic Airway Devices Position
New-Generation GMA Laryngeal Mask Airway Versus Conventional Inflatable Laryngeal Mask Airway
This study aims to compare the new-generation GMA laryngeal mask airway (LMA) with the traditional inflatable LMA in patients undergoing elective surgery under general anesthesia.
- Trial name
- NCT07177586
- Testing
- GMA Laryngeal Mask Airway, Inflatable Laryngeal Mask Airway
- Where
- China
- Volunteers
- 1,384 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Proliferative Diabetic Retinopathy
Pain Management During Panretinal Photocoagulation for Diabetic Retinopathy: Safety and Efficacy of Peribulbar Anesthesia
The purpose of this study was to compare two different anesthesia methods for pain control during panretinal photocoagulation (PRP), a type of laser surgery that treats proliferative diabetic retinopathy (PDR).
- Trial name
- NCT07640256
- Testing
- Peribulbar anesthesia with 0.5% bupivacaine and 2% lidocaine, Tetracaine 5% drops
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Hypotension, Anesthesia; Adverse Effect, Spinal and Epidural
ONDANSETRON AND EFFECTIVE DOSE IN 50% OF SUBJECTS OF PROPHYLACTIC NOREPINEPHRINE INFUSIONS FOR PREVENTING SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING CESAREAN DELIVERY
Spinal anesthesia is the preferred technique for elective cesarean section as per ASA guidelines. Hypotension is the main complication of this technique and is secondary to both sympatholysis and its associated decrease in…
- Conditions
- Hypotension, Anesthesia; Adverse Effect, Spinal and Epidural, Cesarean Section
- Trial name
- NCT04703088
- Testing
- Ondansetron 4 MG, 0.9% Saline
- Volunteers
- 60 people
- Sponsor
- Laval University
Post Operative Pain
Comparison of PSB and RIFPB Combination With PSB and ESPB Combination in Cardiac Surgery With Sternotomy
The goal of this study is to compare the analgesic efficacy of the combination of PSB and RIFPB and the combination of PSB and ESPB in patients undergoing cardiac surgery with sternotomy.
- Trial name
- NCT06553573
- Testing
- Parasternal Block and Recto-İntercostal Fascial Plane Block, Parasternal Block and Erector Spinae Plane Block
- Volunteers
- 24 people
- Sponsor
- Cumhuriyet University
Rotator Cuff Tear
InSpace™ System Implantation in a Procedure Under Local Anesthesia
The study objective is to assess the feasibility, efficacy and safety of the InSpace™ Device implantation in a surgical procedure under local anesthesia using arthroscopic and/or fluoroscopic visualization of the affected…
- Trial name
- NCT02208453
- Testing
- InSpace Implantation
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- OrthoSpace Ltd.
Urinary Retention
Evaluation of the Efficacy of the Addition of Magnesium Sulfate to Morphine on the Occurrence of Acute Urinary Retention Following Epidural Anesthesia for Cesarean Section.
Peri-medullary anesthesia is the preferred anesthetic technique for Caesarean surgery. Compared with general anesthesia, it reduces maternal and fetal morbidity and mortality, as well as postoperative pain.
- Trial name
- EPIMAG (NCT06442995)
- Testing
- Injection of 500 mg magnesium sulfate + 2 mg morphine into the epidural space, Injection of Isotonic saline + 2 mg morphine into the epidural space
- Where
- France
- Volunteers
- 290 people
- Sponsor
- CHU de Reims
Anesthesia
ED50 of Esketamine for Laser Treatment in Children
There is limited research on the combined use of esketamine and alfentanil for anesthesia during facial laser treatment in pediatric patients, and the effective dosage of esketamine for inhibiting body movement remains unclear.
- Trial name
- ESCALATE (NCT06294639)
- Testing
- Esketamine
- Volunteers
- 40 people
- Sponsor
- Air Force Military Medical University, China
Hypotension During Surgery
Study on the Safety and Effectiveness of Remimazolam Tosilate for Injection for Short-term Elective Surgery in Adults
Research objective: To explore the safety and dose exploration of Remimazolam Tosilate for Injection for induction and maintenance of general anesthesia in elective short-term surgery in adults.
- Trial name
- NCT04908553
- Testing
- Remimazolam Tosilate for Injection 0.1mg/kg, Remimazolam Tosilate for Injection 0.15mg/kg, Remimazolam Tosilate for Injection 0.2mg/kg
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Tongji Hospital
Effect of Drug
ED90 of Remimazolam Anesthesia Induction in Drug-induced Sleep Endoscopy in Adults
Exploring the ED90 of remimazolam in Drug-induced Sleep Endoscopy in adults at different BMI groups.
- Trial name
- NCT06333145
- Testing
- Remimazolam
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Tongji Hospital
Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery
This is a multicenter, randomized, double-blinded, propofol-controlled, Phase 3 clinical study to evaluate the efficacy and safety of HSK3486 for induction of general anesthesia in adults undergoing elective surgery.
- Trial name
- NCT04711837
- Testing
- HSK3486, Propofol
- Where
- 13 sites in United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Anesthesia
Different Dose of Esketamine Inhibiting Response to Laryngeal Mask Airway Insertion
Objective To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.
- Trial name
- NCT06370130
- Testing
- Esketamine 0.2mg/kg, Esketamine 0.3mg/kg
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Aerospace Center Hospital
Anesthesia, Thyroid
Analgesic Efficacy of an Intermediate CPB in Neck Surgeries.
This study aims to investigate the analgesic efficacy of Intermediate Cervical Plexus Block combined with GA using two bupivacaine concentrations in patients undergoing neck surgeries (total thyroidectomy or total laryngectomy)
- Conditions
- Anesthesia, Thyroid, Neck, Bupivacaine
- Trial name
- NCT06419556
- Testing
- Cervical Plexus Block
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Cairo University
Cough, Anesthesia
Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia
This study is designed to compare the effects of two bolus doses of intravenous remifentanil given prior to the emergence of anesthesia: on the incidence of perioperative coughing on the time needed for the emergence of a…
- Trial name
- NCT01489072
- Testing
- Remifentanil
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Anesthesia, Thoracic Diseases
The Effectiveness of ThOracic Epidural and Paravertebral Blockade In Reducing Chronic Post- Thoracotomy Pain: 2
An estimated 7200 thoracotomies (surgical incision into the chest wall) are performed annually in the UK, most commonly to treat lung cancer.
- Trial name
- TOPIC-2 (NCT03677856)
- Testing
- Paravertebral blockade, Thoracic epidural block
- Where
- United Kingdom
- Volunteers
- 1,026 people
- Sponsor
- University of Birmingham
Anesthesia Induction
A Trial to Evaluate the Efficacy and Safety of Methoxyetomidate Hydrochloride for Injection (ET-26) for the Induction of General Anesthesia in Elective Surgery Subjects
This is a multicenter, randomized, double-blind, etomidate-controlled phase III clinical trial. The primary objective is to compare the efficacy and safety between ET-26 and etomidate in the induction of general anesthesia in…
- Trial name
- NCT06203431
- Testing
- ET-26, Etomidate Injectable Emulsion
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Intubation Complication
The Effectiveness of Using Bougie or Cooled Nasogastric Tube to Facilitate Nasotracheal Intubation
either uses a bougie or nasogastric tube to assist the nasotracheal tube passing the nasal cavity, nasopharynx, oropharynx and advanced into the trachea
- Trial name
- NCT04087837
- Testing
- bougie, Nasogastric(NG) tube
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Muscle Relaxation, Intubation Complication
Endotracheal Intubation Without Muscle Relaxants
Prospective study conducted between March 2013 and November 2014 at Hospital Universitario Puerta de Hierro-Majadahonda, in Madrid, Spain to identify complications and evaluate the efficacy of pure inhalational anesthesia…
- Trial name
- NCT03112564
- Testing
- Avoidance of rocuronium/cisatracurium, Sevoflurane 8% + Intravenous fentanyl
- Where
- Spain
- Volunteers
- 91 people
- Sponsor
- Puerta de Hierro University Hospital
Prostate Biopsy, Local Anesthesia
A Study of a New Local Anesthesia Method for Transperineal Prostate Biopsy
In comparison with transrectal prostate biopsy, transperineal prostate biopsy has the advantage of better sampling from the anterior area, low risk of infection, and no rectal bleeding.
- Trial name
- NCT03500432
- Testing
- local anesthesia of trnasperineal prostate biopsy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Military Medical University
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