Clinical trials: Anesthesia Induction
Deep Neuromuscular Blockade, Anesthesia, General
The ED95 Dose of Sugammadex to Reverse Rocuronium-Induced Deep Neuromuscular Block Back to Shallow Neuromuscular Block
In the European Society of Anaesthesiology and Intensive Care (ESAIC) guideline on the use of neuromuscular blockers published in 2023, it was suggested that sugammadex could be used to reverse deep and moderate neuromuscular…
- Trial name
- NCT05841316
- Testing
- Sugammadex
- Volunteers
- 40 people
- Sponsor
- Ankara University
Flow Time, Carotid Doppler Ultrasound
Carotis cFT In Prediction Of Hypotension
The aim of our study is to determine the predictive value of pre-anesthesia FTc for hypotension that may develop after general anesthesia induction in patients over 65 years of age and to investigate the correlation between…
- Conditions
- Flow Time, Carotid Doppler Ultrasound, Hypotension, Anesthesia
- Trial name
- NCT05896514
- Testing
- ultrasound-guided carotid artery flow time measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Ventilator-Induced Lung Injury
Pressure Support Ventilation During Laparoscopic and Abdominal Robotic Surgery.
This study is a single-center, blind, prospective, randomized, controlled trial of pressure support ventilation (PSVpro) versus pressure control ventilation - volume guaranteed (PCV - VG) during laparoscopic and robotic abdominal…
- Trial name
- NCT04815733
- Testing
- Mandatory ventilation, pressure support ventilation
- Where
- Russia
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Moscow Clinical Scientific Center
Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural
Can Vena Cava Ultrasound Guided Volume Repletion Prevent Spinal Induced Significant Hypotension in Elective Patients?
Aim of this study is to determine whether Inferior Vena Cava analyzed by trans-thoracic echocardiography is an effective method to guide titrated fluid repletion in non critical patients, in order both to decrease post procedural…
- Conditions
- Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural, Regional Anesthesia Morbidity
- Trial name
- NCT02271477
- Testing
- Ultrasound-guided volemic repletion
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
No Specific Condition (Patients Without Brugada Syndrome)
Effects of Propofol-Induced Anaesthesia on the ST-segment of the ECG
The purpose of this study is to assess the effect of propofol induced general anaesthesia on the ST-segment of the electrocardiogram.
- Trial name
- Prop ST (NCT05185401)
- Testing
- Observational study
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Universitair Ziekenhuis Brussel
Preoperative Fasting and Hypotension
Effect of the Duration of Preoperative Fasting on Hypotension Induced by General Anesthesia in the Elderly Person
This study aims to determine if prolonged fasting represents an independent risk factor for hypotension during induction of general anesthesia in the elderly.
- Trial name
- JEÛNE PREOP (NCT02891122)
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Brest
Hemodynamic Instability, Anesthesia; Adverse Effect
Heart Failure and Hemodynamic Stability During Anesthesia Induction
The study aim is to investigate whether preoperative heart failure has impact on hemodynamic stability during anesthesia induction by target controlled infusion of anesthesia (TCI) in non-cardiac, non-morbidly obese surgery.
- Conditions
- Hemodynamic Instability, Anesthesia; Adverse Effect, Heart Failure, Diastolic Dysfunction
- Trial name
- NCT03576261
- Testing
- Preoperative colloid fluid bolus (Gelofusine), Preoperative transthoracic echocardiography
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Umeå University
Anesthesia
Dose of Remi in Children
Remimazolam has demonstrated the potential as a valuable medication for procedural sedation and general anesthesia. However, the effective dosage of remimazolam in pediatric patients is still unknown.
- Trial name
- DRINK (NCT05990673)
- Testing
- Remimazolam
- Volunteers
- 25 people
- Sponsor
- Zhihong LU
Transversus Abdominis Plane Block
Bupivacaine Pharmacokinetics Following TAP Block
The aims of this study are to determine population PK parameters of bupivacaine in children following TAP block using a population-based PK approach, and to evaluate the influence of patient covariates on drug disposition.
- Trial name
- NCT02015182
- Testing
- Blood sample for bupivicaine pharmacokinetics
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Anesthesia, Neuromuscular Blockade
The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia
Rapid sequence induction (RSI) is a well-known procedure to maintain a safe and rapid airway in patients especially at risk of aspiration. Propofol and rocuronium are generally used agents for RSI.
- Trial name
- NCT02709473
- Testing
- Propofol, Remifentanil, Rocuronium
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara University
Specified Sedative, Hypnotic
Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric
The purpose of this study is to investigate the effect of diphenhydramine on the prevention of sevoflurane induced emergence delirium/ agitation in pediatrics.
- Trial name
- NCT02463929
- Testing
- Diphenhydramine, normal saline, Ketamine
- Volunteers
- 50 people
- Sponsor
- Universitas Diponegoro
Hypotension on Induction, Hypnotic Intoxication
Mean Arterial Pressure Reduction Anesthesia Induction Using Propofol Bolus or Tritiated Target-infusion
To compare haemodynamics and bispectral index values between conventional bolus propofol induction and target-controlled propofol infusion.
- Trial name
- NCT04291794
- Testing
- Propofol, Propofol Injection [Diprivan]
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brasilia University Hospital
Post-induction Hypotension (PIH), Gastrointestinal Tumor Surgery
Carotid Doppler Changes After Passive Leg Raising for Prediction of Post-Induction Hypotension in Gastrointestinal Tumor Surgery
This prospective study aims to investigate the role of the passive leg raise maneuver prior to anesthesia induction in predicting post-induction hypotension among elective gastrointestinal tumor surgery patients using carotid…
- Trial name
- PLR (NCT07777159)
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Ankara City Hospital Bilkent
Anesthesia
Preoxygenation With Positive Inspiratory Pressure During Induction of Anesthesia
Adults patients scheduled for elective surgery were randomly allocated to receive preoxygenation with spontaneous breathing, positive pressure ventilation (positive inspiratory pressure: 12 cmH2O) without PEEP, and with PEEP…
- Trial name
- PREOX (NCT02313766)
- Testing
- PPV : positive pressure ventilation, PEEP : PPV + PEEP
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Spinal Anesthesia Induced Hypotension
COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial
The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension.
- Trial name
- NCT06836986
- Testing
- Norepinephrine Bolus, Phenylephrine bolus
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Dow University of Health Sciences
Atelectasis
Continuous Positive Airway Pressure Decreased Lung Collapse During General Anesthesia Induction in Pediatric Patients
Anesthesia-induced atelectasis is a well-known entity observed in approximately 68-100% of pediatric patients undergoing general anesthesia.
- Trial name
- NCT03461770
- Testing
- CPAP
- Where
- Argentina
- Volunteers
- 42 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Anxiety, Surgery
Could Music be an Alternative to Sedation in Patients Treated Total Knee Arthroplasty With Regional Anesthesia?
Background: Anxiety is a common phenomenon in hospitalized patients. In order to reduce it during the surgical procedure, sedatives and anxiolytics are used, which can cause undesirable side effects for patients.
- Conditions
- Anxiety, Surgery, Drug Toxicity, Anesthesia
- Trial name
- NCT03882541
- Testing
- Music therapy, Sedation with midazolam
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de l'Anoia
Respiratory Failure, Hypotension and Shock
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events.
- Conditions
- Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication
- Trial name
- RAPID PRESS (NCT05355974)
- Testing
- Norepinephrine, Lactated Ringers, Intravenous, normal saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wright State University
Pre-eclampsia
Investigating the Novel Observation of Right-left Difference in Uterine Artery Vascular Resistance in Pre-eclampsia
The investigators previously demonstrated that epidural ropivacaine reduces uterine artery vascular resistance in a dose dependent manner in pre-eclampsia.
- Trial name
- NCT00848679
- Testing
- Epidural lidocaine, Epidural lidocaine 2%
- Where
- Israel
- Sponsor
- Hadassah Medical Organization