Clinical trials: Anesthesia Spinal
Healthy, Pain
Intrathecal Hydromorphone for Post-cesarean Delivery Pain - a Dose Finding Study
Pain relief after cesarean delivery can be provided in a few ways. Most commonly, certain medications called opioids, such as morphine, are given through the vein or into the muscle.
- Conditions
- Healthy, Pain, Pregnancy
- Trial name
- NCT01943565
- Testing
- Hydromorphone 25mcg, Hydromorphone 50mcg, Hydromorphone 100mcg
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Obstetric Anesthesia Problems, High-Risk Pregnancy
Effect of Intra-abdominal Pressure to the Level of the Sensory Block at Caesarean Section Under Spinal Anesthesia
It is known that an increase in intra-abdominal pressure (IAP) causes a decrease in the volume of cerebrospinal fluid in the lumbar and lower thoracic region, which may contribute to the development of more high spinal block.
- Trial name
- IAPSB (NCT02237092)
- Testing
- Measurement of IAP
- Where
- Russia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Tver Regional Perinatal Center
Spinal Anesthesia, Epidural; Anesthesia
Bupivacaine With Epidural Volume Extension
In this study the investigator will address the efficacy of using low dose bupivacaine spinal anesthesia (SA) in combination with epidural volume extension (EVE) for patients undergoing short obstetric procedures.
- Trial name
- NCT03110003
- Testing
- 10 mg Bupivacaine, 5 mg Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Epidural Anesthesia, Spinal Ultrasound
Utility of Ultrasound in Identification of Midline and Placement of Epidural in Severely Obese Parturients
This study will address the utility of ultrasound in the placement of an epidural catheter in severely obese parturients. Identification of midline can often be difficult using the standard method of palpation in obese patients.
- Conditions
- Epidural Anesthesia, Spinal Ultrasound, Obesity
- Trial name
- NCT03100968
- Testing
- Palpation, Ultrasound
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural
Can Vena Cava Ultrasound Guided Volume Repletion Prevent Spinal Induced Significant Hypotension in Elective Patients?
Aim of this study is to determine whether Inferior Vena Cava analyzed by trans-thoracic echocardiography is an effective method to guide titrated fluid repletion in non critical patients, in order both to decrease post procedural…
- Conditions
- Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural, Regional Anesthesia Morbidity
- Trial name
- NCT02271477
- Testing
- Ultrasound-guided volemic repletion
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Spinal Anesthesia, Cesarean Section
Does the Addition of Epinephrine Prolong the Duration of Spinal Anesthesia for Repeat Cesarean Section?
The purpose of this study is to investigate whether the addition of a medication called epinephrine to spinal medications prolongs the duration of the anesthesia.
- Trial name
- NCT02369510
- Testing
- Low-dose epinephrine, High-dose epinephrine, No epinephrine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity, Morbid, Spinal Anesthesia
ED90 for Hyperbaric Bupivacaine in Super Obese Parturients
The aim of this study is to determine the ED90 of hyperbaric intrathecal bupivacaine for the super obese population undergoing cesarean section under a combined spinal epidural technique.
- Conditions
- Obesity, Morbid, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT03781388
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Duke University
Nausea, Vomiting
Minimizing Nausea and Vomiting During Spinals for CS
In parturients undergoing Cesarean section under spinal anesthesia, co-loading of 1 liter of crystalloids, with placing the spinal, along with administering a phenylephrine infusion and glycopyrrolate, enables placing a spinal…
- Trial name
- NCT02872935
- Testing
- Glycopyrrolate, Normal Saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kokila N Thenuwara
Arthropathy of Hip, Arthropathy of Knee
Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash
Bupivacaine spinal is commonly performed as the primary anesthetic for orthopedic procedures. In some cases the duration of the block is inadequate. An epinephrine wash is sometimes performed to prolong the duration of the block.
- Trial name
- NCT02619409
- Testing
- Bupivacaine Only, EPI25, EPI50 group
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Anesthesia, Tubal Ligation
Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES
This study compares general anesthesia and spinal anesthesia for vNOTE tubal sterilization. A direct comparison of these methods has not been done before for this surgical approach.
- Trial name
- NCT05688943
- Testing
- Spinal Anesthesia, General Anesthesia
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Anesthetic Complication Spinal
Variable Rate Phenylephrine Infusion for Prevention of Spinal-induced Hypotension for Cesarean Delivery
Rapid administration of crystalloid immediately after induction of spinal anesthesia (coload) to be more effective in terms of managing hypotension as compared to administering crystalloid before spinal anesthesia (preload).
- Trial name
- NCT01378325
- Testing
- Phenylephrine, saline
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Bladder Cancer
Comparison of Nerve Stimulating Approach and Interfascial Injection Approach During Sono-guided Obturator Nerve Block
Transurethral resection of bladder tumor (TURB) has been essential treatment for bladder tumours. Direct electrical stimulation of an obturator nerve during the TURB procedures can trigger an inadvertent adductor muscle spasm…
- Trial name
- NCT02452944
- Testing
- nerve stimulator (stimuplex HNS12), ultrasound
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Pregnancy Related
Optimizing Anesthesia for Post Partum Tubal Ligations
In this study, the investigators will compare CLOROTEKAL® (1% spinal chloroprocaine) to low-dose isobaric bupivacaine using the epidural volume extension (EVE) technique in patients undergoing post-partum tubal ligation (PPBTL).
- Trial name
- NCT03993314
- Testing
- Chloroprocaine, Bupivacaine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obstetric Anesthesia Problems, Bupivacaine Adverse Reaction
Thoraco Lumbar Vertebral Length and Bupivacaine Dosage in C-Section
Our hypothesis is that the bupivacaine dose determined according to the thoracolumbar vertebral body length (VBL) is more effective in achieving a lower hypotension rate during spinal anesthesia for cesarean delivery than the…
- Trial name
- bupivacaine (NCT06869434)
- Testing
- Group VBL (Thoracolumbal vertebral body length) received 0.2 mg x VBL cm of %0.5 hyperbaric bupivacaine, Group FD (fixed dose) received a volume of 0.5% hyperbaric bupivacaine based on a dose calculated according to the patient's height 0.065 mg/cm, Group AD (adjusted dosage) got intrathecal heavy bupivacaine (0.5%) tailored to the patient's height and weight.
- Where
- Turkey (Türkiye)
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Cardiac Arrythmias
Carbetocin on Myocardial Repolarization Dynamics in Obstetrics Study
Relationship between carbetocin dose on transmural dispersion of repolarization (TDR).
- Trial name
- CaRDIO (NCT03716076)
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Postoperative Nausea and Vomiting
Dexamethasone for the Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Cesarean Sections
Patients who present for scheduled (non-emergent) cesarean section will be given either intravenous dexamethasone or placebo prior to receiving a duramorph containing spinal anesthetic.
- Trial name
- NCT01734161
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Effects of; Anesthesia, in Labor and Delivery
Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery
The purpose of the study is to determine if a medication called phenylephrine, which helps to control blood pressure, is more effective as a continuous intravenous (IV) infusion compared to continuous IV norepinephrine in…
- Trial name
- NCT02354833
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Arthroscopic Knee Surgery
Study to Find Optimal Dose of Local Spinal Anesthetic (Mepivacaine) Combined With Narcotic (Fentanyl) For Knee Surgery
Prolonged motor block and delayed ability to walk are limitations of spinal anesthesia in ambulatory (same-day) surgery. This can be improved by lowering the dose of local anesthetic (a medication that, when injected around…
- Trial name
- NCT01701102
- Testing
- Mepivacaine (24 mg) plus fentanyl, Mepivacaine (27 mg) plus fentanyl, Mepivacaine (30 mg) plus fentanyl
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York