Clinical trials: Anesthesia Spinal
Lower Extremity Surgery
Fospropofol Disodium ED95 for Elderly Spinal Anesthesia Sedation
This study aims to determine the 95% effective dose (ED95) of fospropofol disodium, a new sedative drug, for adjuvant sedation during spinal anesthesia in elderly patients (aged 65 years and older) undergoing lower extremity…
- Trial name
- NCT07333508
- Testing
- Fospropofol Disodium
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ya-Qun Zhou
Anesthesia; Adverse Effect, Spinal and Epidural, Hip Arthropathy
Comparison of Three Different Sitting Positions for Performing Combined Spinal-Epidural Anesthesia
In this prospective and randomized study, we aimed to compare the effect of of three sitting positions (the traditional sitting position (TSP), the harmstring stretch position (HSP), and the squatting position on the success rate…
- Conditions
- Anesthesia; Adverse Effect, Spinal and Epidural, Hip Arthropathy, Knee Arthropathy
- Trial name
- NCT03541798
- Testing
- positions of patients for combined spinal-epidural anesthesia, Combined spinal epidural anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Cesarean Section
Ondansetron Prior Spinal Anaesthesia
Since Ondansetron is commonly used during cesarean deliveries to treat nausea and vomiting, this study will observe the correlation between ondansetron administration and effect on hemodynamics in order to confirm that the use of…
- Trial name
- Ondansetron (NCT06431568)
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assiut University
Effects of; Anesthesia, in Labor and Delivery, Pregnancy
Effects of Analgesic Techniques on Duration of Spontaneously Laboring Patients
The purpose of this study is to determine if there is a difference in the duration of the first stage of labor in nulliparous women in spontaneous labor with whom analgesia is maintained with a combined spinal epidural (CSE)…
- Conditions
- Effects of; Anesthesia, in Labor and Delivery, Pregnancy, Prolonged First Stage of Labor
- Trial name
- NCT01982838
- Testing
- Epidural de novo, CSE
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hypotension After Spinal Anesthesia
Preoperative Oral Heptaminol Hydrochloride in Preventing Hypotension After Spinal Anesthesia
Methodologies and approaches have been implemented with differing degrees of success to prevent neuraxial hypotension. Currently utilized approaches to prevent hypotension during spinal anesthetic administration consist of…
- Trial name
- NCT06564935
- Testing
- Heptaminol Hydrochloride
- Volunteers
- 160 people
- Sponsor
- Cairo University
Spine Surgery
Motor Evoked Potentials and SedLine
To determine if using usual clinical practice plus a depth of anesthesia monitor, SedLine, to guide anesthetic administration improves the quality and ease of MEP monitoring in patients undergoing corrective spinal procedures.
- Trial name
- NCT00805844
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Knee Surgery With Tourniquet
Effect of Spinal or Sevoflurane Anesthesia on Neutrophil Activation During Knee Surgery With Pneumatic Tourniquet
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty.
- Trial name
- NCT03470363
- Testing
- Sevoflurane Volatile Liquid, Bupivacaine / SUFentanil
- Volunteers
- 40 people
- Sponsor
- University of Liege
Shivering
Comparison of MgSO4 Versus Meperidine for Prevention of Shivering During Spinal Anesthesia
This was a double-blind randomized interventional study of 100 patients divided into two groups. Group M received MgSO4 30 mg/kg, and group P received meperidine 0.5 mg/kg intravenously in 100 ml of 0.9% NaCl before undergoing…
- Trial name
- NCT05110469
- Testing
- Magnesium sulfate, Meperidine
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AnestesiaR
Outcome
Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension.
This study aims to explore the effects of different application modes (prophylactic and rescue strategy) of norepinephrine and norepinephrine on neonate umbilical artery pH undergoing cesarean section.
- Trial name
- NCT06508359
- Testing
- Norepinephrine, Phenylephrine
- Where
- China
- Volunteers
- 700 people
- Sponsor
- General Hospital of Ningxia Medical University
Spinal Anesthesia, Cesarean Section Pain
Effect of Single-Dose Dexamethasone on Postoperative Pain After Cesarean Section Under Spinal Anesthesia
This study looked at whether giving a single dose of dexamethasone (a steroid medicine, 8 mg given into the vein) before a cesarean section could reduce pain after the operation.
- Conditions
- Spinal Anesthesia, Cesarean Section Pain, Postoperative Pain
- Trial name
- NCT07718360
- Testing
- Dexamethasone (IV), Normal Saline 0.9% Infusion Solution
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- KRL Hospital, Islamabad
Spinal Anesthesia Induced Hypotension
The Ability of Perfusion Index and Positional Perfusion Index Variation to Predict Spinal Anesthesia-induced Hypotension in Elderly Patients
In this study, we will test the ability of positional perfusion index variation to predict post-spinal anesthesia hypotension in elderly patients.
- Trial name
- NCT05259124
- Testing
- positional perfusion index variation
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Cairo University
Proximal Femur Fracture, Hip Fracture
Ultrasound-Guided PENG Block vs Femoral Nerve Block for Analgesia Before Spinal Anesthesia in Hip Fracture Surgery
This study will compare two types of ultrasound-guided nerve blocks-Pericapsular Nerve Group (PENG) block and Femoral Nerve Block (FNB)-to evaluate their effectiveness in reducing pain before spinal anesthesia in patients who…
- Conditions
- Proximal Femur Fracture, Hip Fracture, Pain Management, Spinal Anesthesia
- Trial name
- NCT06989047
- Testing
- Pericapsular Nerve Group (PENG) Block, Femoral Nerve Block (FNB)
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Hypotension, Obstetrical Complication of Anesthesia
Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients
Incidence of hypotension is high in parturients after spinal anesthesia. Ephedrine could be used to treat hypotension but lead to lower fetal pH as well.
- Conditions
- Hypotension, Obstetrical Complication of Anesthesia, Complications; Cesarean Section
- Trial name
- NCT02542748
- Testing
- Norepinephrine, Ephedrine
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Air Force Military Medical University, China
Coagulation Defect; Bleeding
Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia
Maternal hypotension is the most frequent complication of a spinal Anesthesia. The prevention of spinal hypotension appears more likely to decrease the frequency and severity of associated adverse maternal symptoms than the…
- Trial name
- NCT02622126
- Testing
- hydroxyethyl starch (6% 130/0.4), Hyperbaric bupivacaine, Morphine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Postoperative Pain
Comparative Study of the Analgesic Effect of Spinal Anesthesia or Infiltration Anesthesia for Hemorrhoidectomy
Background and Objectives: Postoperative analgesia and early recovery are relevant for hospital discharge after hemorrhoidectomy.
- Trial name
- NCT02839538
- Testing
- Local Infiltration, Subarachnoidal block
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Spinal Anesthesia-Induced Hypotension
Predictors of Spinal Anesthesia-Induced Hypotension in Hypertensive Patients
This prospective observational study aims to evaluate predictive factors for spinal anesthesia-induced hypotension (SASH) in hypertensive patients undergoing elective surgery.
- Trial name
- NCT06749184
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Konya City Hospital
Anesthesia
Postdural Puncture Headache Relief With Aminophylline and SPGB
The purpose of the study is to compare Sphenopalatine ganglion block (SPGB) and aminophylline in the efficacy and safety management of PDPH.
- Trial name
- NCT05552404
- Testing
- conservative therapy, Aminophylline, trans nasal sphenopalatine ganglion block
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Analgesia, Anesthesia; Functional
Comparison of Two Regional Technics In Knee Artroplasty
Purpose: This prospective, randomised, controlled, single-blind, multicentre study was designed to investigate the effects of peripheral nerve block methods (applied using unilateral spinal anaesthesia [USA] on elderly patients…
- Trial name
- CTRTIKA (NCT03021421)
- Testing
- intratechal (subarachnoidal )injection, lombar plexus and sciatic nerve injection
- Volunteers
- 60 people
- Sponsor
- Ordu University
Hypotension, Carbon Dioxide
The Feasibility of PetCO2 Prediction Hypotension Under Spinal Anesthesia for Cesarean Section
Maternal hypotension is a common side effect after spinal anesthesia for cesarean delivery.Decreased vascular resistance and cardiac output, due to sympathetic blockade1and blood pooling in blocked areas of the body respectively…
- Trial name
- NCT02032355
- Testing
- spinal anesthesia
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Geng guiqi
Arthroscopic Knee Surgery
Study to Find Optimal Dose of Local Spinal Anesthetic (Mepivacaine) Combined With Narcotic (Fentanyl) For Knee Surgery
Prolonged motor block and delayed ability to walk are limitations of spinal anesthesia in ambulatory (same-day) surgery. This can be improved by lowering the dose of local anesthetic (a medication that, when injected around…
- Trial name
- NCT01701102
- Testing
- Mepivacaine (24 mg) plus fentanyl, Mepivacaine (27 mg) plus fentanyl, Mepivacaine (30 mg) plus fentanyl
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York