Clinical trials: Anesthesia and Analgesia
Hepatectomy, Pain, Postoperative
Spinal Anesthesia For Enhanced Recovery After Liver Surgery
This project proposes to compare epidural versus spinal anesthesia in patients having liver resection surgery. The investigators hypothesize that spinal anesthesia will result in improved blood pressure control postoperatively…
- Conditions
- Hepatectomy, Pain, Postoperative, Liver Neoplasms
- Trial name
- SAFER-L (NCT03715517)
- Testing
- Continuous thoracic epidural analgesia, Spinal anesthesia with intrathecal morphine, Bupivacaine 0.75% in Dextrose Inj 8.25%
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University of Manitoba
Analgesia
Evaluation of Surgical Stress Index (SSI) During Sevoflurane/Remifentanil Anesthesia
The aim of the present prospective randomized study was to challenge the ability of SSI to detect painful stimulation during sevoflurane - remifentanil anesthesia.
- Trial name
- NCT00791791
- Testing
- standardized pain stimulus
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Schleswig-Holstein
Hepato Cellular Carcinoma (HCC), Sedation and Analgesia
The Impact of Anaesthesia and Sedation on Inflammation and NETosis in Hepatocellular Carcinoma Ablation
According to recent literature, liver disease causes approximately 2 million deaths annually; 1 million are attributed to the complications of cirrhosis, while the remaining deaths are caused by hepatocellular carcinoma (HCC).
- Conditions
- Hepato Cellular Carcinoma (HCC), Sedation and Analgesia, Ablation Techniques
- Trial name
- NCT07657897
- Testing
- Sedation using combination of Propofol and Fentanyl., Sedation using combination of Propofol and Fentanyl and lidocaine
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Hip Fracture
Comparison of the Ultrasound Supra-inguinal Fascia Iliaca Block vs Femoral Nerve Block
Patients were randomly assigned to tow groups: infrainguinal ultrasound guided iliaca fascia block (FIBSI) and femoral nerve block (FNB) for FIBSI, the probe is placed transversely between anterior superior iliac spine (ASIS) and…
- Trial name
- NCT04692428
- Testing
- Locoregional analgesia
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- University Tunis El Manar
Propofol, Sevoflurane
Comparison of Sevoflurane and Propofol on ANI
The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia.
- Conditions
- Propofol, Sevoflurane, Analgesia Nociception Index
- Trial name
- NCT06907823
- Testing
- propofol, Sevoflurane
- Volunteers
- 30 people
- Sponsor
- Pusan National University Yangsan Hospital
Pain Management, Hysterectomy
Comparison of Sensory Block Coverage and Clinical Effectiveness of TAP and Rectus Sheath Blocks in Pfannenstiel Incisions
Hysterectomy is one of the most common major gynecologic surgeries performed for various indications, and hundreds of thousands of procedures are carried out annually, particularly in developed countries.
- Trial name
- NCT07260396
- Testing
- Group Transversus Abdominis Plane Block, Group Rectus Sheath Block
- Volunteers
- 30 people
- Sponsor
- Samsun University
Analgesia
Comparison of Meperidine and Sufentanil Added to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Cesarean Section
Subarachnoid block is a widely used anesthetic technique for cesarean section. To improve the quality of analgesia and prolong its duration, the addition of intrathecal opioids to local anesthetics has been encouraged.
- Trial name
- NCT04446715
- Testing
- sufentanil, meperidine, Bupivacaine
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Makassed General Hospital
Blepharoptosis
Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid
Conjunctival Mullerectomy is a well known procedure used to correct upper lid ptosis via a posterior approach. Patients who undergo this procedure are often given local anesthesia to alleviate intraoperative and postoperative…
- Trial name
- NCT01350024
- Testing
- Frontal nerve block with 2% lidocaine with 1:100,000 dilution of epinephrine, Subconjunctival injection of 2% lidocaine with 1:100,000 dilution with epinephrine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Analgesic Adverse Reaction
Psoas Compartment Block (PCB) Versus L.A Infiltration and Remifentanil Infusion During EVAR
Endovascular aneurysm repair (EVAR) was introduced in 1990 for the first time as a minimally invasive procedure instead of the conventional open surgical repair, with the aim to decrease morbidity and mortality .
- Trial name
- NCT03443518
- Testing
- Psoas Compartment Block (PCB), Local Anesthesia infiltration, Normal saline 0.9% IV infusion
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- Dr. Erfan and Bagedo General Hospital
Knee Osteoarthritis, Knee Pain Chronic
iPACK Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT06087562
- Testing
- Ropivacaine 0.5% Injectable Solution 20mL, 0,9% normal saline 20mL
- Where
- Poland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Pediatric Dentistry, Local Anesthesia
Pain and Anxiety Evaluation in Children Using Different Techniques of Local Anesthesia for Dental Treatment
Fear and dental anxiety are often associated with the use of needles and syringes for local anesthesia, and painful perception during the administration of local anesthetics is often the main reason for anxiety behaviors and…
- Conditions
- Pediatric Dentistry, Local Anesthesia, Pain Management
- Trial name
- NCT03176446
- Testing
- Local anesthesia with traditional technique, Local anesthesia with computerized technique, Local anesthesia with DentalVibe technique
- Where
- Brazil
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ponta Grossa
Anesthesia, Cardiac Surgery
Oral and Intravenous Methadone for Analgesia in Cardiac Surgery
The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac…
- Trial name
- NCT06720415
- Testing
- Oral methadone, immediately prior to transport, Intravenous methadone
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Pre- and Postoperative Analgesia, Spinal Anesthesia
Randomized Study of Spinal Anesthesia Compared With Traditional Epidural Anesthesia Concerning Peroperative and Postoperative Pain After Open Nephrectomy in Patients With Renal Cell Carcinoma
The study aim to study whether spinal anesthesia (using: bupivacain, morfin och klonidin) can be better than epidural anesthesia during and after open surgery for renal cell carcinoma.
- Conditions
- Pre- and Postoperative Analgesia, Spinal Anesthesia, Renal Cell Carcinoma
- Trial name
- ASA (NCT02030717)
- Testing
- klonidin, epidural anesthesia
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Umeå University
Regional Anesthesia Morbidity
Serratus Anterior Plane Block and Costotransverse Block for Analgesia Following Modified Radical Mastectomy Surgeries
Adequate pain management following modified radical mastectomy (MRM) is crucial for early ambulation and patient satisfaction. Breast cancer is the most common malignancy in females, with an increasing incidence in recent years.
- Trial name
- NCT06260397
- Testing
- serratus anterior plane block, costotransverse block, patient controlled analgesia
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cleft Lip Palate, Orofacial Cleft
Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery
Orofacial clefts are among the most common congenital malformations, affecting approximately 1 in 700-1500 live births worldwide.
- Conditions
- Cleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia Assessment
- Trial name
- NCT07557576
- Testing
- Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Iva Smiljanić
Clavicular Fracture, Pain, Acute
Ultrasound-guided Block of the Supraclavicular Nerves in Clavicular Fractures
A Clavicular fractures (CF) is uncomfortable for the affected patients because the fragments are often strongly displaced by the muscles attached to them and the bony fragments move painfully with every movement of the shoulder.
- Trial name
- US-SCNB_Clav (NCT04685291)
- Testing
- Ultrasound-guided block of the supraclavicular nerves, Conventional pain management
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Eckehart SCHÖLL
Pain
ABC Blocks for Cardiac Surgery
This randomized blinded trial aims to evaluate the effect of parasternal intercostal and rectus sheath blocks ("anterior blocks for cardiac surgery" or ABC blocks) on postoperative recovery in patients undergoing median…
- Trial name
- NCT05589363
- Testing
- ABC block with bupivacaine/liposomal bupivacaine, ABC block with saline
- Where
- United States
- Sponsor
- Duke University
Nephrolithiasis, Postoperative Pain
Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure used to remove large or complex kidney stones. Although effective, dilation of the surgical tract and the placement of a nephrostomy tube cause…
- Conditions
- Nephrolithiasis, Postoperative Pain, Quality of Recovery
- Trial name
- NCT07855068
- Testing
- Ketamine and Dexmedetomidine, Fentanyl
- Volunteers
- 100 people
- Sponsor
- Assiut University
Infertility, Pain
MEOPA Breathing Analgesia for Oocyte Retrieval(KALOVAL)
The purpose of this study is to assess pain, at or after oocyte retrieval, the effectiveness of self-controlled inhalation analgesia by nitrous oxide (N2O of 50% and 50% O2) by the patient compared to a local anesthesia combined…
- Trial name
- KALOVAL (NCT00853177)
- Testing
- MEOPA inhalation, xylocaine
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vitreoretinal Surgeries, Postoperative Nausea and Vomiting
Different Peribulbar Blocks With SPI-guided Anaesthesia for VRS (P&MSPIVRS)
The aim of this randomized trial is to assess the efficacy of preventive analgesia using different peribulbar blocks (PBB) under SPI-guided anaesthesia for vitreoretinal surgery (VRS), presence of PONV (postoperative nausea and…
- Conditions
- Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain, Oculocardiac Reflex
- Trial name
- PBBVRS (NCT03413371)
- Testing
- paracetamol, 0,5 % bupivacaine with of 2% lidocaine, 1 % Ropivacaine
- Where
- Poland
- Volunteers
- 184 people
- Sponsor
- Medical University of Silesia
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