Clinical trials: Anesthesia and Analgesia
Breast Cancer, Postoperative Pain
Comparison of Combined (Superficial and Deep) and Isolated Deep Serratus Anterior Plane Blocks After Breast Surgery
The main purpose of this study is to compare the effectiveness of two different regional anesthesia techniques for pain management after oncological breast surgeries.
- Conditions
- Breast Cancer, Postoperative Pain, Pain Management After Surgery
- Trial name
- NCT07724678
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- SBU Ankara Egitim ve Arastirma Hastanesi
Breast Cancer, Anesthesia
Pain Control in Breast Surgery: Analgesia, Opioid Consumption and Inflammatory Response Evaluation
The serratus anterior muscle plane (SAM) block associated with pectoral nerve block type I (PEC I) may be a safe and effective alternative for the intraoperative of breast surgery, since there is evidence of pain reduction.
- Trial name
- NCT02647385
- Testing
- Block with lidocaine for SAM and PEC I block
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Sirio-Libanes
Physiopathology
Assessment Study of the Effect of NMBA on Bowel Peristalsis
Phase III prospective randomised study : curare vs placebo, comparing bowel peristalsis (abdominal echography) in the first minutes of after general anesthesia induction.
- Trial name
- CURARES (NCT02004015)
- Testing
- injection of NMBA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dental Anxiety, Pain
SleeperOne vs. Conventional Infiltration: Pain Perception in Mandibular Primary Molar Extraction
This clinical trial is being conducted in the Department of Pediatric Dentistry, Faculty of Dentistry, Cairo University. The purpose of the study is to compare the pain perception and comfort of children during tooth extraction…
- Conditions
- Dental Anxiety, Pain, Pain Management, Extraction, Tooth
- Trial name
- SOTIMAN (NCT07156396)
- Testing
- SleeperOne®, dental Hitec, France, Conventional Infiltration
- Volunteers
- 28 people
- Sponsor
- Ameera Alaa Eldin Abdalazim Khalifa
Anesthesia, Analgesia
Use of Intrathecal Analgesia in Appendectomy
Acute appendicitis which is the most common cause of acute abdominal pain, is an acute inflammation of appendix vermiformis. Appendectomy operations can be performed as laparoscopic and open surgery.
- Trial name
- NCT04196946
- Testing
- 25 mcg fentanyl, 250 mcg alfentanil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Caudal Block, Pediatric Urologic Surgeries
Comparison of Caudal Block Combined With General Anesthesia and Penile Block and Intravenous Fentanyl in Pediatric Surgeries
Urogenital surgery is one of the most frequently performed surgical procedures in the pediatric patient population. There is no consensus on which analgesic method is most effective for pain control in these patients.
- Conditions
- Caudal Block, Pediatric Urologic Surgeries, Fentanyl, Pediatric Delirium
- Trial name
- NCT06862271
- Testing
- Group 1 ( Caudal block group ), Group 2 (Penile block and IV Fentanyl group)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Miray Gözde Özdemir
Postoperative Pain
An International Trial to Evaluate the Efficacy and Safety of SABER®-Bupivacaine for Postoperative Pain Control in Patients Following Arthroscopic Shoulder Surgery
The objective is to identify the optimal dose of SABER-Bupivacaine for postoperative pain control in patients undergoing elective arthroscopic shoulder surgery on the basis of pharmacokinetics, efficacy and safety evaluations.
- Trial name
- NCT00993798
- Testing
- SABER-Bupivacaine Treatment 1a, Bupivacaine HCl Treatment 1c, SABER-Bupivacaine Treatment 2a
- Where
- 10 sites in Austria, Germany and 3 more
- Volunteers
- 107 people
- Sponsor
- Durect
Anesthesia, Local Anesthesia
Can Caudal Dexmedetomidine Provide Effective Analgesia?
The goal of this clinical trial is to evaluate if caudal dexmedetomidine can provide effective analgesia during inguinoscrotal surgeries in pediatrics, if used caudally alone (and not as an adjunct to caudal bupivacaine).
- Trial name
- NCT05902780
- Testing
- Caudal Bupivacaine injection, Caudal Dexmedetomidine Injection
- Volunteers
- 50 people
- Sponsor
- Benha University
Colorectal Surgery
Effect of Anesthesia on Insulin Secretion in Patients With Preoperative Decreased Insulin Sensitivity
Epidural anesthesia has been found to manipulate the hyperglycemic response to surgery. It is unclear, however, whether the preoperative metabolic status of the surgical patient plays a role in the degree of this hyperglycemic…
- Trial name
- NCT01739413
- Testing
- Anesthesia
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Gabriele Baldini, MD, MSc, Assistant Professor
Thoracic Anesthesia, Geriatric Anesthesia
The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients
One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt…
- Conditions
- Thoracic Anesthesia, Geriatric Anesthesia, One Lung Ventillation (OLV), POCD - Postoperative Cognitive Dysfunction
- Trial name
- NCT07339124
- Testing
- Cognitive Remediation, Pain Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Spinal Diseases
Desflurane and Sevoflurane on Remifentanil Requirement
The primary purpose of this study is to compare the desflurane and sevoflurane on remifentanil requirement using analgesia nociception index-guided anesthesia in patients undergoing spine surgery.
- Trial name
- NCT06123624
- Testing
- Desflurane Inhalation Solution, Sevoflurane Inhalation Solution
- Volunteers
- 78 people
- Sponsor
- Ajou University School of Medicine
Rotator Cuff Tears, Postoperative Pain
The Effect of Liposomal Bupivacaine Nerve Block (Exparel) in Rotator Cuff Surgery
The goal of this clinical trial is to investigate if there is a difference in pain after an arthroscopic rotator cuff surgery when a nerve block is performed with liposomal bupivacaine versus the standard treatment of bupivacaine…
- Conditions
- Rotator Cuff Tears, Postoperative Pain, Opioid Use
- Trial name
- NCT06139666
- Testing
- Exparel Injectable Solution, Bupivacaine Injectable Solution
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- The Cooper Health System
Perioperative Anxiety, Perioperative Pain Management
Evaluation of the Effectiveness of Virtual Reality as an Adjunct to Standard Care in Managing Perioperative Anxiety and Pain in Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia
The goal of this clinical trial is to evaluate whether virtual reality (VR) can effectively reduce perioperative anxiety and pain in patients undergoing lower limb orthopedic surgery under spinal anesthesia.
- Conditions
- Perioperative Anxiety, Perioperative Pain Management, Hemodynamic Stability, Satisfaction
- Trial name
- NCT07134764
- Testing
- Virtual reality session
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Regional Block
Quadratus Lumborum Block Type 2 Versus Posterior Transversus Abdominus Plane Block
This patient population are at risk of adverse effects secondary to inadequate pain management such as inadequate maternal bonding and late ambulation.
- Trial name
- quadratus (NCT04773730)
- Testing
- Posterior transversus abdominus plane block, Quadratus lumborum block type 2
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Pain, Pain, Postoperative
Effect of Quranic Recitation and Classical Music on Pain Intensity and Interleukin-6 Levels After Lower Limb Orthopedic Surgery With Intrathecal Anesthesia
The goal of this study is to determine the effect of murottal and classical music on postoperative pain intensity and interleukin 6 levels in patients undergoing lower extremity orthopedic surgery with spinal anesthesia.
- Conditions
- Pain, Pain, Postoperative, Inflammation, Orthopedic Surgical Procedures
- Trial name
- QRCM (NCT06713044)
- Testing
- Murottal Therapy Intervention Name: Murottal (Islamic verse recitation), Classical Music Therapy Intervention Name: Classical Music Listening, Standard Care (in control arm)
- Where
- Indonesia
- Volunteers
- 33 people
- Sponsor
- Universitas Jenderal Soedirman
Analgesia
Analgesic Efficacy of Continuous Infusion of Local Anaesthetic Versus Single-shot Injection Interscalene Block
The aim of this study is to study the analgesic efficacy of a continuous infusion of local anaesthetics for interscalene brachial plexus block after major shoulder surgery in the setting of multimodal analgesia, in order to…
- Trial name
- BIGKIS (NCT04394130)
- Testing
- ropivacaine 0.2%
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Eric Albrecht
Postoperative Pain
ESP Versus SPSIP Block for Pain Relief After Shoulder Arthroscopy
This study will compare two regional anesthesia techniques for pain relief after arthroscopic shoulder surgery: high thoracic erector spinae plane (ESP) block and serratus posterior superior intercostal plane (SPSIP) block.
- Trial name
- ESP-SPSIP (NCT07906392)
- Testing
- High Thoracic Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ferit Yetik
Anesthesia , Analgesia
Echo-guided Scalp Blocks and Incidence of Postoperative Pain in Scheduled Supratentorial Intracranial Surgery.
Up to 30% of patients undergoing intracranial surgery present moderate to severe pain. In this type of surgery, the restriction of the pharmacopoeia, which goes against the concept of multimodal analgesia, results in the…
- Trial name
- ULTRASCALP (NCT07149077)
- Testing
- Echo-guided scalp blocks, Classic anesthetic strategy
- Where
- France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Bordeaux
Pain, Acute, Laceration
Prospective Evaluation of Topical Analgesia for Laceration Repair in the Emergency Department
The purpose of this study is to determine if topical analgesia using a lidocaine and prilocaine cream improves pain scores compared to the usual local anesthesia using subcutaneous 1% lidocaine and adrenalin injected near the…
- Trial name
- NCT03071601
- Testing
- Lidocaine-Prilocaine Cream 2.5-2.5%, Lidocaine 1% Epinephrine 0.005mg/mL solution
- Where
- 2 sites in France
- Volunteers
- 132 people
- Sponsor
- Centre Hospitalier le Mans
Postoperative Pain, Arthroscopic Shoulder Surgery
Intravenous Dexamethasone Added to Dexmedetomidine After Superior Trunk Block
This prospective, randomized, placebo-controlled, triple-blind trial will evaluate the effect of adding intravenous dexamethasone to intravenous dexmedetomidine on postoperative analgesia after superior trunk block in adult…
- Conditions
- Postoperative Pain, Arthroscopic Shoulder Surgery, Regional Anesthesia
- Trial name
- STB-DEX (NCT07795281)
- Testing
- Intravenous Dexamethasone, Intravenous Dexmedetomidine, Superior Trunk Block
- Volunteers
- 70 people
- Sponsor
- Gaziantep City Hospital
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