Clinical trials: Anesthesia and Analgesia
Nociceptive Pain, Pain, Postoperative
Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia
General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception.
- Conditions
- Nociceptive Pain, Pain, Postoperative, Analgesia, Postoperative, Anesthesia Recovery Period
- Trial name
- NORA (NCT06905340)
- Testing
- NOL (Nociception Level Index), Control (Standard treatment)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Analgesia, Functional Endoscopic Sinus Surgery
ANI-guided Intraoperative Analgesia in Low-pressure Anesthesia
During functional endoscopic sinus surgery(FESS), low-pressure anesthesia is often applied, aiming to decreased operative blood loss, and anesthetics, narcotics and antihypertensive agents are given to achieve desirable low blood…
- Conditions
- Analgesia, Functional Endoscopic Sinus Surgery, Heart Rate Variability, Opioid Consumption
- Trial name
- NCT04319913
- Testing
- analgesia nociception index
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Mackay Memorial Hospital
Analgesia
Evaluation of Surgical Stress Index (SSI) During Sevoflurane/Remifentanil Anesthesia
The aim of the present prospective randomized study was to challenge the ability of SSI to detect painful stimulation during sevoflurane - remifentanil anesthesia.
- Trial name
- NCT00791791
- Testing
- standardized pain stimulus
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Schleswig-Holstein
Regional Anesthesia, Thoracic Surgery
Serratus Anterior Plane Block: Post-operative Analgesia in Video-assisted Thoracic Surgery
The objective of the study is to compare the efficacy of the Serratus Anterior Plane block (SPB) realised in its deep plane, with a multi-holed catheter in place for twenty four hours, to a standard intravenous analgesia for…
- Conditions
- Regional Anesthesia, Thoracic Surgery, Post-operative Pain, Post-operative Chronic Pain
- Trial name
- Serrathos (NCT03277391)
- Testing
- Serratus anterior plane block, patient-controlled analgesia
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Université Libre de Bruxelles
Postoperative Pain After Cesarean Section
Comparison of Combined Spinal Epidural Analgesia and Erector Spinae Plane Block After Elective Cesarean Section
Postoperative pain after cesarean section can significantly affect maternal recovery, early mobilization, and patient satisfaction.
- Trial name
- CSEA-ESP-CS (NCT07411521)
- Testing
- Combined Spinal Epidural Analgesia, Ultrasound-Guided Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa City Hospital
Cancer
Regional Anesthesia and Endometrial Cancer Recurrence
The purpose of this study is to determine whether recurrence of local and metastatic cancer after open hysterectomy for stage 1 or 2 endometrial cancer is reduced when patients receive epidural anesthesia/analgesia combined with…
- Trial name
- ECA/R (NCT00531349)
- Testing
- propofol general anesthesia, Sevoflurane
- Where
- United States
- Sponsor
- The Cleveland Clinic
Postoperative Pain
Analgesia Nociception Index in Orthognathic Surgery
This study aims to determine whether goal-directed analgesia using ANI(Analgesia/Nociception Index) can improve the quality of postoperative recovery in patients undergoing maxillofacial surgery.
- Trial name
- NCT06205355
- Testing
- Analgesia/Nociception Index (ANI) monitoring, Standard monitoring
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Hospital
Erector Spinae Muscle Plane Block, Serratus Anterior Muscle Plane Block
Analgesic Non Inferiority of the Thoracic Bi-block in Comparison With Thoracic Epidural for VATS.
Video-Assisted thoracic surgery (VATS) is the standard treatment for localized lung cancer. However, there is no consensus on analgesic management in patients undergoing VATS.
- Conditions
- Erector Spinae Muscle Plane Block, Serratus Anterior Muscle Plane Block, Video-Assisted Thoracic Surgery, Lung Cancer
- Trial name
- ANESSTEVATS (NCT04538235)
- Testing
- Thoracic Regional Analgesia
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Postoperative Pain
ESP Versus SPSIP Block for Pain Relief After Shoulder Arthroscopy
This study will compare two regional anesthesia techniques for pain relief after arthroscopic shoulder surgery: high thoracic erector spinae plane (ESP) block and serratus posterior superior intercostal plane (SPSIP) block.
- Trial name
- ESP-SPSIP (NCT07906392)
- Testing
- High Thoracic Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ferit Yetik
Digestive System Disease, Surgery
Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia
The purpose of this study is to evaluate the superiority of IV lidocaine combined with morphine spinal anesthesia versus placebo combined with morphine spinal anesthesia, in reducing postoperative morphine consumption at 48…
- Trial name
- LIDORACHI (NCT07076641)
- Testing
- rachi morphine anesthesia, laparotomy, Lidocaine IV
- Where
- France
- Volunteers
- 76 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anxiety, Postoperative Pain
Sublingual Melatonin for Anxiety and Pain in Elective Gynecologic Surgery
This prospective randomized controlled study aims to evaluate the anxiolytic effect of preoperative sublingual melatonin and its impact on postoperative pain scores when administered in two different doses to female patients…
- Conditions
- Anxiety, Postoperative Pain, Anesthesia
- Trial name
- NCT06997263
- Testing
- Melatonin 3 mg Sublingual, Melatonin 6 mg Sublingual
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Benha University
Thoracic Injuries, Rib Fractures
Serratus Plane Block With Parenteral Opioid Analgesia Versus Patient Controlled Analgesia in Rib Fractures
In this multicentre randomised controlled trial, adult patients with isolated chest trauma and two or more unilateral rib fractures will be randomised to either serratus plane block and patient controlled analgesia or patient…
- Conditions
- Thoracic Injuries, Rib Fractures, Anaesthesia, Local, Levobupivacaine
- Trial name
- COPE (NCT03919916)
- Testing
- Serratus plane block, Patient controlled analgesia
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Postoperative Pain, Mandible Fracture
Postoperative Pain After Bupivacaine Supplementation in Mandibular Fracture Surgery
Pain following open reduction of mandibular fractures is the most reported complaint during the first 24 post-operative hours. The goal of this clinical trial is to evaluate the impact of inferior alveolar nerve block with…
- Conditions
- Postoperative Pain, Mandible Fracture, Analgesia, Anesthesia, Local
- Trial name
- NCT06243263
- Testing
- Bupivacain
- Where
- 2 sites in Tunisia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Femoral Fractures
Comparison of Spinal Anesthesia and Erector Spinae Plane Block in Critically Adult Patients Undergoing Femur Surgery
The goal of this observational study is to compare the regional anesthetic methods (not including general anesthesia) -spinal anesthesia, erector spinae plane (ESP) block- which are in routine practice in critically ill adult…
- Trial name
- NCT06652334
- Testing
- Spinal anesthesia, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Duzce University
Back Pain
Erector Spinae Plane Block vs. Usual Care for ED Patients With Mechanical Back Pain
The goal of this clinical trial is to compare the Erector Spinae plane (ESP) block, a nerve block, to usual care in emergency department patients with back pain.
- Trial name
- NCT05982483
- Testing
- Erector Spinae plane block using 20 ml of bupivicaine 0.25%, Usual care
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Island Health
Depression, Postpartum, Analgesia, Obstetrical
CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)
Postnatal depression affects about 10-15% of women after childbirth. Approximately 3-5% of women experience a moderate-to-severe depression that requires medical attention.
- Conditions
- Depression, Postpartum, Analgesia, Obstetrical, Anesthesia, Obstetrical
- Trial name
- CODEPAD (NCT03167905)
- Testing
- Epidural delivery system, Entonox, Meperidine
- Where
- Singapore
- Volunteers
- 881 people
- Sponsor
- KK Women's and Children's Hospital
Laparoscopic Appendectomy
Comparing Pain Relief Between Two Methods of Freezing Injections in Children Having Their Appendix Removed
Laparoscopic appendectomies are the most common emergency surgeries performed in children. Despite being considered minimally invasive surgeries, they can result in substantial postoperative pain and 2 of 3 patients require…
- Trial name
- NCT06945263
- Testing
- Rectus Sheath Block, Local Anesthetic at the Umbilical Port Site, Intravenous Dexamethasone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Breast Cancer Female
USG PECS vs LIA for Breast Cancer Surgery
Breast cancer is the most common cancer for which women in the UK (United Kingdom) undergo surgery. A novel ultrasound guided regional anaesthetic technique called the 'Pecs 2' block has recently been described.
- Trial name
- NCT03555227
- Testing
- USG PECS2 with Drug A (active), Wound infiltration with Drug A (active)
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- National Health Service, United Kingdom
Anesthesia, Regional Anesthesia
Laparoscopic Sleeve Gastrectomy Surgery and External Oblique Intercostal Block
In obese patients, adequate pain relief in the postoperative period is an important parameter that affects patient comfort and hospital stay.
- Conditions
- Anesthesia, Regional Anesthesia, Morbid Obesity, Postoperative Pain
- Trial name
- NCT05822479
- Testing
- Bilateral ultrasound guided external oblique intercostal block (EOIB), Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Postoperative Pain Breast Reduction, Mammaplasty
SPSIP Block for Pain Control After Breast Reduction Surgery
The goal of this clinical trial is to learn whether an ultrasound-guided serratus posterior superior intercostal plane block (SPSIP block) can lower the need for opioid pain medicine after breast reduction surgery.
- Conditions
- Postoperative Pain Breast Reduction, Mammaplasty, Analgesia, Nerve Block
- Trial name
- SPSIP-RM (NCT07657949)
- Testing
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block, Standard Perioperative Pain Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cumhuriyet University Hospital
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