Clinical trials: Anesthesia and Analgesia
Epidural, Labor Pain
Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour
Labour pain can be intensified for labour inductions and women undergoing inductions often have earlier and more frequent requests for analgesia.
- Conditions
- Epidural, Labor Pain, Induction of Labor Affected Fetus / Newborn, Obstetric Anesthesia Problems
- Trial name
- NCT04011098
- Testing
- Epidural Fentanyl Bolus, Standard Epidural Group
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip
iPACK Block vs. Periarticular Infiltration for TKA Pain Control
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA).
- Trial name
- NCT07267650
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Turgutlu State Hospital
Pain, Acute, Knee Arthropathy
Comparison of Regional Anesthesia Techniques After Total Knee Arthroplasty
Comparison of continuous adductor canal block to continuous femoral nerve block in patients after total knee arthroplasty. All patients will be anesthetized with spinal anesthesia.
- Conditions
- Pain, Acute, Knee Arthropathy, Postoperative Pain, Mobility Limitation
- Trial name
- NCT03143738
- Testing
- continuous anesthesia of adductor canal, continuous anesthesia of femoral nerve, Spinal anesthesia
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lublin
Hip Arthroplasty, Postoperative Pain
DIPB vs. SIFIB for Postoperative Analgesia After Hip Surgery
This randomized, double-blind clinical trial aims to compare the effectiveness of the Deep Iliacus Plane Block (DIPB) and the Suprainguinal Fascia Iliaca Block (SIFIB) for postoperative pain control in patients undergoing primary…
- Conditions
- Hip Arthroplasty, Postoperative Pain, Regional Anesthesia, Acute Postoperative Pain
- Trial name
- NCT07452120
- Testing
- Suprainguinal Fascia Iliaca Block, Deep Iliacus Plane Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sivas Numune Hospital
Dental Fear, Anesthesia, Local
Effectiveness of Synapse Transcutaneous Electronic Nerve Stimulation (TENS) During Dental Procedures Among Children
Dental Fear and Anxiety (DFA) are at higher levels among children and often leads to avoidance of dental treatment. Negative experiences in the early years such as experience of pain during injections, fillings, or extractions…
- Conditions
- Dental Fear, Anesthesia, Local, Pediatric Dentistry
- Trial name
- NCT03779659
- Testing
- Synapse TENS device, Topical anesthetic gel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston University
Anesthesia
Low Dose Dexamethasone to Local Anesthetic in Caudal Analgesia on Healing Process After Orthopaedic Surgery
Addition of dexamethasone to local anesthetics infiltration has been proven to augment postoperative analgesia, prolongs anesthesia time and sometimes reduces the needed dose of local anesthetics and consequently, decreases their…
- Trial name
- NCT05755880
- Testing
- Intrathecal dexamethason
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cardiovascular Surgical Procedures, Pain, Postoperative
Fascial Plane Blocks and Quality of Recovery in Cardiac Surgery
In this randomized trial, the investigators will test the hypothesis that combining regional analgesia techniques-which have the potential to improve the quality of postoperative recovery following median sternotomy-with PIFB…
- Conditions
- Cardiovascular Surgical Procedures, Pain, Postoperative, Cardiovascular Diseases
- Trial name
- NCT07557108
- Testing
- Ultrasound-Guided Pectointercostal Fascial Plane Block, Ultrasound-Guided Rectus Sheath Block, Ultrasound-Guided Recto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Ordu University
Postoperative Delirium, Postoperative Pain, Acute
Postoperative Delirium and Analgesia in Elderly Patients
This study aims to evaluate the effects of different postoperative analgesic approaches on postoperative delirium in elderly patients undergoing total knee arthroplasty.
- Trial name
- NCT07849517
- Testing
- adductor canal block and biFes block including bupivacain, Periarticular infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Hepato Cellular Carcinoma (HCC), Sedation and Analgesia
The Impact of Anaesthesia and Sedation on Inflammation and NETosis in Hepatocellular Carcinoma Ablation
According to recent literature, liver disease causes approximately 2 million deaths annually; 1 million are attributed to the complications of cirrhosis, while the remaining deaths are caused by hepatocellular carcinoma (HCC).
- Conditions
- Hepato Cellular Carcinoma (HCC), Sedation and Analgesia, Ablation Techniques
- Trial name
- NCT07657897
- Testing
- Sedation using combination of Propofol and Fentanyl., Sedation using combination of Propofol and Fentanyl and lidocaine
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Pain
Combined Anesthesia for Laparoscopy Surgery in Gynecology
The purpose of this study is to determine whether combined anesthesia will provide better pain control for the postoperative period following gynecological laparoscopy surgery.
- Trial name
- NCT01246323
- Testing
- Spinal anesthesia with Fentanyl+ Morphine
- Where
- 2 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Pain, Postoperative, Anesthesia
The Efficacy of Serratus Anterior Plane Block (ESAPB) for Thoracotomy: a Prospective Study
Thoracotomy is considered the most painful surgical procedure. Ultrasound-guided serratus anterior plane block (SAPB) is a relatively new truncal block method treating thoracotomy pain.
- Conditions
- Pain, Postoperative, Anesthesia, Thoracotomy
- Trial name
- NCT03839160
- Testing
- Serratus anterior plane block, Intravenous patient-controlled-analgesia morphine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shanghai Zhongshan Hospital
Anesthesia, General Anesthesia
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia
- Trial name
- RUMBLE (NCT04144933)
- Testing
- Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Anesthesia
Ultrasound-guided Interscalene Brachial Plexus Block: Single Bolus vs Continuous Catheter Placement in Arthroscopic Rotator Cuff Repair
Shoulder arthroscopy is a minimally invasive procedure frequently used for rotator cuff repair. Patients may experience severe postoperative (PO) pain, that can last for a month and can influence successful rehabilitation.
- Trial name
- ISB (NCT06855381)
- Testing
- the ISBC group, SonoPlex needle and E-catheter, single bolus injection
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Foggia
Primary Total Hip Arthroplasty
Opioid Free Anesthesia in Total Hip Arthroplasty
Total hip arthroplasty (THA) is one of the most common orthopedic surgical procedure and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.
- Trial name
- OFATHA (NCT05072704)
- Testing
- Sufentanil, Dexmedetomidine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CMC Ambroise Paré
Postoperative Pain
Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control
This is a randomized, assessor-blinded, non-inferiority clinical trial comparing continuous thoracic paravertebral block (BPV) versus continuous thoracic epidural block (BPD) for postoperative pain control in adult patients…
- Trial name
- NCT07763249
- Testing
- Continuous Thoracic Paravertebral Block, Continuous Thoracic Epidural Block
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Post-operative Delirium, Cognitive Dysfunction
Effect of Epidural Analgesia on Burst Suppression
It has been shown in previous studies that burst suppression has an effect on the development of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Post-operative Delirium, Cognitive Dysfunction, Electroencephalography
- Trial name
- NCT05688449
- Testing
- Bupivacaine-fentanyl, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bezmialem Vakif University
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Post Operative Pain
Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve Block
Background: Multimodal analgesia for control of postoperative pain in cardiac surgical patients helps in early recovery and ambulation.
- Trial name
- NCT05897307
- Testing
- Ropivacaine
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Fayoum University Hospital
Analgesia
Correlation Between qNOX and Analgesia Nociception Index (ANI) Values During General Anesthesia
qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia. No trials have compared them, so with this trial authors want to explore the correlations between them.
- Trial name
- ANI (NCT06351072)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Padova
Liver Tumor
Is Thoracic Paravertebral Block a Better Option Than Conscious Sedation for PRFA of Liver Tumors
Percutaneus radiofrequency ablation (RFA) of liver tumors causes acute pain during the periooperative setting. In order to facilitate tumor access, patient should collaborate with a surgeon during the procedurę, therefore should…
- Trial name
- NCT04241887
- Testing
- thoracic paravertebral blockade, local anaesthesia
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- University of Warmia and Mazury
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