Clinical trials: Anesthesia and Analgesia
Analgesia
Comparison of Meperidine and Sufentanil Added to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Cesarean Section
Subarachnoid block is a widely used anesthetic technique for cesarean section. To improve the quality of analgesia and prolong its duration, the addition of intrathecal opioids to local anesthetics has been encouraged.
- Trial name
- NCT04446715
- Testing
- sufentanil, meperidine, Bupivacaine
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Makassed General Hospital
Contraception, Pain, Acute
Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed.
- Conditions
- Contraception, Pain, Acute, Anesthesia, Local
- Trial name
- EPIC (NCT06960317)
- Testing
- Buffered Lidocaine, Unbuffered lidocaine, Xylocaine jelly 2%
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hip Fracture
Analgesia for Positioning Hip Fracture Patients for Spinal Anesthesia
The purpose of this study is to compare two analgesic methods performed preoperatively to assist positioning patients for performance of spinal anesthesia, namely fascia iliaca blockade and intravenous fentanyl.
- Trial name
- NCT02037633
- Testing
- Fentanyl, Fascia iliaca compartment block, ropivacaine
- Where
- Greece
- Volunteers
- 41 people
- Sponsor
- Asklepieion Voulas General Hospital
Preemptive Analgesia, Sex Difference
Sex Difference in Preemptive Analgesic Effects With Flurbiprofen Axetil on Postoperative Pain and Sleep Quality
In humans and animals, circadian rhythm sleep cycle plays an important role on maintaining and regulating basic physiological homeostasis, such as cognitive function, glucose metabolism, memory consolidation, immune function and…
- Conditions
- Preemptive Analgesia, Sex Difference, Flurbiprofen Axetil, Postoperative Pain
- Trial name
- NCT04627779
- Testing
- preemptive analgesia with flurbiprofen axetil
- Volunteers
- 100 people
- Sponsor
- Beijing Friendship Hospital
Hip Fractures
PENG Block vs Fascia Iliaca Block for Emergency Department Analgesia in Hip Fractures
Pain management is a crucial aspect of the care of hip fracture patients. Patients with poorly controlled pain have an increased risk of delirium, long-term functional impairment, and remain hospitalized longer.
- Trial name
- NCT05370586
- Testing
- Pericapsular nerve Group Block, Infrainguinal Fascia Iliaca Block
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Epidural Anesthesia
Comparison of the Effects of Epidural Analgesia and Local Infiltrative Analgesia Methods on Pain Control
Total knee arthroplasty (TKA) is one of the major orthopedic surgeries that cause severe postoperative pain. 60% of the patients undergoing TKA have severe pain and 30% have moderate pain postoperatively.
- Trial name
- NCT05344079
- Testing
- 18-Gauge Touhy (Egemen®, Combifix Standard Spinal Epidural Combined Set, İzmir, Turkey), 20-gauge infiltrative analgesia catheter connected to an ON-Q elastomeric pump
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Samsun Education and Research Hospital
Analgesia
Postoperative Analgesia by Epidural vs IV Ketamine Concurrent With Caudal Anesthesia in Pediatric Orthopedic Surgery
Preemptive analgesia can improve postoperative pain management. Ketamine may prevent central sensitization during surgery and result in preemptive analgesia.
- Trial name
- NCT00532662
- Testing
- S(+)-ketamine
- Where
- 2 sites in Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Postpartum Hemorrhage
Retrospective Evaluation of the Impact of Epidural on the Risk of Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is a major complication of childbirth. Epidurals are often implicated in the onset of postpartum hemorrhages.
- Trial name
- NCT06816654
- Testing
- Data extraction from medical records
- Where
- Belgium
- Volunteers
- 5,753 people
- Sponsor
- Tatiana Besse-Hammer
Pain, Postoperative
The Effect of Remifentanil on Rebound Pain
The investigators will evaluate the influence of intraoperative remifentanil infusion on the postoperative hyperalgesia in patients receiving rotator cuff repair after brachial plexus block for postoperative analgesia.
- Trial name
- NCT04236323
- Testing
- Not used remifentanil infusion
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Anesthesia, Analgesia
Transversus Abdominis Plan (TAP) Block for Transcatheter Aortic Valve Implantation (TAVI)
Hemodynamic stability is the main goal of the anesthetic method during Transcatheter Aortic Valve Implantation (TAVI). Pain during the procedure may cause patients to move therefore hemodynamic instability.
- Conditions
- Anesthesia, Analgesia, Block, Aortic Valve Stenosis
- Trial name
- NCT06762288
- Testing
- Ultrasound, Local anesthesia and sedation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Spinal Anesthesia, Hip Fractures
Peri-Capsular Nerve Group and Supra Inguinal Fascia Iliaca BLOCK for Analgesia and Ease of Positioning During Neuraxial Anesthesia in Hip Fracture Patients
Severe pain associated with fractured hip often results in difficulty during positioning for spinal anesthesia (SA). Among many regional analgesic techniques, the fascia iliaca compartment block (FICB) is popular among…
- Trial name
- NCT05987254
- Testing
- suprainguinal fascia iliaca block, pericapsular nerve group block
- Where
- 3 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Analgesia, Obstetrical, Cesarean Section
Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose
Both hydromorphone and morphine are administered as part of spinal anesthesia to help improve pain control after cesarean delivery.
- Trial name
- NCT02009722
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Mayo Clinic
Dental Anxiety, Pain Management
Wand STA vs SleeperOne for Pediatric Local Anesthesia (WASO-Kids)
This randomized, single-blind, split-mouth trial compares the acceptance of two computer-controlled local anaesthetic delivery (CCLAD) systems - Wand® STA and SleeperOne⑤ - in children aged 4-9 years undergoing comparable…
- Trial name
- WASO-Kids (NCT07754851)
- Testing
- Computer-controlled local anesthetic delivery system (pressure-sensing, single-tooth anesthesia type), Computer-controlled local anesthetic delivery system (corded, pen-style electronic type)
- Where
- Greece
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Pain, Postoperative
The Effect of Bilateral Erector Spina Plane Block on Postoperative Analgesia in Cesarean Section Under SpinalAnaesthesia
Acute pain after cesarean section (SC) can be variable. Untreated pain can affect patients' life quality. Currently regional nerve blocks are frequently used as a part of multimodal analgesia.
- Trial name
- NCT05695625
- Testing
- Spinal anesthesia + bilateral erector spine plane block, Spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ankara University
Osteoarthritis, Hip
Systemic Steroids for Peripheral Nerve Blocks
This study will investigate the ability of systemic dexamethasone to prolong the sensory block duration for lumbar plexus nerve blockade.
- Trial name
- NCT02464176
- Testing
- Dexamethasone, Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Intraoperative Analgesia, Postoperative Pain
PECS II Versus ICBN Block Plus SCNB for AV Fistula Creation in CRF Patients
Brachial plexus block (BPB) is often utilized for proximal arm arteriovenous access creation. However, the medial upper arm and axilla are often inadequately anesthetized, as the Intercostobrachial nerve (which provides sensory…
- Trial name
- NCT04988776
- Testing
- ultrasUltrasound-guided Intercostobrachial nerve block supplemental to supraclavicular block with 30 ml 0.25% bupivacaine (15 ml 0.5% bupivacaine will be added to 15 m, ultrasound-guided pectoral nerves block type II supplemental to supraclavicular block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Hip Fractures, Anesthesia, Local
Shamrock - Ultrasound/MR Image Fusion Guided Lumbar Plexus Block
The main objective is to complete a double-blinded randomized controlled crossover trial of lumbar plexus block with the Shamrock technique guided by ultrasound (US)/magnetic resonance imaging (MRI) image fusion vs.
- Conditions
- Hip Fractures, Anesthesia, Local, Pain, Postoperative
- Trial name
- NCT02718976
- Testing
- Lidocaine-epinephrine added gadoterate meglumine
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hip Arthroplasty, Total, Post Operative Pain, Acute
Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty
Hip replacement surgery is one of the most commonly performed surgical procedures in France, with approximately 150,000 procedures per year.
- Conditions
- Hip Arthroplasty, Total, Post Operative Pain, Acute, Nerve Block
- Trial name
- SOSBIFSI (NCT06982625)
- Testing
- Ultrasound guided supra inguinal fascia iliaca block, Surgical and anesthetic protocol
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Institut Mutualiste Montsouris
Pain
Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious
This study aims to assess the usefulness of pupillometry as a nociceptive indicator during elective orotracheal intubation in patients given intravenous lignocaine pre-intubation as compared to a placebo pre-intubation.
- Trial name
- NCT04000126
- Testing
- Pupil reflex dilation measurement (PRD), PPI (Pupillary Pain Index), lidocaine
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Warmia and Mazury
Hip Fractures, Supra-inguinal Fascia Iliaca Block
Preoperative Supra-inguinal Fascia Iliaca Block for Positioning Analgesia in Hip Fracture Patients Undergoing Spinal Anesthesia
The goal of the clinical trial is to learn if preoperative Superficial Inguinal Fascia Iliaca (SIFI) block works to reduce pain during positioning for spinal anesthesia.
- Conditions
- Hip Fractures, Supra-inguinal Fascia Iliaca Block, Spinal Anesthesia
- Trial name
- NCT07556614
- Testing
- Isobaric bupivacaine 0.5%
- Where
- Pakistan
- Volunteers
- 132 people
- Sponsor
- Ghurki Trust and Teaching Hospital
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