Clinical trials: Anesthetics, Intravenous
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Postoperative Delirium (POD), Postoperative Pain
Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery
This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients…
- Conditions
- Postoperative Delirium (POD), Postoperative Pain, PONV, Burst Suppression
- Trial name
- NCT07357480
- Testing
- Target Controlled Infusion, Total Intravenous Anesthesia(TIVA)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Istanbul University - Cerrahpasa
Laparoscopic Appendectomy
Comparing Pain Relief Between Two Methods of Freezing Injections in Children Having Their Appendix Removed
Laparoscopic appendectomies are the most common emergency surgeries performed in children. Despite being considered minimally invasive surgeries, they can result in substantial postoperative pain and 2 of 3 patients require…
- Trial name
- NCT06945263
- Testing
- Rectus Sheath Block, Local Anesthetic at the Umbilical Port Site, Intravenous Dexamethasone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Conscious Sedation, Remifentanil
Local Anaesthesia and Remifentanil Sedation Versus Total Intravenous Anaesthesia for Hysteroscopic Surgery in an Ambulatory Surgery Department.
The purpose of this study is to compare a new method: the combination of conscious sedation with remifentanil (a shortlasting opioid drug) and local anaesthesia, with the traditional general anaesthesia for hysteroscopic surgery.
- Conditions
- Conscious Sedation, Remifentanil, Hysteroscopic Surgery, Anesthesia Recovery Period
- Trial name
- NCT00763789
- Testing
- local anaesthesia and remifentanil sedation, total intravenous anaesthesia
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Copenhagen University Hospital at Herlev
Coronary Artery Disease, General Anesthetic Drug Allergy
Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery
Xenon is a gaseous anaesthetic agent registered in several European countries. It has been administered safely during cardiac surgery in pilot studies.
- Conditions
- Coronary Artery Disease, General Anesthetic Drug Allergy, Coronary Artery Bypass Graft Surgery
- Trial name
- NCT01294163
- Testing
- Xenon, Sevoflurane, Propofol
- Where
- 17 sites in France, Germany and 2 more
- Volunteers
- 509 people
- Sponsor
- Air Liquide Santé International
Colorectal Neoplasms
Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB
The purpose of this study is to check if lidocaine intravenous administration during surgery and 24 hours after surgery, associated with standardised management of the patient, helps to accelerate recovery and to improve the…
- Trial name
- NCT00236249
- Testing
- Lidocaine
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Maternal Hypotension
Norepinephrine on Maternal Hypotension After Combined Lumbar and Epidural Anaesthesia
Norepinephrine has emerged as a potential alternative for stabilizing blood pressure during spinal anesthesia for cesarean section, purportedly maintaining maternal heart rate and cardiac output more effectively than…
- Trial name
- NCT06498115
- Testing
- Norepinephrine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Third People's Hospital of Bengbu
Endovascular Repair of Aortic Aneurysm, Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities
Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.
Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital.
- Trial name
- NCT02107170
- Testing
- Sevoflurane, Propofol, Remifentanil
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Tao Zhang
Total Intravenous Anesthesia
The Effect of Mild Hypercapnia During Anesthetic Emergence on Recovery Time From TIVA
We hypothesized that patients with mild hypercapnia during anesthetic emergence after TIVA had a shorter recovery time than patients with normal blood carbonate levels.
- Trial name
- NCT05401266
- Testing
- mild hypercapnia
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Propofol, Anesthesia
Investigating Near-Threshold Perception During Anesthetic Sedation
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia, and to evaluate if the use of ultrasonic brain stimulation accelerates return to consciousness.
- Conditions
- Propofol, Anesthesia, fMRI
- Trial name
- NCT06403852
- Testing
- Functional Magnetic Resonance Imaging (fMRI) with propofol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Postoperative Ileus
Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy
Epidural local anesthetics are the gold standard for shortening duration of bowel dysfunction after bowel surgery. Previous studies suggest that their effect may be in part a result of actions of the local anesthetic outside the…
- Trial name
- NCT00600158
- Testing
- bupivacaine with hydromorphone, lidocaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Virginia
Obese
Anaesthesia for Laparoscopic Sleeve Gastrectomy
Background: Laparoscopic sleeve gastrectomy is commonly done with total intravenous anaesthesia (TIVA) or balanced anaesthesia using intravenous and an inhalation agent.
- Trial name
- NCT03029715
- Testing
- Propofol, Remifentanil, Dexmedetomidine
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Intravenous Anesthetic Interaction "Unrecognized Condition"
Effect of Intravenous Lidocaine on BIS-guided Propofol Requirements During General Anesthesia
The purpose of this randomized clinical trial is to evaluate the interaction of lidocaine infusion initiated and maintained during surgery, on propofol requirements during general anesthesia.
- Trial name
- NCT01366300
- Testing
- Intravenous lidocaine infusion, Propofol 1% (intravenous infusion), Placement of arterial line
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Obesity (BMI>30), Postoperative Cognitive Function
Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients
Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial.
- Trial name
- NCT07665645
- Testing
- Sevoflurane (Volatile Anesthetic), propofol, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Morbid Obesity, Bariatric Surgery Candidate
Anesthetics and Cerebral Oxygenation in LSG
Obesity is a global health issue that affects different organ systems and may cause severe health issues. Patients with a BMI > 40 kg/m2 or those with a BMI > 35 kg/m2 with accompanying comorbidities are candidates for weight…
- Conditions
- Morbid Obesity, Bariatric Surgery Candidate, Anesthesia
- Trial name
- NCT03946657
- Testing
- Inhalational anesthetic, Intravenous anesthetic
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Lung Cancer, Progression, Disease
The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action
This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary early lung cancer.
- Conditions
- Lung Cancer, Progression, Disease, Anesthesia
- Trial name
- NCT05663242
- Testing
- Propofol, Sevoflurane
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Local Anaesthesia
Forearm Tourniquet With Small Dose Intravenous Lidocaine
The safety and effectiveness of the "mini-dose" Bier block, a technique of i.v. regional anesthesia using low-dose lidocaine (1.5 mg/kg) without routine premedication, was evaluated in the emergency department treatment of…
- Trial name
- NCT02857686
- Testing
- intravenous regional anaesthesia, forearm IVRA
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Breast Cancer
The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)
Because neoplastic disease is one of the leading causes of death worldwide and breast cancer is one of the most frequent neoplasia among women, the possibility of influencing the evolution of patients starting from the moment of…
- Trial name
- TIVA/TCI-BC (NCT02839668)
- Testing
- Lidocaine, Sevoflurane, TIVA-TCI
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Healthy
Study to Assess the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of AZD3043
This is a Phase I, single centre, open label study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of intravenous AZD3043 after single ascending doses in healthy male volunteers.
- Trial name
- NCT00918515
- Testing
- AZD3043
- Where
- Sweden
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Lung Diseases, Total Intravenous Anesthesia
Effects of Adding Different Drugs for Preventing Cough Induced by Bronchoscopic Spraying of Local Anesthetics
Cough is the most unwanted response during bronchoscopic interventions for hemodynamic instability, hypoxemia, and interruption of interventions.
- Conditions
- Lung Diseases, Total Intravenous Anesthesia, Bronchoscopic Interventions
- Trial name
- NCT05072236
- Testing
- bronchoscopic insertion
- Where
- Taiwan
- Volunteers
- 108 people
- Sponsor
- National Taiwan University Hospital