Clinical trials: Anesthetics, Local
Analgesia, Surgery
Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery
This study is being done to see if preoperative transversus abdominis plane (TAP) analgesia will provide similar postoperative pain control, hospital length of stay, and postoperative outcomes compared to surgeon-initiated wound…
- Trial name
- NCT06213454
- Testing
- TAP Anesthesia, Surgeon-Initiated Local Anesthetic
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Wisconsin, Madison
Local Anesthetic
Ultrasound Guided Supraclavicular Nerve Block
This study will test the hypothesis that sequential injection of 1.5% mepivacaine followed 90 seconds later by 0.5% ropivacaine in ultrasound guided supraclavicular block provides a quicker onset and a longer duration of…
- Trial name
- NCT00825786
- Testing
- Ropivacaine, Mepivacaine
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The Cleveland Clinic
Fractured Neck of Femur, Postoperative Pain
Postoperative Analgesia for Fractured Neck of Femur With Periarticular Infiltration of Local Anaesthetic
The purpose of this study is to determine that periarticular levobupivacaine infiltration after surgical fixation of fractured neck of femur will improve the early postoperative pain sensation.
- Trial name
- NCT02057601
- Testing
- Levobupivacaine infiltration group
- Where
- Ireland
- Volunteers
- 37 people
- Sponsor
- Cork University Hospital
Thoracic Surgery
Local Anesthetic as Single Shot Versus Catheter in Patients Undergoing Video Assisted Thoracoscopic Surgery
The purpose of this research is to compare a single shot long acting local anesthetic to catheter infusion of local anesthetic in patients undergoing video assisted thoracoscopic (VAT) surgery.
- Trial name
- NCT04559347
- Testing
- Liposomal Bupivacaine (EXPAREL®)/Bupivacaine, Ropivacaine (0.5% bolus followed by 0.2% infusion)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Poovendran Saththasivam
Postoperative Complications
The Effect of Local Anaesthesia Technique on the Recovery After Dental Treatment in General Anaesthesia
Use of local anaesthesia during full mouth dental rehabilitation under general anaesthesia is an everyday practice. It enables better control of the post-extraction bleeding and better control of physiological responses.
- Trial name
- NCT04156334
- Testing
- Extraction of teeth in general anaesthesia using either computer-controlled intraosseous anesthesia device or carpule for local anaesthesia
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- University of Ljubljana
Opioid Use, Post-thoracotomy Pain Syndrome
Serratus Anterior Plane Block for Management of Post Thoracotomy Pain
This is a single-center, randomized, prospective study evaluating the effect of serratus anterior plane block performed after induction of anesthesia, but before the start of surgery on postoperative opioid requirements.
- Conditions
- Opioid Use, Post-thoracotomy Pain Syndrome, Local Anaesthetic Agent Overdose, Local Anesthetic Complication
- Trial name
- SAPB (NCT04258436)
- Testing
- Serratus anterior block
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Indiana University
Fracture Fixation, Internal, Metacarpal Fracture
The Effect of Forearm Nerve Blocks on Pain-free Tourniquet Time Compared to Local Anesthetic for Awake Hand Surgery
Wide-awake surgery with local anesthesia is a widely described approach to performing numerous minor hand procedures, such as tendon repairs and percutaneous fracture pinning, but is less frequently used for longer procedures…
- Conditions
- Fracture Fixation, Internal, Metacarpal Fracture, Finger Fracture, Anesthesia, Local
- Trial name
- NCT04787835
- Testing
- Forearm nerve block, Local anesthetic infiltration
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Clubfoot
Clubfoot Tenotomy Trial
Infants undergoing Ponseti treatment for idiopathic clubfoot often require percutaneous tendoachilles lengthening (TAL) after serial casting.
- Trial name
- ClubTT (NCT04766684)
- Testing
- Jet injection of 1% lidocaine, 4% liposomal lidocaine cream
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Cataract
Dexmedetomidine Versus Midazolam for Peribulbar Block
50 patients of both sexes, ages 18 to 75, who were scheduled for cataract surgery and had physical status I or II according to the American Society of Anesthesiologists were included in this study.
- Trial name
- peribulbar (NCT06784843)
- Testing
- Dexmedetomidine as an adjuvant to local anesthesia for peribulbar block, Midazolam as an adjuvant to local anesthesia for peribulbar block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Suez Canal University
Pain
Comparison Between the Dentapen and Vibraject
A split-mouth, controlled trial aimed to assess patient-reported pain levels during local anaesthesia administration to the buccal side of the maxillary posterior teeth using Vibraject-assisted injection and the Dentapen® system…
- Trial name
- NCT06790433
- Testing
- Vibraject, Dentapen
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Analgesia
Pediatric Postoperative Analgesia Herniorrhaphy Study
This is a Phase 2 study in pediatric subjects undergoing inguinal herniorrhaphy.
- Trial name
- NCT03922048
- Testing
- HTX-011, Bupivacaine HCl, Luer Lock Applicator
- Sponsor
- Heron Therapeutics
Appendicitis Acute
Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult
Acute appendicitis is one of the most common acute abdomens that need surgical intervention. Laparoscopic surgery much decreases postoperative pain of wound, however, pain remains an important determinant of recovery after…
- Trial name
- NCT03481517
- Testing
- Bupivacaine
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- National Taiwan University Hospital
Injection Site Haematoma, Local Anesthetic Toxicity
U/S Guided SAPB Versus Conventional IV Analgesics in Postoperative Pain Management in MRM
The aim of this study is to compare the effect of ultra-sound guided serratus anterior plane block versus conventional IV analgesics in postoperative pain management in modified radical mastectomy (MRM)
- Trial name
- SAPB (NCT05126394)
- Testing
- ultrasound guided serratus anterior plane block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, Local
Intralipid® 20% for Reversal of Local Anesthetics
In order to determine if Intralipid 20% can be used to reverse the effects of local anesthetics, the investigators will recruit 18 volunteers who will be asked to come to HSS for two study visits.
- Trial name
- NCT03968822
- Testing
- Lidocaine 2%, Lidocaine 1%, Bupivacaine 0.25%
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Pain, Needle Phobia
The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children
This study compares the efficacy of the Synera patch with Eutectic Mixture of Local Anesthetics (EMLA) as a topical anesthetic for venipuncture in pediatric patients.
- Trial name
- NCT00530803
- Testing
- EMLA Cream, Synera Patch
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Montefiore Medical Center
Needlestick Injuries
The Influence of Injection Speed on Pain During Administration of Local Anaesthetic.
This study will investigate the influence of injection speed on pain during injection of lidocaine. It is anticipated that a longer injection time will lead to less pain for the patient during the injection.
- Trial name
- NCT02107742
- Testing
- Normal speed lidocaine injection, Slow lidocaine injection, Fast lidocaine injection
- Where
- Norway
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Heart Surgery Via Sternotomy, Post-operative Analgesia
Advantage of Tramadol in Local Analgesia Post-Sternotomy
Sternotomy, the reference approach for heart surgery, may induce profound and intense post-operative pain. One method of analgesia used is patient-controlled intravenous morphine.
- Trial name
- ATLAS (NCT02851394)
- Testing
- Levobupivacaine, tramadol
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pain, Postoperative
Injection of Local Anesthetic to Trocar Insertion Sites After Laparoscopy
The primary objective of this study is to assess if injection of local anesthetic to the laparoscopic trocar sites after a hysterectomy will make a difference in a patient's pain after surgery.
- Trial name
- NCT01688596
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Milton S. Hershey Medical Center
Laparotomy
IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia
The purpose of this research study is to determine if the two common ways of administering additional opioids (morphine like substance, narcotic) with an epidural, either mixed in the epidural solution or given separately through…
- Trial name
- NCT06559969
- Testing
- Intravenous administered opioid, Epidural administered opioid
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Iowa
Chronic Low Back Pain
Epidural Study of Patients With Chronic Lower Back Pain
The purpose of this study is to examine 4 different epidural dosing regimes of local anaesthetic solution in a series of 3 epidural injections over a period of 12 months to determine the optimum dose of anaesthetic solution for…
- Trial name
- NCT00887003
- Testing
- Bupivacaine, Depo-Medrol
- Where
- Canada
- Volunteers
- 252 people
- Sponsor
- McMaster University