Clinical trials: Anesthetics
Thyroid Operation Under General Anesthesia
Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40
Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia.
- Trial name
- NCT01760018
- Testing
- desflurane group, TIVA group
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Yonsei University
Failed Back Surgery Syndrome
Value of Target-controlled Intravenous Anaesthesia (TCIVA) in Spinal Cord Stimulation
Study design 60 patients Monocenter prospective study Randomized in 2 groups 36 months Objectives Demonstrate the superiority of target controlled intravenous anesthesia versus total anesthesia with the low back paresthesia…
- Trial name
- AIVOC (NCT02821897)
- Testing
- Target-controlled intravenous anaesthesia, Total anaesthesia
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Poitiers University Hospital
General Anesthetics Toxicity, Neurodevelopment
Neurodevelopment of Infants Exposed to General Anesthesia: a Multi-center Investigation
Numerous preclinical evidence has confirmed that most commonly-used general anesthetics can affect neurodevelopment of young animals adversely, causing both structural defect of brain and cognitive impairment.
- Conditions
- General Anesthetics Toxicity, Neurodevelopment, Infant
- Trial name
- GENIUS (NCT03629093)
- Testing
- General Anesthetics
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital
Dexmedetomidine, Sedation
Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings
The goal of this clinical trial is to assess the viability of dexmedetomidine hydrochloride nasal spray under minimal or no supervision and to further investigate novel clinical applications for this medication.
- Conditions
- Dexmedetomidine, Sedation, Safety, Preanesthetic Medication
- Trial name
- NCT07298525
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Open Angle Glaucoma
Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow
Anaesthetic procedures in ophthalmology surgery have been a subject rapidly evolving in the past decades. When deciding for a retrobulbar block, the local injection of varying mixtures and volumes of fast-acting anesthetics (such…
- Trial name
- NCT01840215
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Low Flow Anesthesia, Sevoflurane
Low Flow Anesthesia in Children Undergoing Strabismus Surgery
Emergence agitation (EA) involves restlessness, disorientation, excitation, non-purposeful movement, inconsolability, thrashing, and incoherence during early recovery from general anesthesia.
- Conditions
- Low Flow Anesthesia, Sevoflurane, Strabismus, Emergence Delirium
- Trial name
- LFA in child (NCT06560268)
- Testing
- Sevoflurane; In our study, the effects of sevoflurane in different FGFs administered in children undergoing strabismus surgery on EA and anesthetic agent consumption will be investigated.
- Volunteers
- 150 people
- Sponsor
- Cukurova University
Adverse Effect of Other General Anesthetics, Sequela
Automated Assessment of Difficult Airway With Facial Recognition Techniques
General anaesthesia mandates artificial ventilation and tracheal intubation in order to provide patients with artificial breathing.
- Trial name
- PeScho (NCT02022397)
- Where
- Switzerland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Pain, Constipation
Effect of Lidocaine and Esmolol to Improve the Quality of Recovery
The purpose of this prospective, randomized, double-blinded, active-controlled study is: To assess the effectiveness of systemic administration of lidocaine and esmolol in combination (vs.
- Conditions
- Pain, Constipation, Nausea, Vomiting
- Trial name
- NCT01114997
- Testing
- Lidocaine, Esmolol, Lidocaine + Esmolol (Combo)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Cedars-Sinai Medical Center
Pain, Postoperative
The Effect of IV Dexamethasone on the Duration of Analgesia of Spinal Anaesthesia for C-Sections at a Jamaican Hospital
Dexamethasone is one of many adjuncts tested to prolong the duration of spinal anesthesia and its analgesic effect. The intent of this, a single-site, double-blinded, randomized controlled trial, is to determine if a single…
- Trial name
- NCT04624360
- Testing
- Dexamethasone
- Where
- Jamaica
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Anesthesia Complication
Efficacy of Dexmedetomidine for Cough Suppression in Patients Undergoing Thyroid Surgery
Maintenance of a remifentanil infusion during anesthetic emergence has been reported to decrease the incidence of coughing and thereby help to ensure a smooth emergence.
- Trial name
- EDCSTS (NCT03312413)
- Testing
- Dexmedetomidine Hydrochloride, Normal Saline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Min Su
Pain, Postoperative
Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty
Total shoulder arthroplasty (TSA) is considered to be a major surgical procedure resulting in severe postoperative pain, especially in the first 48 hours after surgery.
- Trial name
- NCT02876055
- Testing
- Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cohort Studies
Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.
- Trial name
- NCT06307717
- Testing
- volatile anaesthetic (sevoflurane, isoflurane, desflurane)
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Neuromuscular Blockade, Neuromuscular Monitoring
Development and Validation of an Android-based Application for Anaesthesia Neuromuscular Monitoring
The present study aims to assess the accuracy of a newly developed Android Smartphone Application in measuring the degree of Neuromuscular block in the perioperative period.
- Trial name
- NCT03605225
- Testing
- mobile cellphone application test
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Universitair Ziekenhuis Brussel
Local Infiltration, Anesthesia
Painless Local Anaesthesia With Bicarbonate Admixture
This study examines whether the injection of local anesthesia mixed with sodium bicarbonate in the ratio of 3:1 creates a less burning sensation and is as effective regarding the anesthetic effect as in the ratio of 9:1.
- Trial name
- NCT03238625
- Testing
- Lidocaine and sodium bicarbonate, Lidocaine, Sodium cloride 0.9%
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Airway Obstruction, Difficult Intubation
A Study of Laryngoscopic Vision With the TotalTrack Device Versus Indirect Laryngoscopy
Assessment of the airway forms part of routine anesthetic practice. However, the predictions referred to intubation or ventilation difficulties are usually inconclusive.
- Trial name
- MULTITOTAL (NCT03208140)
- Where
- 2 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Formacion Internacional para la Docencia e Investigación de la Vía Aérea
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Liver Cancer, Hepatectomy
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing…
- Conditions
- Liver Cancer, Hepatectomy, Anesthesia Techniques, Postoperative Pain
- Trial name
- NCT07097220
- Testing
- General Anesthesia (GA) group, General-Epidural Anesthesia (GEA) group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine,
Postoperative Pain
Effects of TIVA With Propofol Versus Inhalational Anaesthesia on Postoperative Pain After Hepatectomy
Propofol is a commonly used intravenous anaesthetic drugs both for induction and maintenance of general anaesthesia. Advantages of total intravenous anaesthesia (TIVA) with propofol include reduced nausea and vomiting, reduced…
- Trial name
- NCT03597997
- Testing
- Propofol, Sevoflurane
- Where
- 2 sites in Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Hip Fractures
Conventional Spinal Anaesthesia Versus Fractional Spinal Anaesthesia on Hemodynamics
compare the systemic haemodynamic response to fractional spinal anaesthesia versus conventional spinal anaesthesia , in a group of elderly and comorbid patients with hip fracture.
- Trial name
- NCT06583213
- Testing
- Fractional Spinal Anaesthesia., Conventional Spinal Anaesthesia
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Ain Shams University
Hemodynamic Instability, Anesthesia
Hemodynamic Changes and Propofol Pharmacokinetic Variation During Anesthesia Induction and Knee-chest Positioning
Induction of anesthesia and the knee-chest position are associated with hemodynamic changes that may impact patient outcomes. Changes from baseline in cardiac output and other hemodynamic variables following induction of…
- Conditions
- Hemodynamic Instability, Anesthesia, Surgery
- Trial name
- NCT03961958
- Testing
- Propofol reduction
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca