Clinical trials: Aneurysm, Brain
Intracranial Aneurysm
Effect of Different Heparinization Schemes on Prognosis of Intracranial Aneurysm
The goal of this clinical trial is to compare intracranial aneurysm patients. The main question it aims to answer are: Which heparinization regimen is most beneficial to patients during surgery for intracranial aneurysms.
- Trial name
- EODHS-IA (NCT05749393)
- Testing
- Heparin sodium
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cerebrovascular Event, Stent Stenosis
Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation
APICES trial is an investigator-initiated, multicenter, multicenter, randomized, double-blind, placebo-controlled clinical trial that plans to enroll 396 patients with a 1-year follow-up, including a neurovascular imaging…
- Conditions
- Cerebrovascular Event, Stent Stenosis, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT06308952
- Testing
- Atorvastatin 20mg
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Duan Chuanzhi
Unruptured Cerebral Aneurysm
Real-time Deflectable Guidewire in Neuro-interventions Study
The aim of the study is to assess the safe and successful use of the SmartGUIDE guidewire in neuro interventions and to compare to standard of care guidewires on the market.
- Trial name
- NCT05564325
- Testing
- SmartGUIDE (deflectable guidewire)
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- Artiria Medical
Intracranial Aneurysm
Prospective, Post-registration, Interventional, Randomized, in Parallel Groups, Multicenter Eurasian Clinical Study of DERIVO®/DERIVO® Mini Aneurysm Embolization Device, Europe-Asia
Prospective, post-registration, interventional, randomized, in parallel groups, multicenter Eurasian clinical study of DERIVO®/DERIVO® mini Aneurysm Embolization Device, Europe-Asia
- Trial name
- NCT06400940
- Testing
- ticagrelor (tablets, 180 mg) or prasugrel (tablets, 10 mg)., combination of clopidogrel (tablets, 75 mg) and acetylsalicylic acid (ASA, tablets, 100 mg) or a combination of ticagrelor (tablets, 180 mg) and ASA (tablets, 100 mg).
- Where
- Russia
- Volunteers
- 640 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Aortic Dissection
Cerebral and Spinal Protection of Xenon Post-conditioning in Patients Undergoing Aortic Dissection Repair
With more and more people developing hypertension and atherosclerosis, the morbidity rate of Acute Aortic Dissection（AAD） has been increasing. Emergency surgery is the main treatment for Acute Aortic Dissection.
- Trial name
- NCT02774096
- Testing
- xenon
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Subarachnoid Hemorrhage, Ruptured Intracranial Aneurysm
Safety and Efficacy Study of a Single Dose of NA-1 in Patients Undergoing Endovascular Repair of Ruptured Aneurysms
This is a randomized, double-blind, placebo-controlled, single-dose study investigating the safety and efficacy of NA-1 in patients with subarachnoid hemorrhage (SAH) undergoing endovascular repair of ruptured intracranial…
- Trial name
- ENACT-2 (NCT02056574)
- Testing
- NA-1
- Where
- 12 sites in United States, Canada
- Sponsor
- NoNO Inc.
Intracranial Aneurysms
Prospective Study of High-penetration Super-resolution Transcranial Ultrasound for Early Identification of Postoperative Intracranial Metallic Targets After Aneurysm Clipping
To evaluate the patient-level early diagnostic performance of high-penetration super-resolution transcranial ultrasound for identifying intracranial metallic targets, and to further assess clip-level detection, localization…
- Trial name
- HPSR-TCUS Clip (NCT07583225)
- Volunteers
- 78 people
- Sponsor
- Chinese PLA General Hospital
Unruptured Intracranial Aneurysm
Unruptured Cerebral Aneurysm: Prediction of Evolution
The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening.
- Trial name
- U-CAN (NCT04578808)
- Testing
- Unruptured intracranial aneurysms
- Where
- 29 sites in France, Netherlands and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
Aneurysm, Intracranial
Evaluation of Safety and Effectiveness of Stryker Surpass Evolve™ Flow Diverter System
The primary objective of this study is to evaluate the safety and effectiveness of the Surpass™ Evolve Flow Diverter System in the treatment of unruptured, wide-neck intracranial aneurysms measuring ≤ 12 mm and located on the ICA…
- Trial name
- EVOLVE (NCT04195568)
- Testing
- Surpass Evolve Flow Diverter System
- Where
- 37 sites in United States, Australia and 1 more
- Volunteers
- 248 people
- Sponsor
- Stryker Neurovascular
Cerebral Arterial Disease, Cerebral Aneurysm
Esmolol Infusion in Patients Undergoing Craniotomy
Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in blunting adrenergic response to several perioperative…
- Trial name
- NCT02455440
- Testing
- Esmolol, Propofol and sevoflurane
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- George Papanicolaou Hospital
Intracranial Aneurysm
A Retrospective, Multicenter, Controlled Clinical Trail: to Evaluate the Clinical Efficiency of Intracranial Aneurysm Assistive Software in the Morphological Measurement
the goal of this clinical trail is to evaluate the clinical efficiency of intracranial aneurysm assistive software in the morphological measurement. The trail is designed as retrospective, multicenter, controlled clinical trail.
- Trial name
- NCT05804474
- Testing
- Observational study
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tiantan Hospital
Abdominal Aortic Aneurysm, Coronary Heart Disease
Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study
Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease, Sudden Cardiac Death, Intracerebral Haemorrhage
- Trial name
- NCT02176174
- Volunteers
- 1,068,318 people, healthy volunteers welcome
- Sponsor
- University College, London
Intracranial Aneurysm, Aneurysm
Coated Mongolian Aneurysm Treatment Study 2
The purpose of this study is to assess safety and effectiveness of the p64 MW HPC or p48 MW HPC Flow Modulation Device under prasugrel.
- Conditions
- Intracranial Aneurysm, Aneurysm, Vascular Diseases
- Trial name
- COMATS 2 (NCT04305704)
- Where
- Mongolia
- Volunteers
- 90 people
- Sponsor
- Phenox GmbH
Intracranial Aneurysm
Evaluation of Postoperative Cognitive Function, Anxiety, Depression and Quality of Life in Patients With Unruptured Intracranial Aneurysms
This prospective single-center cohort study aims to identify the incidence of cognitive dysfunction after unruptured aneurysm operation and explore the influencing factors.
- Trial name
- NCT03494608
- Volunteers
- 350 people
- Sponsor
- Xuanwu Hospital, Beijing
Abdominal Aortic Aneurysm, Acute Myocardial Infarction
Body Mass Index and Initial Presentations of Cardiovascular Diseases
The association between obesity and cardiovascular disease (CVD) has mostly been studied using broad endpoints or have focused on cause-specific mortality.
- Conditions
- Abdominal Aortic Aneurysm, Acute Myocardial Infarction, Stroke, Heart Failure
- Trial name
- CALIBER (NCT01704300)
- Where
- United Kingdom
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Randomized Controlled Trial, Intracranial Aneurysm
Comparison of Clipping Via Keyhole Versus Traditional Approaches and Coiling for Ruptured Aneurysms
Endovascular coiling has become a strategy of choice of intracranial aneurysms due to its minimally invasiveness. However, there has few prospective randomized controlled studies on the comparison of therapeutic effect between…
- Conditions
- Randomized Controlled Trial, Intracranial Aneurysm, Microsurgery, Endovascular Procedures
- Trial name
- NCT05049564
- Testing
- keyhole microneurosurgery, conventional microneurosurgery, endovascular coiling
- Volunteers
- 150 people
- Sponsor
- ZhuQing
Self Efficacy, Medical Device Complication
Chinese Registry of Assisted Embolization for Unruptured Wide Necked Intracranial Aneurysm Using LVIS Stent
This study aims to investigating the efficacy and safety of low profile visualized intraluminal support (LVIS) stents for the treatment of unruptured intracranial saccular aneurysms.
- Trial name
- CRANIAL-1 (NCT02830373)
- Testing
- LVIS stents
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Cerebral Aneurysm
Remote Ischemic Preconditioning for Intracranial Aneurysm Treatment
The RIPAT study is a prospective, randomized, double-blind study organized by the neurovascular group of the Clinical Department of Neurosurgery of Innsbruck Medical University, Innsbruck, Austria.
- Trial name
- RIPAT (NCT02162654)
- Testing
- Remote ischemic preconditioning
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Medical University Innsbruck
Intracranial Aneurysm
Brain Low-risk Aneurysm Stereotactic Radiosurgical Trial
The goal of this clinical trial is to confirm the feasibility and safety of performing radiosurgery on unruptured, low-risk aneurysms in humans. Participants will choose if they want to undergo radiosurgery or not.
- Trial name
- BLAST (NCT06047951)
- Testing
- Stereotactic RadioSurgery (SRS)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Dr David Mathieu
Cerebrovascular Disease, Intracranial Aneurysm
Investigation of Hemodynamics and Radiomics Based on High Resolution Magnetic Resonance Imaging for Predicting the Outcomes of Intracranial Dissecting Aneurysm
This study aims to conduct a comprehensive analysis by integrating clinical factors, aneurysm morphological characteristics, and factors reflecting pathophysiological processes (such as hemodynamic and radiomics features), in…
- Conditions
- Cerebrovascular Disease, Intracranial Aneurysm, Intracranial Arterial Dissection
- Trial name
- NCT07335029
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Beijing Neurosurgical Institute