Clinical trials: Aneurysm, Intracranial
Intracranial Aneurysm
Coil Assisted Flow Diversion Safety and Performance Study
Cerus Endovascular is sponsoring a prospective, single arm, multi-center study to document the safety and performance of Neqstent in adjunctive therapy.
- Trial name
- CAFI (NCT04187573)
- Testing
- Neqstent
- Where
- 7 sites in Austria, Canada and 3 more
- Volunteers
- 38 people
- Sponsor
- Cerus Endovascular, Inc.
Cerebral Aneurysm
Remote Ischemic Preconditioning for Intracranial Aneurysm Treatment
The RIPAT study is a prospective, randomized, double-blind study organized by the neurovascular group of the Clinical Department of Neurosurgery of Innsbruck Medical University, Innsbruck, Austria.
- Trial name
- RIPAT (NCT02162654)
- Testing
- Remote ischemic preconditioning
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Medical University Innsbruck
Subarachnoid Hemorrhage
Impact of Ultra-Early Intracranial Aneurysm Treatment in SAH
This is the first prospective study in Hong Kong that recruit patients with poor neurological status after intracranial aneurysm rupture in all seven public neurosurgical services in Hong Kong.
- Trial name
- UEAT (NCT03894202)
- Where
- China
- Volunteers
- 293 people
- Sponsor
- Chinese University of Hong Kong
Subarachnoid Hemorrhage, Aneurysmal, Subarachnoid Hemorrhage
Remote Ischemic Preconditioning in Subarachnoid Hemorrhage
Rupture of brain aneurysms is a common cause of death and disability, accounting for as many as 10% of stroke cases in the United States.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Subarachnoid Hemorrhage, Cerebral Vasospasm, Intracranial Aneurysm
- Trial name
- RIPC-SAH (NCT01158508)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Aneurysmal Subarachnoid Hemorrhage, Neurobehavioral Manifestations
Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin
A Blind-adjudication Multi-center Phase II Randomized Clinical Trial of Continuous Low-dose Intravenous Heparin Therapy in Coiled Low-grade Aneurysmal Subarachnoid Hemorrhage Patients with Significant Hemorrhage Burden.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Neurobehavioral Manifestations, Vasospasm, Intracranial, Intracranial Aneurysm
- Trial name
- ASTROH (NCT02501434)
- Testing
- Continuous Low-Dose IV Unfractionated Heparin Infusion
- Where
- 9 sites in United States
- Volunteers
- 88 people
- Sponsor
- Robert F. James
Ruptured and Unruptured Intracranial Aneurysms
Mid-term Data Collection of the Treatment of Intracranial Aneurysms With the WEB™ Aneurysm Embolization System
Flow disruption is a new endovascular approach for treatment of both ruptured and unruptured intracranial aneurysms, which involves placement of an endosaccular device (WEB) which modifies the blood flow at the level of the neck…
- Trial name
- NCT03379714
- Testing
- WEB aneurysm embolization system
- Where
- Belgium
- Sponsor
- Medical Therapy Solutions
Cerebral Aneurysm, Thromboembolic Disease
Prospective, Single-Arm, Multicenter Study to Evaluate the Effectiveness and Safety of Endovascular Treatment in Patients With Cerebral Aneurysms Using P64 and P48 Flow-Diverter Stents
The use of flow-diverting stents for the endovascular treatment of cerebral aneurysms has proven to be effective and efficient in several clinical studies, leading to its widespread adoption.
- Trial name
- pSPAIN_HPC (NCT06201598)
- Testing
- Group 1 - Intervention 1
- Where
- 11 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario Central de Asturias
Subarachnoid Hemorrhage of Aneurysmal Cause
Observational Study on Mortality and Outcome of Patients Hospitalized for Subarachnoid Hemorrhage of Aneurysmal Origin in Martinique Between 2013 and 2021
The aim of our study is to analyze mortality and sequelae of subarachnoid hemorrhage of aneurysmal origin in hospitalized patients in Martinique. Predictive factors of poor prognosis will also be analyzed.
- Trial name
- HSA Rankin (NCT06525012)
- Testing
- Usual patient care for patients hospitalized for subarachnoid hemorrhage of aneurysmal origin
- Where
- Martinique
- Volunteers
- 122 people
- Sponsor
- University Hospital Center of Martinique
Intracranial Aneurysm
INCA: Intracranial Aneurysm Treatment With NeXsys
Prospective, single center first-in-man study of use of device for intracranial aneurysm occlusion
- Trial name
- INCA (NCT02507531)
- Testing
- NeXsys Embolization System
- Where
- Argentina
- Volunteers
- 3 people
- Sponsor
- Cerus Endovascular, Inc.
Intracranial Arterial Aneurysm
Safety and Efficacy of the Surpass Evolve Flow Diverter in Treating Intracranial Aneurysms
Safety and Efficacy of the Surpass Evolve Flow Diverter in Treating Intracranial Aneurysms
- Trial name
- NCT06731946
- Testing
- Flow diverting
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Yibin Fang
Intracranial Aneurysm
LVIS™ Evo™ and HydroCoil® Embolic System for Intracranial Aneurysm Treatment
This is a prospective multicenter international single-arm observational study to demonstrate that use of stent-assisted coiling with LVIS™ Evo™ and HydroCoil® Embolic System (HES) in intracranial aneurysm treatment is effective…
- Trial name
- SEALANT (NCT04999423)
- Testing
- LVIS EVO and HydroCoil Embolic System
- Where
- 19 sites in Belgium, France and 3 more
- Volunteers
- 206 people
- Sponsor
- Microvention-Terumo, Inc.
Cerebral Vasospasm, Cerebral Aneurysm
Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage
Cerebral vasospasm is a devastating complication of subarachnoid hemorrhage after cerebral aneurysm rupture leading to cerebral ischemia and potentially cerebral infarction.
- Conditions
- Cerebral Vasospasm, Cerebral Aneurysm, Subarachnoid Hemorrhage
- Trial name
- NCT00962546
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Acute Ischemic Stroke, Intracranial Arterial Stenosis
Post-Market Active Surveillance and Health Economic Evaluation of Cerebrovascular Diagnostic and Therapeutic Devices
The research focuses on "post-market active surveillance and health economic evaluation of non-pharmacological therapies and innovative cerebrovascular diagnostic and therapeutic devices".
- Conditions
- Acute Ischemic Stroke, Intracranial Arterial Stenosis, Extracranial Arterial Stenosis, Intracranial Aneurysms
- Trial name
- NCT07828379
- Testing
- Endovascular Treatment for Acute Ischemic Stroke
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Aneurysm Cerebral (Unruptured)
Dual Antiplatelet Therapy Adherence With Reminder App Usage
The purpose of this study is to evaluate Dual Antiplatelet Therapy adherence in patients undergoing stent-based endovascular treatment for unruptured cervical and intradural, intracranial aneurysms.
- Trial name
- NCT05071027
- Testing
- Endovascular Neurosurgery
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Montefiore Medical Center
Intracranial Aneurysm
Intravascular Neuro OCT Imaging System for Aneurysm Treatment Evaluation
This is an investigational study for a new medical device called the nOCT (neuro optical coherence tomography) Imaging System, which is manufactured by Spryte Medical, LLC.
- Trial name
- INSYTE (NCT07214220)
- Testing
- Endovascular Intracranial aneurysm treatment, nOCT imaging
- Where
- 8 sites in United States, Argentina and 1 more
- Volunteers
- 67 people
- Sponsor
- Spryte Medical
Subarachnoid Hemorrhage, Aneurysmal
Study of EG-1962 Compared to Standard of Care Oral Nimodipine in Adults With Aneurysmal Subarachnoid Hemorrhage
This study compares EG-1962 to enteral nimodipine in the treatment of aneurysmal subarachnoid hemorrhage.
- Trial name
- NEWTON2 (NCT02790632)
- Testing
- EG-1962 (nimodipine microparticles), Enteral Nimodipine
- Where
- 79 sites in United States, Australia and 9 more
- Volunteers
- 374 people
- Sponsor
- Edge Therapeutics Inc
Intracranial Aneurysms
Post-Market Product Surveillance of Intracranial ANeurysms Treated With Commercial ReGistered ACANDIS Devices in FrancE
The aims of this clinical data collection are to investigate mortality, morbidity and neurological outcome 12 months after treatment of subject's intracranial aneurysm(s) and additionally to evaluate potential residual risks…
- Trial name
- ANCRAGE PMS (NCT06940934)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Acandis GmbH
Intracranial Aneurysm, Subarachnoid Hemorrhage
Familial Intracranial Aneurysm Study II
The purposes of this study are to identify possible genes that may increase the risk of aneurysm development in the brain, and to determine the effect of environmental factors such as cigarette smoking and high blood pressure on…
- Trial name
- NCT00071565
- Where
- 16 sites in United States
- Volunteers
- 5,875 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Ruptured Aneurysm of Intracranial Artery, Stent-Assisted Coiling
Safety and Efficacy Analysis of Stent-assisted Coil Embolization in the Treatment of Acute Ruptured Intracranial Aneurysms in the Perioperative Period.
To determine the perioperative safety and efficacy of stent-assisted coil embolization of intracranial aneurysms in the acute phase.
- Conditions
- Ruptured Aneurysm of Intracranial Artery, Stent-Assisted Coiling, Efficacy and Safety
- Trial name
- NCT07683377
- Testing
- Perform stent-assisted aneurysm embolization on patients who meet the enrollment criteria, and administer antiplatelet drugs postoperatively according to the established trial protocol.
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Tang-Du Hospital
Intracranial Aneurysm
Stenting in the Treatment of Aneurysm Trial
The STAT trial aims at comparing coiling versus coiling plus stenting in patients with aneurysms prone to recurrence, that is large aneurysms or recurring aneurysms after previous coiling or wide-necked aneurysms.
- Trial name
- STAT (NCT01340612)
- Testing
- endovascular coiling with any type of currently approved coil (first or second generation), endovascular stenting with or without coiling. The stent may be any of the currently approved stents for intracranial aneurysms.
- Where
- 5 sites in Canada, France
- Volunteers
- 205 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)