Clinical trials: Aneurysmal Subarachnoid Haemorrhage
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration
Nimodipine reduces the risk of poor outcome and delayed cerebral ischemia in patients suffering aneurysmal subarachnoid haemorrhage (SAH), but its mode of action is unknown.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral
- Trial name
- NCT04649398
- Testing
- Nimodipine
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Stroke Hemorrhagic, Depression
Poststroke Depression in Hemorrhagic Stroke
A double-blinded placebo-controlled randomized trial to evaluate the effect of preventative treatment of depression in survivors of aneurysmal subarachnoid hemorrhage (aSAH), a type of stroke.
- Trial name
- NCT03826875
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Washington
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral
Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm
The investigators propose a technique using cone beam CT perfusion (CBCTP) imaging with an acetazolamide challenge as a potential diagnostic tool to detect a defect in cerebral autoregulation at a time when it has not yet caused…
- Trial name
- NCT03377049
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Wisconsin, Madison
Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block
Stellate Ganglion Block and Prognosis of Neurological Function After Subarachnoid Hemorrhage
The incidence of cerebral vasospasm after aneurysm subarachnoid hemorrhage (aSAH) is as high as 70%; cerebral vasospasm（CVS） is closely related to delayed cerebral ischemia （DCI）, which is one of the important reasons for poor…
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block, Neurological Prognosis
- Trial name
- NCT07652749
- Testing
- Intervention group
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage
Lumbar Drainage in Subarachnoid Haemorrhage
Subarachnoid haemorrhage affects approximately 8000 people per year in the UK. The average age of a patient with subarachnoid haemorrhage is 50 years, although it is often seen in younger people (25-45 years).
- Trial name
- LUMAS (NCT00842049)
- Testing
- Lumbar Drain (Medtronic lumbar drainage system), No lumbar drain
- Where
- United Kingdom
- Volunteers
- 210 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Subarachnoid Hemorrhage, Vasospasm, Intracranial
The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product).Depletion of NO synthase (19,20,21) was also noted after SAH.CSF is produced from…
- Trial name
- NCT00745758
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Subarachnoid Hemorrhage, Aneurysmal
Safety/Pharmacokinetic Study Comparing Intracisternal EG-1962 to Standard of Care Enteral Nimodipine in Adults With aSAH
Safety and Pharmacokinetic study comparing intracisternal EG-1962 to enternal nimopidine in the treatment of aneurysmal subarachnoid hemorrhage.
- Trial name
- NCT02893826
- Testing
- EG-1962 (nimodipine microparticles), Enteral Nimodipine
- Where
- 4 sites in United States, Canada
- Volunteers
- 6 people
- Sponsor
- Edge Therapeutics Inc
Aneurysmal Subarachnoid Haemorrhage
CytoSorb SAH Trial
In aSAH high levels of IL-6 (a pro-inflammatory cytokine) in the cerebrospinal fluid, as well as systemically have been linked to the severity grade and the occurrence of vasospasm and delayed cerebral ischemia caused by…
- Trial name
- NCT05259514
- Testing
- CytoSorb
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Emanuela Keller
Subarachnoid Hemorrhage, Headache
Efficacy of Percutaneous SPG Block in Aneurysmal SAH
Researchers are trying to develop alternative means to help patients with headache pain secondary to aneurysmal subarachnoid hemorrhage (bleeding about the brain).
- Trial name
- NCT04331938
- Testing
- Regional anesthetic SPG block-bilateral
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Ruptured Aneurysm, Memory Deficits
Memory Training in Aneurysmal Subarachnoid Hemorrhage Patients
The study aim is to determine if periodic online cognitive exercises (Lumosity) improve memory function in ruptured cerebral aneurysm patients with disabling baseline memory deficits within the first 24 months after rupture.
- Conditions
- Ruptured Aneurysm, Memory Deficits, Subarachnoid Hemorrhage
- Trial name
- MASH (NCT02864940)
- Testing
- Lumosity, Crossword puzzle
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rush University Medical Center
Subarachnoid Hemorrhage, Spontaneous, Subarachnoid Hemorrhage, Aneurysmal
Hemodynamic Instability of Patient With Spontaneous Subarachnoid Hemorrhage
The goal of this observational study is to learn about the role of biomarkers in spontaneous subarachnoid hemorrhage (sSAH) as predictors of severity of clinical outcome.
- Trial name
- HISAHES (NCT06218654)
- Testing
- biomarkers
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Subarachnoid Hemorrhage, Intracranial Aneurysm
Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage
This is a randomized, placebo-controlled, single-center clinical trial investigating the effectiveness of administrating intravenous Cerebrolysin™ (EVER NEURO Pharma, Austria), a preparation of low-molecular weight neurotrophic…
- Conditions
- Subarachnoid Hemorrhage, Intracranial Aneurysm, Delayed Cerebral Ischemia, Delayed Ischemic Neurological Deficit
- Trial name
- CESAR (NCT01787123)
- Testing
- Intravenous Cerebrolysin, Normal Saline
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Kwong Wah Hospital
Aneurysmal Subarachnoid Hemorrhage
Delayed Cerebral Ischaemia and Coagulation Alterations After Aneurysmal Subarachnoid Haemorrhage
Despite the advances in neurosurgical and -radiological techniques and intensive care, the mortality and morbidity rates in SAH have not changed in recent years.
- Trial name
- NCT03985176
- Testing
- ROTEM, EEG, bilateral compression ultrasound of the lower extremity veins
- Where
- Finland
- Volunteers
- 62 people
- Sponsor
- Tampere University Hospital