Clinical trials: Aneurysmal Subarachnoid Hemorrhage
Subarachnoid Hemorrhage, Aneurysmal, Cognitive Dysfunction
Gamma Entrainment Stimulation for Cognitive Dysfunction After aSAH
The goal of this clinical trial is to Explore and verify whether 40Hz audio and binaural beat 40Hz audio can improve the postoperative cognitive dysfunction seen in patients with aneurysmal subarachnoid hemorrhage.
- Trial name
- GES-aSAH (NCT06346015)
- Testing
- Gamma Entrainment Stimulation
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal
Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding into the space between the brain and the tissues that surround the brain as a result of a ruptured aneurysm and is a type of stroke associated with high morbidity and…
- Trial name
- PENDULUM (NCT05032118)
- Testing
- Ketamine Hydrochloride, Propofol
- Sponsor
- Jenna L Leclerc MD, PhD
Aneurysmal Subarachnoid Hemorrhage, Intacranial Hypertension
aSAH Treatment Based on Intraventricular ICP Monitoring: A Prospective, Multicenter, Randomized and Controlled Trial
ASTIM is a multicenter, prospective, randomised, blinded end-point assessed trial, to investigate the efficacy and safety of treatment based on intracranial pressure monitoring in improving the prognosis of patients with…
- Trial name
- ASTIM (NCT06288659)
- Testing
- Intraventricular ICP monitoring-guided management
- Where
- China
- Volunteers
- 372 people
- Sponsor
- Huashan Hospital
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Intrasaccular neCk Occlusion deVice Treatment of Intracranial Aneurysm in Acute Subarachnoid hemorRhAGE
Rationale: Intrasaccular neck occlusion devices have been used for unruptured aneurysm without safety concerns and good occlusion rates.
- Trial name
- COVERAGE (NCT05171465)
- Testing
- Neqstent or Contour
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Anesthesia, Local, Cerebral Vasospasm
Cervical Sympathetic Block in Patients With Cerebral Vasospasm
The purposes of this study are twofold: 1) to assess the effect of a cervical sympathetic block on cerebral blood flow in patients suffering from cerebral vasospasm, after aneurysmal subarachnoid hemorrhage; 2) to evaluate the…
- Conditions
- Anesthesia, Local, Cerebral Vasospasm, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- NCT05230134
- Testing
- Cervical sympathetic block
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Subarachnoid Hemorrhage, Aneurysmal
Efficacy and Safety of Bivalirudin Versus Heparin During Coil Embolization in Patients With Ruptured Intracranial Aneurysms
This is a randomized, open label, multi-center, positive-controlled study, in which a total of 236 patients will be enrolled and randomly assigned to receive bivalirudin or heparin in a 1:1 ratio during coil embolization in…
- Trial name
- BUILD (NCT04532333)
- Testing
- Bivalirudin 250 MG Injection, Heparin
- Volunteers
- 236 people
- Sponsor
- Changhai Hospital
Subarachnoid Hemorrhage, Aneurysmal, Headache
BLOCK-SAH - PPF-Block for Post-SAH Headache
BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injections with 20mg ropivacaine +…
- Trial name
- BLOCK-SAH (NCT06008795)
- Testing
- Pterygopalatine Fossa Nerve Block with Ropivacaine and Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 195 people
- Sponsor
- University of Florida
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage
This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
- Trial name
- NCT07577739
- Testing
- Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Aneurysmal Subarachnoid Hemorrhage
Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to evaluate the safety and potential therapeutic benefit of use of clazosentan in reversing cerebral vasospasm (a narrowing of blood vessels in the brain due to the presence of blood in the space…
- Trial name
- REVERSE (NCT02560532)
- Testing
- Clazosentan
- Where
- 11 sites in Finland, France and 1 more
- Volunteers
- 25 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Subarachnoid Aneurysm Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Nimodipine Variability in SAH
Aneurysmal subarachnoid hemorrhage (SAH) is a life-threatening neurological illness: it is bleeding in the brain after a bulging blood vessel (a brain aneurysm) ruptures.
- Trial name
- ASH-II (NCT07065903)
- Where
- 3 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- University of Alberta
Subarachnoid Hemorrhage
Ketamine Infusion in Neurologic Deficit
Subarachnoid hemorrhage (SAH) or bleeding in the brain as a result of ruptured aneurysm is a devastating type of stroke. Many patients who undergo emergent neurosurgery to repair the aneurysm and remove the bleeding suffer from…
- Trial name
- KIND (NCT02636218)
- Testing
- Ketamine, 0.9% NaCl
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Unity Health Toronto
Aneurysmal Subarachnoid Hemorrhage, Delayed Neurological Deficit
Effects of Donepezil on Regional Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage
Introduction Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding around the under surface of the brain caused by rupture of an aneurysm arising from a blood vessel.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Delayed Neurological Deficit, Delayed Cerebral Ischemia, Vasospasm
- Trial name
- DASH (NCT02222727)
- Testing
- Donepezil
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- St George's, University of London
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Ultra-early STatin in Patients With Aneurysmal subaRachnoid Hemorrhage (Ue-STAR)
A researcher-initiated and conducted multicenter, randomized controlled trial aimed at evaluating the efficacy and safety of ultra-early statin therapy in the treatment of acute aneurysmal subarachnoid hemorrhage (aSAH).
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Aneurysmal Subarachnoid Hemorrhage, Hemorrhage, Aneurysmal Subarachnoid
- Trial name
- Ue-STAR (NCT06559072)
- Testing
- Atorvastatin
- Where
- China
- Sponsor
- The George Institute
Subarachnoid Hemorrhage, Aneurysmal
Predicting 28-Day Mortality in Subarachnoid Hemorrhage
The investigators investigated the predictive ability of clinical and radiological scores, including the Glasgow coma scale (GCS), Hunt-Hess, World Federation of Neurological Surgeons (WFNS), and modified Fisher scales, as well…
- Trial name
- SAHstdy (NCT06563219)
- Testing
- Glasgow coma scale, Hunt-Hess scale, World Federation of Neurological Surgeons (WFNS) scale
- Where
- Turkey (Türkiye)
- Volunteers
- 451 people
- Sponsor
- Haseki Training and Research Hospital
Aneurysmal Subarachnoid Hemorrhage, Neurobehavioral Manifestations
Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin
A Blind-adjudication Multi-center Phase II Randomized Clinical Trial of Continuous Low-dose Intravenous Heparin Therapy in Coiled Low-grade Aneurysmal Subarachnoid Hemorrhage Patients with Significant Hemorrhage Burden.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Neurobehavioral Manifestations, Vasospasm, Intracranial, Intracranial Aneurysm
- Trial name
- ASTROH (NCT02501434)
- Testing
- Continuous Low-Dose IV Unfractionated Heparin Infusion
- Where
- 9 sites in United States
- Volunteers
- 88 people
- Sponsor
- Robert F. James
Subarachnoid Hemorrhage, Stroke
Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH
This study compares the bioavailability of IV and PO acetaminophen in both blood and the cerebrospinal fluid (CSF) of patients following subarachnoid hemorrhage.
- Trial name
- aSAH (NCT02549716)
- Testing
- IV acetaminophen, Oral acetaminophen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Subarachnoid Hemorrhage
Constitution of Cerebrospinal Fluid and Blood Database/Specimen in Acute Stage of Subarachnoid Hemorrhage (aSAH) Patients
Neuropeptide Y (NPY) may play a major role in the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH). To investigate the correlation of NPY in cerebrospinal fluid (CSF) and blood (serum) and the neurological outcome in…
- Trial name
- NCT01292278
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Regensburg
Aneurysmal Subarachnoid Hemorrhage
Hypercapnia to Prevent Secondary Ischemia in SAH
Delayed cerebral vasospasm and secondary ischemic infarction are feared complications after aneurysmal subarachnoid hemorrhage (aSAH). To date, there is no effective therapy to prevent these ischemic complications.
- Trial name
- SAHCO2 (NCT01799525)
- Testing
- Hypercapnia by reduction of respiratory volume
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Wuerzburg University Hospital
Intracranial Aneurysms, Subarachnoid Hemorrhage, Aneurysmal
Screening in Relatives With Elevated Risk for Unruptured Intracranial Aneurysms
The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms.
- Trial name
- SIREN (NCT07387575)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- University of Novi Sad
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety Study of Carotid Body Neurostimulation to Treat Cerebral Vasospasm
The purpose of this study is to evaluate the safety and performance of the Delta system in the treatment of cerebral vasospasm post aneurysmal subarachnoid hemorrhage (aSAH) patients.
- Trial name
- NCT02129413
- Testing
- Delta system
- Where
- 7 sites in Czechia, Germany and 1 more
- Volunteers
- 23 people
- Sponsor
- Samson NeuroSciences