Clinical trials: Aneurysmal Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Haemorrhage, Delayed Ischemic Neurological Deficit
Diagnosis and Treatment of Late Neurological Ischemic Deficit in Patients Suffering From Subarachnoid Hemorrhage.
Recent studies state that patients affected by aneurysmal subarachnoid hemorrhage (aSAH) today survive longer because they are treated early.
- Trial name
- DINTESA (NCT06804421)
- Where
- 33 sites in Italy
- Volunteers
- 1,400 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Subarachnoid Aneurysm Hemorrhage
Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Aneurysmal Subarachnoid Hemorrhage
Despite its lower incidence rate within the stroke population and tendency to affect younger individuals, SAH carries the highest risk of PSCI.
- Trial name
- NCT06648187
- Testing
- Early motor-cognitive integrative training (e-MCIT)
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- National Taiwan University Hospital
Subarachnoid Aneurysm Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Nimodipine Variability in SAH
Aneurysmal subarachnoid hemorrhage (SAH) is a life-threatening neurological illness: it is bleeding in the brain after a bulging blood vessel (a brain aneurysm) ruptures.
- Trial name
- ASH-II (NCT07065903)
- Where
- 3 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- University of Alberta
Subarachnoid Hemorrhage, Aneurysmal
Complement Inhibition: Attacking the Overshooting Inflammation @Fter Subarachnoid Hemorrhage (CIAO@SAH)
Aneurysmal subarachnoid hemorrhage (SAH) can lead to devastating outcomes for patients, like cognitive decline. This is caused by early brain injury (EBI) followed by delayed cerebral ischemia (DCI).
- Trial name
- CIAO@SAH (NCT06359782)
- Testing
- C1 Esterase Inhibitor Injection [Cinryze]
- Where
- Netherlands
- Volunteers
- 128 people
- Sponsor
- Haaglanden Medical Centre
Aneurysm, Ruptured, Hyperglycemia
Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood
The goal of this study is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and ventriculo-peritoneal-shunt (VPS)-dependency also evaluating the influence of blood glucose on VPS…
- Conditions
- Aneurysm, Ruptured, Hyperglycemia, Hydrocephalus
- Trial name
- HCP-Glc (NCT06486909)
- Testing
- Cerebrospinal Fluid (CSF) Sample, Blood Serum Sample
- Where
- 3 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Isabel Hostettler
Aneurysmal Subarachnoid Hemorrhage
Early Versus Ultra Early Surgical Treatment of Ruptured Intracranial Aneurysms
The goal of this clinical trial is to determine the most effective timing for clipping in adults with ruptured intracranial aneurysms.
- Trial name
- NCT06457347
- Testing
- Ultra early (<24 hours) ruptured aneurysm clipping, Early (24-72 hours) ruptured aneurysm clipping
- Volunteers
- 100 people
- Sponsor
- Revaz Dzhindzhikhadze
Cerebral Ischemia, Subarachnoid Hemorrhage
Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage
The objective of this multi-centre, randomized controlled trial is to investigate the outcome after induced hypertension versus no induced hypertension in patients with delayed cerebral ischemia (DCI) after aneurysmal…
- Trial name
- HIMALAIA (NCT01613235)
- Testing
- Induced hypertension
- Where
- 2 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI)
Bioavailability of Medium Chain Triglycerides (MCTs) in Comatose Patients With Acute Brain Injury (ABI)
This study will be targeting patients suffering from acute brain injury (ABI), including those with severe trauma brain injury (sTBI) and those with aneurysmal sub arachnoid hemorrhage (aSAH).
- Conditions
- Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI), Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- MCTs and ABI (NCT02716532)
- Testing
- Peptamen AF
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Société des Produits Nestlé (SPN)
Aneurysmal Subarachnoid Hemorrhage
Relative Bioavailability of Intravenous GTX-104 Compared to Oral Nimodipine Capsules in Healthy Subjects
This is a Phase 1, single center, randomized, two-period crossover study in healthy male and female subjects designed to evaluate the relative bioavailability (BA) and safety at steady state of two formulations of nimodipine: GTX…
- Trial name
- NCT05418348
- Testing
- GTX-104, Nimodipine Capsules
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Grace Therapeutics Inc.
Aneurysmal Subarachnoid Hemorrhage
Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients With Aneurysmal Subarachnoid Hemorrhage (HOMA)
This was a randomized, single-center trial. On the basis of standard-of-care, patients in the treatment group inhaled H2-O2 (66% hydrogen; 33% oxygen) at 3 L/min via nasal cannula by using the Hydrogen/Oxygen Generator (model…
- Trial name
- HOMA (NCT05282836)
- Testing
- Hydrogen Oxygen Generator with Nebulizer
- Volunteers
- 206 people
- Sponsor
- Beijing Tiantan Hospital
Aneurysmal Subarachnoid Hemorrhage
Degradation of the Glycocalyx in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
This study will provide novel information to the literature base for the pathophysiology of aneurysmal subarachnoid hemorrhage. The association of breakdown products in the serum of aSAH patients were reported in a very small…
- Trial name
- NCT03706768
- Testing
- Glycocalyx
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Virginia
Subarachnoid Hemorrhage, Aneurysmal
Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding into the space between the brain and the tissues that surround the brain as a result of a ruptured aneurysm and is a type of stroke associated with high morbidity and…
- Trial name
- PENDULUM (NCT05032118)
- Testing
- Ketamine Hydrochloride, Propofol
- Sponsor
- Jenna L Leclerc MD, PhD
Aneurysmal Subarachnoid Hemorrhage
Multi-Center Registry Cohort Study on Prognostic Factors and Prediction Model Construction in Aneurysmal SAH
PROSAH-MPC, a collaborative research project among neurosurgical centers in China, focuses on aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- PROSAH-MPC (NCT05738083)
- Testing
- Machine Leaning Models
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Subarachnoid Hemorrhage
Treating Patients With Aneurysmal SubArachnoid Hemorrhage (SAH) With Epoetin Alfa
This is a prospective, randomized, double-blinded, placebo controlled pilot safety study that will enroll a total of twenty subjects.
- Trial name
- EPO (NCT00626574)
- Testing
- Epoetin alfa, Saline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of South Florida
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal
Study of EG-1962 Compared to Standard of Care Oral Nimodipine in Adults With Aneurysmal Subarachnoid Hemorrhage
This study compares EG-1962 to enteral nimodipine in the treatment of aneurysmal subarachnoid hemorrhage.
- Trial name
- NEWTON2 (NCT02790632)
- Testing
- EG-1962 (nimodipine microparticles), Enteral Nimodipine
- Where
- 79 sites in United States, Australia and 9 more
- Volunteers
- 374 people
- Sponsor
- Edge Therapeutics Inc
Aneurysm, Intracranial Aneurysm
Appraising the Embolization of Aneurysms Using Balt Optima™ Coil System (APPLY Study)
In recent years, many developments have been made to the tools and techniques used to treat IAs via endovascular intervention. Specifically, to the detachable coils themselves.
- Conditions
- Aneurysm, Intracranial Aneurysm, Ruptured Aneurysm, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- APPLY (NCT04499508)
- Testing
- Optima Coil System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vascular Neurology of Southern California Inc.
Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage: Red Blood Cell Transfusion and Outcome
The purpose of this study is to determine the feasibility of conducting a large trial examining the effect on clinical outcome of a liberal red blood cell (RBC) transfusion strategy compared to a restrictive strategy (usual care)…
- Trial name
- SAHaRA Pilot (NCT02483351)
- Testing
- Liberal Red Blood Cell Transfusion Strategy, Restrictive Red Blood Cell Transfusion Strategy
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Subarachnoid Hemorrhage, Aneurysmal
Predictive Role of f-QRST Angle in Subarachnoid Hemorrhage
The investigators investigated the association between the frontal QRS/T angle measured on admission ECG and 28-day mortality, as well as neurological outcome in patients with non-traumatic aneurysmal SAH.
- Trial name
- f-QRST in SAH (NCT07196891)
- Testing
- frontal-QRST angle, Hunt-Hess scale, modified Fisher scale
- Where
- Turkey (Türkiye)
- Volunteers
- 354 people
- Sponsor
- Haseki Training and Research Hospital
Hyperglycemia, Aneurysmal Subarachnoid Hemorrhage
Admission HbA1C in Aneurysmal Subarachnoid Hemorrhage
In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration…
- Trial name
- NCT02081820
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- Heinrich-Heine University, Duesseldorf