Clinical trials: Angina Pectoris, open to volunteers
Angina (Stable), Ischemic Heart Disease (IHD)
Angina After PCI: a Systems Medicine Study
Angina may persist or recur in patients treated by coronary angioplasty. The angioplasty involves a balloon treatment to open a blocked heart blood vessel and usually a stent (thin metal tube) is placed.
- Trial name
- CorMicA-PCI (NCT06854302)
- Testing
- Cardiovascular magnetic resonance imaging, Coronary physiology
- Where
- 4 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- NHS National Waiting Times Centre Board
Cardiovascular Diseases, Ischaemic Heart Disease
Machine Learning in Quantitative Stress Echocardiography
Greater diagnostic accuracy is required to find out who is at risk of a heart attack as this can reduce the requirement of more invasive downstream tests and thereby improve the patient experience and also reduce their exposure…
- Trial name
- MLQSE (NCT04193475)
- Testing
- Analysis
- Where
- United Kingdom
- Volunteers
- 1,250 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Microvascular Angina
The Value of Measuring Retinal Vascular Density by Optical Coherence Tomography-Angiography (OCT-A) in Patients With Microvascular Angina Confirmed by Myocardial Microcirculatory Resistance Index (MRI).
Microvascular angina is thought to affect around 112 million patients worldwide. However, this figure is underestimated due to the difficulty of making the diagnosis.
- Trial name
- EYE-NOCA (NCT06692751)
- Testing
- Blood sampling, Ophthalmological examination, angina severity questionnaire
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Acute Coronary Syndromes, STEMI
Early Single Antiplatelet Therapy After IVUS-Guided PCI in Acute Coronary Syndrome
This is a prospective, open-label, multicenter, randomized, phase IV clinical trial designed to evaluate the safety and efficacy of early aspirin discontinuation followed by potent P2Y12 inhibitor monotherapy after intravascular…
- Conditions
- Acute Coronary Syndromes, STEMI, NSTEMI, Unstable Angina
- Trial name
- SAPT-ACS (NCT07684742)
- Testing
- Early P2Y12 Inhibitor Monotherapy, Standard Dual Antiplatelet Therapy
- Where
- South Korea
- Volunteers
- 2,200 people
- Sponsor
- Gyeongsang National University Hospital
Acute Kidney Injury, Mechanical Ventilation
Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy
The goal of the BRAVE-HEART study is to learn if an amino acid infusion can reduce the risk of developing acute kidney injury after cardiac surgery in children. The main questions it aims to answer are: 1.
- Trial name
- BRAVE-HEART (NCT07212595)
- Testing
- Amino Acid infusion, Lactated ringers solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana Fuhrman
Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris
A Multi-center, Real-World Clinical Trial of caIMR on Two Specific Kinds of Patients.
The coronary angiography-derived index of microcirculatory resistance (caIMR) can be used to provide a binary assessment whether patients（with stable angina, unstable angina, suspected myocardial ischemia, or coronary artery…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris, Unstable Angina Pectoris, Myocardial Ischemia, Angina Pectoris
- Trial name
- FlashV (NCT06945094)
- Testing
- caIMR
- Volunteers
- 508 people
- Sponsor
- Ge Junbo
Microvascular Coronary Dysfunction, Microvascular Angina
Microvascular Coronary Rehabilitation For Improving Treatment - Feasibility Study
The goal of this clinical trial is to assess the feasibility of undertaking a randomized controlled trial assessing the impact of a personalised, intense cardiac rehabilitation programme involving high intensity interval exercise…
- Conditions
- Microvascular Coronary Dysfunction, Microvascular Angina, Coronary Microvascular Dysfunction (CMD)
- Trial name
- MICROFIT (NCT06681896)
- Testing
- MICROFIT - personalised high intensity interval training exercise rehabilitation and dietary advice
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Chest Pain, Ischemia
Evaluation of Patients With Non-obstructive Coronary Arteries
Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment.
- Trial name
- noCAD (NCT00823563)
- Testing
- 30 cc blood draw, Intravascular ultrasound (IVUS), Coronary pressure/flow wire testing
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Stanford University
Coronary Heart Disease
Unstable Angina Pectoris in Comorbidity With Anxiety-depressive Syndrome
Introduction: Today it is necessary to emphasize that coronary heart disease is often associated with anxiety disorders. Research over the years has shown several and sometimes surprising links between coronary heart disease and…
- Trial name
- NCT04599621
- Testing
- Collection of blood samples to determine the level of certain cytokines (TNF-α, IL-1β, IL-4 and IL-10),Collection of blood samples to determine the level of uric acid
- Where
- Uzbekistan
- Volunteers
- 3 people
- Sponsor
- Samarkand State Medical Institute
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Stable Angina, Coronary Artery Disease
Stable Angina Management and Treatment
The Prospective REgistry of Stable Angina manaGEment and Treatment (PRESAGE) is an observational study on an all-comer stable angina population hospitalised in a highly specialized cardiovascular centre with cardiac surgery…
- Trial name
- PRESAGE (NCT03781492)
- Where
- Poland
- Volunteers
- 25,000 people
- Sponsor
- Silesian Centre for Heart Diseases
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
MINOCA, Shortness of Breath
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease…
- Conditions
- MINOCA, Shortness of Breath, Atherosclerotic Heart Disease of Native Coronary Artery
- Trial name
- NCT07182955
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Nebivolol ANOCA Treatment Randomized Trial
To determine the effectiveness of the beta-blocker nebivolol in controlling symptoms and improving the quality of life in patients with angina and coronary microvascular dysfunction.
- Trial name
- MOTORS (NCT06755801)
- Testing
- Nevibolol
- Volunteers
- 150 people
- Sponsor
- Spanish Society of Cardiology
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Development of a Novel Risk Prediction Tool for Emergency Department Patients Symptoms of Coronary Artery Disease
Patients with chest pain and symptoms of acute coronary syndromes (ACS) account for over 600,000 emergency department (ED) visits annually in Canada.
- Trial name
- NCT06743672
- Where
- Canada
- Volunteers
- 6,500 people
- Sponsor
- University of Calgary
Acute Coronary Syndrome, Unstable Angina Pectoris
The International Survey of Acute Coronary Syndromes-ARCHIVES
ISACS ARCHIVES network is part of ISACS TC (NCT01218776) health care program. It is a collaborative network of research centers that support the rapid development of new scientific information and analytic tools.
- Conditions
- Acute Coronary Syndrome, Unstable Angina Pectoris, Myocardial Infarction, Coronary Disease
- Trial name
- ISACS-ARCHIVES (NCT04008173)
- Testing
- Non-interventional patient registry
- Where
- Italy
- Volunteers
- 130,000 people
- Sponsor
- University of Bologna
Stable Angina Pectoris, Coronary Artery Disease
1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease
1. Objective Objective: > The purpose of this study is to evaluate whether a short-term (1-month) dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy (SAPT) is non-inferior to the standard 6-month DAPT in…
- Trial name
- D-ONE (NCT07592507)
- Testing
- 1-Month DAPT followed by SAPT, 6-Month DAPT followed by SAPT
- Volunteers
- 1,484 people
- Sponsor
- Daejeon St. Mary's hospital
Coronary Microvascular Disease
Qishenyiqi Dripping Pill for Coronary Microvascular Disease
To investigate the efficacy and safety of Qishenyiqi in patients with microvascular angina pectoris. Long-term follow-up of 1 year will be performed to evaluate the effect of Qishenyiqi on coronary flow reserve and adverse…
- Trial name
- CMVD (NCT06699420)
- Testing
- Qishenyiqi dripping pills 1 bag, three times a day
- Where
- 3 sites in China
- Volunteers
- 162 people
- Sponsor
- Qilu Hospital of Shandong University