Clinical trials: Anginal Pain
Refractory Angina Pectoris, Gene Transfer
Adenovirus Vascular Endothelial Growth Factor D (AdvVEGF-D) Therapy for Treatment of Refractory Angina Pectoris
The purpose of the study is to evaluate the safety and efficacy of catheter mediated endocardial adenovirus-mediated vascular endothelial growth factor-D (AdVEGF-D) regenerative gene transfer in patients with refractory angina to…
- Conditions
- Refractory Angina Pectoris, Gene Transfer, Coronary Artery Disease
- Trial name
- ReGenHeart (NCT03039751)
- Testing
- AdvVEGF-D, Control Rx
- Where
- 2 sites in Denmark, Finland
- Volunteers
- 63 people
- Sponsor
- Kuopio University Hospital
Heart Failure, Microvascular Angina
Relationship Between Coronary Microvascular Dysfunction and Improvement of Left Ventricular Systolic Function in Patients With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology
This study aims to evaluate the incidence of coronary microvascular dysfunction (CMD) and its prognostic implication for the improvement of left ventricular function in patients who have been diagnosed with heart failure with…
- Conditions
- Heart Failure, Microvascular Angina, Non-ischemic Cardiomyopathy
- Trial name
- HFrEF-CMD (NCT06243653)
- Testing
- CMD test
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Angina Pectoris
Efficacy and Safety of Intracoronary Ad5FGF-4 in Patients With Stable Angina (AGENT-3)
The purpose of this study is to determine whether a single intracoronary infusion of Ad5FGF-4 is effective in improving exercise capacity measured by exercise treadmill testing, angina functional class, patient symptoms, quality…
- Trial name
- NCT00346437
- Volunteers
- 416 people
- Sponsor
- Cardium Therapeutics
Cardiovascular Disease, Coronary Heart Disease
Periodontitis and Cardiovascular Events or "PAVE"
The purpose of this study is to determine if treating periodontal infections (gum problems) will lead to fewer heart problems in patients at high risk for cardiovascular disease.
- Conditions
- Cardiovascular Disease, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00066053
- Testing
- Periodontal Treatment: SRP, Referral
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- University at Buffalo
Acute Coronary Syndrome, Angina Pectoris, Unstable
Incremental Value of Point of Care H-FABP Testing in Primary Care Patients Suspected of Acute Coronary Syndrome
Rationale: Thoracic complaints, possibly due to a cardiac ischemic cause are a diagnostic challenge in general practice. When an underlying ischemic cardiac condition (AMI (acute myocardial infarction), UAP (unstable angina…
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Unstable, Angina Pectoris, Stable, Thoracic Diseases
- Trial name
- RAPIDA (NCT01826994)
- Testing
- heart type fatty acid binding protein testing
- Where
- 7 sites in Belgium, Netherlands
- Volunteers
- 303 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease
STACCATO: Stent sTrut Apposition and Coverage in Coronary ArTeries: an Optical Coherence Tomography (OCT) Study
Assessment of vessel healing after DES implantation in STEMI, NSTEMI and stable/unstable angina patients: a randomized comparison between everolimus and biolimus A9-eluting stents: an optical coherence tomography (OCT) and…
- Trial name
- STACCATO (NCT01065519)
- Testing
- Xience V everolimus eluting stent, Biolimus A9-eluting Biomatrix stent
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atherosclerotic Coronary Vascular Disease
Evaluation of Exercise Treadmill Test (ETT) Indices in Participants With Cardiovascular Disease
The study was designed to evaluate the use of ETT electrocardiogram (ECG) indices as biomarkers in the assessment of atherosclerotic coronary vascular disease (ASCVD).
- Trial name
- NCT01562041
- Testing
- Ranolazine 500 mg
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Novartis Pharmaceuticals
Ischemia, Angina
Comparison Of Left Ventricular Volume And Wall Stress With Dobutamine And Exercise Echocardiography
This study will compare the physiologic responses between exercise stress echocardiography and pharmacologic stress echocardiography on left ventricular volume and wall stress.
- Trial name
- NCT00774891
- Where
- United States
- Sponsor
- Lahey Clinic
Atherosclerosis, Stable Angina
Remote Ischemic Preconditioning as a Method Against Subclinical Renal Injury and Contrast-induced Nephropathy
Contrast-induced nephropathy (CIN) has remained significant and severe complication of angiographic procedures despite the increasing use of preventative methods.
- Conditions
- Atherosclerosis, Stable Angina, Peripheral Artery Disease, Contrast-induced Nephropathy
- Trial name
- NCT02700958
- Testing
- Remote ischemic preconditioning
- Where
- Estonia
- Volunteers
- 160 people
- Sponsor
- Tartu University Hospital
Coronary Heart Disease (CHD)
Clinical Evidence Based and TCM Phenotype Group Study of Zhilong Huoxue Tongyu Capsule in the Treatment of Stable Angina Pectoris of Coronary Heart Disease (Qi Deficiency and Blood Stasis Syndrome)
This study intends to prove the clinical effect of Zhidong Huoxue Tongyu capsule in the treatment of stable angina pectoris with qi deficiency and blood stasis syndrome from the perspective of TCM syndrome differentiation and…
- Trial name
- NCT06709638
- Testing
- Zhilong Huoxue Tongyu capsule
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Jiang Hanmei
Coronary Artery Disease, Angina Pectoris
Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain
The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with coronary artery disease to select appropriate candidates for coronary…
- Conditions
- Coronary Artery Disease, Angina Pectoris, Unstable Angina, Acute Coronary Syndrome
- Trial name
- PROSPECT (NCT00705458)
- Testing
- Coronary Computed Tomography Angiography, Stress Nuclear Myocardial Perfusion Imaging
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Montefiore Medical Center
Unstable Angina, Myocardial Infarction
SYNERGY: Open Study of Enoxaparin Versus Unfractionated Heparin in Patients With Acute Coronary Syndromes
Patients experiencing a mild heart attack will receive one of two medications which thin the blood to discern which is superior.
- Conditions
- Unstable Angina, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT00043784
- Testing
- enoxaparin
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Sanofi
Unstable Angina or Non ST Elevated Myocardial Infarction
Downstream Versus Upstream Strategy for the Administration of P2Y12 Receptor Blockers
To evaluate the impact on outcomes of the currently accepted antithrombotic strategies based on the administration of newer P2Y12 receptor blockers (prasugrel and ticagrelor) in a population of non ST elevated ACS (NSTEACS)…
- Trial name
- DUBIUS (NCT02618837)
- Testing
- Downstream strategy, Upstream strategy
- Where
- Italy
- Volunteers
- 2,520 people
- Sponsor
- University of Padova
Microvascular Angina, Hypertension
Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris
The purpose of this study is to determine if long-term vasodilatory treatment is more effective than the standard treatment in hypertensive patients with microvascular angina pectoris
- Trial name
- NCT00424801
- Testing
- Lercanidipine, Valsartan, Nicorandil
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Coronary Artery Diseases
BIOFLOW III Satellite-Italy Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02028728
- Where
- 18 sites in Italy
- Volunteers
- 609 people
- Sponsor
- Biotronik Italia S.p.A.
Acute Coronary Syndrome, Stable Chronic Angina
Angiographic Control Vs. Ischemia-driven Management of Patients Treated with PCI on Left Main with Drug-eluting Stents
The present study aims to compare a planned angiographic control (PAC) follow-up strategy vs. conservative management for patients treated with drug-eluting stents on unprotected left main artery in a prospective, randomized…
- Conditions
- Acute Coronary Syndrome, Stable Chronic Angina, Coronary Artery Disease, Left Main Coronary Artery Disease
- Trial name
- PULSE (NCT04144881)
- Testing
- coronary computed tomography
- Where
- 3 sites in Italy
- Volunteers
- 606 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Angina Pectoris, Variant
BVS Implantation in Patients With Variant Angina and MODerate Coronary Artery Disease
The purpose of this study is to determine whether BVS(Bioresorbable Vascular Scaffold) implantation with optimal medical therapy can improve the outcome of patients with variant angina and moderate coronary artery disease.
- Trial name
- BIVA-pilot (NCT02932553)
- Testing
- BVS+OMT
- Where
- South Korea
- Sponsor
- Seung-Jung Park
Safety Issues, Efficacy, Self
Lower Silesia Sinus Reducer Registry
Lower Silesia Sinus Reducer Registry is a , single-center, single-arm registry including patients with chronic disabling refractory angina pectoris (Canadian Cardiovascular Society [CCS] classes 2-4) despite maximally tolerated…
- Trial name
- LSSRR (NCT06288165)
- Testing
- Coronary Sinus Reducer Implantation
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Coronary Artery Disease, Angina Pectoris
Effect of Alirocumab(Proprotein Convertase Subtilisin/Kexin type9 Inhibitor) and Rosuvastatin or Rosuvastatin Alone on Lipid Core Plaques in Coronary Artery Disease Evaluated by Near-infrared Spectroscopy Intravascular Ultrasound
The purpose of this study is to verify whether additional administration of Alirocumab exerts a stronger stabilizing effect on the vulnerable plaque in CAD, compared with statin alone administration in patients receiving PCI.
- Trial name
- ANTARES (NCT03529253)
- Testing
- Alirocumab 75 MG/ML [Praluent]+ Rosuvastatin 10mg/daily, Rosuvastatin calcium10mg
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kobe University
Angina, Stable, Congestive Heart Failure
Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
This feasibility trial will focus on older adults 60+ who are candidates for cardiac or pulmonary rehabilitation and who are vulnerable, mildly or moderately frail.
- Conditions
- Angina, Stable, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05562037
- Testing
- Stepped Care
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- Peter Lindenauer, MD
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