Clinical trials: Anginal Pain
Coronary Disease
CT Calcium Scoring in Suspected Stable Angina
Patients with stable chest pain presenting to general practitioners in UK are routinely referred to the chest pain clinics in the hospitals.
- Trial name
- NCT01660594
- Testing
- CT calcium scoring
- Where
- United Kingdom
- Volunteers
- 705 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Angina, Stable, Angina, Unstable
Atherosclerotic Lesion Proteomics by Harvesting Angioplasty Balloons (ALPHA).
The purpose of the study is to identify proteins, metabolites and signal pathways related directly to symptomatic atherosclerosis and to disease progression.
- Conditions
- Angina, Stable, Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT05319366
- Where
- 2 sites in Denmark
- Volunteers
- 225 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stable Angina, Unstable Angina, NSTEMI
Evaluation of a Novel Non-Invasive Automated Fractional Flow Reserve Software System in Patients With Coronary Artery Disease
This retrospective study will evaluate the coronary angiograms of approximately 100 patients who have undergone invasive angiography and fractional flow reserve (FFR).
- Trial name
- NCT06183294
- Testing
- Collecting invasive FFR measurements.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Cardiovascular Diseases, Heart Diseases
Incidence of Diabetes and Cardiovascular Disease in Mexican Americans
To determine the incidence of type II diabetes and cardiovascular disease among Mexican-American and non-Hispanic whites in a 15 to 24 year follow-up of the San Antonio Heart Study 1 participants.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Angina Pectoris
- Trial name
- NCT00005205
- Sponsor
- The University of Texas Health Science Center at San Antonio
Microvascular Angina
Sex Difference of Coronary Microvascular Dysfunction in Patients With Non-obstructive Coronary Artery Disease
Sex difference of coronary microvascular dysfunction evaluated by coronary flow reserve will be assessed in patients with non-obstructive coronary artery disease
- Trial name
- NCT06076551
- Testing
- Adenosine stress echocardiography
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Korea University Anam Hospital
Coronary Artery Disease, Atherosclerosis
Drug-eluting Balloon in Bifurcations Trial
The purpose of the DEBIUT study is to assess procedural, clinical and angiographic outcomes of: 1. Provisional T-stenting use for dilation the Paclitaxel-eluting PCI-balloon (DiorTM) in comparison to dilation with a standard…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Stable Angina, Unstable Angina
- Trial name
- DEBIUT (NCT00857441)
- Testing
- Drug eluting balloon, Liberté, PTCA balloon catheter
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Stable Angina, Coronary Disease
Research on Nicorandil Treatment of Patients Diagnosed as CHD (Coronary Heart Disease) With Stable Angina
This study of 402 cases of stable angina subjects who were diagnosed as Coronary Heart Disease (CHD) is a randomized, blank controlled, multi-center clinical study.
- Trial name
- SIGMART (NCT01396395)
- Testing
- Nicorandil, Standard Treatment
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Angina Pectoris, Atherosclerosis
Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease 2
In a cohort of symptomatic patients referred to coronary computed tomography angiography (CCTA), the investigators aim: 1. To investigate and compare the diagnostic precision of Rubidium Positron Emission Tomography (Rb PET) and…
- Conditions
- Angina Pectoris, Atherosclerosis, Coronary Artery Disease, Myocardial Ischemia
- Trial name
- Dan-NICAD 2 (NCT03481712)
- Testing
- Diagnostic tests
- Where
- 5 sites in Denmark
- Volunteers
- 1,732 people
- Sponsor
- University of Aarhus
Refractory Angina
Intramyocardial Delivery of Autologous Bone Marrow
A randomized study to assess the safety, feasibility and effectiveness of direct intramyocardial percutaneous delivery of autologous bone marrow-derived total mononuclear cells or selected CD34+ cells in patients with refractory…
- Trial name
- NCT00820586
- Testing
- Mononuclear bone marrow derived cells
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- IRCCS San Raffaele
Coronary Microvascular Disease
Qishenyiqi Dripping Pill for Coronary Microvascular Disease
To investigate the efficacy and safety of Qishenyiqi in patients with microvascular angina pectoris. Long-term follow-up of 1 year will be performed to evaluate the effect of Qishenyiqi on coronary flow reserve and adverse…
- Trial name
- CMVD (NCT06699420)
- Testing
- Qishenyiqi dripping pills 1 bag, three times a day
- Where
- 3 sites in China
- Volunteers
- 162 people
- Sponsor
- Qilu Hospital of Shandong University
Refractory Angina
Study Protocol of Intramyocardial Injection of Autologous Bone Marrow Stem Cells for Refractory Angina
Therapeutic neovascularization is an innovative strategy for cardiac tissue recovery due to chronic, intense ischemia. Thus stem cell therapy has become a promising procedure for the large number of patients with refractory…
- Trial name
- ReACT (NCT01966042)
- Testing
- Local sedation, Bone Marrow Aspiration, Minithoracotomy
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- CellPraxis Bioengenharia Ltda.
Acute Coronary Syndrome, Percutaneous Coronary Intervention
A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention (PCI) Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy
This is a multi-national, multi-centre, randomized study comparing the trans-radial PCI access strategy and the trans-femoral PCI access strategy in ACS patients with UA or NSTEMI or STEMI planned to be treated with an invasive…
- Trial name
- RIVAL (NCT01014273)
- Testing
- Percutaneous Coronary Intervention
- Where
- Canada
- Volunteers
- 7,021 people
- Sponsor
- Population Health Research Institute
Myocardial Infarction, Ischemic Stroke
Emulation of the Moderate Alcohol and Cardiovascular Health Trial (MACH15)
The aim of this study is to assess how long-term alcohol consumption influences health risks by emulating the Moderate Alcohol and Cardiovascular Health Trial (MACH15).
- Conditions
- Myocardial Infarction, Ischemic Stroke, Angina Pectoris, Coronary Revascularization
- Trial name
- NCT06583161
- Testing
- Moderate drinking, Quitting, Social drinking
- Volunteers
- 503,325 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Chronic Kidney Disease, Stable Angina
Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Chronic Kidney Disease
Impaired renal function is associated with reduced responsiveness to clopidogrel. There are no studies which have shown a means by which to overcome platelet hyporesponsiveness in patients with chronic kidney disease (CKD).
- Trial name
- CKD (NCT01328470)
- Testing
- Clopidogrel, cilostazol
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Kyunghee University Medical Center
Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions
A Trial in Stable Intermediate Coronary Lesions and Grey-zone FFR Values
In this randomised controlled trial of patients with stable angina and documented intermediate coronary disease with indeterminate or "grey-zone" Fractional Flow Reserve (FFR) we will randomise patients to either optimal medical…
- Conditions
- Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions, Stable Angina, Coronary Physiology
- Trial name
- GzFFR (NCT02425969)
- Testing
- PCI, Optimal Medical Therapy
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Golden Jubilee National Hospital
Acute Coronary Syndrome, Unstable Angina Pectoris
The International Survey of Acute Coronary Syndromes-ARCHIVES
ISACS ARCHIVES network is part of ISACS TC (NCT01218776) health care program. It is a collaborative network of research centers that support the rapid development of new scientific information and analytic tools.
- Conditions
- Acute Coronary Syndrome, Unstable Angina Pectoris, Myocardial Infarction, Coronary Disease
- Trial name
- ISACS-ARCHIVES (NCT04008173)
- Testing
- Non-interventional patient registry
- Where
- Italy
- Volunteers
- 130,000 people
- Sponsor
- University of Bologna
Angina Refractory, Angina Pectoris
Extracorporeal Shockwave Myocardial Revascularization in Refractory Angina
This is a prospective cohort study to examine the efficacy of ESMR application in patients with refractory angina despite optimal medical therapy, not suitable for further PCI or CABG.
- Trial name
- NCT03516643
- Testing
- Extracorporeal Shockwave Myocardial Revascularization
- Volunteers
- 122 people
- Sponsor
- University of Turin, Italy
Angina, Stable, Coronary Artery Disease
Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology
The ORACLE study is an observational cohort study designed to explore the feasibility of providing an assessment of chest pain for patients with suspected angina within one working day of referral to specialist services.
- Trial name
- ORACLE (NCT06325020)
- Testing
- The assessment of patients with possible angina using the ORACLE pathway
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Edinburgh
Percutaneous Coronary Intervention
Comparison of Anticoagulation for All-comers Undergoing Percutaneous Coronary Revascularization Trial
The purpose of this trial is to determine whether bivalirudin is non-inferior to unfractionated heparin in patients with stable angina, unstable angina, or non-ST segment elevation myocardial infarction undergoing percutaneous…
- Trial name
- CALIFORNIA (NCT02448550)
- Testing
- Bivalirudin, Unfractionated heparin
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Kaiser Permanente
Stable Angina
Does Mean Platelet Volume Change With Clopidogrel
Platelets play a major role in thrombus formation and platelet size, measured by Mean Platelet Volume (MPV) correlates with platelet activity.
- Trial name
- NCT02550301
- Testing
- Mean Platelet Volume
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
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