Clinical trials: Anginal Pain
Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram
Endothelin Role In COronary Microcirculation
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries.
- Conditions
- Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram, Microvascular Angina
- Trial name
- ERICOM (NCT07670091)
- Testing
- Cardiac MRI, Invasive Coronary Angiogram, Endothelin Receptor Antagonist
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Stable Angina, Multivessel Coronary Artery Disease
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery…
- Trial name
- ORBITA-MOON (NCT06400290)
- Testing
- Percutaneous coronary intervention (PCI), Symptom assessment during experimentally induced ischaemia
- Where
- 8 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Stable Angina, Coronary Stenosis
The Treatment of Coronary De-novo Lesions With the Elutax Paclitaxel-eluting Balloon Alone, a Pilot Study
A randomised open-label pilot study to assess the safety and efficacy of treatment with a drug eluting balloon alone in coronary de novo lesions).
- Trial name
- EXPEL (NCT01899235)
- Testing
- drug eluting balloon, drug eluting stent
- Where
- Denmark
- Sponsor
- Aalborg University Hospital
Acute Coronary Syndrome, Unstable Angina
Metformin Continuation Versus Interruption Following Coronary Angiography: a Pilot Randomized Controlled Trial
This pilot randomized controlled trial aims to evaluate the feasibility for safety examination of continued metformin therapy in patients with type 2 diabetes (T2D) following invasive coronary angiography.
- Conditions
- Acute Coronary Syndrome, Unstable Angina, Diabetes Mellitus, Metformin Adverse Reaction
- Trial name
- NCT03980990
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Saskatchewan
Acute Coronary Syndrome, Angina, Unstable
Crushed Ticagrelor Versus Eptifibatide Bolus + Clopidogrel
Patients with troponin-negative acute coronary syndrome (ACS) are not routinely pre-treated with P2Y12 inhibitors and the rate of high on-treatment platelet reactivity (HPR) remains elevated after a loading dose of ticagrelor at…
- Trial name
- NCT02925923
- Testing
- Ticagrelor, Eptifibatide, Clopidogrel
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Triple Vessel Disease, Unstable Angina
Comparison of Saphenous Vein Graft Harvested From Upper Versus Lower Leg in Coronary Artery Bypass Grafting
In coronary artery bypass grafting, saphenous veins are widely used as a composite grafts that are Y-anastomosed to in-situ left internal thoracic artery.
- Conditions
- Triple Vessel Disease, Unstable Angina, Stable Angina, Myocardial Infarction
- Trial name
- COSAVEGUL-1 (NCT01974492)
- Testing
- Upper leg vein harvesting, Lower leg vein harvesting
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Seoul National University Hospital
Unstable Angina Pectoris
Danhong Injection in the Treatment of Unstable Angina Pectoris
The purpose of this study is to determine the efficacy and safety of Danhong injection in the treatment of unstable angina pectoris.
- Trial name
- NCT02007187
- Testing
- Danhong injection, Standard medical care
- Where
- 9 sites in China
- Volunteers
- 160 people
- Sponsor
- China Academy of Chinese Medical Sciences
Obesity, Morbid Obesity
Safety and Efficacy of Lean Body Weight-based IV Heparin Dosing in Obese/Morbidly Obese Patients
Standard weight-based IV heparin for normal weight patients is based on actual body weight (ABW). However, no well-defined guidelines have been established for patients considered to be obese or morbidly obese.
- Conditions
- Obesity, Morbid Obesity, Venous Thromboembolism, Atrial Fibrillation
- Trial name
- NCT01363193
- Testing
- Lean Body Weight-based heparin dose
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nazareth Hospital
Non-ST-elevation Acute Coronary Syndrome, Unstable Angina
Ticagrelor or Prasugrel Versus Clopidogrel in Elderly Patients With an Acute Coronary Syndrome and a High Bleeding Risk: Optimization of Antiplatelet Treatment in High-risk Elderly
A randomized controlled, open label, multicenter trial with 1000 patients aged 70 years and older, presenting with Non-ST-elevation acute coronary syndrome.
- Conditions
- Non-ST-elevation Acute Coronary Syndrome, Unstable Angina, Non-ST-elevation Myocardial Infarction
- Trial name
- POPular AGE (NCT02317198)
- Testing
- Clopidogrel, Ticagrelor or Prasugrel
- Where
- Netherlands
- Volunteers
- 1,011 people
- Sponsor
- St. Antonius Hospital
Atherosclerosis, Coronary, Emotional Stress
Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque Instability
Emotional stress is associated with future cardiovascular events. However, the biological interconnection between brain emotional neural activity and acute plaque instability is not fully understood.
- Conditions
- Atherosclerosis, Coronary, Emotional Stress, Inflammation, Hematopoiesis
- Trial name
- NCT04853511
- Testing
- OCT-FLIM (optical coherence tomography-fluorescence life time)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Angina Pectoris, Coronary Heart Disease
A Study to Assess the Safety, Tolerability, and Effects of MK-0974 (Telcagepant) on Exercise Tolerance in Patients With Stable Angina (MK-0974-014)
This study will assess the safety of telcagepant in coronary artery disease (CAD) participants with stable angina during exercise treadmill testing and evaluate whether calcitonin gene-related peptide (CGRP) receptor antagonism…
- Conditions
- Angina Pectoris, Coronary Heart Disease, Calcitonin Gene-related Peptide Receptor
- Trial name
- NCT01294709
- Testing
- telcagepant
- Volunteers
- 64 people
- Sponsor
- Merck Sharp & Dohme LLC
Angina, Coronary Disease
Prospective, Controlled and Randomized Clinical Trial on Cardiac Cell Regeneration With Laser and Autologous Bone Marrow Stem Cells, in Patients With Coronary Disease and Refractory Angina
Coronary disease is one of the most frequent pathology of the modern world and the leading cause of death in the investigators country.
- Trial name
- NCT01214499
- Testing
- Transmyocardial revascularization (TMR) with Holmium YAG laser, Transmyocardial revascularization (TMR) with Holmium YAG laser plus the patient's own stem cells extracted from bone marrow.
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Cardiovascular Diseases, Heart Diseases
Evans County Studies
To conduct surveillance of cardiovascular morbidity and mortality and its correlation with known risk factors in all cohort study groups in Evans County, Georgia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Angina Pectoris
- Trial name
- NCT00005122
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atherosclerotic Heart Disease With Angina Nos
Clinical Study on Adjuvant Treatment of Coronary Heart Disease Angina Pectoris With Chinese Patent Medicine
A prospective cohort study was performed in patients with angina pectoris who were treated with oral Chinese patent medicine and Western medicine.Collect primary and secondary efficacy indicators such as the incidence of…
- Trial name
- CSCD-TCM (NCT04022031)
- Testing
- Chinese patent medicine
- Where
- China
- Volunteers
- 12,400 people
- Sponsor
- Tianjin University of Traditional Chinese Medicine
Acute Coronary Syndrome, STEMI - ST-segment Elevation Myocardial Infarction
Kitasato PCI Registry
The Kitasato PCI Registry is a single-center, observational, prospective study. This study aims to investigate the impact of characteristics in clinical manifestation, patients' background, procedure of percutaneous coronary…
- Conditions
- Acute Coronary Syndrome, STEMI - ST-segment Elevation Myocardial Infarction, NSTEMI - Non-ST-Segment Elevation Myocardial Infarction, Atherosclerosis
- Trial name
- NCT05308329
- Testing
- Intra-coronary imaging device, PCI procedural characteristics
- Where
- Japan
- Volunteers
- 4,500 people
- Sponsor
- Kitasato University
Hypertension, Angina
Improving Service Delivery Through Access Points
CBOCs represent one of VA's main managed care strategies for shifting the focus of care from the inpatient to the outpatient setting and for improving the health of our nation's veterans.
- Conditions
- Hypertension, Angina, Diabetes
- Trial name
- NCT00012623
- Where
- United States
- Volunteers
- 39,481 people
- Sponsor
- US Department of Veterans Affairs
Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
First-in-Human Study Using the SiroMax™ Sirolimus-Coated Balloon Catheter as a Percutaneous Transluminal Coronary Angioplasty (PTCA) Balloon Catheter to Treat Subjects Who Have Coronary Artery Disease (CAD) Involving In-Stent Restenosis (ISR) or an Unstented Lesion in a Small Coronary Vessel (DNSV).
The goal of this clinical trial is to learn if the SiroMax™ drug-coated balloon catheter is safe and works to treat stenotic coronary lesions in adults.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), In-Stent Restenosis or De Novo Coronary Artery Lesions, In-Stent Stenosis (Restenosis) of Coronary Artery Stent
- Trial name
- SMART-I (NCT07811024)
- Testing
- Sirolimus-coated balloon catheter
- Where
- 2 sites in Uzbekistan
- Volunteers
- 60 people
- Sponsor
- Tonic Medical, Inc.
Angina
Double Blind Atorvastatin Amlodipine Study
To evaluate and compare the safety and efficacy of amlodipine, atorvastatin and the combination in patients with symptomatic myocardial ischemia.
- Trial name
- DUAAL (NCT00159718)
- Testing
- amlodipine, atorvastatin
- Where
- 33 sites in Croatia, Czechia and 9 more
- Volunteers
- 360 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Heart Diseases, Arrhythmia, Cardiac
Evaluation of the LVivo Image Quality Scoring (IQS)
The study includes two parts: Part 1: 100 examinations of patient referred for echo evaluation, containing clips that were acquired from the 4CH apical view were collected retrospectively.
- Conditions
- Heart Diseases, Arrhythmia, Cardiac, Angina Pectoris, Unstable Angina
- Trial name
- NCT05563701
- Where
- Israel
- Volunteers
- 164 people
- Sponsor
- DiA Imaging Analysis Ltd
Angina Attacks, Non Obstructive Coronary Artery Disease
The Anti-Anginal Effects of N-Acetylcysteine (NAC) in Patients with Angina and Non-Obstructive Coronary Arteries (ANOCA)
The goal of this clinical trial is to determine if N-acetylcysteine (NAC) can reduce angina frequency in women with Angina with Non-Obstructive Coronary Arteries (ANOCA).
- Trial name
- NANA (NCT06890507)
- Testing
- N-Acetylcysteine (NAC)
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- University of Adelaide
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.