Clinical trials: Angioplasty
Coronary Artery Disease, Ischaemic Heart Disease
Coronary Artery Endothelial Dysfunction With Drug Coated Balloons
Use of intracoronary acetylcholine to investigate endothelial function in coronary arteries treated with either drug coated balloon angioplasty of drug eluting stents.
- Conditions
- Coronary Artery Disease, Ischaemic Heart Disease, Endothelial Dysfunction
- Trial name
- SPARTAN-VM (NCT04901767)
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Peripheral Artery Disease
Sirolimus- vs. Paclitaxel-Drug Coated Ballons in Patients With Peripheral Artery Disease
This study is a prospective, interventional, multi-center 1:1 randomized non-inferiority trial. The trial evaluates the safety and efficacy of the Magic Touch PTA sirolimus drug-coated balloon in comparison to the treatment with…
- Trial name
- SIRONA (NCT04475783)
- Testing
- Percutaneous Transluminal Angioplasty (PTA)
- Where
- 22 sites in Austria, Germany
- Volunteers
- 478 people
- Sponsor
- Jena University Hospital
Coronary Artery Disease
Relationship Between Coronary Angiography Findings and Fractional Flow Reserve After Balloon Angioplasty
The goal of this prospective observational study is to learn about in patients who need percutaneous coronary intervention for coronary artery disease.
- Trial name
- PROBE-FFR (NCT05716997)
- Where
- 2 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Peripheral Artery Disease, Vascular Disease
Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging
This is a prospective, multicenter, randomized trial to determine the mechanisms of vascular healing. The study will evaluate subjects with peripheral artery disease (PAD) who require an endovascular intervention of the…
- Conditions
- Peripheral Artery Disease, Vascular Disease, Critical Limb Ischemia
- Trial name
- INVADER_MRI (NCT02807779)
- Testing
- Dexamethasone infusion, Drug coated balloon, Plain balloon angioplasty
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of California, San Francisco
Arteriovenous Fistula Renal Dialysis Devices Obstruction
Primary Patency in Post-angioplasty Dysfunctional Arteriovenous Fistula in Renal Dialysis: Paclitaxel-releasing PTA Balloon Catheter vs PTA Balloon
In recent years the use of paclitaxel releasing percutaneous transluminal angioplastic (PTA) balloon catheter is spreading in vascular pathology, mainly in stenosis infrainguinal arteries.
- Trial name
- FISBAL (NCT02565953)
- Testing
- Paclitaxel-releasing PTA balloon catheter, PTA balloon catheter
- Where
- 4 sites in Spain
- Volunteers
- 134 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Peripheral Artery Disease, Critical Limb Ischemia
Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinically driven target lesion…
- Trial name
- TANGO-3 (NCT04433572)
- Testing
- Temsirolimus
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Mercator MedSystems, Inc.
Cardiogenic Shock
The Current Status and Clinical Outcomes of Patients With Cardiogenic Shock II
The investigation of patient characteristics and prognostic factors of the patients presented with cardiogenic shock (CS) will guide us to identify the better management strategy for these critically ill patients.
- Trial name
- RESCUE II (NCT04143893)
- Testing
- Mechanical circulatory support, Optimal medical treatment
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
REVEAL Study: Vessel Healing After Angioplasty
To address early vessel healing and thrombus formation after deployment of three distinct groups of stents
- Trial name
- REVEAL (NCT00799344)
- Testing
- Catania Stent
- Where
- Italy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- CeloNova BioSciences, Inc.
Congenital Disorders
Percutaneous Interventions in Adults With CHD
The primary objective of this study is to determine the clinical benefits of percutaneous intervention to improve pulmonary blood flow on oxygen saturations, symptoms, exercise tolerance and hematocrit in patients with complex…
- Trial name
- NCT00266916
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Healthcare of Atlanta
Myocardial Infarction
Routine Angioplasty and Stenting After Fibrinolysis for Acute Myocardial Infarction
Background: In Canada, most patients with acute myocardial infarction (AMI) present to hospitals without cardiac catheterization facilities. Thrombolytic therapy remains the standard-of-care in these centres.
- Trial name
- NCT00164190
- Testing
- Routine Early Percutaneous Coronary Intervention after Thrombolysis
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Canadian Heart Research Centre
Coronary Artery Bypass, Atherosclerosis
Study of the Xience V Everolimus-eluting Stent in Saphenous Vein Graft Lesions
The specific aim of the SOS-Xience V study is to examine the 12-month incidence of binary angiographic in-stent restenosis after implantation of the Xience V stent in aortocoronary saphenous vein bypass graft lesions.
- Trial name
- SOS-Xience V (NCT00911976)
- Testing
- Xience V coronary stent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- North Texas Veterans Healthcare System
Femoropopliteal Artery Disease
Combination Therapy of Atherectomy Plus Drug-coated Balloon Versus Drug-coated Balloon for Complex Femoropopliteal Artery Disease
Prospective, multi-center, randomized, controlled comparison study A total of 300 subjects with complex femoropopliteal artery disease will be included according to inclusion and exclusion criteria.
- Trial name
- ARTEMIS (NCT05307263)
- Testing
- Combination therapy of atherectomy and DCB, DCB alone
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Acute Myocardial Infarction
Erythropoietin in Acute Myocardial Infarction
Erythropoietin (EPO) is a naturally occuring hormone which regulates the body's response to lack of oxygen and controls the number of red cells in the blood.
- Trial name
- NCT00149058
- Testing
- Erythropoietin
- Where
- 2 sites in United Kingdom
- Volunteers
- 124 people
- Sponsor
- Hammersmith Hospitals NHS Trust
Critical Limb Ischemia, Peripheral Artery Disease
Tolerability and Efficacy of Intravenous Infusion of Autologous MSC_Apceth for the Treatment of Critical Limb Ischemia
MSC_Apceth are GMP-manufactured, autologous ex-vivo expanded non-hemapoietic bone-marrow derived stem cells for the treatment of Critical Limb Ischemia
- Trial name
- NCT01351610
- Testing
- PTA + Infusion of MSC_Apceth, PTA
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Apceth GmbH & Co. KG
Arterial Occlusive Disease
Infrapopliteal Drug Eluting Angioplasty Versus Stenting
In total 50 patients diagnosed with long-segment infrapopliteal arterial disease will be randomized in two groups. The patients randomized in the Drug coated balloons (DCB) study arm will undergo a percutaneous transluminal…
- Trial name
- IDEAS-I (NCT01517997)
- Testing
- Paclitaxel coated balloon angioplasty., Infrapopliteal Primary Drug Eluting Stenting
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Patras
Atherosclerosis, Ischemia Limb
Efficacy and Safety Comparison of the Endovascular and the Hybrid Methods for the Treatment of Prolonged Atherosclerotic Lesions of the Femoral-popliteal Segment Above the Knee, TASC II, Type D
A recent study, where the authors studied the effectiveness of stenting of prolonged lesions (>200 mm) of the femoral-popliteal segment with nitinol stents (TASC II, D), showed unsatisfactory primary patency rates (45%) within 2…
- Conditions
- Atherosclerosis, Ischemia Limb, Superficial Femoral Artery Occlusion, Popliteal Artery Occlusion
- Trial name
- NCT04590131
- Testing
- recanalization of the femoral-popliteal arterial segment above the knee with angioplasty and stenting with a biomimetic interwoven nitinol stent, supplemented by fasciotomy in Hunter's canal., recanalization of the femoral-popliteal arterial segment above the knee with angioplasty and stenting with a biomimetic interwoven nitinol stent.
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Artery Disease, Acute Coronary Syndrome
Shanghai Registry of Acute Coronary Events
SRACE is an multicenter observational database of outcomes for patients who are hospitalized with an acute coronary events. SRACE includes over 20 hospitals in Shanghai China that have enrolled a total of more than 3,000 patients…
- Trial name
- NCT00713557
- Testing
- drug-eluting stent, Tirofiban
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Critical Limb Ischemia
Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study)
Prospective, randomized, controlled, multi-center study A total of 390 subjects with critical limb ischemia will be included according to inclusion and exclusion criteria.
- Trial name
- NCT02829151
- Testing
- Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) ), Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel, Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
- Where
- South Korea
- Volunteers
- 390 people
- Sponsor
- Yonsei University
Orthostatic Hypotension, Dysautonomic, Orthostatic Intolerance
The STAND-UP Study
Orthostatic hypotension (OH) and orthostatic intolerance (OI) are common conditions where blood pressure drops when standing up, causing dizziness, fainting, or fatigue.
- Trial name
- NCT07195903
- Testing
- Angioplasty or stenting
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- St. Francis Hospital, New York
Chronic Thromboembolic Pulmonary Hypertension
BPA vs. PEA in CTEPH
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and potentially life-threatening progressive disease that evolves from unresolved pulmonary embolism.
- Trial name
- GO-CTEPH (NCT05110066)
- Testing
- Pulmonary endarterectomy, Balloon pulmonary angioplasty
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 139 people
- Sponsor
- University of Aarhus