Clinical trials: Angioplasty Patients
Acute Coronary Syndrome
Safety of 6-month Duration of Dual Antiplatelet Therapy After Acute Coronary Syndromes (SMART-DATE)
1. Objective : To test the safety of 6 month-duration of dual antiplatelet therapy (DAPT) compared to conventional 12-month-or-longer duration after second-generation drug-eluting stent (DES) implantation in patients with acute…
- Trial name
- SMART-DATE (NCT01701453)
- Testing
- P2Y12 inhibitor (clopidogrel, ticagrelor, prasugrel)
- Where
- South Korea
- Volunteers
- 2,712 people
- Sponsor
- Samsung Medical Center
Coronary Disease, Heart Diseases
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Myocardial Ischemia
- Trial name
- PIV-EPIC (NCT06535568)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Thromboembolic Pulmonary Hypertension, Chronic Disease
Initial Dual Oral Combination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterised by an obstruction of proximal or more distal pulmonary arteries by residual organized thrombi, combined with a variable microscopic pulmonary vasculopathy…
- Conditions
- Thromboembolic Pulmonary Hypertension, Chronic Disease, Inoperable Disease
- Trial name
- IMPACT-CTEPH (NCT04780932)
- Testing
- Macitentan 10mg
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myocardial Infarction
Phase 1 Study of Potential Anti-Inflammatory Effects of Glucose Control During Acute Myocardial Infarction.
The purpose of this study is to determine if intense control of high glucose levels in patients treated with angioplasty for heart attack has anti-inflammatory and anti-thrombotic effects.
- Trial name
- NCT00209144
- Testing
- Intensive insulin therapy
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Emory University
Coronary Artery Disease
Safety of High-dose Tirofiban During Coronary Angioplasty
This single-centre study is intended to retrospectively check the safety of high-dose bolus of tirofiban in patients who underwent percutaneous angioplasty.
- Trial name
- SANTISS (NCT00566891)
- Testing
- tirofiban, Clopidogrel
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- S. Anna Hospital
Coronary Artery Disease
The E-SERIES Registry for Supralimus® Coronary Stent for the Treatment of Unselected Patients With Coronary Lesions
E-SERIES Registry evaluate the procedural and clinical outcomes of the Supralimus® SES in the treatment of unselected, high risk patients having coronary Artery blockage in the real world clinical practice.
- Trial name
- NCT01368627
- Testing
- Supralimus® Sirolimus-Eluting Coronary Stent
- Where
- 7 sites in Brazil
- Volunteers
- 1,274 people
- Sponsor
- Sahajanand Medical Technologies Limited
Dialysis Access Dysfunction, Endovascular Procedure
A Neuromodulation Auditory System to Optimize Patient Experience During Dysfunctional Dialysis Access Endovascular Procedures
Peri-procedural stress is a common challenge in interventional radiology that can negatively impact patient tolerance and the overall procedural experience.
- Conditions
- Dialysis Access Dysfunction, Endovascular Procedure, Patient Experience, Neuromodulation
- Trial name
- NCT07467642
- Testing
- Neuromodulation auditory system
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Efficacy/Long-term Effectiveness Endovascular Therapy in PAD
PTA-Registry, a Prospective, Multicenter Study With 24-Month Follow-up
The PTA-Registry (PTA-REG) is a prospective health services research registry to monitor and follow-up patients with peripheral arterial disease undergoing endovascular peripheral intervention.
- Trial name
- PTAReg (NCT03045224)
- Testing
- PTA, balloon angioplasty, stent
- Volunteers
- 1,760 people
- Sponsor
- Vascular Center Berlin
Ischemic Heart Disease, Coronary Atherosclerosis
Stress-MRI Assessment After Right Coronary Artery CTO Recanalization
The hypothesis of this study is that Stress-MRI is a clinically significant method of myocardial perfusion assessment after coronary angioplasty with stenting of right coronary artery (RCA) chronic total occlusion (CTO) is…
- Conditions
- Ischemic Heart Disease, Coronary Atherosclerosis, Coronary Artery Disease, Coronary Artery Stenosis
- Trial name
- NCT02769650
- Testing
- CTO coronary angioplasty, Optimal medicamentous treatment, Stress-MRI
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Aortic Isthmus Stenosis
Vascular Changes in Patients With Aotic Isthmus Stenosis After Interventional Therapy
This controlled clinical study investigates arterial blood pressure and vascular remodling before and 4 weeks after catheter interventional treatment of re-stenosis of the aortic isthmus (Recoarctatio Aortae).
- Trial name
- ISTHA (NCT05903586)
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Coronary Heart Disease, Angioplasty, Balloon
Drug-coated Balloons and Drug-eluting Stents in Diabetic Patients
Drug-eluting stents (DES) have long been recommended as the default device for patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT05937230
- Testing
- Drug-coated balloon, Drug-eluting stents
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Xijing Hospital
Coronary Disease, Coronary Artery Disease
SPIRIT II: A Clinical Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System
Prospective, randomized, active-control, single blind, parallel two-arm multi-center clinical trial comparing XIENCE V® Everolimus Eluting Coronary Stent System to the approved commercially available active control TAXUS™…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- SPIRIT II (NCT00180310)
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent, TAXUS™ EXPRESS2™ Paclitaxel Eluting Coronary Stent
- Where
- 32 sites in Austria, Belgium and 11 more
- Volunteers
- 300 people
- Sponsor
- Abbott Medical Devices
Critical Limb Ischemia
Efficacy and Safety of Apixaban in Reducing Restenosis and Limb Loss in PAD Patients.
This study will evaluate the efficacy and safety of apixaban 2.5 mg twice daily plus aspirin compared to the standard treatment (clopidogrel plus aspirin) in patients with critical limb ischemia undergoing infrapopliteal arterial…
- Trial name
- AGRIPPA (NCT04229264)
- Testing
- Apixaban, ASA, Clopidogrel 75mg
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Science Valley Research Institute
Stable Angina, Unstable Angina
Low Rate Fluoroscopy to Reduce Radiation Dose During Coronary Angiography and Intervention
Objectives: To determine the efficacy of low rate fluoroscopy at 7.5 frames per second (FPS) vs. conventional 15 FPS for reduction of operator and patient radiation dose during diagnostic coronary angiography and percutaneous…
- Conditions
- Stable Angina, Unstable Angina, Acute Coronary Syndrome
- Trial name
- NCT01990924
- Testing
- 15 FPS, 7.5 FPS
- Where
- Canada
- Volunteers
- 385 people
- Sponsor
- Laval University
Chronic Thromboembolic Pulmonary Hypertension
Switching of Sildenafil to Riociguat in CTEPH Patients
This study was designed to investigate the safety and efficacy of replacing phosphodiesterase 5 inhibitors (PDE5i) with riociguat in patients with Chronic thromboembolic pulmonary hypertension (CTEPH) who have undergone pulmonary…
- Trial name
- S2R (NCT06715280)
- Testing
- Riociguat (Adempas)
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Disease
Infinnium-Core™ Registry for the Treatment of Patients With De Novo Coronary Lesions
The primary objective of Infinnium-Core™ Registry is to assess the safety and efficacy of the Infinnium-Core™ Paclitaxel Eluting Coronary Stent System in de novo Coronary Lesions.
- Trial name
- NCT00936780
- Testing
- Infinnium-Core™ Paclitaxel eluting Coronary Stent
- Where
- 7 sites in India
- Volunteers
- 67 people
- Sponsor
- Sahajanand Medical Technologies Limited
Coronary Occlusion, Angioplasty, Balloon, Coronary
Functional Assessment-guided Angioplasty in Patients With Coronary Chronic Total Occlusion
The aim of this study is to investigate the role of functional evaluation for predicting clinical outcome in patients with coronary chronic total occlusion (CTO) undergoing percutaneous coronary intervention (PCI), and to…
- Trial name
- FAGA-CTO (NCT03522038)
- Testing
- percutaneous coronary intervention
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Critical Limb Ischemia, Peripheral Artery Disease
Tolerability and Efficacy of Intravenous Infusion of Autologous MSC_Apceth for the Treatment of Critical Limb Ischemia
MSC_Apceth are GMP-manufactured, autologous ex-vivo expanded non-hemapoietic bone-marrow derived stem cells for the treatment of Critical Limb Ischemia
- Trial name
- NCT01351610
- Testing
- PTA + Infusion of MSC_Apceth, PTA
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Apceth GmbH & Co. KG
Heart Diseases, Heart Failure
Mindfulness & Stress Management Study for Cardiac Patients
The guideline-recommended standard of care for patients who have experienced a heart attack, heart failure, or other coronary event or procedure is exercise-based cardiac rehabilitation (CR).
- Conditions
- Heart Diseases, Heart Failure, Myocardial Infarction, Chronic Stable Angina
- Trial name
- NCT02722213
- Testing
- Mindfulness-Based Stress Reduction (MBSR).
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Minnesota
CTEPH, Pulmonary Hypertension (PH)
Arterial Wave Energy Flux and Multidimensional Recovery in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Balloon Pulmonary Angioplasty
The goal of this observational study is to learn if advanced heart pressure wave analysis (called WIA and REPA) can help track and predict clinical improvement in adults (aged 18-85) with Chronic Thromboembolic Pulmonary…
- Trial name
- WE FIX BPA (NCT07522203)
- Testing
- Balloon Pulmonary Angioplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital