Clinical trials: Ankle
Pareses, Lower Extremity
C-Brace Prospective Registry
To gather prospective safety and effectiveness data for the C-Brace System following the standard of care.
- Trial name
- NCT04640584
- Testing
- C-Brace
- Where
- 76 sites in United States, Australia and 2 more
- Volunteers
- 250 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Surgery, Foot Deformities
Induce XT™ Bone Graft in Foot and Ankle Fusion
The goal of this study is to evaluate how effective Induce XT is in patients undergoing foot and/or ankle surgery. Induce XT is a bone graft material used in surgeries to fill gaps where bone is missing, such as during foot and…
- Conditions
- Surgery, Foot Deformities, Ankle Arthropathy
- Trial name
- NCT06662266
- Testing
- Induce XT™ is a mixture of human cortical bone fibers and microparticulates that have been processed into Natural Matrix Protein® (NMP®) to which cancellous bone microparticulates have been added
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Red Rock Regeneration Inc.
Osteoarthritis
ARTEBONE Bone Void Filler in Arthrodesis Procedure of the Ankle
The purpose of this investigation is to assess safety and performance of ARTEBONE Bone Void Filler in the single arthrodesis procedure.
- Trial name
- NCT02480868
- Testing
- ARTEBONE
- Where
- 5 sites in Finland, Poland
- Volunteers
- 34 people
- Sponsor
- BBS-Bioactive Bone Substitutes Oy
Ankle Sprain
Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain
The safety and the efficacy of the Esflurbiprofen Hydrogel Patch will be assessed in comparing with placebo in the treatment of acute pain due to ankle sprain
- Trial name
- NCT02729207
- Testing
- Esflurbiprofen Hydrogel Patch
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Teikoku Seiyaku Co., Ltd.
Acute Pain, Ankle Sprain
Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Ankle Sprain
The primary purpose of this study is to assess the effectiveness of once daily application of a diclofenac sodium topical patch in reducing acute pain due to mild to moderate ankle sprains when applied to the painful area.
- Trial name
- SUPPORT 2 (NCT00869180)
- Testing
- Diclofenac Sodium
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Cerimon Pharmaceuticals
Chemotherapy-induced Peripheral Neuropathy, Chemotherapy-induced Neuropathic Pain
Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN)
Peripheral neuropathy is a disorder caused by damage to the peripheral nerves. Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of certain chemotherapy drugs, such as platinum-based compounds, taxanes…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Chemotherapy-induced Neuropathic Pain, CIPN - Chemotherapy-Induced Peripheral Neuropathy, Peripheral Neuropathic Pain
- Trial name
- NCT07072468
- Testing
- VMD-3866 Gel
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- VM Therapeutics LLC
Ankle Osteoarthritis
Evaluating Intra-articular Injection of Axolotl Ambient Compared to Saline in Subjects With Ankle Osteoarthritis
A Double-blind, Multi-Center, Prospective, Randomized Placebo-controlled Pilot Study Evaluating Intra-articular Injection of Axolotl Ambient Compared to Saline in Subjects with Ankle Osteoarthritis.
- Trial name
- Phoenix (NCT05092646)
- Testing
- Axolotl Ambient
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Axolotl Biologix
Ankle Arthritis, Foot Arthritis
The Use of a Dynamic Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis
The purpose of this study is to determine the clinical efficacy of a novel sustained dynamic compression intramedullary nail for tibiotalocalcaneal (TTC) arthrodesis.
- Trial name
- NCT04784273
- Testing
- Tibiotalocalcaneal Arthrodesis, DynaNail
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- MedShape, Inc
Ankle Sprain, Infectious Colitis
Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication
The purpose of this "before-after" prospective multicenter study is to assess the impact of six Patient Information Leaflets (PILs) on Doctor Patient Communication scale (DPC) and adherence scale for common acute illnesses in…
- Conditions
- Ankle Sprain, Infectious Colitis, Diverticulitis, Pyelonephritis
- Trial name
- EDIFIP (NCT02246361)
- Testing
- Patient Information Leaflet (PIL)
- Where
- 2 sites in France
- Volunteers
- 211 people
- Sponsor
- Floralis
Hypertension, Oedema
A Clinical Study Comparing Ankle Swelling Caused by Two Different Blood Pressure Medications, Levamlodipine and Amlodipine, in Post-menopausal Women With Mild High Blood Pressure.
High blood pressure is often treated with a medication called Amlodipine, but it can cause uncomfortable ankle swelling, especially in women.
- Trial name
- TERESA (NCT07618806)
- Testing
- Amlodipine
- Volunteers
- 344 people
- Sponsor
- Zentiva, k.s.
Joint Instability
A Multi-Site Evaluation of the Pain Relief, Support, Fit and Comfort From Use of a Custom Knee or Ankle Brace in Persons Suffering From Chronic Ankle or Knee Pain and Instability
This study will look to examine the overall performance of a custom fit knee or ankle brace as a means of providing ankle or knee joint support in subjects that have determined the need for bracing based upon chronic joint…
- Trial name
- NCT02682654
- Testing
- Dr. Scholl's Prototype Ankle Brace, Dr. Scholl's Prototype Knee Brace
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- Bayer
Ankle Arthritis, Arthritis Foot
The Use of a Dynamic Sustained Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis
The purpose of this study is to determine the clinical efficacy of a novel sustained dynamic compression intramedullary nail for tibiotalocalcaneal (TTC) arthrodesis utilizing longitudinal weight-bearing computed tomographic…
- Trial name
- NCT04831645
- Testing
- DynaNail, Tibiotalocalcaneal Arthrodesis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- MedShape, Inc
Ligament Injury
A RCT for Y-Knot All-suture Anchor in Ankle Ligaments Injury Repair
Purpose of this study is to evaluate the effectiveness and safety of Y-Knot all-suture anchor by comparing patients' clinical outcome after ankle ligaments repair surgery.
- Trial name
- NCT04310956
- Testing
- Y-Knot all-suture anchor, Biocomposite suture anchor
- Where
- 4 sites in China
- Volunteers
- 148 people
- Sponsor
- ConMed Linvatec Beijing
Ankle Fusion, Hindfoot Arthrodesis
Orthofix PhysioStim PEMF Ankle Fusion Retrospective
This study examines the effect of using the PhysioStim bone growth stimulator on subjects undergoing treatment for ankle and hindfoot fusion surgery.
- Conditions
- Ankle Fusion, Hindfoot Arthrodesis, Ankle Arthrodesis, Tibiotalar Arthrodesis
- Trial name
- PSAF (NCT07282067)
- Testing
- Pulsed electromagnetic field (PEMF) stimulation, Control
- Where
- 8 sites in United States
- Volunteers
- 200 people
- Sponsor
- Orthofix Inc.
Osteoarthritis, Hip, Osteoarthritis Thumb
Evaluate Clinical Benefit of Local Treatment With KD Intra-Articular® Gel in Patients With Osteoarthritis (NO-DOLOR2)
Prospective observational, national, multicentre, open study with a class III medical device with EC marking. Study to evaluate the clinical benefit of local treatment with KD intra-articular® gel in patients with osteoarthritis…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis Thumb, Osteoarthritis Ankle
- Trial name
- NO-DOLOR2 (NCT05275244)
- Testing
- KD Intra-Articular® gel
- Where
- Spain
- Volunteers
- 67 people
- Sponsor
- Procare Health Iberia S.L.
Arthritis
A Study Evaluating Amplex Compared To Autograft Bone In Foot and Ankle Fusion Surgery
The current research study evaluates an investigational medical device called Amplex B2A(TM) Peptide Enhanced Ceramic Granules ("Amplex") for use in foot and ankle fusion. Amplex is a synthetic bone graft material.
- Trial name
- NCT01224119
- Testing
- Amplex, Autograft bone
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- BioSurface Engineering Technologies, Inc
Defect of Articular Cartilage, Degenerative Joint Disease of Ankle and/or Foot
Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle
The objective of this study is to evaluate the efficacy and safety of Chondron (Autologus Chondrocyte) in patients with cartilage defects in their ankle for 18 months
- Conditions
- Defect of Articular Cartilage, Degenerative Joint Disease of Ankle and/or Foot, Ankle (Ligaments); Instability, Familial
- Trial name
- NCT02537067
- Testing
- CHONDRON
- Where
- 2 sites in South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Hemiparesis;Poststroke/CVA, Gait, Hemiplegic
Comparison of Thermo-plastic Versus Carbon Foot Ankle Orthosis to Improve Gait and Reduce Fatigue in Post-stroke Patients: a Biomechanical and Neurophysiological Study
Approximately 20% of stroke survivors have difficulties to dorsiflex the ankle and clear the ground during walking. This impairment, termed as "foot drop", is caused by an association of weak dorsiflexors and increased spasticity…
- Trial name
- MECASPRY (NCT04323943)
- Testing
- Ankle Foot orthosis (AFO)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Thuasne
Ankle Sprains, Lateral Ankle Sprain
Study of the AxisBoard Single-Leg Balance Board in Adults With Lateral Ankle Sprain
The goal of this study is to learn whether a 28-day home exercise program using the AxisBoard Single-Leg Balance Board improves ankle function in adults who are still having symptoms 6 weeks to 6 months after a lateral (outer)…
- Trial name
- NCT07860125
- Testing
- AxisBoard Single-Leg Balance Board
- Volunteers
- 80 people
- Sponsor
- DITU Inc.
Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease
Post-Market Registry of AURYON Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease
The PATHFINDER Registry is a prospective, non-randomized, single arm, multicenter observational study. This pilot registry is aimed to evaluate the performance (peri-procedural) and clinical outcomes (intermediate and long-term)…
- Conditions
- Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease, PAD
- Trial name
- PATHFINDER (NCT04229563)
- Testing
- AURYON Atherectomy System
- Where
- 10 sites in United States
- Volunteers
- 102 people
- Sponsor
- Angiodynamics, Inc.