Clinical trials: Anorectal Disorders
Anorectal Malformation
National Study on the Quality of Life of Patients With Anorectal Malformation
Anorectal malformations, occurring approximately 1 in 5000 live births, mainly involve the distal anus and rectum, but also sometimes the urinary and genital tracts.
- Trial name
- MARQOL (NCT02029248)
- Testing
- Quality of life questionnaire
- Where
- 37 sites in France
- Volunteers
- 762 people
- Sponsor
- Nantes University Hospital
Achalasia, Nutcracker Esophagus
Comparison of Esophageal and Anorectal Manometry Catheters
The primary objective of this study is to compare the accuracy of esophageal and anorectal manometric pressure measurements using a newly developed air filled balloon catheter with present standard solid state esophageal and…
- Conditions
- Achalasia, Nutcracker Esophagus, Scleroderma, Esophageal Spasm
- Trial name
- NCT00204763
- Testing
- Air filled balloon catheter, Solid state catheter
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Anorectal Disorder
Caudal Block,Saddle Block, Anorectal Surgery
Anorectal surgery includes pilonidal sinus, hemorrhoidectomy, anal fissure, and anal fistula operations. Various surgical and anesthetic techniques have been used to increase the level of analgesia in perioperative period and…
- Trial name
- NCT03498547
- Testing
- caudal block, saddle block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Double Incontinence, Faecal Incontinence
Prospective Database of Factors Associated With Faecal vs. Double Incontinence in Patients Referred for High Resolution Anorectal Manometry.
This study aims to verify the results from our previous retrospective cohort analysis by establishing a database of well-characterised patients prospectively.
- Conditions
- Double Incontinence, Faecal Incontinence, Urinary Incontinence
- Trial name
- NCT05550675
- Testing
- Questionnaires
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Pain Management, Hemorrhoids Third Degree
Topical Lidocaine 23%/Tetracaine 7% Ointment for Post-Hemorrhoidectomy Analgesia: A Randomized Controlled Trial
The goal of this clinical trial is to learn if a topical ointment containing two local anesthetics (lidocaine 23% and tetracaine 7%) can reduce pain after hemorrhoid surgery in adults.
- Conditions
- Pain Management, Hemorrhoids Third Degree, Hemorrhoids Fourth Degree, Hemorrhoids Second Degree
- Trial name
- NCT07688031
- Testing
- Lidocaine 23% / Tetracaine 7% topical ointment (compounded)
- Where
- Chile
- Volunteers
- 74 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Spinal Cord Injury
At-Home Genital Nerve Stimulation for SCI Bowel
The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries.
- Trial name
- NCT06836739
- Testing
- Genital nerve stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MetroHealth Medical Center
Parkinson Disease, Constipation
Parkinson's Disease and Digestive Health
This study focuses on the relationship between the brain and the gut, and additionally will foster collaboration between Movement Disorder experts and Neurogastroenterologists to provide critical information and lead to…
- Conditions
- Parkinson Disease, Constipation, Gastro-Intestinal Disorder
- Trial name
- NCT04032262
- Testing
- Gastrointestinal and Parkinson's Disease
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Augusta University
Constipation, Fecal Incontinence
Treating Anorectal Dysfunction in MS
The investigators seek to test whether incorporating the scheduled dosing of a bisacodyl 10 mg rectal suppository every other day improves bowel-related symptoms in patients with multiple sclerosis.
- Conditions
- Constipation, Fecal Incontinence, Multiple Sclerosis
- Trial name
- NCT02609607
- Testing
- Bisacodyl
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- David Levinthal
Body Image, Urinary Incontinence
Pelvic Floor Dysfunction and Its Influence on Body Image and Sexual Function
The first objective to determinate the prevalence of pelvic floor dysfunction in pregnant women and in the first year postpartum.
- Conditions
- Body Image, Urinary Incontinence, Anal Incontinence, Anorectal Disorder
- Trial name
- PFD-BI (NCT03591393)
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anorectal Fistula
Anal Sphincter Reconstruction After High Recurrent Anorectal Fistula Excision
A retrospective analysis of patients treated for recurrent posterior anorectal fistula, who previously had undergone radical excision of fistula-in-ano, was performed.
- Trial name
- NCT04357210
- Testing
- fistula tract excision and anal sphincter reconstruction
- Volunteers
- 14 people
- Sponsor
- Russian Society of Colorectal Surgeons
Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection
Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples
This study aims to compare the sensitivity of detecting Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium by real-time multiplex PCR in a pooled analysis (i.e.
- Conditions
- Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection, Mycoplasma Genitalium Infection, Sensitivity
- Trial name
- ISTPOOL (NCT03568695)
- Testing
- Two samples on each of the three sites (pharynx, rectum, urine)
- Where
- 5 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Rectal Cancer
Side-to-end Anastomosis Versus Colon J Pouch for Reconstruction After Low Anterior Resection for Rectal Cancer (SAVE)
Primary hypothesis: Side-to-end anastomosis is non-inferior to colon J pouch for reconstruction after low anterior resection for rectal cancer in fecal incontinence (Wexner score).
- Trial name
- SAVE (NCT01006577)
- Testing
- side-to-end anastomosis, colon j pouch
- Where
- Germany
- Volunteers
- 306 people
- Sponsor
- Charite University, Berlin, Germany
Traumatic Brain Injury
Descriptive and Prospective Study of Sphincter Disorders in the Severe Traumatic Brain Injury Population
Severe traumatic brain injury (TCI), defined by an initial GCS of ≤ 8 and/or admitted to a neurosurgical intensive care unit, are responsible for diffuse brain lesions that can lead to multiple deficits, including impairment of…
- Trial name
- TCG (NCT05163262)
- Testing
- sexuality questionnaire
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anal Fistulas, Rectal Fistulas
A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas
The study is designed as a prospective, non-randomized clinical trial comparing safety and effectiveness of the CuraSeal PICS-AF device to historical data from commercially available devices for the treatment of anorectal…
- Trial name
- NCT02456324
- Testing
- PICS-AF Device, Historical Controls Treated with Commercially Available Fistula Plugs
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Curaseal Inc.
Anorectal Disorders
Anal Resting Pressure After Bidet, Compared to Sitz Bath
Sitz bath is conventional and empirical remedy and commonly recommended for non-operative treatment of various anal diseases. However, as there was no substitute for sitz bath until now, the patients have to accept the…
- Trial name
- Bidet(2) (NCT02244840)
- Testing
- Electronic bidet, Sitz bath
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Fecal Incontinence, Constipation
Studies in Patients With Defecatory Disorders
Defecatory disorders like chronic constipation and faecal incontinence affect 25% of the population with rising incidence. Defecatory disorders pose a major health care burden and are poorly recognized and treated.
- Trial name
- NCT03317938
- Testing
- Fecobionics
- Where
- 2 sites in Hong Kong
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Giome
Hemorrhoids, Fissure in Ano
Pre-Emptive Analgesia in Ano-Rectal Surgery
The perianal region is the region around the anus. Administering a pain medication before a surgery starts is called preemptive analgesia.
- Conditions
- Hemorrhoids, Fissure in Ano, Rectal Fistula, Anal Condyloma
- Trial name
- PEAARS (NCT02402543)
- Testing
- Gabapentin, Ketamine, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Vermont
Fecal Incontinence
Fecal Incontinence Subtypes in Women With Pelvic Floor Disorders
Fecal incontinence (FI) is clinically subtyped as urge FI and passive FI based on symptoms, however the pathophysiologic significance of this subtyping is not known.
- Trial name
- FIST (NCT02772874)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Fecal Incontinence
Effect of Anorectal Biofeedback on Encopresis in School Aged Girls After Sexual Assault
Females who have been sexually abused anally, have a disturbed anorectal motility. They have an increased resting pressure at the lower part of the anal canal.
- Trial name
- NCT04652024
- Testing
- Anorectal manometry
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Badr University
Crohn Disease
Anorectal Function in Perianal Crohn's Disease
Perianal Crohn's disease is a disabling disease associated with increased morbidity and impaired quality of life. It is associated with pain, discharge, fecal incontinence and sexual and psychological impairment.
- Trial name
- NCT03819257
- Testing
- Endoanal ultrasound, High-resolution anorectal manometry, Balloon expulsion test
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust