Clinical trials: Anorectal Disorders
Pelvic Radiotherapy, Vaginal Stenosis
Vaginal Dilator Therapy After Pelvic Radiation
This study is testing a new program to help women who have had pelvic radiation therapy to use vaginal dilators more regularly. Vaginal dilators are important tools that can help prevent or treat vaginal narrowing (called vaginal…
- Conditions
- Pelvic Radiotherapy, Vaginal Stenosis, Pelvic Cancer, Gynecologic Cancers
- Trial name
- NCT07216456
- Testing
- Improving Engagement with Vaginal Dilator Therapy after Pelvic Radiation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Duke University
Anorectal Malformations
Outcomes in ARMs: Comparison Between Surgical Techniques in Patients With Perineal or Vestibular Fistula - a Multicenter Italian Study
This is a national, multicenter, retro-prospective longitudinal cohort study evaluating mid- and long-term outcomes of different surgical techniques used for the correction of anorectal malformations (ARM) with perineal or…
- Trial name
- MAR-ITA (NCT07438691)
- Where
- 21 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Meyer Children's Hospital IRCCS
Children, Anorectal Disorder
Normal Values for 3D High Resolution Anorectal Manometry in Children
Anorectal 3D high resolution manometry (3D HRM) is the most advanced version of manometry equipment and has been recently introduced into clinical practice.
- Trial name
- NCT02236507
- Testing
- 3D high resolution anorectal manometry
- Where
- Poland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Hemorrhoids, Anal Fissure
Topical vs Oral Metronidazole After Benign Anorectal Surgery
While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole.
- Conditions
- Hemorrhoids, Anal Fissure, Anal Fistula
- Trial name
- NCT05038605
- Testing
- Topical metronidazole, oral metronidazole
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Fecal Incontinence, Childhood ALL
Management of FI After Surgery of ARM
The posterior sagittal approach to anorectal malformation (ARM) has radically changed the outcome of these patients, improving the preservation of anal sphincters, owing to their anatomical identification.
- Conditions
- Fecal Incontinence, Childhood ALL, Anorectal Malformations
- Trial name
- NCT05621629
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Exanimation
The Use of Chaperone in Routine Anorectal Examination
Background and aim: The use of chaperone in routine anorectal examination of women attending to Coloproctology clinics has not been studied to this date.
- Trial name
- NCT03615586
- Testing
- With Chaperone, Without Chaperone
- Where
- Brazil
- Volunteers
- 188 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Anorectal Malformations
Study of Antenatal and Postnatal Data of Anorectal Malformations Diagnosed at Montpellier University Hospital Over a 10-year Period (2010-2020)
Objective : Anorectal malformations (ARMs) are part of a spectrum of malformations due to an abnormal separation between the urogenital and digestive tracts during embryonic life.
- Trial name
- NCT05045560
- Where
- France
- Volunteers
- 98 people
- Sponsor
- University Hospital, Montpellier
Fecal Incontinence
Study of the Efficacy of 4 Treatments for Fecal Incontinence in Community-dwelling Women
This is a RCT aimed to assessing efficacy of kegel exercises,biofeedback, electrostimulation and transcutaneous neuromodulation on women with fecal incontinence, measuring its impact on anorectal physiology, cortical plasticity…
- Trial name
- NCT03394794
- Testing
- Pelvic floor rehabilitation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Colorectal Disorders, Anorectal Disorder
A Multimodal Enhanced Recovery Program in Anorectal Surgery
The goal of this study is to establish whether an opioid-sparing Enhanced Recovery After Surgery (ERAS) program in ambulatory anorectal surgery can be safely introduced at a single tertiary referral center without an increase in…
- Conditions
- Colorectal Disorders, Anorectal Disorder, Patient Satisfaction, Pain, Postoperative
- Trial name
- ARSE (NCT03992079)
- Testing
- ReCOVER Enhanced Recovery Protocol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Anorectal Disorder
Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal Surgery
The purpose of the study is to evaluate whether being randomized to an aggressive postoperative non-narcotic pain regimen that treats pain from multiple different pathways may decrease postoperative pain levels, decrease…
- Trial name
- NCT03738904
- Testing
- ERAS, Standard of care
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Children, Anorectal Disorder
3D High Resolution Anorectal Manometry in Children After Surgery for Anorectal Disorders
3D high resolution anorectal manometry (3DHRAM) is the most precise tool to assess function and 3D topographic picture of pressures along the anal canal.
- Conditions
- Children, Anorectal Disorder, Anorectal Atresia, Hirschsprung Disease
- Trial name
- NCT02296008
- Testing
- 3D high resolution anorectal manometry
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Medical University of Warsaw
Pain, Prostate Cancer
Anorectal Application of 5% Lidocaine Cream Reduces Pain Prior to Periprostatic Nerve Block During Transrectal Ultrasound Guided Biopsy
Transrectal ultrasound guided prostate biopsy is performed with a periprostatic nerve block to the neurovascular bundle bilaterally. This does not reduce the pain due to probe insertion and manipulation prior to nerve blockage.
- Conditions
- Pain, Prostate Cancer, Rectal/Anal
- Trial name
- NCT04064047
- Testing
- Trans rectal ultrasound guided prostate biopsy, Trans rectal ultrasound, Prostate biopsy
- Volunteers
- 284 people
- Sponsor
- Assaf-Harofeh Medical Center
Gastrointestinal Motility Disorder
Gastrointestinal Motor Disorders (Esophageal and Anorectal) After COVID-19
The patients who had COVID-19 infection, and after that reported for one of the signs of gastrointestinal disorder (esophageal and anorectal) will be underwent to esophageal and anorectal motor monitoring investigation (HRM…
- Trial name
- NCT04988438
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University Hospital Dubrava
Oesophageal Atresia, Congenital Diaphragmatic Hernia
Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
This study is a multi-centre, international, prospective cohort study of congenital anomalies to compare outcomes between LMICs and high-income countries (HICs) globally.
- Conditions
- Oesophageal Atresia, Congenital Diaphragmatic Hernia, Intestinal Atresia, Gastroschisis
- Trial name
- NCT03666767
- Testing
- Comparisons will be made between LMICs and HICs
- Where
- United Kingdom
- Volunteers
- 3,850 people
- Sponsor
- King's College London
Fistula in Ano
Efficacy of an Anorectal Fistula Plug With Sealing of the Internal Opening as a Treatment for Perianal Fistula
The investigators aim to assess the efficacy of the Curaseal anal plug in patients with idiopathic uncomplicated fistulous tracts. Healing of the fistula tract will be assessed both clinically and radiologically with MR imaging.
- Trial name
- NCT03381365
- Testing
- CuraSeal Percutaneous Intraluminal Closure System
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- London North West Healthcare NHS Trust
Rectal Cancer
Cross-sectional Study of Anorectal Function and Quality of Life in Patients With Middle and Low Rectal Cancer
Understanding the quality of life and anorectal function changes in patients with middle and low rectal cancer after surgery can guide patients to recover after surgery and provide a valuable reference for surgeons in the…
- Trial name
- NCT04697303
- Testing
- anorectal function test
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Quan Wang
Chronic Constipation
Sacral Neuromodulation as Treatment for Chronic Constipation
The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.
- Trial name
- NCT03819062
- Testing
- Low Level Laser Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Fecal Incontinence
Treatment of Patients With Fecal Incontinence
The purpose of this study is to determine if a behavioral treatment method called biofeedback will reduce the frequency of episodes of leakage of fecal material in patient suffering from fecal incontinence.
- Trial name
- NCT00292318
- Testing
- Biofeedback Therapy for Fecal Incontinence: A Randomized Control Study, control group
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- US Department of Veterans Affairs