Clinical trials: Antenatal Care
Unspecified Fetal and Neonatal Jaundice
Health Literacy of Parents Regarding Neonatal Jaundice
This study will be conducted as a relational descriptive study to determine the health literacy level of parents with infants between 0-28 days of age regarding neonatal jaundice.
- Trial name
- NCT05964426
- Testing
- Turkey Health Literacy Scale (TSOY-32)
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ege University
Labor Onset and Length Abnormalities
Engagement of Fetal Head as a Predictor of a Successful Vaginal Delivery in Primigravidas Presented in Early Labor.
In primigravida, Delayed engagement of fetal head has been theorized that it is more likely in women with a possible cephalo-pelvic disproportion, so far they are associated with higher risk of cervical dystocia, which led to…
- Trial name
- NCT05084326
- Testing
- Engagement of fetal head as a predictor of a successful vaginal delivery
- Where
- Egypt
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- mohamed abosena
Autosomal Recessive Disorder, Aneuploidy
Prenatal Computer-Aided Genetics Education Module
A standard part of obstetrical care is offering prenatal genetic screening. Numerous professional guidelines have emphasized the importance of pretest counseling for prenatal genetic screenings.
- Trial name
- CAGEM (NCT03449225)
- Testing
- Computer-Aided Genetic Education Module
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Sickle Cell Disease
Oxygen Therapy and Pregnancy in Sickle Cell Disease
The purpose of this study is to assess the efficiency of the preventive oxygen therapy on the occurrence of vaso-occlusive complications, which last more than 24 hours and require hospitalisation, in women with sickle cell…
- Trial name
- DRO2G (NCT02813850)
- Testing
- oxygen therapy
- Where
- France
- Volunteers
- 178 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
The purpose of this study is to determine whether inhaled iloprost is safe and effective in pediatric patients with pulmonary hypertension who are sick in the intensive care unit.
- Conditions
- Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure, Persistent Pulmonary Hypertension of Newborn, Congenital Heart Defects
- Trial name
- NCT00981591
- Testing
- Iloprost
- Sponsor
- Seattle Children's Hospital
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
Preterm Delivery
Serum Ferritin Concentration and Fetal MCA Doppler as Predictors for Preterm Delivery
Pregnant women with iron deficiency anemia during third trimester will be assessed for serum ferritin and peak systolic value for fetal middle cerebral artery to find out their correlation with preterm delivery.
- Trial name
- SFMCA (NCT02420743)
- Testing
- serum ferritin, MCA Doppler
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Pregnancy
Quarenta Semanas: Innovative Intervention in Prenatal Care for Reduction of Prematurity
The goal of Quarenta Semanas is to remove risk factors for preterm birth by linking women to prenatal care in the first trimester; supporting, educating and empowering women in pregnancy to reduce maternal stress and interrupt…
- Trial name
- quarenta (NCT02506725)
- Testing
- prenatal care in groups
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Oswaldo Cruz Foundation
Iodine Overload in Pregnancy
Registry Study for Pregnant Women With Iodine Overload
Pre-gestational performance of hysterosalpingography (HSG) using an oil-soluble iodinated contrast medium has been demonstrated to be the main cause of excessive iodine exposure for pregnant women.
- Trial name
- NCT03470597
- Testing
- dietary iodine restriction on subjects with iodine overload
- Volunteers
- 195 people
- Sponsor
- Peking Union Medical College Hospital
Fetal Anomalies
Perinatal Diagnosis of GIT Anomalies
fetal gastro intestinal abnormalities can be accurately diagnosed in second trimester
- Trial name
- NCT03514940
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Maternal Syphilis During Pregnancy - Baby Not Yet Delivered, Congenital Syphilis
Point-Of-Care Testing for Congenital Syphilis in Mothers and Newborns
A dramatic rise in syphilis has been recently reported in the US between 2000-2017, which was followed also by a dramatic rise in congenital syphilis (CS).
- Trial name
- NCT03814096
- Testing
- Syphilis Health Check POC-test (Diagnostics Direct LLC, NJ)
- Where
- 2 sites in United States
- Sponsor
- Stanford University
Pregnancy Related, Atopic Dermatitis
Study to Compare Maternal, Fetal, and Infant Outcomes of Women With Mild to Moderate Atopic Dermatitis Exposed to Ruxolitinib Cream During Pregnancy With an Unexposed Control Population
This observational (enrollment into the registry while the pregnancy is ongoing) study is being conducted to compare the frequency of major congenital malformation (MCM)s among infants of women exposed to ruxolitinib cream during…
- Trial name
- OPERA-1 (NCT06259669)
- Testing
- Ruxolitinib Cream
- Where
- United States
- Volunteers
- 958 people
- Sponsor
- Incyte Corporation
Pregnancy, Previous Cesarian Section
Management of Labor in Patients With Previous Cesarian Section
Induction of labor in women desiring TOLAC has long been a topic of controversy. The paucity of published data on mechanical cervical ripening in the setting of TOLAC and term PROM has led us to undertake the present clinical…
- Conditions
- Pregnancy, Previous Cesarian Section, Premature Rupture of Membranes (PROM)
- Trial name
- NCT02196103
- Testing
- Double balloon cervical catheter
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Spontaneous Abortion, Fetal Death
Environmental Factors and Embryonic Development Project
The Environmental Factors and Embryonic Development Project was set up to investigate environmental exposures and behavioral factors responsible for embryonic dysplasia and gestational complications in pregnant women.
- Conditions
- Spontaneous Abortion, Fetal Death, Stillbirth, Birth Defects
- Trial name
- EFED (NCT04182503)
- Testing
- No intervention
- Where
- 19 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Neonatal Infection
Maternal- Fetal Infection
The purpose of the protocol is to validate a novel point of care multiplex system to detect and characterize microorganisms responsible for neonatal sepsis, as well as biomarkers of infection, from a simple vaginal sample, in…
- Trial name
- InSPIRe (NCT03371056)
- Testing
- Bacteriological analyses on clinical samples performed with swabs
- Where
- 3 sites in France
- Volunteers
- 2,569 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia
Chronic Remote Ischemic Preconditioning as a Complement to Conventional Prenatal Care for Preeclampsia
Pre-eclampsia is a disease specific to pregnancy that affects 3-5% of women. It is defined by the appearance of high blood pressure after 20 weeks of amenorrhea associated with the presence of proteins in the urine, dysfunction…
- Trial name
- RIPC (NCT05564988)
- Testing
- Preconditionning
- Volunteers
- 58 people
- Sponsor
- DAVID DESSEAUVE
Trisomy 21, Trisomy 18
Study of the Efficacy of New Non-invasive Prenatal Tests for Screening for Fetal Trisomies Using Maternal Blood
Each year, 450,000 Canadian women become pregnant and, as a result of their participation in prenatal screening for Down syndrome, approximately 10,000 of them will have an amniocentesis (i.e.
- Conditions
- Trisomy 21, Trisomy 18, Trisomy 13
- Trial name
- PEGASUS (NCT01925742)
- Testing
- Integrated prenatal screening for Down's syndrome, Serum QUAD Assay for aneuploidy screening, Semiconductor MPSS NIPT assay using ccfDNA in maternal blood
- Where
- 5 sites in Canada
- Volunteers
- 3,819 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Stillbirth and Fetal Death, Perinatal Death
Mothers Working to Prevent Early Stillbirth Study 20-28
This project aims to identify factors linked to pregnancy losses occurring between 20 and 28 weeks of pregnancy that can be modified by changing mother's behaviour or healthcare provision.
- Trial name
- MiNESS20-28 (NCT06005272)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 948 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Pregnancy-Associated Heart Disease, Fetal Congenital Heart Disease
Maternal-Fetal Heart Sound/Electrocardiogram Monitoring and Cardiac Risk Early Warning
This is a prospective observational cohort study conducted at Beijing Anzhen Hospital. The study aims to establish reference ranges of heart sound and electrocardiogram (ECG) parameters for both mothers and fetuses.
- Conditions
- Pregnancy-Associated Heart Disease, Fetal Congenital Heart Disease, Autoimmune-Related Fetal Heart Block, Perinatal Adverse Events
- Trial name
- NCT07526662
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Yihua He,MD
Persistent Pulmonary Hypertension of the Newborn
Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN
Respiratory failure in newborns is common and has high rates of death. Where conventional intensive care strategies have failed, newborn children are referred to treatment with Extra- Corporeal Membrane Oxygenation (ECMO).
- Trial name
- Mi-ECMO (NCT02940327)
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Leicester