Clinical trials: Anterior Cerebral Circulation
Infarction, Middle Cerebral Artery, Infarction, Anterior Cerebral Artery
Effect of Mesenchymal Stem Cells(MSCs) Transplantation for Acute Cerebral Infarction Patients
This is a placebo controlled, randomized, double blinded study including Phase 1 and Phase 2. Phase I study is a safety assessment and Phase 2 study is incline to assess effectiveness of MSCs.
- Conditions
- Infarction, Middle Cerebral Artery, Infarction, Anterior Cerebral Artery, Cerebral Infarction, Stroke, Ischemic
- Trial name
- NCT04093336
- Testing
- human umbilical cord mesenchymal stem cells, standardized treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai East Hospital
Acute Ischemic Stroke Related to Tandem Occlusion, Acute Ischemic Stroke Due to Isolated Cervical Artery Occlusion
Risk Factors and Outcomes of Ischemic Stroke Associated With Tandem or Isolated Cervical Artery Occlusion in Anterior and Posterior Circulation
CERES-TANDEM is a multicenter study designed to improve the understanding of "tandem" ischemic stroke -those caused by two blockages in series, one in a neck artery and one in a brain artery-.
- Trial name
- CERES-TANDEM (NCT06965036)
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 4,230 people
- Sponsor
- Azienda Unità Sanitaria Locale della Romagna
Ischemic Stroke
Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy
Endovascular thrombectomy (EVT) is a procedure that improves recovery for people who suffer from a stroke by removing blood clots from large blood vessels in the brain.
- Trial name
- LEAST (NCT07511543)
- Testing
- Semaglutide
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Stroke, Acute Ischemic
Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke
Stroke is a leading cause of disability and mortality worldwide. Despite the clinical benefit of mechanical thrombectomy, 1 out of 2 patients treated are functionally independent at 90 days.
- Trial name
- IA-SUCCESS (NCT06768138)
- Testing
- Intra-arterial infusion of Alteplase
- Where
- France
- Volunteers
- 626 people
- Sponsor
- Central Hospital, Nancy, France
Acute Ischemic Stroke, Anterior Circulation Brain Infarction
Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy（RECAST-MT）
For patients with acute ischemic stroke caused by large vessel occlusion, endovascular thrombectomy has been demonstrated to be the most effective therapy, as approximately 90% of the occluded vessels can be recanalized.
- Trial name
- RECAST-MT (NCT06559241)
- Testing
- 14-day remote ischemic conditioning, 30-day remote ischemic conditioning, Endovascular thrombectomy
- Where
- 56 sites in China
- Volunteers
- 2,105 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours
This study will address the efficacy and safety of Tenecteplase administered in non-endovascular capable center (nECC) in patients with acute ischemic stroke (AIS) caused by anterior circulation large vessel occlusion (acLVO) who…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Transportation of Patients
- Trial name
- TREASURE (NCT07253181)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Where
- 2 sites in China
- Volunteers
- 572 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Stroke
Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours
To evaluate the hypothesis that mechanical embolectomy with the Solitaire FR device is superior to medical management alone in achieving favorable outcome in the distribution of the modified Rankin Scale scores at 90 days in…
- Trial name
- REVASCAT (NCT01692379)
- Testing
- Solitaire FR device, Medical treatment
- Where
- 4 sites in Spain
- Volunteers
- 206 people
- Sponsor
- Fundacio Ictus Malaltia Vascular
Acute Cerebrovascular Accident, Acute Ischemic Stroke
To Assess the Effectiveness and Safety of Catheter-based Focal Intracranial Hypothermia Combined With Endovascular Reperfusion Therapy for Patients With Acute Anterior Circulation Large Artery Occlusion
A multicenter, prospective, open-label, blinded-endpoint, randomized controlled trial to assess the effectiveness and safety of catheter-based focal intracranial hypothermia combined with endovascular reperfusion therapy for…
- Conditions
- Acute Cerebrovascular Accident, Acute Ischemic Stroke, Internal Carotid Artery, Middle Cerebral Artery Occlusion
- Trial name
- CHILL-ART (NCT06758609)
- Testing
- Mechanical thrombectomy, 4°C saline infusion, Normothermic saline infusion
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Guangdong Second Provincial General Hospital
Acute Ischemic Stroke
Mechanical Thrombectomy of Acute Ischemic Stroke Anterior Circulation Distal Vessel Occlusion
Ischemic stroke continues to be of the leading causes of disability and death. Distal vessel occlusion one of most presenting and disabling varieties of ischemic stroke.
- Trial name
- NCT06427187
- Testing
- an array of devices are used in thrombectomy. These include guide catheters, stent-retrievers, microcatheters, aspiration catheters, and aspiration pump systems
- Volunteers
- 30 people
- Sponsor
- Assiut University
Acute Ischemic Stroke, Large Vessel Occlusion
Sivelestat Sodium as an Adjunct to Endovascular Thrombectomy for Acute Anterior Circulation Large-Vessel Occlusion
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as a standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Neutrophil Extracellular Trap Formation
- Trial name
- NCT07552610
- Testing
- Sivelestat sodium, Endovascular Thrombectomy
- Where
- 2 sites in China
- Volunteers
- 868 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Artery Diseases, Thrombectomy
Thrombectomy In TANdem Occlusion
Tandem occlusion is defined by an acute ischemic stroke (AIS) with concomitant steno-occlusive disease of the extra cranial carotid artery and concerned about 10% of AIS patients.
- Conditions
- Carotid Artery Diseases, Thrombectomy, Tandem Occlusion, Stroke
- Trial name
- TITAN (NCT03978988)
- Testing
- Carotid Stenting, Procedural Aspirin, Dual dual antiplatelet therapy after 24-hours imaging follow-up
- Where
- France
- Volunteers
- 432 people
- Sponsor
- Central Hospital, Nancy, France
Stroke, Stroke, Acute
BELgian CT-perFUSion Study to Select Acute Stroke Patients for Thrombectomy
The goal of this clinical trial is to test whether perfusion CT can be used as a selection tool in stroke patients with a major anterior circulation occlusion, to exclude patients from thrombectomy because of a predicted…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- BELFUS (NCT05685043)
- Testing
- perfusion CT
- Sponsor
- University Hospital, Ghent
Mild Stroke, Acute Ischemic Stroke
Endovascular Treatment for Mild Stroke With Acute Anterior Circulation Large Vessel Occlusion
Exploring the Efficacy and Safety of Emergent Endovascular Treatment in Patients with Mild Ischemic Stroke Caused by Acute Anterior Circulation Large Vessel Occlusion based on Perfusion Imaging Screening
- Conditions
- Mild Stroke, Acute Ischemic Stroke, Endovascular Treatment, Perfusion Imaging
- Trial name
- NCT06179017
- Testing
- Experimental group:Intervention Group, Control group:best medical treatment
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhangzhou Municipal Hospital
Stroke, Ischemic, Infarction, Middle Cerebral Artery
Testing of Identification Markers for Stroke
Stroke is the third leading cause of death and the first cause of physical disability and dementia worldwide. Ischemic stroke caused by large vessel occlusion (LVO) is responsible for the vast majority of deaths and disabilities.
- Conditions
- Stroke, Ischemic, Infarction, Middle Cerebral Artery, Infarction, Anterior Circulation, Brain
- Trial name
- TIME (NCT04292600)
- Testing
- POCKiT diagnostics' algorithm for LVO detection
- Where
- 3 sites in United States
- Volunteers
- 383 people
- Sponsor
- POCKiT diagnostics Ltd
Ischemic Stroke
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study
Ischaemic stroke causes significant morbidity and mortality and is a leading cause of disability within an ageing United Kingdom (UK) population.
- Trial name
- RICE PAC (NCT03152799)
- Testing
- RIPC Remote Ischaemic Pre-Conditioning
- Volunteers
- 60 people
- Sponsor
- University College, London
Large Vessel Occlusion, Stroke
Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)
Endovascular thrombectomy (EVT), also known as clot retrieval, is a procedure that improves recovery for people who suffer a stroke by removing blood clots from large blood vessels in the brain.
- Conditions
- Large Vessel Occlusion, Stroke, Ischemic Stroke
- Trial name
- HoBIT (NCT07367633)
- Testing
- Head of bed position of 0-degrees, Head of bed position of 30-degrees or greater
- Where
- 2 sites in Canada
- Volunteers
- 2,240 people
- Sponsor
- Population Health Research Institute
Ischemic Stroke
Glyburide Advantage in Malignant Edema and Stroke Pilot
The primary objective of this study is to assess the feasibility of enrolling, evaluating, and treating with glyburide for injection severe anterior circulation ischemic stroke participants, whether or not treated with standard…
- Trial name
- GAMES-PILOT (NCT01268683)
- Testing
- Glyburide for Injection
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Remedy Pharmaceuticals, Inc.
Ischemic Stroke
Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke
The purpose of the study is to understand whether a new treatment of stroke - endovascular clot removal - can be added to the current standard of care to improve patient outcomes.
- Trial name
- ESCAPE (NCT01778335)
- Testing
- Endovascular thrombectomy/thrombolysis
- Where
- Canada
- Volunteers
- 316 people
- Sponsor
- University of Calgary
Acute Ischemic Stroke
SUPERSTAR: Aspiration vs. Stent Retriever in Anterior Circulation LVO
This is a multicenter, open-label, blinded-endpoint, randomized controlled trial comparing super large bore catheter aspiration versus stent retriever thrombectomy as the first-line technique for anterior circulation large vessel…
- Trial name
- SUPERSTAR (NCT07555977)
- Testing
- Super Large Bore Catheter, Stent Retriever Thrombectomy
- Where
- China
- Volunteers
- 708 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Acute Ischemic Stroke
Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation Thrombectomy
Ischemic stroke accounts for a relatively high proportion of strokes. In recent years, intravenous thrombolysis and endovascular therapy have significantly improved the revascularization rate in patients with large vessel…
- Trial name
- NCT05845372
- Where
- 19 sites in China
- Volunteers
- 2,592 people
- Sponsor
- Nanfang Hospital, Southern Medical University