Clinical trials: Anterior Cruciate Ligament Reconstruction
ACL Injury, Pain
Effect of Biophysical Stimulation on Intraspongious Bone Edema in Anterior Cruciate Ligament Reconstruction
The following study has as main objective to evaluate whether the use of I-ONE® therapy can reduce post-operative pain thanks to the modulation of inflammation in patients with bone bruise on the knee after anterior cruciate…
- Conditions
- ACL Injury, Pain, Magnetic Field Exposure
- Trial name
- NCT04255407
- Testing
- I-ONE® therapy, Anti-inflammatory drug
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Istituto Ortopedico Rizzoli
Anterior Cruciate Ligament Injuries
Ultrasound Evaluation of Hamstring Tendon Regeneration After ACL Reconstruction and Its Influence
High incidence rate of knee osteoarthritis and gait analysis are important for early assessment of biomechanics. ACL injury is an ideal clinical model for studying knee osteoarthritis.
- Trial name
- NCT04961736
- Testing
- no intervention
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Injuries
Perturbation Training vs Functional Activities on Pain, ROM, Balance, and Function Post-ACL
Anterior cruciate ligament (ACL) injuries are among the most common and functionally disabling knee injuries, particularly in physically active individuals.
- Trial name
- NCT07642752
- Testing
- Perturbation Training Group, Task-Oriented Functional Activities Group, Control Group (Standard Rehabilitation Protocol)
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Anterior Cruciate Ligament Rupture
Comparison of Remnant Preserving Versus Remnant Resecting Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament injury is very common knee injury. Especially Anterior cruciate ligament complete rupture leads to knee joint instability and degenerative change of the knee.
- Trial name
- NCT02555917
- Testing
- anterior cruciate ligament reconstruction
- Volunteers
- 40 people
- Sponsor
- The Catholic University of Korea
Anterior Cruciate Ligament Reconstruction
Effectiveness of Kneehab in Strengthening the Quadriceps of Patients Post Anterior Cruciate Ligament (ACL) Reconstruction
Prospective, controlled, randomized, single blind study in patients undergoing rehabilitation following anterior cruciate ligament reconstruction. 96 patients were randomly assigned to one of three groups.
- Trial name
- NMES (NCT00737750)
- Testing
- Kneehab, Poli-Stim, Control
- Where
- Germany
- Volunteers
- 131 people
- Sponsor
- Bio-Medical Research, Ltd.
Anterior Cruciate Ligament Reconstruction
Mental Imagery to Improve Quadriceps Strength Post Anterior Cruciate Ligament Reconstruction: a Feasibility Study
The goal of this clinical trial is to understand if people recovering from anterior cruciate ligament reconstruction (ACLR) surgery will complete mental imagery training and if this will improve their injured leg's strength.
- Trial name
- NCT06858293
- Testing
- Mental Imagery Open Chain, Mental Imagery Closed Chain
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Marquette University
Adductor Canal Block
Effect of Combining Peri-hamstring Injection or Anterior Obturator Nerve Block on the Analgesic Efficacy of Adductor Canal Block for Arthroscopic Anterior Cruciate Ligament Reconstruction Under General Anesthesia
Pain after anterior cruciate ligament reconstruction with autologous hamstring graft can be attributed to both arthroscopic surgery and the graft donor site.
- Trial name
- NCT06398717
- Testing
- adductor canal block
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anterior Cruciate Ligament Reconstruction
Multi-scale Modeling for Predictive Characterization of Ligaments and Grafts Behavior in ACL Reconstruction
The objective of this clinical trial is provide in vivo data thus to model the ligament biomechanical behavior within the physiologically healthy joint and to use the implemented model to predict risk and success rates focusing…
- Trial name
- MULTI-ACL (NCT06058494)
- Testing
- Anterior Cruciate Ligament Reconstruction
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Anterior Cruciate Ligament Rupture
Obtain Safety and Effectiveness of CT-ACL001, a Regenerative Ligament Using Biological Tissue, in ACLR
A randomized, multicenter study comparing the safety and efficacy of CT-ACL001, a regenerative ligament, with standard treatment in anterior cruciate ligament reconstruction
- Trial name
- NCT07129694
- Testing
- Anterior cruciate ligament reconstruction
- Where
- 6 sites in Japan
- Volunteers
- 64 people
- Sponsor
- CoreTissue BioEngineering Inc.
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
The PreOperative Management of Patients Awaiting Anterior Cruciate Ligament Reconstruction
Patient experiences of the NHS ACL treatment pathway are unknown. This study aims to explore patient experiences of anterior cruciate ligament ruptures at three different time points on the patient pathway: (1) 12 participants up…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Rehabilitation
- Trial name
- POP-ACLR (NCT05529511)
- Testing
- Phase 1 - semi-structured interviews, Phase 2 - consensus meeting
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Anterior Cruciate Ligament Injury
Effectiveness of Rehabilitation After Arthroscopic ACL Reconstruction Using Inertial Exercises
The primary aim of the study was to compare the effectiveness of two rehabilitation protocols for patients following ACL reconstruction.
- Trial name
- NCT06726044
- Testing
- Standard rehabilitaion after ACL reconstruction, Standard rehabilitaion after ACL reconstruction plus inertial exercises
- Where
- Poland
- Volunteers
- 24 people
- Sponsor
- University in Zielona Góra
Anterior Cruciate Ligament Rupture, Acute Pain
Femoral Triangle + IPACK Blocks for ACL Reconstruction Analgesia
An adequate balance between analgesia and motor function is an essential requirement to facilitate functional recovery and early discharge after anterior cruciate ligament (ACL) reconstruction surgery. Proximal nerve blocks (i.e.
- Conditions
- Anterior Cruciate Ligament Rupture, Acute Pain, Pain, Postoperative, Knee Injuries
- Trial name
- NCT05068063
- Testing
- Bupivacaine Injection, normal Saline
- Where
- 2 sites in Chile
- Volunteers
- 48 people
- Sponsor
- University of Chile
Anterior Cruciate Ligament Reconstruction Rehabilitation
Effectiveness of a Session of Analgesic Electrostimulation (Invasive and Non-invasive) Applied to the Quadriceps Muscle in Patients After Knee Surgery.
The anterior cruciate ligament (ACL) injury is one of the most prevalent injuries in the musculoskeletal system. Consequently, its surgical reconstruction is among the most commonly performed procedures in current clinical…
- Trial name
- NCT06910150
- Testing
- Non-invasive analgesic electrostimulation, Invasive analgesic electrostimulation
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Universidad de Murcia
Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament
Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction
The purpose of this randomized clinical trial is to determine the difference in quality of life outcome at two years, in patients undergoing an Anterior Cruciate Ligament (ACL) reconstruction procedure with either a patellar…
- Conditions
- Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament, Chronic Instability of Knee, Anterior Cruciate Ligament Injury
- Trial name
- NCT00529958
- Testing
- Patellar Tendon, Hamstring Tendon, Double-Bundle
- Where
- Canada
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Anterior Cruciate Ligament Reconstruction
Gait Retraining to Reduce Joint Loading, Inflammation, and PTOA Risk
The purpose of this study is to determine changes to knee joint loading, biological markers, and cartilage structure following a novel active feedback gait retraining program in anterior cruciate ligament reconstructed patients.
- Trial name
- NCT03551678
- Testing
- Active feedback gait retraining
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Palo Alto Health Care System
Anterior Cruciate Ligament Rupture
A Clinical Trial of the Round-tunnel and Flat-tunnel Technique of ACL Reconstruction
This study intends to perform round-tunnel and flat-tunnel ACL reconstruction technique in 144 patients, and compare the clinical outcomes of the two surgical procedures through follow-up.
- Trial name
- NCT04953676
- Testing
- round tunnel technique, flat tunnel technique
- Volunteers
- 144 people
- Sponsor
- Peking University Third Hospital
Arthroscopic Anterior Cruciate Ligament Reconstruction
Pain Evaluation After Anterior Cruciate Ligament (ACL) Ligamentoplasty
The "All-inside" method is a new minimally invasive procedure for anterior cruciate ligament reconstruction (ACL). It consists of incomplete bone tunnels drilling and cortical fixation.
- Trial name
- NCT01448278
- Testing
- "All-inside", Classical technique
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hospital Ambroise Paré Paris
ACL Injury, Anterior Cruciate Ligament Rupture
Prospective Clinical Results of 3 Different Femoral Fixation in ACL Reconstruction
Anterior cruciate ligament (ACL) tears are one of the most common injuries of the knee. In today's world, due to developing sports industry , the increase in sports traumas of both genders and ages ACL injuries and treatments are…
- Trial name
- NCT04677218
- Testing
- Arthroscopic ACL reconstruction with retensioned hamstring autograft, Arthroscopic ACL reconstruction with retensioned and knotted hamstring autograft
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Emre Kocazeybek
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Clinical and Biological Outcomes of BioBrace-Augmented ACL Reconstruction
This prospective, single-center, single-arm observational cohort study aims to evaluate the clinical, radiological, and arthroscopic outcomes and safety of primary anterior cruciate ligament (ACL) reconstruction augmented with…
- Trial name
- NCT07906860
- Testing
- BioBrace® Reinforced BioInductive Implant
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Anterior Cruciate Ligament (ACL) Injury, Athletic Injuries
Correlation Between Psychological Readiness, Knee Function, and Isokinetic Performance After Anterior Cruciate Ligament Reconstruction (ACLR) Using Peroneus Longus Tendon Graft (PL-ACL-2025)
This clinical trial aims to investigate the correlation between psychological readiness, knee function, and isokinetic performance after anterior cruciate ligament reconstruction (ACLR) using the Peroneus Longus tendon graft…
- Conditions
- Anterior Cruciate Ligament (ACL) Injury, Athletic Injuries, Knee Injuries
- Trial name
- PL-ACLR (NCT07201597)
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University