Clinical trials: Anterior Resection Syndrome
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study
Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study.
- Trial name
- NCT07267767
- Testing
- nCRT, BMI, Distance from AV
- Volunteers
- 3,500 people
- Sponsor
- Northern Jiangsu People's Hospital
Low Anterior Resection Syndrome
Transanal Irrigation for Low Anterior Resection Syndrome.
The aim of this study is to investigate whether the high-volume transanal irrigation (TAI) performed by the Peristeen Plus® system is superior to the low-volume TAI performed by standard 250ml water enema for the treatment of Low…
- Trial name
- HiLoV_TAI (NCT05245331)
- Testing
- Peristeen® Transanal irrigation system with the conic catheter, Standard reusable enema
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari de Bellvitge
LARS - Low Anterior Resection Syndrome
The Efficacy of Antegrade and Retrograde Enemas Management in Low Anterior Resection Syndrome and Improving the Rate of Ileostomy Reversal
Anterior rectal resection has become the primary surgical treatment for rectal cancer. However, studies have reported that up to 80%-90% of patients who undergo anterior rectal resection experience varying degrees of defecation…
- Trial name
- NCT07082699
- Testing
- antegrade enema, retrograde enema
- Volunteers
- 72 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Colorectal Cancer, Postoperative Ileus
Effect of Thread Embedding Acupuncture on Postoperative Ileus Recovery After Colorectal Cancer Surgery: A Multicenter Randomized Controlled Trial
This multicenter, randomized, controlled trial aims to evaluate the efficacy and safety of thread embedding acupuncture (TEA) in promoting gastrointestinal recovery after laparoscopic colorectal cancer surgery.
- Conditions
- Colorectal Cancer, Postoperative Ileus, LARS - Low Anterior Resection Syndrome
- Trial name
- THREAD-POI (NCT07071987)
- Testing
- Thread Embedding Acupuncture+Electroacupuncture, Electroacupuncture
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Northern Jiangsu People's Hospital
Rectal Neoplasm
Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome
Low anterior resection syndrome refers to changes in bowel habits such as frequent defecation, urgent defecation, and fecal incontinence, which result in decreased bowel function.
- Trial name
- NCT07041515
- Testing
- Mobile app, standard
- Volunteers
- 320 people
- Sponsor
- National Cancer Center, Korea
Gastroenterology, LARS - Low Anterior Resection Syndrome
A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients
The purpose of this post-market clinical follow up study is to assess the efficacy on clinical symptoms of LARS of low volume Transanal Irrigation by MiniGo in conjunction with conservative treatment versus conservative treatment…
- Conditions
- Gastroenterology, LARS - Low Anterior Resection Syndrome, Rectal Cancer
- Trial name
- MINIGO (NCT06923150)
- Where
- 9 sites in France
- Volunteers
- 78 people
- Sponsor
- Qufora A/S
Low Anterior Resection Syndrome
Retrograde and Antegrade Enema for Prevention of LARS After LAR: a Randomized Controlled Trial
The goal of this clinical trial is to learn if enema works to prevent low anterior resection syndrome (LARS) in adults. The main questions it aims to answer are: 1.
- Trial name
- NCT06717854
- Testing
- transanal irrigation, antegrade enema
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Rectal Cancer
The Longitudinal Study of Low Anterior Resection Syndrome in Patients with Newly Diagnosed Rectal Cancer.
The aims are to identify the trajectory of LAR Syndrome and explore the adaptation process and coping strategies of LAR Syndrome in patients newly diagnosed with rectal cancer.
- Trial name
- NCT05445245
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- Chang Gung Memorial Hospital
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Rectal Cancer, Surgery
Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled Trial
After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS).
- Conditions
- Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection
- Trial name
- NCT03828318
- Testing
- Patient Activation Booklet and nursing support for patients with LARS
- Where
- 6 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Jewish General Hospital
Patient Empowerment, Low Anterior Resection Syndrome
Interactive Online Informational and Peer Support App for Patients with Low Anterior Resection Syndrome
After surgery for rectal cancer, many people undergo changes in bowel habits, which may include the need to empty their bowels more often, accidental leakage of stool or gas, the sudden urge to go to the bathroom, and more.
- Conditions
- Patient Empowerment, Low Anterior Resection Syndrome, Colo-rectal Cancer, Peer Group
- Trial name
- NCT04469426
- Testing
- Interactive online informational and peer support app
- Where
- 5 sites in Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Rectum Cancer, Faecal Incontinence
Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.
The occurrence of colorectal cancer has increased from the third most common cancer in 2018 to the second most common cancer in 2023.
- Conditions
- Rectum Cancer, Faecal Incontinence, Faecal Incontinence with Faecal Urgency, Low Anterior Resection Syndrome
- Trial name
- NCT06601985
- Testing
- J-pouch anastomosis, direct anastomosis
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai 10th People's Hospital
Low Anterior Resection Syndrome
The Effects of Colorectal Prehabilitation Via Reinfusion or Retention Enema of Ileal Contents Filtrate on the Defecation Functions for the LAR Patients With Ileostomy Before Stoma Closure
This study was a single-center RCT study to compare the effect of preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon with that of traditional…
- Trial name
- NCT06569966
- Testing
- preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon
- Where
- China
- Volunteers
- 154 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Rectal Cancer, Rectum Neoplasm
Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Trial
Study Purpose: This study aims to understand how pelvic floor rehabilitation (PFR) after low anterior resection (LAR) surgery for rectal cancer affects bowel control and quality of life compared to usual care.
- Conditions
- Rectal Cancer, Rectum Neoplasm, Rectal Neoplasms, Rectal Adenocarcinoma
- Trial name
- PERECARE (NCT06524362)
- Testing
- Pelvic Floor Physiotherapy (PFR), Conventional group
- Where
- India
- Volunteers
- 77 people
- Sponsor
- GEM Hospital & Research Center
Prevention, LARS - Low Anterior Resection Syndrome
Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)
The main aim of this randomized study will be to determine the effectiveness of pelvic floor exercises on the incidence or severity of LAR syndrome in patients after mini-invasive rectal resection.
- Conditions
- Prevention, LARS - Low Anterior Resection Syndrome, Pelvic Floor Disorders, Rectal Cancer
- Trial name
- CH1 (NCT06519006)
- Testing
- Pelvic floor exercise
- Where
- Slovakia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- F. D. Roosevelt University Hospital
Low Anterior Resection Syndrome
Randomized Clinical Trial on Transanal Irrigation
Objective The primary objective is to demonstrate superiority of the Peristeen cone catheter compared to standard of care. The secondary objective is to investigate quality of life and different benefits and aspects of treatment…
- Trial name
- NCT04586634
- Testing
- Peristeen cone catheter
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Coloplast A/S
Low Anterior Resection Syndrome, Rectal Cancer
Evaluation of a Decision Aid Tool in Rectal Cancer patiënts
Adapt and evaluate a decision aid for patients with rectal cancer. Phase 1 : decision aid testing (Delphi) multicentric Phase 2: pilot test decision aid
- Trial name
- NCT04938336
- Testing
- Delphi Procedure and interviews
- Where
- 2 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Colorectal Cancer, Low Anterior Resection Syndrome
Effect of Exercise on Bowel Function in Colorectal Cancer Survivors
The survival rate of colorectal cancer patients is increasing due to the development of medical technology. However, many colorectal cancer survivors (CRCs) have bowel dysfunction unlike other cancer survivors.
- Trial name
- NCT05420870
- Testing
- exercise
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Low Anterior Resection Syndrome, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation in the Treatment of Major LARS
Randomized trial to assess FMT efficacy in improving bowel function for major LARS patients. 40 subjects, blinded, randomized to FMT or probiotics.
- Trial name
- FMT-LARS (NCT06475430)
- Testing
- fecal microbiota transplantation, Formulated probiotic supplements
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Rectal Cancer, Low Anterior Resection Syndrome
Impact of Quality of Life in the Patients With Sleep Disturbance From Low Anterior Resection Syndrome in Advanced Rectal Cancer Patients
The preservation surgery of the anal sphincter has become a standard procedure for the treatment of rectal cancer and is now possible even when the tumor is close to the anus, thanks to the advancement of surgical techniques.
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, Insomnia
- Trial name
- NCT06271629
- Testing
- Insomnia severity index
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital