Clinical trials: Anterior Resection Syndrome
Patient Empowerment, Low Anterior Resection Syndrome
Interactive Online Informational and Peer Support App for Patients with Low Anterior Resection Syndrome
After surgery for rectal cancer, many people undergo changes in bowel habits, which may include the need to empty their bowels more often, accidental leakage of stool or gas, the sudden urge to go to the bathroom, and more.
- Conditions
- Patient Empowerment, Low Anterior Resection Syndrome, Colo-rectal Cancer, Peer Group
- Trial name
- NCT04469426
- Testing
- Interactive online informational and peer support app
- Where
- 5 sites in Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Low Anterior Resection Syndrome
The Effects of Colorectal Prehabilitation Via Reinfusion or Retention Enema of Ileal Contents Filtrate on the Defecation Functions for the LAR Patients With Ileostomy Before Stoma Closure
This study was a single-center RCT study to compare the effect of preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon with that of traditional…
- Trial name
- NCT06569966
- Testing
- preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon
- Where
- China
- Volunteers
- 154 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Trial name
- Treatable (NCT06274190)
- Testing
- bowel e-diary
- Where
- Belgium
- Volunteers
- 158 people
- Sponsor
- KU Leuven
LARS - Low Anterior Resection Syndrome
The Efficacy of Antegrade and Retrograde Enemas Management in Low Anterior Resection Syndrome and Improving the Rate of Ileostomy Reversal
Anterior rectal resection has become the primary surgical treatment for rectal cancer. However, studies have reported that up to 80%-90% of patients who undergo anterior rectal resection experience varying degrees of defecation…
- Trial name
- NCT07082699
- Testing
- antegrade enema, retrograde enema
- Volunteers
- 72 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
LARS - Low Anterior Resection Syndrome
HEM1036 Phase 2 Study in Low Anterior Resection Syndrome
Double-blind, randomized, placebo controlled phase 2 study to explore the efficacy and safety of HEM1036 in the treatment of subjects with LARS
- Trial name
- NCT05527301
- Testing
- Lactobacillus Fermentum
- Volunteers
- 67 people
- Sponsor
- HEM Pharma Inc.
Rectal Disorders, Low Anterior Resection Syndrome
Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection Syndrome
The treatment of rectal cancer is currently based on surgical resection of the rectum with total excision of the mesorectum, associated with neoadjuvant radiochemotherapy.
- Conditions
- Rectal Disorders, Low Anterior Resection Syndrome, Low Anterior Resection
- Trial name
- LARS (NCT05368168)
- Testing
- Posterior tibial nerve stimulation (PTNS)
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Innovacion en Cirugía Vigo
Rectal Cancer, Surgery
Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled Trial
After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS).
- Conditions
- Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection
- Trial name
- NCT03828318
- Testing
- Patient Activation Booklet and nursing support for patients with LARS
- Where
- 6 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Jewish General Hospital
Low Anterior Resection Syndrome
Paula Method of Exercises in Patients With LARS Syndrome:Randomized Controlled Trial
Sphincter sparing rectal resection surgery, either total mesorectal excision (TME) with a temporary loop ileostomy or partial mesorectal excision (PME), is the mainstay of rectal cancer treatment , however, these treatments are…
- Trial name
- NCT05682157
- Testing
- Paula Method of muscle exercises
- Where
- 2 sites in Israel
- Volunteers
- 62 people
- Sponsor
- Hadassah Medical Organization
Gastroenterology, LARS - Low Anterior Resection Syndrome
A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients
The purpose of this post-market clinical follow up study is to assess the efficacy on clinical symptoms of LARS of low volume Transanal Irrigation by MiniGo in conjunction with conservative treatment versus conservative treatment…
- Conditions
- Gastroenterology, LARS - Low Anterior Resection Syndrome, Rectal Cancer
- Trial name
- MINIGO (NCT06923150)
- Where
- 9 sites in France
- Volunteers
- 78 people
- Sponsor
- Qufora A/S
Low Anterior Resection Syndrome, Faecal Incontinence With Faecal Urgency
Understanding and Tailored Treatment of Low Anterior Resection Syndrome
The goal of this observational study is to learn why some patients develop low anterior resection syndrome (LARS) after colorectal cancer treatment.
- Conditions
- Low Anterior Resection Syndrome, Faecal Incontinence With Faecal Urgency, Faecal Incontinence, Colorectal (Colon or Rectal) Cancer Survivors
- Trial name
- PATO-LARS (NCT07573371)
- Where
- 3 sites in Denmark
- Volunteers
- 145 people
- Sponsor
- Aalborg University Hospital
Rectal Cancer, Low Anterior Resection Syndrome
The Effect of Different Reconstruction Methods on Anterior Resection Syndrome
The incidence of prerectal resection syndrome (LARS) after middle and low rectal cancer surgery is as high as 70%, which seriously affects the quality of life of patients.
- Trial name
- TEDRMARS (NCT04023448)
- Testing
- transverse coloplasty pouch
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Low Anterior Resection Syndrome
Transanal Irrigation - Best Treatment Possibility for Low Anterior Resection Syndrome? Multicenter, Randomized Clinical Trial
Introduction: About 50% of patients who undergo rectal resection (mostly as a treatment for rectal cancer) suffer from various and partly severe functional problems, despite the preservation of the anal fold.
- Trial name
- NCT05920681
- Testing
- Transanal irrigation, Best supportive care
- Where
- Lithuania
- Volunteers
- 40 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Low Anterior Resection Syndrome, Rectal Carcinoma
A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients
This clinical trial studies if a bowel management program with a retrograde rectal enema (RRE) for the treatment of low anterior resection syndrome (LARS) in rectal cancer patients is better than medical management alone.
- Trial name
- NCT06424522
- Testing
- Dietary Fiber, Enema Administration, Loperamide Hydrochloride
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Rectal Cancer
Effects of Dried Plum (Prune) Intake on the Incidence of Low Anterior Resection Syndrome in Patients With Rectal Cancer
Colorectal cancer is the third leading cause of cancer death and the fourth most commonly diagnosed cancer in the world. The importance of improving the quality of life of patients after colorectal cancer surgery has been…
- Trial name
- NCT05907642
- Testing
- Prune (dried plum)
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Samsung Medical Center
Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy
Effectiveness of Sacral Neuromodulation in Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is a complex disorder suffered by patients who undergo rectal resection mainly due to rectal cancer.
- Conditions
- Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy, Rectal Cancer
- Trial name
- SANLARS (NCT03598231)
- Testing
- Sacral neuromodulation
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Bowel Dysfunction, Rectal Cancer
A Prospective Multi-Center Research on Bowel Dysfunction After Sphincter Preservative Surgery
This research plans to collect rectal cancer patients after sphincter-preserving surgery from 14 institutions in China mainland, observe the incidence and risk factors about bowel dysfunction after operation.
- Trial name
- PMCRBDSPS (NCT03009747)
- Volunteers
- 460 people
- Sponsor
- Peking University People's Hospital
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study
Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study.
- Trial name
- NCT07267767
- Testing
- nCRT, BMI, Distance from AV
- Volunteers
- 3,500 people
- Sponsor
- Northern Jiangsu People's Hospital
Rectal Cancer Patients
Validation of the Moroccan Arabic Version of the Low Anterior Resection Syndrome (LARS) and Wexner Score of Continence Among Rectal Cancer Patients
In the past decade, colorectal cancer management improved considerably with total mesorectal excision as well as the multidisciplinary management relying on neoadjuvant radiochemotherapy.
- Trial name
- MA_LARSWEX (NCT04128657)
- Testing
- MA_LARS
- Where
- 2 sites in Morocco
- Volunteers
- 143 people
- Sponsor
- Moroccan Society of Surgery
Low Anterior Resection Syndrome, Rectal Cancer
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome
The study is a multicentre randomized controlled trial with the objective to compare the effect of transanal irrigation with glycerol suppositories in patients suffering from major Low Anterior Resection Syndrome (LARS).
- Trial name
- NCT04087421
- Testing
- Qufora Irrisedo Cone System, Glycerol "OBA"
- Where
- Denmark
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Aarhus