Clinical trials: Anterior Resection Syndrome
Low Anterior Resection Syndrome
Acupuncture in Low Anterior Resection Syndrome Treatment
Acupuncture has it's role in treating patients with fecal incontinence and diarrhea-predominant irritable bowel syndrome. There is no trial or case-report assessing it's role in treatment of Low anterior resection syndrome.
- Trial name
- AcuLARS (NCT03916549)
- Testing
- Acupuncture
- Where
- Lithuania
- Volunteers
- 10 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Low Anterior Resection Syndrome
The Effect of Melatonin in Patients With Low Anterior Resection Syndrome
The primary objective of the study is to investigate whether treatment with melatonin has an alleviating effect on Low Anterior Resection Syndrome (LARS) symptoms.
- Trial name
- MELLARS (NCT05042700)
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Ismail Gögenur
Rectal Cancer
Efficacy of Ondansetron in LARS Treatment
Patients will be randomized (1:1 ratio) to receive either 4 weeks of Ondansetron followed by 4 weeks of placebo (O-P sequence) or 4 weeks of placebo followed by 4 weeks of Ondansetron (P-O sequence).
- Trial name
- Hodolar (NCT03182179)
- Testing
- Ondansetron 4 MG
- Where
- 2 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Low Anterior Resection Syndrome, Cancer
Contributing Factors to Anterior Resection Syndrome and Its Impact on Quality of Life: A Retrospective Cohort Study
This study adds to the understanding of the contributing factors leading to LARS, the long term effects of this syndrome post-operatively and its impact on quality of life.
- Conditions
- Low Anterior Resection Syndrome, Cancer, Quality of Life
- Trial name
- NCT04114591
- Testing
- anterior resection
- Where
- Malta
- Volunteers
- 179 people
- Sponsor
- University of Malta
Robotic Surgical Procedure, Thymoma
A Prospective, Single-Center Investigation of the da Vinci SP® Surgical System in Anterior Mediastinal Disease
Endpoints (Outcome measures)： 1. Primary endpoint: Incidence of conversion rate during surgery The primary performance endpoint will be assessed as the ability to successfully complete the planned mediastinal procedure with da…
- Conditions
- Robotic Surgical Procedure, Thymoma, Myasthenia Gravis
- Trial name
- NCT05455840
- Testing
- Da Vinci SP surgical platform
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Chang Gung Memorial Hospital
Low Anterior Resection Syndrome (LARS)
Early Implementation of Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome.
A randomized, prospective, multicenter, open-label, pragmatic pilot study of patients with Low Anterior Resection Syndrome treated early (<120 days after discharge following intestinal bypass reconstruction) with sacral nerve…
- Trial name
- NCT07761884
- Testing
- Sacral neuromodulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Low Anterior Resection Syndrome, Quality of Life
Low Anterior Resection Syndrome After Rectum Resection for Rectal Carcinoma.
The ACO-ASSO (Austrian Society of Surgical Oncology) colorectal group and Austrian Working Group for Coloproctology present the LARS Austria study. It is a prospective, multicenter observational study.
- Conditions
- Low Anterior Resection Syndrome, Quality of Life, Incontinence
- Trial name
- LARS-Austria (NCT05506111)
- Where
- 3 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Paracelsus Medical University
Low Anterior Resection Syndrome
Randomized Clinical Trial on Transanal Irrigation
Objective The primary objective is to demonstrate superiority of the Peristeen cone catheter compared to standard of care. The secondary objective is to investigate quality of life and different benefits and aspects of treatment…
- Trial name
- NCT04586634
- Testing
- Peristeen cone catheter
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Coloplast A/S
Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant
Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal Neoplasia
Rectal neoplasia is one of the most prevalent cancers in Spain, and the treatment of choice is total mesorectal excision (TME), as it has demonstrated significant oncological improvements.
- Conditions
- Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant, Quality of Life (QOL), Fecal Incontinence (FI)
- Trial name
- NCT07632196
- Testing
- Posterior tibial nerve stimulation intervention group, Control group
- Where
- 2 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Rectal Cancer, Low Anterior Resection Syndrome
Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal Cancer
This prospective, single-center, single-arm, open-label clinical study aims to evaluate whether autologous fecal microbiota transplantation can improve bowel and anal function after ileostomy reversal in patients with rectal…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, Fecal Incontinence, Diversion Colitis
- Trial name
- NCT07711509
- Testing
- Autologous Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Conditions
- Rectal Cancer, LARS - Low Anterior Resection Syndrome, Active Surveillance
- Trial name
- Treatable (NCT06914245)
- Testing
- Electronic bowel diary, Faecal Incontinence Quality of Life questionnaire (FIQL), EuroQoL 5 dimensions, 5 levels (EQ-5D-5L)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- KU Leuven
Sphincter Ani Incontinence, Rectal Cancer
Patient Reported Outcomes Following Cancer of the Rectum
The surgical management of rectal cancer includes a Total Mesorectal Excison (TME); depending on the height of the tumor, the problem of preservation of the anal sphincter arises, being able to perform a low anterior resection…
- Trial name
- PROCaRe (NCT04936581)
- Testing
- Open Total Mesorectal Excision, Laparoscopic Total Mesorectal Excision, Robotic Total Mesorectal Excision
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- University Hospital Gregorio Marañón
Rectal Cancer
"Impact of Pelvic Floor Prehabilitation Using Biofeedback on the Severity of the Low Anterior Resection Syndrome in Patients Undergoing a Total Mesorectal Excision for Rectal Cancer"
There is currently no specific treatment and only few measures to prevent the low anterior resection syndrome (LARS). The LARS often results in a severe alteration of quality of life.
- Trial name
- CONTICARE (NCT03876561)
- Testing
- Pelvic floor prehabilitation
- Where
- 6 sites in France
- Volunteers
- 120 people
- Sponsor
- Nantes University Hospital
Rectal Cancer, Low Anterior Resection Syndrome
Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery
The study aims to evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS) associated with conservative therapy (arm A) for the treatment of low anterior resection syndrome (LARS) compared with only conservative…
- Trial name
- NCT02177084
- Testing
- PTNS
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Colorectal Cancer, Postoperative Ileus
Effect of Thread Embedding Acupuncture on Postoperative Ileus Recovery After Colorectal Cancer Surgery: A Multicenter Randomized Controlled Trial
This multicenter, randomized, controlled trial aims to evaluate the efficacy and safety of thread embedding acupuncture (TEA) in promoting gastrointestinal recovery after laparoscopic colorectal cancer surgery.
- Conditions
- Colorectal Cancer, Postoperative Ileus, LARS - Low Anterior Resection Syndrome
- Trial name
- THREAD-POI (NCT07071987)
- Testing
- Thread Embedding Acupuncture+Electroacupuncture, Electroacupuncture
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Northern Jiangsu People's Hospital
Ovarian Cancer, Low Anterior Resection Syndrome
Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer
This study aims to evaluate the incidence of low anterior resection syndrome and quality of life after cytoreductive surgery for advanced ovarian cancer patients.
- Conditions
- Ovarian Cancer, Low Anterior Resection Syndrome, Quality of Life
- Trial name
- LAPSODY (NCT05431530)
- Testing
- Cytoreductive surgery
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Rectal Cancer
Anterior Resection Syndrome Following Sphincter-preserving Surgery
Bowel cancer is the third most common cancer in the UK in both males and females. The rectum is the most commonly affected part of the bowel.
- Trial name
- NCT02190656
- Where
- United Kingdom
- Volunteers
- 1,197 people
- Sponsor
- Queen Mary University of London
Colorectal Cancer
Incidence and Risk Factors of Low Anterior Resection Syndrome
Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome.
- Trial name
- NCT06359730
- Testing
- LARS score questionnaire
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome
ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens
OBJECTIVE Low anterior resection syndrome (LARS) is a term for functional bowel complaints occurring after low anterior resection.
- Conditions
- Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome, Rectal Resection, Low Anterior Resection
- Trial name
- ProLARS (NCT07339904)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Colonic Diverticuar Disease, Defecatory Functions
Effects of Inferior Mesenteric Artery Preservation in Laparoscopic Colorectal Resection for Diverticular Disease.
This is a prospective randomized study aimed to verifying the short and long-term results of inferior mesenteric artery preservation following colorectal resection for diverticular disease
- Conditions
- Colonic Diverticuar Disease, Defecatory Functions, Fecal Incontinence, Constipation
- Trial name
- EIMAP (NCT06506552)
- Testing
- IMA preserving, IMA sectioning
- Volunteers
- 300 people
- Sponsor
- University of Roma La Sapienza