Clinical trials: Anterior Segment Diseases
Glaucoma, Angle-Closure
Anterior Segment Anatomic Parameters for Risk Profiling of Primary Angle-closure Glaucoma
The goal of this observational study is to examine the anterior segment anatomical parameters associated with the scleral spur and cornea for risk profiling of primary angle-closure glaucoma (PACG).
- Trial name
- NCT06143943
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Min Ke
Meibomian Gland Dysfunction, Cataract
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation
- Trial name
- NCT03461978
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Diabetes, Proteinuria
The Effect of Renin Angiotensin System Blockage (RAS) Blockade On PTX3 Levels In Diabetic Patients With Proteinuria
Long pentraxin 3 (PTX3) is a recently discovered multimeric inflammatory mediator structurally linked to CRP and serum amyloid P-component.
- Conditions
- Diabetes, Proteinuria, Renin Angiotensin System
- Trial name
- NCT00674596
- Testing
- ramipril
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Strabismus, Tomography, Optical Coherence
Measurement of Insertion of Extraocular Muscles Using Anterior Segment Optical Coherence Tomography
Study designed to determine the ability and accuracy of anterior segment optical coherence tomography (AS-OCT) to measure the distance between the corneoscleral limbus and the insertion site of the extraocular muscles (EOM) in…
- Trial name
- NCT02454920
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Miami
Anophthalmia, Microphthalmia
National Cohort on Congenital Defects of the Eye
Congenital malformations of the eye comprise various developmental defects including microphthalmia, anophthalmia, aniridia, and anterior segment anomalies (such as Peters and Axenfeld-Rieger anomalies).
- Conditions
- Anophthalmia, Microphthalmia, Aniridia, Anterior Segment Dysgenesis 6, Peters Anomaly Subtype
- Trial name
- RaDiCoACOEIL (NCT05954403)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intraoperative Floppy Iris Syndrome, Cataract
Pupillary Dilator Muscle Thickness as a Potential Predictor of Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome (IFIS) is a potencial complication encountered during cataract surgery in patients treated with α1-adrenergic receptor antagonists (α1-ARAs) for lower urinary tract symptoms.
- Conditions
- Intraoperative Floppy Iris Syndrome, Cataract, Age-related Cataract, Adrenergic Receptor Antagonist Adverse Reaction
- Trial name
- NCT07517094
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Olomouc
Dry Eyes
Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis
Conjunctivochalasis refers to loose redundant, non-edematous inferior conjunctiva that is situated between the globe and lower eyelid, and usually it occurs bilaterally.
- Trial name
- NCT01933178
- Testing
- Cirrus AS-OCT
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Eye Injuries
Anterior Segment Spectral-domain Optical Coherence Tomography in Patients With Closed Globe Injury
This study use anterior segment spectral-domain optical coherence tomography (SD-OCT) to exam patients with closed globe injury, and compared with slit lamp examination.
- Trial name
- NCT02638025
- Testing
- OCT
- Volunteers
- 16 people
- Sponsor
- Huizhou Municipal Central Hospital
Diabetes, Cataract
Healing of Corneal Incision After Cataract Surgery in Diabetic Patients
The objective of this observational study was to understand the healing of corneal incision after cataract surgery in diabetic patients and its influencing factors.
- Trial name
- NCT07076420
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhongnan Hospital
Anterior Segment Diseases
Multimodal Deep Learning Model for Multi-task Diagnosis and Triage Suggestions of Ophthalmic Diseases
Accurate and comprehensive interpretation of anterior segment diseases from slit-lamp and smartphone photographs remains a clinical challenge due to the limited specificity and structure of existing Artificial Intelligence tools.
- Trial name
- NCT07447973
- Testing
- Multimodal Vision-language Model Diagnosis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Spinal Fusion
Risk Factors of Second Surgery for Adjacent Segment Disease Following Anterior Cervical Discectomy and Fusion
Although the incidence of second surgery for adjacent segment disease (ASD) after anterior cervical discectomy and fusion (ACDF) has been reported, its risk factors remain elusive.
- Trial name
- 2nd ACDF (NCT03826329)
- Testing
- observational study
- Where
- Taiwan
- Volunteers
- 5,565 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cytomegalovirus Anterior Segment Infection, Anterior Uveitis
Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis
Objective of this study is to investigate the intracameral level of ganciclovir following topical application of 0.15% ganciclovir gel (VIRGAN©) for Cytomegalovirus (CMV) anterior uveitis and endothelitis.
- Conditions
- Cytomegalovirus Anterior Segment Infection, Anterior Uveitis, Endotheliitis
- Trial name
- Virgan (NCT01647529)
- Testing
- Ganciclovir
- Where
- Singapore
- Volunteers
- 29 people
- Sponsor
- Singapore National Eye Centre
Aphakia
Intraocular Position of Secondary Iris-Fixated IOLs in Aphakic Eyes
The purpose of this study is to evaluate the intraocular stability and safety of secondary iris-fixated IOLs in aphakic patients.
- Trial name
- NCT00773266
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Ankylosing Spondylitis (AS), Spine Fracture
A Retrospective Cohort Study About Surgical Efficacy for Lower Cervical Fractures in Ankylosing Spondylitis
The purpose of this retrospective cohort study was to observe and compare the efficacy of anterior cervical long segment fixation, posterior long segment fixation, and combined anterior and posterior fixation for the treatment of…
- Trial name
- NCT06873074
- Testing
- anterior long segment cervical fixation, posterior long segment cervical fixation, combined anterior and posterior fixation
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Zhou Fang
Glaucoma, Cataract
Comparative Study of the Cornea/Anterior Segment OCT CASIA2 and the RTVue XR OCT Avanti With AngioVue Software
This study is a prospective comparative, randomized, single center study to gather agreement and precision data in all subjects.
- Trial name
- NCT04486976
- Testing
- Cornea/Anterior Segment OCT CASIA2, Optovue RTVue XR Avanti
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Tomey Corporation
Cataract Extraction
Comparison of Acular LS With Lotemax to Prevent Inflammation After Cataract Surgery and Intraocular Lens Implantation
The purpose of this study is to compare the effectiveness of Acular LS® and Lotemax® in the prevention of inflammation in the eye after cataract surgery. Acular LS is made by Allergan, Inc.
- Trial name
- NCT00366691
- Testing
- Acular LS, Lotemax
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Refractive Errors, Myopia
Correlation Between Preoperative Refraction and Anterior Segment Parameters With ICL Vault
This prospective non-comparative interventional study aims to analyse the pre-operative factors affecting the range of optimal ICL vaulting.
- Conditions
- Refractive Errors, Myopia, Myopic Astigmatism
- Trial name
- NCT05670626
- Testing
- Refractive Surgery
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Glaucoma
Anterior Segment Changes After Pars Plana Vitrectomy With SO Using AS-OCT
To evaluate changes in ACA induced by pars plana vitrectomy with SO 1000cs injection in vitreo-retinal surgery in phakic eyes using AS-OCT and changes in the IOP preoperatively, post-operatively and post-silicone oil evacuation.
- Trial name
- NCT06524661
- Testing
- AS-OCT after vitrectomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Acute Anterior Myocardial Infarction
The INFUSE - Anterior Myocardial Infarction (AMI) Study
This is a multicenter, open-label, controlled, single-blind, randomized study with up to 452 subjects enrolled in up to 50 US and European sites.
- Trial name
- NCT00976521
- Testing
- Abciximab local infusion, No local infusion, Thrombus aspiration
- Where
- 38 sites in United States, Austria and 4 more
- Volunteers
- 452 people
- Sponsor
- Atrium Medical Corporation
Angle Closure Glaucoma, Glaucoma
Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies
Purpose: To evaluate short-term angle opening after argon peripheral iridoplasty using AS-OCT and to report its complications at 1-week and 1-month follow up in patients that did not achieve a satisfactory clinical angle opening…
- Trial name
- ALPIECA (NCT02199158)
- Testing
- Argon Laser Peripheral Iridoplasty
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana