Clinical trials: Anti Cholinergics
Pulmonary Disease, Chronic Obstructive
GSK573719 Dose Ranging Study in Chronic Obstructive Pulmonary Disease
The study will evaluate the dose response, safety, and pharmacokinetics of GSK573719 compared with placebo in subjects with COPD.
- Trial name
- NCT00950807
- Testing
- Tiotropium, GSK573179
- Where
- 19 sites in United States, Germany
- Volunteers
- 176 people
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
Chronic Obstructive Pulmonary Disease (COPD)-Related Outcomes and Costs for Patients on Combination Fluticasone Propionate-Salmeterol Xinafoate 250/50mcg Versus Anticholinergics in a COPD-Comorbid Depression/Anxiety Population
The objective of this study was to examine COPD-related outcomes for patients with comorbid depression/anxiety who are on combination fluticasone propionate/salmeterol xinafoate compared to those receiving anticholinergics.
- Trial name
- NCT01337336
- Testing
- fluticasone propionate/salmeterol xinafoate, Anticholinergics
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Malnutrition Severe, Dementia
Drug Burden Index is Associated With Malnutrition in Community-dwelling Dementia Patients
Malnutrition leads to poor clinical outcomes in dementia patients. The investigator aimed to examine the association between drug burden index (DBI) and anticholinergic burden (ACB) scores with nutrition status in…
- Conditions
- Malnutrition Severe, Dementia, Drug Use, Anticholinergic Toxicity
- Trial name
- NCT06447259
- Where
- Turkey (Türkiye)
- Volunteers
- 415 people
- Sponsor
- Sultan Keskin Demircan
Major Depressive Disorder
Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder
Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. Scopolamine infusions produced also a significant improvement in depression that was sustained over time.
- Trial name
- NCT01613820
- Testing
- Ketamine, Scopolamine
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Overactive Bladder
Urinary Biomarkers in Overactive Bladder in Children
It is a single-center, prospective, interventional, single-arm study. Aim is to investigate which variables are significantly correlated with prolonged anticholinergic treatment (>6 months) in children with overactive bladder…
- Trial name
- NCT02704013
- Testing
- Oxybutynin
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Children's Hospital Zagreb
Overactive Bladder, Dementia
Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder
Women presenting with overactive bladder symptoms will be randomized to one of 3 arms (anticholinergic, beta-3 agonist, placebo). They will undergo baseline cognitive testing, functional MRI of the brain.
- Conditions
- Overactive Bladder, Dementia, Lower Urinary Tract Symptoms, Incontinence, Urge
- Trial name
- NCT03817931
- Testing
- Anticholinergic, Beta-3 Agonists, Adrenergic, Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Patients With Low Bladder Compliance of 20ml/H2O or Less Despite Taking Anticholinergics
Effect of Mirabegron on Bladder Compliance
In many cases of neurogenic bladder patients, bladder compliance is lowered, which is a factor that deteriorates renal function.
- Trial name
- NCT05745584
- Testing
- Mirabegron (beta3-adrenoceptor agonist), Anticholinergics
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Yonsei University
Anticholinergic Syndrome, Anticholinergic Adverse Reaction
The Effects Of Anticholinergic Burden On Daily Living Activities In Elderly Patients
The anticholinergic burden was calculated based on the medications that the patients had used for more than 10 days. Short-term medications used by patients were not evaluated.
- Conditions
- Anticholinergic Syndrome, Anticholinergic Adverse Reaction, Antispasmodic Adverse Reaction, Antiarrhythmic Drug Adverse Reaction
- Trial name
- NCT05902676
- Volunteers
- 180 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Anticholinergic Toxicity
Rivastigmine to Prevent Recurrence of Antimuscarinic Delirium
Antimuscarinic delirium (AMD) is a common and dangerous toxicology condition caused by poisoning by medications and other chemicals that block muscarinic receptors.
- Trial name
- RIVA-AP (NCT06399679)
- Testing
- Rivastigmine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Cognition
A Study to Compare Two Medications With an Inactive Medication and Look at the Effect on a Person's Mental Ability
The purpose is to compare solifenacin and oxybutynin with an inactive tablet and assess any potential effects on mental ability.
- Trial name
- SENIOR (NCT01126424)
- Testing
- Solifenacin, Oxybutynin
- Where
- 3 sites in United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Overactive Bladder
Evaluation of Autonomic System Before and After Anticholinergic Treatment in Women With Overactive Bladder
The aim of the study is to evaluate changes in autonomic nervous system following treatment with anticholinergic medication for OAB symptoms.
- Trial name
- NCT01409512
- Testing
- ECG recording
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rambam Health Care Campus
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications
Postoperative Cognitive Dysfunction in Geriatric Patients
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting.
- Conditions
- Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications, Memory Disorders
- Trial name
- NCT00512200
- Where
- Switzerland
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Male Urogenital Diseases
Early Oxybutinin Treatment for Boys With Posterior Urethral Valves
Boys with posterior urethral valves have bladder dysfunction of varying severity. Early treatment of these children with anticholinergics is recommended by some teams, although there have never been any clear studies on the…
- Trial name
- PRETIPUV (NCT04526353)
- Testing
- Oxybutynin 1 mg/ml Syrup
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Polypharmacy, Cholinergic Antagonists
DBI - Tool for Medication Reviews in Older People
Older people often use medications with anticholinergic or sedative side effects which increase the risk of falling, fractures caused by falls and cognitive impairment.
- Trial name
- NCT02317666
- Testing
- Medication Review
- Where
- Netherlands
- Volunteers
- 157 people
- Sponsor
- University of Groningen
Frailty, Fall
Frailty Status and Increased Risk for Falls
We hypothesized that the use of anticholinergic medications may precipitate falls differently by frailty status in older adults.
- Conditions
- Frailty, Fall, Anticholinergic Toxicity
- Trial name
- NCT04233541
- Testing
- Fall assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Pulmonary Disease, Chronic Obstructive
QTc Study GSK573719+GW642444
This is a randomized, placebo controlled, four period incomplete block,crossover thorough QT study to estimate the effect of repeat dose GSK573719/GW642444M (Vilanterol) combination and GSK573719 monotherapy on the QTc interval…
- Trial name
- NCT01521377
- Testing
- Moxifloxacin, GSK573719/Vilanterol 125/25mcg, GSK573719
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Glaucoma, Angle-Closure
Effect of Tiotropium on Eye Findings in the Treatment of Chronic Obstructive Pulmonary Disease
This study aimed to examine the effect of Tiotropium, which is used in the treatment of COPD, on eye symptoms.The study was conducted prospectively. Patients were examined in three groups.
- Trial name
- NCT06525051
- Testing
- Tiotropium
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Giresun University
Acute Lower Gastrointestinal Dysfunction
Should Colon or Non-colon Originated Lesions be Distinguished?
This prospective study was designed to compare the difference of effects of conventional treatment, medicine intervention, endoscopic therapy, and surgery between colon originated and non-colon originated ALGID in critical…
- Trial name
- NCT02939508
- Testing
- Colon originated: Neostigmin, Colonoscopy decompression, Surgery, Non-colon originated: Neostigmin, Colonoscopy decompression
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Chinese Medical Association
Frailty in Older Adults, Functional Decline
Prevalence of Anticholinergics in Geriatric Patients With Acute Functional Deterioration
This study investigates the anticholinergic burden on patients seen in the Subacute mobile outpatient geriatric clinic in Aalborg, Denmark, between the years of 2024 and 2025.
- Conditions
- Frailty in Older Adults, Functional Decline, Anticholinergic Syndrome
- Trial name
- NCT07165574
- Testing
- No intervention as the study is observational
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aalborg University Hospital
Postoperative Complications
The Relationship Between Anticholinergic Burden and Postoperative Complications After Cardiac Surgery in Older Adults
Drugs with anticholinergic properties are widely prescribed in the elderly population, despite increasing evidence in the literature regarding side effects and adverse outcomes.
- Trial name
- NCT05312684
- Testing
- cardiac surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Gulhane Training and Research Hospital