Clinical trials: Anti Cholinergics
COPD
Effect of a New Combination Bronchodilator on Exercise in GOLD Stage II Moderate COPD
Preliminary information from our laboratory indicated that even patients with milder chronic obstructive pulmonary disease (COPD) can have significant physiological derangements which become more pronounced during exercise…
- Trial name
- NCT01491802
- Testing
- LAMA/LABA, LAMA
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Queen's University
Rheumatoid Arthritis (RA), Anticholinergic Adverse Reaction
Anticholinergic Burden and Osteoporosis in Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory rheumatological disease. Use of corticosteroids for more than 3 months in RA treatment is considered an important risk factor in terms of developing…
- Conditions
- Rheumatoid Arthritis (RA), Anticholinergic Adverse Reaction, Fractures, Bone
- Trial name
- NCT06812481
- Testing
- Anticholinergic load was calculated using anticholinergic cognitive load (ACB)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Balikesir University
Overactive Bladder (OAB)
Postmarketing Study to Evaluate add-on Therapy With Anticholinergics in Patients With Overactive Bladder (OAB) on Mirabegron.
The objective of the study was to evaluate the safety and efficacy of add-on therapy with anticholinergics in patients with OAB on mirabegron.
- Trial name
- NCT02294396
- Testing
- Mirabegron tablet, Solifenacin tablet, Propiverine tablet
- Where
- 7 sites in Japan
- Volunteers
- 649 people
- Sponsor
- Astellas Pharma Inc
Frailty in Older Adults, Functional Decline
Prevalence of Anticholinergics in Geriatric Patients With Acute Functional Deterioration
This study investigates the anticholinergic burden on patients seen in the Subacute mobile outpatient geriatric clinic in Aalborg, Denmark, between the years of 2024 and 2025.
- Conditions
- Frailty in Older Adults, Functional Decline, Anticholinergic Syndrome
- Trial name
- NCT07165574
- Testing
- No intervention as the study is observational
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aalborg University Hospital
Postoperative Complications
Preventive Effects of Penehyclidine Hydrochloride Inhalation on Postoperative Pulmonary Complications
Postoperative pulmonary complications (PPCs) are major causes of postoperative morbidity, mortality, and prolonged hospital stay.The incidence of PPCs may be as high as 41% to 75% in high-risk patients.
- Trial name
- NCT02644876
- Testing
- Penehyclidine inhalation
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Peking University First Hospital
Older Adults (60 - 85 Years Old)
The Feasibility and Acceptability of a Collaborative Deprescribing Intervention to Reduce Anticholinergic Burden Among Hospitalised Older Patients
Why this research is important? It is estimated that over one third of all older adults are prescribed medication which are known to have "anticholinergic" side effects.
- Trial name
- DART (NCT07489677)
- Testing
- DART
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Pulmonary Disease, Chronic Obstructive
A 24-week Evaluation of GSK573719/Vilanterol (62.5/25mcg) and Components in COPD
This is a phase III multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of GSK573719/GW642444 Inhalation Powder, GSK573719 Inhalation Powder, GW642444 Inhalation…
- Trial name
- DB2113373 (NCT01313650)
- Testing
- 62.5/25mcg, 62.5mcg, 25mcg
- Where
- 165 sites in United States, Bulgaria and 11 more
- Volunteers
- 1,538 people
- Sponsor
- GlaxoSmithKline
Urinary Bladder, Neurogenic, Multiple Sclerosis
Botulinum Toxin A vs Anticholinergic Treatment of Neurogenic Overactive Bladder in Patients With Multiple Sclerosis
Botulinum toxin type A injections into the detrusor at a dose of 200 units (U) of BOTOX® are a recognized second-line treatment for the treatment of adult neurogenic lower urinary tract disorders.
- Trial name
- SEPTOX (NCT04819360)
- Testing
- VESIcare 10Mg Tablet, Botox 100 UNT Injection
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Brigitte Schürch
Overactive Bladder (OAB), Drug Delivery Systems
Transdermal Versus Oral Oxybutynin in Pediatric OAB
This is a prospective, randomized controlled clinical trial designed to compare the efficacy and safety of transdermal versus oral oxybutynin in children diagnosed with overactive bladder (OAB) who remain symptomatic despite…
- Conditions
- Overactive Bladder (OAB), Drug Delivery Systems, Anticholinergic Side Effects, Children and Adolescents, Boys and Girls
- Trial name
- NCT07081906
- Testing
- Oral Oxybutynin, transdermal oxybutinin
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Major Depressive Disorder
Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder
Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. Scopolamine infusions produced also a significant improvement in depression that was sustained over time.
- Trial name
- NCT01613820
- Testing
- Ketamine, Scopolamine
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Healthy
Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With Two Reference Products
The purpose of this study is to compare the absorption of three different inhalation products with the reference products in healthy volunteers.
- Trial name
- NCT02627625
- Testing
- Tiotropium
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Urinary Urge Incontinence
Comparison of Combination Therapy vs Single Agent Therapy for Treatment of Urge Incontinence.
This is a randomized double-blind placebo-controlled clinical trial of posterior tibial nerve stimulation (PTNS) plus extended release oxybutynin versus PTNS alone (placebo pills) in women undergoing treatment of urgency urinary…
- Trial name
- APP (NCT02176642)
- Testing
- Oxybutynin extended release, Posterior Tibial Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Duke University
Pulmonary Disease, Chronic Obstructive
Effect of GSK704838 In Healthy Volunteers
GSK704838C is a potent, pan-active mAChR antagonist, which is being developed for once-daily treatment of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00539825
- Testing
- GSK704838
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Urinary Incontinence, Bladder Dysfunction
Neuropathic Investigation and Anticholinergic Treatment of Bladder Dysfunction in Diabetes and Stroke Patients
Develop and quantify methods for evaluating bladder dysfunction in diabetes and stroke
- Trial name
- NCT00713921
- Testing
- Fesoterodine Oral Product
- Where
- United States
- Sponsor
- Saint Thomas Health
Lupus Erythematosus, Systemic, Musculoskeletal Pain
Using the Cholinergic Anti-Inflammatory Pathway to Treat Systemic Lupus Musculoskeletal Pain
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune, inflammatory disease and musculoskeletal pain is one of the most common symptoms.
- Trial name
- NCT02822989
- Testing
- Vagus nerve stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwell Health
Deprescribing Anticholinergic and Sedative Medications, Physical Function
Impact in Older Adults of Reducing Anticholinergic and Sedative Rx Burden on Physical Function Measured by Wearables
Medications with sedative or anticholinergic effects such as antidepressants, benzodiazepines, or opioids have been associated with impaired cognitive and physical function.
- Trial name
- NCT05735379
- Testing
- Deprescribing anticholinergic and sedative mediications
- Where
- Canada
- Volunteers
- 182 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Chest Pain
A Study of the Use of Combination of Anti-cholinergic and Minor Tranquilliser in the Treatment of Non-cardiac Chest Pain - a Double Blind Placebo Controlled Study
Non-cardiac chest pain is a common clinical problem encountered in our practice but at present, the results of treatments are unsatisfactory.
- Trial name
- NCT00516854
- Testing
- chlordiazepoxide 5 mg, clidinium 2.5 mg, twice daily
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Hospital Authority, Hong Kong
Acute Bronchitis
Effectiveness of Antitussives, Anticholinergics and Honey Versus Usual Care in Adults With Acute Bronchitis.
This study, which is aimed at comparing the effectiveness of 3 symptomatic therapies (dextromethorphan, ipratropium and honey) associated with usual care and the usual care in adults with acute bronchitis, is a multicentre…
- Trial name
- AB4T (NCT03738917)
- Testing
- Dextromethorphan 15 milligrams, Ipratropium Bromide 20Micrograms Inhaler, Honey 30 g (full tablespoon)
- Where
- 12 sites in Spain
- Volunteers
- 668 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Alzheimer Disease, Dementia
Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease
This study is an RCT to evaluate the effectiveness of Brain Safe on reducing anticholinergic exposure. Over 42 months, the trial will enroll 700 community-dwelling older adults who were prescribed one or more strong…
- Trial name
- NCT04121858
- Testing
- Brain Safe App, Attention Control App
- Where
- 2 sites in United States
- Volunteers
- 706 people
- Sponsor
- Indiana University
Diphenhydramine Causing Adverse Effects in Therapeutic Use, Hyperthermia
Diphenhydramine and Sweating
In 2012, it was estimated that nearly 1 in 4 Canadians suffer from allergic rhinitis. To add, 78% of individuals working in predisposing environments are predicted to develop occupational rhinitis.
- Conditions
- Diphenhydramine Causing Adverse Effects in Therapeutic Use, Hyperthermia, Allergic Rhinitis, Sweating
- Trial name
- BENEXE2022 (NCT05586477)
- Testing
- Diphenhydramine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lakehead University