Clinical trials: Anti Cholinergics
Acetylcholine, Cognition
The Role of Serum Anticholinergic Activity in ACVB Patients
Drugs with anticholinergic potential increase the risk of postoperative transient and persistent cognitive dysfunction especially in cardiac patients.
- Conditions
- Acetylcholine, Cognition, BIS-EEG
- Trial name
- NCT00782938
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Asthma, Depression
Defining and Treating Depression-related Asthma
Depression is seen more often in people with asthma, and may lead to increased development and severity of asthma. This study will investigate whether children with depression and asthma have less allergic disease and less…
- Conditions
- Asthma, Depression, Childhood Asthma
- Trial name
- NCT04617015
- Testing
- Ipratropium Bromide
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- State University of New York at Buffalo
Asthma
Study of Efficacy and Safety of NVA237 in Patients With Poorly Controlled Asthma
The study will assess efficacy, safety and tolerability of NVA237 compared to placebo in patients with poorly controlled asthma over 52 weeks of treatment.
- Trial name
- NCT02127697
- Testing
- NVA237, salbutamol/ albuterol
- Sponsor
- Novartis Pharmaceuticals
Chronic Inducible Urticaria
Study of Efficacy and Safety of Ligelizumab in Adolescents and Adults With Chronic Inducible Urticaria Who Remain Symptomatic Despite Treatment With H1- Antihistamines
This was a placebo controlled, phase 3 study designed to evaluate the efficacy and safety of ligelizumab in participants with chronic inducible urticaria who are inadequately controlled with H1-antihistamines
- Trial name
- PEARL-PROVOKE (NCT05024058)
- Testing
- Ligelizumab
- Where
- 24 sites in United States, Australia and 7 more
- Volunteers
- 39 people
- Sponsor
- Novartis Pharmaceuticals
Anticholinergic Side Effects
Reduction of Adverse Events of Anticholinergic Drugs by Multidisciplinary Medical Reviews in Norwegian Nursing Homes
Thesis: Is drug-induced anticholinergic activity additive resulting in a total anticholinergic load causing harmful side effects in old, fragile patients? Is it possible to reduce the anticholinergic load by multidisciplinary…
- Trial name
- PRADA (NCT00854438)
- Testing
- Multidisciplinary drug reviews by pharmacist and physician
- Where
- Norway
- Volunteers
- 87 people
- Sponsor
- Ullevaal University Hospital
Acute Lower Gastrointestinal Dysfunction
Should Colon or Non-colon Originated Lesions be Distinguished?
This prospective study was designed to compare the difference of effects of conventional treatment, medicine intervention, endoscopic therapy, and surgery between colon originated and non-colon originated ALGID in critical…
- Trial name
- NCT02939508
- Testing
- Colon originated: Neostigmin, Colonoscopy decompression, Surgery, Non-colon originated: Neostigmin, Colonoscopy decompression
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Chinese Medical Association
Atropine Bioequivalence
Sublingual Atropine Bioequivalence by Route of Administration (SABER)
A randomized, two-period, two-sequence, crossover study to assess the bioequivalence, bioavailability, and pharmacokinetics (PK) of a single dose of atropine administered sublingually (SL) or intramuscularly (IM) in healthy adult…
- Trial name
- SABER (NCT06366087)
- Testing
- Atropine Sulfate Ophthalmic Solution USP, 1%, Atropine Sulfate Injection, USP 8 mg/20 mL (0.4 mg/mL)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Biomedical Advanced Research and Development Authority
Overactive Bladder
AQUA: Anticholinergic Side Effects QUestionnAire
Overactive bladder syndrome (OAB) is very frequent and increase with age. Antimuscarinics allows improvement for OAB symptoms, quality of life and urodynamic parameters.
- Trial name
- AQUA (NCT04791111)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Pierre and Marie Curie University
Health, Subjective, Hyperreactivity, Bronchial
Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers
Interventional open-labeled study in parallel groups is aimed to evaluate changes of beta receptors in healthy volunteers under the influence of inhaled metacholine, long-acting anticholinergics and beta-agonists using modified…
- Trial name
- NCT04137029
- Testing
- Formoterol, Tiotropium Bromide, metacholine test
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, Pulmonology Scientific Research Institute
Schizophrenia, Schizoaffective Disorder
Anticholinergic Burden in Schizophrenia
Anticholinergic antiparkinsonian agents often cause side-effects including cognitive impairment, dry mouth, and constipation while they diminish antipsychotic-induced parkinsonian symptoms.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Delusional Disorder
- Trial name
- NCT00715377
- Testing
- Benztropine
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Centre for Addiction and Mental Health
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications
Postoperative Cognitive Dysfunction in Geriatric Patients
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting.
- Conditions
- Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications, Memory Disorders
- Trial name
- NCT00512200
- Where
- Switzerland
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Palmar Hyperhidrosis
Stellate Ganglion Block Versus Oral Medication in Treatment of Palmar Hyperhidrosis
The aim of the study is to compare between ganglion block versus combined oral anticholinergic and antidepressant drugs on treatment of palmar hyperhidrosis
- Trial name
- NCT06731101
- Testing
- Bupivacaine + Lidocaine +dexamethasone, Tryptizole + Librax
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Pulmonary Disease, Chronic Obstructive
GSK573719 Dose Ranging Study in Chronic Obstructive Pulmonary Disease
The study will evaluate the dose response, safety, and pharmacokinetics of GSK573719 compared with placebo in subjects with COPD.
- Trial name
- NCT00950807
- Testing
- Tiotropium, GSK573179
- Where
- 19 sites in United States, Germany
- Volunteers
- 176 people
- Sponsor
- GlaxoSmithKline
Urgency Urinary Incontinence
Behavioral Interventions Versus Pelvic Floor Muscle Therapy as Adjuncts to Anticholinergic Pharmacotherapy for Urgency Urinary Incontinence: A Non-Inferiority Trial
Urgency urinary incontinence (UUI) is a common condition that significantly affects women's quality of life. Pharmacotherapy is often used as first-line treatment, but its effectiveness can be limited unless combined with…
- Trial name
- NI-UUI-2025 (NCT07259148)
- Testing
- Pelvic Floor Muscle Training (PFMT), Behavioral Bladder Training Program, Oxybutynin / Mirabegron (Standardized Pharmacotherapy)
- Where
- Nicaragua
- Volunteers
- 80 people
- Sponsor
- Emilio José Dávila Álvarez
Eligible Patients Are Aged 65 Years or More Admitted to One of the Five Medicines for Older People Wards, Who Have ACB Score of 3 or More
The Feasibility and Acceptability of a Collaborative Deprescribing Intervention to Reduce Anticholinergic Burden Among Hospitalised Older Patients
The feasibility and acceptability of a collaborative deprescribing intervention to reduce anticholinergic burden among hospitalised older patients
- Trial name
- DART (NCT07599735)
- Testing
- Patients will receive a collaborative deprescribing intervention
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Southampton
Abdominal Obesity Metabolic Syndrome
Galantamine Effects in Patients With Metabolic Syndrome
It is recognized that inflammation can be modulated by cholinergic stimulation and that galantamine, an inhibitor of acetylcholinesterase enzyme with central nervous system action, has showed an anti-inflammatory effect, reducing…
- Trial name
- GALANTA-MS (NCT02283242)
- Testing
- Galantamine
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Head and Neck Surgery, Chronic Sinusitis
Sugammadex v.s. Neostigmine/Glycopyrrolate
The aim of study is to clarify the role of sugammadex in ENT surgery patients with a prior history of postoperative urinary retention, benign prostatic hypertrophy, or a history of prostate cancer, to prevent postoperative…
- Conditions
- Head and Neck Surgery, Chronic Sinusitis, Chronic Otitis Media, Laryngeal Disease
- Trial name
- NCT06398899
- Testing
- Group S: sugammadex injection, Group N: neostigmine/glycopyrrolate
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Anticholinergics, Cognitive Function
Anticholinergic Burden - Treatment Optimization
There is increasing evidence that medications with anticholinergic effects may adversely impact cognitive function. Older adults are particularly sensitive to these effects due to age-related changes in pharmacokinetics and…
- Trial name
- NCT03208569
- Where
- Sweden
- Volunteers
- 663 people, healthy volunteers welcome
- Sponsor
- Region Skane
Subjects Undergoing Flexible Bronchoscopy
A RCT to Compare the Effectiveness of Nebulized Anticholinergics for Cough Suppression During Flexible Bronchoscopy
No study has examined the role of inhaled glycopyrrolate on mucus secretion. We hypothesize that nebulized glycopyrrolate will improve bronchoscopy procedure by effectively suppressing airway mucus secretion, thereby decreasing…
- Trial name
- NAFCOF (NCT06376942)
- Testing
- Glycopyrronium, Ipratropium, Saline
- Where
- India
- Volunteers
- 1,050 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Anticholinergic Delirium, Clozapine Poisoning
Rivastigmine as an Antidote for Clozapine-induced Central Nervous System Depression and Delirium
This study aims to evaluate the clinical efficacy and safety of rivastigmine in reversing the full spectrum of anticholinergic delirium including hypoactive delirium which is presented with CNS depression and hyperactive or…
- Conditions
- Anticholinergic Delirium, Clozapine Poisoning, Antipsychotic Toxicity, CNS Depression
- Trial name
- NCT07545382
- Testing
- Rivastigmine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University