Clinical trials: Anti-Bacterial Agents
Febrile Neutropenia
Adjustment of Antibiotic Dosage in Pediatric Oncology Patients With Febrile Neutropenia and Augmented Renal Clearance
This clinical trial focuses on children with cancer who face infections after receiving chemotherapy. Chemotherapy affects the bone marrow, leading to a decrease in the production of certain white blood cells, particularly those…
- Trial name
- DAR-ARC (NCT06293677)
- Testing
- Dosage Adjustment Rules for Augmented Renal Clearance (DAR-ARC) for piperacillin-tazobactam and meropenem, Standard dosages of piperacillin-tazobactam or meropenem
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Dental Implants
Comparison Between Two Different Antibiotic Regimens for the Placement of Dental Implants
In order to prevent infections and complications, it has been initially established with the dental implant placement protocol that pre- and post-operative antibiotics should be prescribed to the patient receiving dental…
- Trial name
- NCT01851681
- Testing
- Amoxicillin
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Université de Montréal
Multidrug-Resistant Gram-Negative Bacterial Infections, Antimicrobial Resistance
The Effect of Adjunctive Melatonin With Colistin in Patients With Multidrug-Resistant Gram-Negative Bacterial Infections
This study evaluates whether adding melatonin to standard colistin therapy improves outcomes in patients with multidrug-resistant (MDR) Gram-negative bacterial infections.
- Trial name
- NCT07503600
- Testing
- Melatonin
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Amputation, Osseointegration
Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients
This will be a prospective observational trial enrolling 20 patients with osseointegrated prostheses. Participants will be recruited from the orthopaedic outpatient clinic at Walter Reed National Military Medical Center in…
- Trial name
- NCT06777511
- Testing
- 5-aminolevulinic acid (5-ALA), Photodynamic therapy (PDT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Root Canal Disinfection
Estimate the Effect of aPDT on Root Canal Disinfection
The aim of this study is to compare the clinical effect of traditional root canal disinfection and aPDT on root canal disinfection. And provide the reference for clinical application and experience.
- Trial name
- NCT02929927
- Testing
- Rubber dam isolation, aPDT, 1% iodine tincture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Infection Rate After Fingertip Amputation
Prophylactic Antibiotic in Treatment of Fingertip Amputation
Fingertip amputation is a common injury. Considerable controversy exists as to whether prophylactic antibiotics are necessary for this injury.
- Trial name
- NCT02077400
- Testing
- Cephazolin
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Lower Resp Tract Infection
An Algorithm to Decide on Antibiotic Prescription in Lower Respiratory Tract Infection in Primary Care
The study is randomized clustered pragmatic trial whose objective is to decrease unnecessary antibiotic prescription in adult patients with lower respiratory tract infection managed at primary care level in Switzerland, using a…
- Trial name
- UltraPro (NCT03191071)
- Testing
- UltraPro, Procalcitonin, Blood sampling
- Where
- Switzerland
- Volunteers
- 469 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Helicobacter Eradication
Prospective Study : Helicobacter Pylori Eradication Therapy in Accordance With Past Antibiotics Use
Prospective study : Helicobacter pylori eradication therapy in accordance with past antibiotics use.
- Trial name
- NCT01938534
- Testing
- Helicobacter pylori eradication
- Where
- South Korea
- Volunteers
- 440 people
- Sponsor
- Ajou University School of Medicine
Dental Pulp Cavity
Evaluation of Triple Antibiotic Paste Pulp Therapy Compared to Vitapex in Primary Molars.
The aim of the study was to compare the clinical and radiographic success of triple antibiotic paste (TAP) which includes (metronidazole, ciprofloxacin, and minocycline) and Vitapex (calcium hydroxide/iodoform paste) for root…
- Trial name
- NCT04547764
- Testing
- triple antibiotic paste (TAP), Vitapex (calcium hydroxide/iodoform paste)
- Where
- Saudi Arabia
- Volunteers
- 54 people
- Sponsor
- King Abdulaziz University
Sinusitis
Sinuclean's Treatment Of Sinusitis' Symptoms
The goal of the study is to demonstrate that SINUclean DM® spray, added to the standard (amoxicillin/clavulanate) therapy of the acute episode of sinusitis (acute, subacute or chronic), is safe ad capable to determine the…
- Trial name
- SToSS (NCT00747747)
- Testing
- Saline solution, Sinuclean DM Spray
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Galsor S.r.l.
Irreversible Pulpitis
Effect of Temperature Elevation on the Antimicrobial Efficacy of Two Root Canal Irrigants in Primary Root Canal Infections: A Randomized Controlled Clinical Trial
evaluate the antimicrobial efficacy of preheated sodium hypochlorite and dexamethasone sodium phosphate and at room temperature in patients with primary root canal infection.
- Trial name
- NCT07906925
- Testing
- Dexamethasone Sodium Phosphate 10 MG/ML, Sodium Hypochlorite 2,5%
- Volunteers
- 40 people
- Sponsor
- Tanta University
Acute Kidney Insufficiency, Anti-Infective Agent Toxicity
Computer-based Dosage Calculation for Antibiotics
Adequate dosing of antiinfective therapy in critically ill patients with impaired or lost renal function or continuous renal replacement therapy is nearly impossible without measuring the drug concentration in blood samples.
- Trial name
- NCT03036826
- Testing
- Piperacillin/tazobactam, Meropenem
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
Dental Pulp Diseases, Dental Pulp Necrosis
Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy
The purpose of this study is to to compare root canal therapy success between two root canal filler materials: 1) gutta percha (GP), 2) gutta percha modified with nanodiamonds and amoxicillin (NDGX).
- Conditions
- Dental Pulp Diseases, Dental Pulp Necrosis, Nerve Root Pain Nec
- Trial name
- NDGX (NCT03376984)
- Testing
- ND and AMOX modified Gutta Percha, Gutta Percha
- Where
- United States
- Sponsor
- University of California, Los Angeles
Mutans Streptococci, Oral Health
Antimicrobial Effect of Different Pastes on Streptococcus Mutans in Children
This study is a randomized controlled trial involving 127 children ages between 4 and 5 years to investigate the efficacy of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in reducing Streptococcus mutans (S.
- Trial name
- NCT03526315
- Testing
- CPP-ACP paste, Fluoride toothpaste, Both (Fluoride and CPP-ACP)
- Where
- Jordan
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Antibiotic Prescribing for Acute Respiratory-tract Infections
Effect of CRP and SAA Point-of-care Testing on Antibiotic Prescribing for Acute Respiratory-tract Infections
The study was a practical, cluster-randomized controlled trial to evaluate the impact of CRP and SAA point-of-care testing (CRP\&SAA POCT) on antibiotic prescribing in patients with acute respiratory-tract infections (ARI) at…
- Trial name
- NCT06568432
- Testing
- CRP+SAA POCT
- Where
- China
- Volunteers
- 35,108 people
- Sponsor
- Huazhong University of Science and Technology
Urothelial Carcinoma, Urothelial Carcinoma Recurrent
uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto
The purpose of this registry is to evaluate real world experience and outcomes of patients with Upper Tract Urothelial Cancer (UTUC) treated with Jelmyto in the United States.
- Conditions
- Urothelial Carcinoma, Urothelial Carcinoma Recurrent, Urothelial Carcinoma Ureter, Urothelial Carcinoma Ureter Recurrent
- Trial name
- uTRACT (NCT05874921)
- Testing
- Jelmyto (mitomycin) for pyelocalyceal solution
- Where
- 22 sites in United States
- Volunteers
- 450 people
- Sponsor
- UroGen Pharma Ltd.
Antibiotic Reaction
Antimicrobial Resistance Rate In Escherichia Coli And Klebsiella Pneumonia : A Retrospective Study
Antibiotics are medicines used to avoid and treat bacterial infections. Antibiotic resistance is increasing to dangerous level globally.
- Trial name
- NCT04196387
- Testing
- urine culture
- Volunteers
- 1,000 people
- Sponsor
- Batool Mutar
Catheter-Related Infections
Expanded Access: Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI
This is an Intermediate-Size Expanded Access, Open-Label Study for Use of Mino-Lok Therapy (MLT) in Combination with Systemic Antibiotics in the Treatment of Central Line Associated Bloodstream Infection.
- Trial name
- MLK (NCT04513821)
- Testing
- Mino-Lok Therapy (MLT)
- Where
- 30 sites in United States, Puerto Rico
- Sponsor
- Leonard-Meron Biosciences, Inc.
Postoperative Infection
RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section
Background Women undergoing Caesarean Section (CS) have an increased risk of postpartum infections compared to women undergoing vaginal delivery. In Denmark the incidence of post-CS infections is 7-10%.
- Trial name
- APIPICS (NCT02009098)
- Testing
- Cefuroxime
- Where
- 3 sites in Denmark
- Sponsor
- Odense University Hospital
Tonsillectomy
Effect of Duration of Antibiotic Therapy on Recovery Following Tonsillectomy
To determine whether a 3-day course of postoperative antibiotics is effective as a 7-day course in reducing pain and reducing time to resumption of normal diet and activity following pediatric tonsillectomy
- Trial name
- NCT00662987
- Testing
- 7 days of amoxicillin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
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